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1. 发明授权

US07049103B2 Method of evaluating drug efficacy and toxicity 失效
公开(公告)号：US07049103B2
公开(公告)日：2006-05-23
申请号：US10266605
申请日：2002-10-09
申请人： Takahiko Ishiguro , Kiyoshi Yasukawa , Shigeo Tsuchiya
发明人： Takahiko Ishiguro , Kiyoshi Yasukawa , Shigeo Tsuchiya
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： G01N33/5014 , C12Q2600/158 , G01N2800/52
摘要： A method of assaying the efficacy and/or toxicity of a test substance by expression of a specific gene in a cell or a microorganism, which comprises treating the cell or the microorganism with the test substance, a step of amplifying an RNA having a sequence homologous or complementary to a specific sequence in a target RNA obtained as the result of transcription of the specific gene, and a step of determining whether the target RNA is transcribed through the expression of the specific gene by detecting the RNA amplified in the previous amplification step.

2. 发明申请

US20100196962A1 IL-6 RECEPTOR IL-6 DIRECT FUSION PROTEIN 有权
标题翻译： IL-6受体IL-6直接融合蛋白
公开(公告)号：US20100196962A1
公开(公告)日：2010-08-05
申请号：US12407170
申请日：2009-03-19
申请人： Teiji EKIDA , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
发明人： Teiji EKIDA , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
IPC分类号： C12P21/00 , C07H21/04 , C12N1/19
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C12N2501/125
摘要： The present invention intends to provide an IL-6R.IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker.The IL-6 receptor.IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.
摘要翻译：本发明意图提供IL-6R.IL-6融合蛋白等，其中IL-6R和IL-6直接连接而不连接。本发明的IL-6受体-IL-6融合蛋白具有构成IL-6受体的一个氨基酸残基和构成IL-6的一个氨基酸残基直接结合的结构。

3. 发明授权

US07105319B2 Oligonucleotides for detecting tubercle bacillus and method therefor 失效
标题翻译：用于检测结核杆菌的寡核苷酸及其方法
公开(公告)号：US07105319B2
公开(公告)日：2006-09-12
申请号：US10381256
申请日：2002-07-24
申请人： Shigeo Tsuchiya , Noriyoshi Masuda , Takahiro Maruyama , Takao Matsuba , Takahiko Ishiguro
发明人： Shigeo Tsuchiya , Noriyoshi Masuda , Takahiro Maruyama , Takao Matsuba , Takahiko Ishiguro
IPC分类号： C12P19/34
CPC分类号： C12Q1/689
摘要： An oligonucleotide, capable of specific cleavage and amplification of a pab gene which codes for pab, an antigenic protein of Mycobacterium tuberculosis, or an RNA derived therefrom, as well as being useful in high sensitive detection and identification thereof, is provided. Further, a combination of oligonucleotides, useful in specific amplification, high sensitive detection and identification of an RNA derived from Mycobacterium tuberculosis pab gene as well as a process for detecting Mycobacterium tuberculosis by using said combination, are provided.
摘要翻译：提供了能够特异性切割和扩增编码pab的pab基因，结核分枝杆菌的抗原性蛋白质或其衍生的RNA的寡核苷酸，并且可用于高灵敏度检测和鉴定。此外，提供了可用于特异性扩增的寡核苷酸，来自结核分枝杆菌pab基因的RNA的高灵敏度检测和鉴定以及通过使用所述组合检测结核分枝杆菌的方法的组合。

4. 发明授权

US07901911B2 Polynucleotide encoding IL-6 receptor/IL-6 fusion protein 有权
标题翻译：编码IL-6受体/ IL-6融合蛋白的多核苷酸
公开(公告)号：US07901911B2
公开(公告)日：2011-03-08
申请号：US12407170
申请日：2009-03-19
申请人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
发明人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
IPC分类号： C12N5/10 , C12N15/24 , C12N15/62
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C12N2501/125
摘要： The present invention intends to provide an IL-6R.IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker.The IL-6 receptor.IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.
摘要翻译：本发明意图提供IL-6R.IL-6融合蛋白等，其中IL-6R和IL-6直接连接而不连接。本发明的IL-6受体-IL-6融合蛋白具有构成IL-6受体的一个氨基酸残基和构成IL-6的一个氨基酸残基直接键合的结构。

5. 发明授权

US07531644B2 IL-6 receptor•IL-6 direct fusion protein 有权
标题翻译： IL-6受体.IL-6直接融合蛋白
公开(公告)号：US07531644B2
公开(公告)日：2009-05-12
申请号：US11544639
申请日：2006-10-10
申请人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
发明人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
IPC分类号： C07K14/52 , C07K14/705
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C12N2501/125
摘要： The present invention intends to provide an IL-6R•IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker.The IL-6 receptor•IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.
摘要翻译：本发明意图提供IL-6R.IL-6融合蛋白等，其中IL-6R和IL-6直接连接而不连接。本发明的IL-6受体-IL-6融合蛋白具有构成IL-6受体的一个氨基酸残基和构成IL-6的一个氨基酸残基直接结合的结构。

6. 发明申请

US20070031376A1 IL-6 receptor. IL-6 direct fusion protein 有权
标题翻译： IL-6受体。 IL-6直接融合蛋白
公开(公告)号：US20070031376A1
公开(公告)日：2007-02-08
申请号：US11544639
申请日：2006-10-10
申请人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
发明人： Teiji Ekida , Harutaka Yagame , Hiroshi Iida , Kiyoshi Yasukawa , Shigeo Tsuchiya , Teruhiko Ide
IPC分类号： A61K38/20 , C07K14/715 , C07K14/54 , C07H21/04 , C12P21/04 , C12N1/18 , C12N15/74
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C12N2501/125
摘要： The present invention intends to provide an IL-6R•IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker. The IL-6 receptor•IL-6 fusion protein of the present invention has a structure in which one amino:acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.
摘要翻译：本发明意图提供IL-6R.IL-6融合蛋白等，其中IL-6R和IL-6直接连接而不连接。本发明的IL-6受体-IL-6融合蛋白具有构成IL-6受体的一个氨基酸残基和构成IL-6的一个氨基酸残基直接结合的结构。

7. 发明授权

US06111832A Disk discrimination method and device 失效
标题翻译：磁盘鉴别方法及装置
公开(公告)号：US06111832A
公开(公告)日：2000-08-29
申请号：US961099
申请日：1997-10-30
申请人： Shigeo Tsuchiya , Tatsuro Shimizu , Hiroshi Nakane
发明人： Shigeo Tsuchiya , Tatsuro Shimizu , Hiroshi Nakane
IPC分类号： G11B7/00 , G11B7/004 , G11B7/085 , G11B7/09 , G11B7/135 , G11B19/12
CPC分类号： G11B7/1372 , G11B19/125 , G11B7/085 , G11B7/08511 , G11B7/0945 , G11B7/126 , G11B2007/0006 , G11B2007/0013 , G11B7/0925 , G11B7/0943
摘要： An optical disk has a reflecting layer and a transparent substrate formed on the reflecting layer. The type of the optical disk changes depending on the physical characteristics of the reflecting layer and the thickness of the transparent substrate. When discriminating such a disk, an objective lens which focuses an optical beam on the disk is moved toward the disk. Along with this movement, a detection signal that detects an optical beam reflected by the disk generates a detection signal. First, a peak accompanying mirror surface reflection of the surface of the disk appears, and then a peak accompanying reflection of the reflecting layer appears. The type of the disk which concerns the transparent substrate of the optical disk is discriminated from the time interval between the two peaks. The characteristics and reflection level of the RF component of detection signal generated by the detector change in accordance with the count of reflecting layers and the reflectance of the reflecting layer(s). This discriminates the physical characteristics of the reflecting surface and the type of the optical disk. In this manner, with the disk type discrimination method and device according to the present invention, discrimination can be performed within a substantially constant, short period of time after the disk is set in the device until the disk is recognized.
摘要翻译：光盘具有形成在反射层上的反射层和透明基板。光盘的类型根据反射层的物理特性和透明基板的厚度而变化。当识别这样的盘时，将光束聚焦在盘上的物镜朝向盘移动。随着这种移动，检测由盘反射的光束的检测信号产生检测信号。首先，出现伴随镜面表面反射的峰的峰值，然后出现伴随反射层反射的峰。与两个峰值之间的时间间隔区分与光盘的透明基板相关的盘的类型。由检测器产生的检测信号的RF分量的特性和反射水平根据反射层的数量和反射层的反射率而变化。这鉴别出反射面的物理特性和光盘的种类。以这种方式，利用根据本发明的盘类型识别方法和装置，可以在将盘设置在装置中之后的基本上恒定的短时间内进行判别，直到盘被识别为止。

8. 发明申请

US20140114260A1 MEDICAL TUBE 有权
标题翻译：医用管
公开(公告)号：US20140114260A1
公开(公告)日：2014-04-24
申请号：US14126123
申请日：2012-08-08
申请人： Yuta Kawakatsu , Shigeo Tsuchiya , Masaharu Yamada , Tomoya Ohashi , Wataru Takahama
发明人： Yuta Kawakatsu , Shigeo Tsuchiya , Masaharu Yamada , Tomoya Ohashi , Wataru Takahama
IPC分类号： A61L33/00 , A61L33/06 , A61L33/08
CPC分类号： A61L33/0094 , A61L29/16 , A61L33/0011 , A61L33/068 , A61L33/08 , A61L2300/42 , A61M1/3673 , A61M25/0009 , A61M25/0045 , A61M39/08 , A61M2025/0047 , A61M2205/0238 , F04C2270/041 , C08L33/08
摘要： The present invention provides a medical tube mainly comprising a thermoplastic resin wherein the surface contacting the blood has been subjected to a heparinizing treatment and wherein quality defect due to whitening and oil defect is reduced.According to the present invention, there is provided a medical tube wherein an antithrombotic material is coated on the inner surface of a tube prepared by a melt extrusion molding of a composition comprising a thermoplastic resin and a plasticizer, characterized in that the difference (ΔL) between the brightness of the medical tube before coating and the brightness of the medical tube after coating measured in accordance with JIS Z 8722 is 1 or less.
摘要翻译：本发明提供一种主要包含热塑性树脂的医疗管，其中与血液接触的表面已进行肝素化处理，并且其中由于美白和油缺陷引起的质量缺陷降低。根据本发明，提供了一种医用管，其中抗血栓形成材料被涂覆在通过包含热塑性树脂和增塑剂的组合物的熔融挤出成型制备的管的内表面上，其特征在于，差异（＆Dgr; 涂布前的医疗管的亮度与根据JIS Z 8722测定的涂敷后的医疗用管的亮度之比L为1以下。

9. 发明申请

US20100035331A1 METHOD FOR EXTRACTING OF NUCLEIC ACID FROM BIOLOGICAL MATERIAL 审中-公开
标题翻译：从生物材料中提取核酸的方法
公开(公告)号：US20100035331A1
公开(公告)日：2010-02-11
申请号：US12162997
申请日：2007-02-14
申请人： Shigeo Tsuchiya , Toshinori Hayashi
发明人： Shigeo Tsuchiya , Toshinori Hayashi
IPC分类号： C12N1/08
CPC分类号： C12N15/1006
摘要： A method of extracting biological material-derived nucleic acid from samples containing biological material, the method comprising mixing biological material with an aqueous solution containing at least a surfactant, subjecting the mixture to heating treatment and then removing the aqueous solution to separate the biological material, adding a solid powder suspension to the biological material, agitating or sonicating it to disrupt the biological material, and extracting nucleic acid from the biological material.
摘要翻译：一种从含有生物材料的样品中提取生物材料衍生的核酸的方法，所述方法包括将生物材料与至少含有表面活性剂的水溶液混合，对混合物进行加热处理，然后除去水溶液以分离生物材料，向生物材料中加入固体粉末悬浮液，搅拌或超声处理以破坏生物材料，并从生物材料中提取核酸。

10. 发明授权

US09295763B2 Medical tube 有权
标题翻译：医用管
公开(公告)号：US09295763B2
公开(公告)日：2016-03-29
申请号：US14126123
申请日：2012-08-08
申请人： Yuta Kawakatsu , Shigeo Tsuchiya , Masaharu Yamada , Tomoya Ohashi , Wataru Takahama
发明人： Yuta Kawakatsu , Shigeo Tsuchiya , Masaharu Yamada , Tomoya Ohashi , Wataru Takahama
IPC分类号： A61M5/32 , A61L33/00 , A61L33/06 , A61L33/08 , A61L29/16 , A61M39/08 , A61M1/36 , A61M25/00
CPC分类号： A61L33/0094 , A61L29/16 , A61L33/0011 , A61L33/068 , A61L33/08 , A61L2300/42 , A61M1/3673 , A61M25/0009 , A61M25/0045 , A61M39/08 , A61M2025/0047 , A61M2205/0238 , F04C2270/041 , C08L33/08
摘要： The present invention provides a medical tube mainly comprising a thermoplastic resin wherein the surface contacting the blood has been subjected to a heparinizing treatment and wherein quality defect due to whitening and oil defect is reduced.According to the present invention, there is provided a medical tube wherein an antithrombotic material is coated on the inner surface of a tube prepared by a melt extrusion molding of a composition comprising a thermoplastic resin and a plasticizer, characterized in that the difference (ΔL) between the brightness of the medical tube before coating and the brightness of the medical tube after coating measured in accordance with JIS Z 8722 is 1 or less.
摘要翻译：本发明提供一种主要包含热塑性树脂的医疗管，其中与血液接触的表面已进行肝素化处理，并且其中由于美白和油缺陷引起的质量缺陷降低。根据本发明，提供了一种医用管，其中抗血栓形成材料被涂覆在通过包含热塑性树脂和增塑剂的组合物的熔融挤出成型制备的管的内表面上，其特征在于，差异（＆Dgr; 涂布前的医疗管的亮度与根据JIS Z 8722测定的涂敷后的医疗用管的亮度之比L为1以下。

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