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1. 发明授权

US08512940B2 Method for preserving liver in a solution comprising dibutyryl cAMP 有权
标题翻译：在包含二丁酰cAMP的溶液中保存肝脏的方法
公开(公告)号：US08512940B2
公开(公告)日：2013-08-20
申请号：US13222407
申请日：2011-08-31
申请人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Koichi Tanaka , Masami Nakamura
发明人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Koichi Tanaka
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved, liver transplantation can be performed with a high engrafted rate.
摘要翻译：本发明提供含有海藻糖和二丁酰基cAMP的肝保存液。保存溶液中硝酸甘油的含量优选低于0.44mM。在本发明的肝保存液中，由于在肝脏保存期间观察到的硝酸甘油的毒性已经得到改善，因此可以以高的移植率进行肝移植。

2. 发明申请

US20110311959A1 SOLUTION FOR PRESERVING LIVER 有权
标题翻译：解决方案保存肝脏
公开(公告)号：US20110311959A1
公开(公告)日：2011-12-22
申请号：US13222407
申请日：2011-08-31
申请人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Masami Nakamura , Koichi Tanaka
发明人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Masami Nakamura , Koichi Tanaka
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved, liver transplantation can be performed with a high engrafted rate.
摘要翻译：本发明提供含有海藻糖和二丁酰基cAMP的肝保存液。保存溶液中硝酸甘油的含量优选低于0.44mM。在本发明的肝保存液中，由于在肝脏保存期间观察到的硝酸甘油的毒性已经得到改善，因此可以以高的移植率进行肝移植。

3. 发明申请

US20090239206A1 SOLUTION FOR PRESERVING LIVER 审中-公开
标题翻译：解决方案保存肝脏
公开(公告)号：US20090239206A1
公开(公告)日：2009-09-24
申请号：US12083503
申请日：2006-10-12
申请人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Masami Nakamura , Koichi Tanaka
发明人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Masami Nakamura , Koichi Tanaka
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved, liver transplantation can be performed with a high engrafted rate.
摘要翻译：本发明提供含有海藻糖和二丁酰基cAMP的肝保存液。保存溶液中硝酸甘油的含量优选低于0.44mM。在本发明的肝保存液中，由于在肝脏保存期间观察到的硝酸甘油的毒性已经得到改善，因此可以以高的移植率进行肝移植。

4. 发明申请

US20090246212A1 DEVELOPMENT OF METHOD FOR SCREENING FOR DRUG CAPABLE OF IMPROVING PRODUCTION OF REGULATORY T CELLS AND METHOD FOR PRODUCING REGULATORY T CELLS USING IMMUNOSUPPRESSIVE MACROLIDE ANTIBIOTIC 审中-公开
标题翻译：用于筛选用于改善调节性T细胞产生的药物的方法的开发和使用免疫抑制性大鼠抗生素制备调节性T细胞的方法
公开(公告)号：US20090246212A1
公开(公告)日：2009-10-01
申请号：US12088812
申请日：2006-09-29
申请人： Takaaki Koshiba , Atsushi Ito , Shimon Sakaguchi , Koichi Tanaka , Yanling Wu , Mayuko Narumoto
发明人： Takaaki Koshiba , Atsushi Ito , Shimon Sakaguchi , Koichi Tanaka , Yanling Wu , Mayuko Narumoto
IPC分类号： A61K39/00 , C12Q1/02 , C12N5/00 , C12N5/06 , C12Q1/68
CPC分类号： G01N33/505 , C12N5/0636
摘要： The present invention provides a screening method for a compound capable of inducing regulatory T cells, comprising the following steps:(1) a step for culturing CD4+ T cells having a naïve phenotype in the presence of a test compound, and isolating T cells from the culture product; (2) a step for evaluating the immunosuppressive function of the T cells isolated in the step (1); (3) a step for obtaining the foregoing test compound as a compound capable of inducing regulatory T cells if the results of the evaluation in the step (2) show that the T cells isolated in the step (1) have immunosuppressive function. The present invention also provides a method of producing regulatory T cells, comprising culturing CD4+ T cells having a naïve phenotype in the presence of a rapamycin compound to obtain regulatory T cells. The regulatory T cell produced by the method can be used as an immunomodulator for the prophylaxis or treatment of the rejection in organ transplantation, an allergic disease, an autoimmune disease, a graft-versus-host disease (GVHD), infertility and the like.
摘要翻译：本发明提供了能够诱导调节性T细胞的化合物的筛选方法，包括以下步骤：（1）在试验化合物存在下培养具有初始表型的CD4 + T细胞的步骤，文化产品; （2）评价步骤（1）中分离的T细胞的免疫抑制功能的步骤。（3）如果步骤（2）中的评价结果表明在步骤（1）中分离的T细胞具有免疫抑制功能，则获得作为能诱导调节性T细胞的化合物的上述试验化合物的步骤。本发明还提供了一种产生调节性T细胞的方法，包括在雷帕霉素化合物存在下培养具有初始表型的CD4 + T细胞以获得调节性T细胞。通过该方法产生的调节性T细胞可用作免疫调节剂，用于预防或治疗器官移植排斥反应，过敏性疾病，自身免疫性疾病，移植物抗宿主病（GVHD），不育症等。

5. 发明申请

US20090297539A1 PROCESS FOR PRODUCTION OF REGULATORY T CELL 审中-公开
标题翻译：生产调节细胞的方法
公开(公告)号：US20090297539A1
公开(公告)日：2009-12-03
申请号：US11910294
申请日：2006-03-31
申请人： Takaaki Koshiba , Atsushi Ito , Koichi Tanaka , Shimon Sakaguchi
发明人： Takaaki Koshiba , Atsushi Ito , Koichi Tanaka , Shimon Sakaguchi
IPC分类号： A61K39/00 , C12N5/06
CPC分类号： A61K35/17 , A61K2039/5158 , C12N5/0636 , C12N2501/23
摘要： The present invention provides a method of producing a regulatory T cell, which includes culturing a peripheral CD25+CD4+ T cell of a naive phenotype to give the regulatory T cell. The CD25+CD4+ T cell can be cultured under stimulation with an antigen. According to the method, a mammalian regulatory T cell can be produced in vitro and an antigen-specific regulatory T cell can also be produced. The regulatory T cell produced by the method is useful as an immunomodulator for the prophylaxis or treatment of rejection reaction in organ transplantation, allergic disease, autoimmune disease, graft-versus-host disease (GVHD), infertility and the like.
摘要翻译：本发明提供了调节性T细胞的制备方法，其包括培养天然表型的外周CD25 + CD4 + T细胞以产生调节性T细胞。可以用抗原刺激CD25 + CD4 + T细胞。根据该方法，可以在体外产生哺乳动物调节性T细胞，也可以产生抗原特异性调节性T细胞。通过该方法产生的调节性T细胞可用作用于预防或治疗器官移植，过敏性疾病，自身免疫性疾病，移植物抗宿主病（GVHD），不育症等中的排斥反应的免疫调节剂。

6. 发明授权

US09064929B2 Method for reducing the thickness of an SOI layer 有权
标题翻译：降低SOI层厚度的方法
公开(公告)号：US09064929B2
公开(公告)日：2015-06-23
申请号：US12153519
申请日：2008-05-20
申请人： Shoji Akiyama , Yoshihiro Kubota , Atsuo Ito , Koichi Tanaka , Makoto Kawai , Yuuji Tobisaka
发明人： Shoji Akiyama , Yoshihiro Kubota , Atsuo Ito , Koichi Tanaka , Makoto Kawai , Yuuji Tobisaka
IPC分类号： H01L21/762 , H01L21/3065 , H01L21/66
CPC分类号： H01L21/76254 , H01L21/3065 , H01L22/12 , H01L22/20 , H01L2924/014
摘要： There is disclosed a method for manufacturing an SOI wafer comprising: a step of implanting at least one of a hydrogen ion and a rare gas ion into a donor wafer to form an ion implanted layer; a step of bonding an ion implanted surface of the donor wafer to a handle wafer; a step of delaminating the donor wafer at the ion implanted layer to reduce a film thickness of the donor wafer, thereby providing an SOI layer; and a step of etching the SOI layer to reduce a thickness of the SOI layer, wherein the etching step includes: a stage of performing rough etching as wet etching; a stage of measuring a film thickness distribution of the SOI layer after the rough etching; and a stage of performing precise etching as dry etching based on the measured film thickness distribution of the SOI layer. There can be provided A method for manufacturing an SOI wafer having high film thickness uniformity of an SOI layer with excellent productivity.
摘要翻译：公开了一种用于制造SOI晶片的方法，包括：将氢离子和稀有气体离子中的至少一种注入施主晶片以形成离子注入层的步骤; 将施主晶片的离子注入表面接合到处理晶片的步骤; 在离子注入层分层施主晶片以降低施主晶片的膜厚，从而提供SOI层的步骤; 以及蚀刻所述SOI层以减小所述SOI层的厚度的步骤，其中所述蚀刻步骤包括：执行粗蚀刻的阶段，如湿蚀刻; 在粗蚀刻之后测量SOI层的膜厚分布的阶段; 以及基于所测量的SOI层的膜厚分布，进行干蚀刻的精确蚀刻的阶段。可以提供一种以优异的生产率制造具有SOI层的高膜厚均匀性的SOI晶片的方法。

7. 发明申请

US20150148174A1 ELECTRIC VEHICLE TRANSAXLE 审中-公开
标题翻译：电动车辆传动桥
公开(公告)号：US20150148174A1
公开(公告)日：2015-05-28
申请号：US14534470
申请日：2014-11-06
申请人： Koichi Nakamura , Koichi Tanaka
发明人： Koichi Nakamura , Koichi Tanaka
IPC分类号： F16D41/07 , F16H1/28 , F16H57/04 , B60K17/04
CPC分类号： F16D41/07 , B60K1/00 , B60K2001/001 , B60Y2306/03 , F16D41/06 , F16D2041/0601 , F16D2300/06 , F16H1/28 , F16H57/0467
摘要： Providing an electric vehicle transaxle suppressing occurrence of wear, seizure, etc. of a one-way clutch as compared to a conventional one. When an electric motor MG is driven and a one-way clutch 34 moves in a rotation axis C1 direction, the one-way clutch 34 comes into contact with a flange portion 46b of an inner race 46 or a supporting portion 30b of a transaxle housing 30 via a sliding washer 74 and, therefore, direct contact is prevented between the one-way clutch 34 and the flange portion 46b of the inner race 46 or the supporting portion 30b and wear, seizure, etc. of the one-way clutch 34 are suppressed.
摘要翻译：提供一种电动车辆驱动桥，与传统的相比，抑制单向离合器的磨损，咬合等的发生。当电动机MG被驱动并且单向离合器34沿旋转轴线C1方向移动时，单向离合器34与内座圈46的凸缘部分46b或驱动桥壳体的支撑部分30b接触因此，单向离合器34与内座圈46或支承部30b的凸缘部46b之间的直接接触被防止，单向离合器34的磨损，咬住等被压制。

8. 发明授权

US09003926B2 Oil passage structure of chain-drive oil pump 有权
标题翻译：链传动油泵油路结构
公开(公告)号：US09003926B2
公开(公告)日：2015-04-14
申请号：US13057422
申请日：2009-04-28
申请人： Yoshihiro Mizuno , Koichi Tanaka , Yusuke Ogata
发明人： Yoshihiro Mizuno , Koichi Tanaka , Yusuke Ogata
IPC分类号： F16H41/30 , F16H47/06 , F16H41/02 , F16H7/06 , F16H45/02 , F16H57/04
CPC分类号： F16H41/02 , F16H7/06 , F16H41/30 , F16H45/02 , F16H57/0441 , Y10T74/19149 , Y10T74/19153
摘要： An oil passage structure of a chain-driven oil pump includes three lines of oil passages for supplying oil from the center support to the torque converter, a first oil passage for supplying oil to the torque converter through the inside of an input shaft of the torque converter, a second oil passage for supplying oil to the torque converter through a space defined by the outer periphery surface of the input shaft and the inner periphery surface of a stator shaft, and a third oil passage for supplying oil to the torque converter by bypassing the drive sprocket. The third oil passage is provided on the outer periphery side of the drive sprocket and in a position where it does not interfere with the operation of a chain. Accordingly, it is possible to utilize the flex lock-up to a maximum extent, and to reduce the diameter of the sprocket.
摘要翻译：链式油泵的油路结构包括从中心支撑件向变矩器供给油的三条油路，用于通过扭矩输入轴的内部向变矩器供给油的第一油路转换器，用于通过由输入轴的外周面和定子轴的内周面限定的空间向变矩器供给油的第二油路，以及用于通过旁路向变矩器供油的第三油路驱动链轮。第三油路设置在驱动链轮的外周侧，并且在不干扰链的操作的位置。因此，可以最大程度地利用弯曲锁定，并且减小链轮的直径。

9. 发明授权

US08881883B2 Park lock for narrow transmission 有权
标题翻译：公园锁为狭窄的传输
公开(公告)号：US08881883B2
公开(公告)日：2014-11-11
申请号：US13460349
申请日：2012-04-30
申请人： Augusto E. Barton , William Randall Fong , Gary Allen Pinkley , Edwin Marcum Pearce, Jr. , Kunio Morisawa , Kazunori Kaneko , Koichi Tanaka
发明人： Augusto E. Barton , William Randall Fong , Gary Allen Pinkley , Edwin Marcum Pearce, Jr. , Kunio Morisawa , Kazunori Kaneko , Koichi Tanaka
IPC分类号： F16H63/38 , B60T1/06
CPC分类号： B60T1/062 , F16H63/3425 , Y10T74/19637
摘要： A park lock of a transmission, including a park gear; a park pawl rotating about a pawl shaft, the park pawl having a pawl portion locking the park gear, the park pawl including a cam contact portion; a park rod responsive to an operation of a controller, the park rod having a cam portion pressing the cam contact portion to have park pawl engage the park gear; a park sleeve receiving the cam portion and defining a first contact point providing a reactive force to the cam contact portion of the park pawl pressing against the cam portion at a second contact point; a pawl torsional spring biasing the park pawl towards disengagement; and a pawl stopper limiting the rotation of the park pawl wherein motions are constrained within a plane of the transmission and components are rotatingly disposed in parallel axis bores in one half of a transmission case.
摘要翻译：变速器的公园锁，包括公园装备; 围绕棘爪轴旋转的驻车爪，所述停车爪具有锁定所述公园齿轮的棘爪部分，所述驻车棘爪包括凸轮接触部分; 响应于控制器的操作的停放杆，所述停放杆具有按压所述凸轮接触部分以具有驻车爪的凸轮部分接合所述驻车齿轮; 接收所述凸轮部分并且限定向所述驻车棘爪的凸轮接触部分提供反作用力的第一接触点，所述第一接触点在第二接触点处抵靠所述凸轮部分; 一个棘爪扭力弹簧将公园爪偏压分离; 以及限制驻车爪的旋转的棘爪止动器，其中运动被限制在变速器的平面内，并且部件在变速箱的一半中旋转地设置在平行的轴孔中。

10. 发明授权

US08765576B2 Process for producing laminated substrate and laminated substrate 有权
标题翻译：叠层基板和叠层基板的制造方法
公开(公告)号：US08765576B2
公开(公告)日：2014-07-01
申请号：US12550340
申请日：2009-08-28
申请人： Shoji Akiyama , Atsuo Ito , Yoshihiro Kubota , Koichi Tanaka , Makoto Kawai , Yuuji Tobisaka
发明人： Shoji Akiyama , Atsuo Ito , Yoshihiro Kubota , Koichi Tanaka , Makoto Kawai , Yuuji Tobisaka
IPC分类号： H01L21/30 , H01L21/762 , H01L21/3105
CPC分类号： H01L21/76254 , H01L21/31051 , H01L21/76251 , H01L31/1892 , Y02E10/50
摘要： A method of manufacturing a laminated substrate is provided. The method includes: forming an oxide film on at least a surface of a first substrate having a hardness of equal to or more than 150 GPa in Young's modulus, and then smoothing the oxide film; implanting hydrogen ions or rare gas ions, or mixed gas ions thereof from a surface of a second substrate to form an ion-implanted layer inside the substrate, laminating the first substrate and the second substrate through at least the oxide film, and then detaching the second substrate in the ion-implanted layer to form a laminated substrate; heat-treating the laminated substrate and diffusing outwardly the oxide film.
摘要翻译：提供一种制造叠层基板的方法。该方法包括：在杨氏模量下，在硬度为150GPa以上的第一基板的至少表面形成氧化膜，然后平滑氧化膜; 从第二基板的表面注入氢离子或稀有气体离子或其混合气体离子以在基板内部形成离子注入层，至少通过氧化物膜层压第一基板和第二基板，然后将在离子注入层中形成第二衬底以形成层压衬底; 对层压基板进行热处理并向外扩散氧化膜。

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