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1. 发明申请

US20080299664A1 Reagent For Lead Assay 审中-公开
标题翻译：铅分析试剂
公开(公告)号：US20080299664A1
公开(公告)日：2008-12-04
申请号：US11571035
申请日：2005-07-28
申请人： Takaharu Asano , Naoki Harada
发明人： Takaharu Asano , Naoki Harada
IPC分类号： G01N33/20
CPC分类号： G01N31/22 , C07D487/22
摘要： A reagent for lead assay whereby a lead concentration can be accurately assayed even if an analyte contains calcium ions, and a method for assaying the lead concentration using the reagent for lead assay are provided. The reagent for lead assay contains a porphyrin nucleus-incorporated polymer, which is obtained by radical copolymerization of a porphyrin compound with a vinylene monomer, and calcium ions.
摘要翻译：即使分析物含有钙离子也可以准确测定铅浓度的铅测定用试剂，提供使用铅测定用试剂测定铅浓度的方法。用于铅测定的试剂含有通过卟啉化合物与亚乙烯基单体的自由基共聚和钙离子获得的引入卟啉核的聚合物。

2. 发明申请

US20120215109A1 ULTRASONIC DIAGNOSTIC SYSTEM 审中-公开
标题翻译：超声诊断系统
公开(公告)号：US20120215109A1
公开(公告)日：2012-08-23
申请号：US13505140
申请日：2010-11-10
申请人： Naoto Kubota , Norihiro Koizumi , Hongen Liao , Takaharu Asano , Kazuhito Yuhashi , Mamoru Mitsuishi , Shin Ohnishi , Takashi Mochizuki , Ichiro Sakuma , Takashi Kadowaki
发明人： Naoto Kubota , Norihiro Koizumi , Hongen Liao , Takaharu Asano , Kazuhito Yuhashi , Mamoru Mitsuishi , Shin Ohnishi , Takashi Mochizuki , Ichiro Sakuma , Takashi Kadowaki
IPC分类号： A61B8/14 , A61B5/107
CPC分类号： A61B8/5223 , A61B5/4872 , A61B8/085 , A61B8/0858 , A61B8/14 , A61B8/4209 , A61B8/4227
摘要： When an amount of visceral fat is measured using ultrasonic waves during medical examination of metabolic syndrome, three contact positions are defined on the surface of the abdominal region, and three distances inside the living body are measured by bringing a probe into contact with the surface of the abdominal region at the contact positions. Specifically, three measurement paths having a starting point at the center of the descending aorta are set, and the distances from the center to a surface of the fat layer adjacent to the surface of the body (inner surface of the subcutaneous layer) in the measurement paths are observed. An approximate area of a visceral fat region can be determined from the three distances and two angles defined by the three measurement paths, and an index value is calculated on the basis of the area. A probe holder having three holding portions is desirably used.
摘要翻译：当在代谢综合征的体格检查期间使用超声波测量内脏脂肪的量时，在腹部区域的表面上限定三个接触位置，并且通过使探针与表面接触来测量活体内的三个距离在接触位置的腹部区域。具体而言，设定在下降主动脉中心具有起点的三个测量路径，并且测量与测量中的与身体表面（皮下层的内表面）相邻的脂肪层的中心到表面的距离观察路径。可以从由三个测量路径定义的三个距离和两个角度确定内脏脂肪区域的近似区域，并且基于面积计算指数值。期望使用具有三个保持部的探针保持器。

3. 发明申请

US20090263907A1 REAGENT FOR LEAD CONCENTRATION DETERMINATION AND METHOD OF DETERMINING LEAD CONCENTRATION 审中-公开
标题翻译：铅浓度测定试剂和铅浓度测定方法
公开(公告)号：US20090263907A1
公开(公告)日：2009-10-22
申请号：US12377476
申请日：2007-08-27
申请人： Takaharu Asano , Katsumi Yabusaki , Keiichi Mizushina
发明人： Takaharu Asano , Katsumi Yabusaki , Keiichi Mizushina
IPC分类号： G01N33/20
CPC分类号： G01N31/22 , G01N21/77
摘要： To provide a lead concentration determination reagent which realizes accurate determination of the lead concentration of a sample solution in a simple manner with safety, even when the sample solution contains zinc ions, and a lead concentration determination method making use of the reagent.The lead concentration determination reagent contains (A) a porphyrin derivative and (B) at least one species selected from among ethylenediamine-N,N′-dipropionic acid, ethylenediamine-N,N′-diacetic acid, and 1,6-diaminohexane-N,N,N′,N′-tetraacetic acid.
摘要翻译：为了提供铅浓度测定试剂，即使在样品溶液含有锌离子的情况下，也能够以简单的方式实现对样品溶液的铅浓度的准确测定，以及利用试剂的铅浓度测定方法。铅浓度测定试剂含有（A）卟啉衍生物和（B）至少一种选自乙二胺-N，N'-二丙酸，乙二胺-N，N'-二乙酸和1,6-二氨基己烷 - N，N，N'，N'-四乙酸。

4. 发明授权

US06437067B1 Porphyrin-nucleus introduced polymers 失效
标题翻译：卟啉 - 核引入聚合物
公开(公告)号：US06437067B1
公开(公告)日：2002-08-20
申请号：US09996563
申请日：2001-11-30
申请人： Takaharu Asano , Hiroshi Nakao
发明人： Takaharu Asano , Hiroshi Nakao
IPC分类号： C08F12606
CPC分类号： C08F216/08 , C08F226/06
摘要： Provided are porphyrin-nucleus introduced polymers obtained by radical copolymerization of a radically polymerizable monomer with a porphyrin compound represented by formula (1) or (2): where R represents a hydrogen atom or a C1-6 alkyl group. Also provided are a trace metal measuring reagent and a trace metal removing agent, each containing the porphyrin-nucleus introduced polymer. The porphyrin-nucleus introduced polymer can be obtained as a compound having desired properties or reactivity by making use of easily available porphyrin compounds. The polymer is useful as a reagent for measuring or an agent for removing heavy metals.
摘要翻译：提供了通过自由基聚合性单体与式（1）或（2）表示的卟啉化合物自由基共聚获得的卟啉 - 核引入聚合物：其中R表示氢原子或C1-6烷基。还提供了痕量金属测定试剂和痕量金属去除剂，每种试剂含有引入卟啉 - 核的聚合物。通过使用容易获得的卟啉化合物，可以获得引入卟啉 - 核的聚合物作为具有所需性质或反应性的化合物。聚合物可用作测量试剂或用于除去重金属的试剂。

5. 发明申请

US20130309704A1 METHOD AND APPARATUS FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE DERIVED FROM ORGANISM 审中-公开
标题翻译：用于测量从有机体衍生的生理活性物质的方法和装置
公开(公告)号：US20130309704A1
公开(公告)日：2013-11-21
申请号：US13981893
申请日：2012-01-26
申请人： Katsuya Inada , Shigeatsu Endo , Taisuke Hirono , Takaharu Asano
发明人： Katsuya Inada , Shigeatsu Endo , Taisuke Hirono , Takaharu Asano
IPC分类号： G01N21/82
CPC分类号： G01N21/82 , G01N33/54313 , G01N33/54393 , G01N33/579
摘要： The purpose of the present invention is to improve the measurement accuracy in the measurement of the concentration of a physiologically active biological substance in a sample by a stirring turbidimetry, a light scattering method or an AL-bound beads method, wherein the purpose can be achieved by preventing the occurrence of aggregation or gelation that is caused by the stirring of a mixed solution and is not associated with the physiologically active substance. AL is mixed with a sample containing a physiologically active biological substance, and the aggregation of a protein which is associated with the reaction between AL and the physiologically active substance in the mixed solution is detected while stirring the mixed solution, wherein the occurrence of the aggregation or gelation of a protein which is not associated with the reaction between AL and the physiologically active substance in the mixed solution can be prevented by adding a specific protein that has been heated in advance and/or a specific surfactant to the mixed solution.
摘要翻译：本发明的目的是通过搅拌比浊法，光散射法或AL结合珠法提高测定生物活性生物物质浓度的测量精度，其目的是实现通过防止混合溶液的搅拌引起的聚集或凝胶化的发生，与生理活性物质不相关。将AL与含有生理活性生物物质的样品混合，并在搅拌混合溶液的同时检测与混合溶液中AL与生理活性物质之间的反应相关的蛋白质的聚集，其中发生聚集或者与混合溶液中的AL与生理活性物质的反应无关的蛋白质的凝胶化可以通过将预先加热的特定蛋白质和/或特定的表面活性剂加入到混合溶液中来防止。

6. 发明授权

US08133739B2 Reagent for measurement of concentration of lead, and method for measurement of concentration of lead 失效
标题翻译：铅浓度测定用试剂，铅浓度测定方法
公开(公告)号：US08133739B2
公开(公告)日：2012-03-13
申请号：US12669572
申请日：2008-07-18
申请人： Takaharu Asano
发明人： Takaharu Asano
IPC分类号： G01N21/00
CPC分类号： G01N31/22
摘要： To provide a lead concentration determination reagent which realizes accurate, high-sensitivity, and simple-manner determination of the lead ion concentration (also referred to simply as “lead concentration”) of a sample solution in the presence of calcium ions, and a lead concentration determination method employing the reagent. The lead concentration determination reagent contains (A) a water-soluble porphyrin derivative or a salt thereof, (B) at least one member selected from among polyacrylamide, polyvinyl alcohol, and polyethylene glycol, and (C) a calcium-ion-supplying compound.
摘要翻译：提供铅浓度测定试剂，其在钙离子存在下实现对样品溶液的铅离子浓度（也称为“铅浓度”）的精确，高灵敏度和简单的测定，以及铅浓度测定方法。铅浓度测定试剂含有（A）水溶性卟啉衍生物或其盐，（B）选自聚丙烯酰胺，聚乙烯醇和聚乙二醇中的至少一种，（C）钙离子供给化合物。

7. 发明申请

US20100184234A1 REAGENT FOR MEASUREMENT OF CONCENTRATION OF LEAD, AND METHOD FOR MEASUREMENT OF CONCENTRATION OF LEAD 失效
标题翻译：用于测量铅浓度的试剂和测量铅浓度的方法
公开(公告)号：US20100184234A1
公开(公告)日：2010-07-22
申请号：US12669572
申请日：2008-07-18
申请人： Takaharu Asano
发明人： Takaharu Asano
IPC分类号： G01N21/00
CPC分类号： G01N31/22
摘要： To provide a lead concentration determination reagent which realizes accurate, high-sensitivity, and simple-manner determination of the lead ion concentration (also referred to simply as “lead concentration”) of a sample solution in the presence of calcium ions, and a lead concentration determination method employing the reagent.The lead concentration determination reagent contains (A) a water-soluble porphyrin derivative or a salt thereof, (B) at least one member selected from among polyacrylamide, polyvinyl alcohol, and polyethylene glycol, and (C) a calcium-ion-supplying compound.
摘要翻译：提供铅浓度测定试剂，其在钙离子存在下实现对样品溶液的铅离子浓度（也称为“铅浓度”）的精确，高灵敏度和简单的测定，以及铅浓度测定方法。铅浓度测定试剂含有（A）水溶性卟啉衍生物或其盐，（B）选自聚丙烯酰胺，聚乙烯醇和聚乙二醇中的至少一种，（C）钙离子供给化合物。

8. 发明授权

US06515089B1 Trace metal measuring method 失效
标题翻译：痕量金属测量方法
公开(公告)号：US06515089B1
公开(公告)日：2003-02-04
申请号：US09996564
申请日：2001-11-30
申请人： Takaharu Asano , Hiroshi Nakao
发明人： Takaharu Asano , Hiroshi Nakao
IPC分类号： C08F12606
CPC分类号： G01N21/31 , G01N31/22
摘要： Provided are a method, upon radical copolymerization of a vinyl-containing porphyrin compound and a radically polymerizable monomer, thereby obtaining a porphyrin-nucleus introduced polymer, of controlling reactivity of the porphyrin-nucleus introduced polymer with a metal by selecting the radically polymerizable monomer; and a method for measuring a trace metal by measuring a change in absorbance caused by a complex forming reaction between a porphyrin-nucleus introduced polymer, which has been obtained by radical copolymerization of a vinyl-containing porphyrin compound and a radically polymerizable monomer, and a heavy metal ion, the radically polymerizable monomer being selected so as to heighten reaction selectivity of the porphyrin-nucleus introduced polymer to a metal to be measured. The present invention makes it possible to control the properties or reactivity of the porphyrin-nucleus introduced polymers, which have been obtained from easily available porphyrin compounds without any modification, and by making use of this technique, to provide a highly sensitive method for measuring heavy metals.
摘要翻译：提供了一种使含乙烯基的卟啉化合物和可自由基聚合的单体自由基共聚的方法，从而获得引入卟啉 - 核的聚合物，通过选择可自由基聚合的单体来控制卟啉 - 核引入的聚合物与金属的反应性; 以及通过测量由含乙烯基的卟啉化合物与可自由基聚合的单体的自由基共聚获得的卟啉 - 引入的聚合物之间的络合物形成反应引起的吸光度变化的痕量金属测定方法，重金属离子，可自由基聚合的单体被选择以提高引入卟啉 - 核的聚合物对待测金属的反应选择性。本发明使得可以通过使用这种技术来控制从容易获得的卟啉化合物获得的卟啉 - 核引入聚合物的性质或反应性，并且通过使用这种技术来提供测量重的高灵敏度的方法金属。

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