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1. 发明申请

US20100168366A1 NOVEL SYNTHETIC N-LINKED SIALO-GLYCAN-CONTAINING POLYMER AND METHOD FOR PRODUCING THE SAME 失效
标题翻译：新型合成N-连接的含有糖的聚糖聚合物及其制造方法
公开(公告)号：US20100168366A1
公开(公告)日：2010-07-01
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中唾液酸聚糖用一端具有氨基和另一端的羧基并由结构式（I）表示的化合物缩合成γ-聚谷氨酸，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

2. 发明授权

US08450441B2 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same 失效
标题翻译：合成的N-连接唾液酸聚糖聚合物及其制备方法
公开(公告)号：US08450441B2
公开(公告)日：2013-05-28
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00 , C07H15/06 , C12Q1/70
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中使用一端具有氨基的化合物和另一端的羧基并由结构式（I）表示的唾液酸聚糖与γ-聚谷氨酸缩合，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

3. 发明申请

US20090269734A1 METHOD FOR DETERMINATION OF RECOGNITION SPECIFICITY OF VIRUS FOR RECEPTOR SUGAR CHAIN 审中-公开
标题翻译：用于确定受体糖链的病毒识别特异性的方法
公开(公告)号：US20090269734A1
公开(公告)日：2009-10-29
申请号：US12427636
申请日：2009-04-21
申请人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
发明人： Yasuo SUZUKI , Akira Asai , Takashi Suzuki , Ilpal Jwa , Takeomi Murata , Taiichi Usui , Sou Takeda , Kohei Yamada , Toshitada Noguchi
IPC分类号： C12Q1/70 , C07K9/00 , C12P19/18
CPC分类号： G01N33/548 , G01N33/56983
摘要： A method in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus is provided. In a method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host infected in accordance with the mutation of virus comprising, a sample of the virus is brought into contact with a support having a polymer with sialo-oligosaccharide immobilized on the surface thereof; and the degree of binding therein is assayed to determine the recognition specificity of said virus for said receptor sugar chain and to determine the change in a host range. The method is suitable for the surveillance of virus.
摘要翻译：提供了利用简单的仪器或装置容易地确定病毒对受体糖链的识别特异性的方法。在用于确定受体糖链病毒的识别特异性或根据病毒突变感染的宿主的变化的方法中，使病毒样品与具有聚合物的载体接触，唾液酸寡糖固定在其表面上; 并测定其中的结合程度以确定所述病毒对所述受体糖链的识别特异性并确定宿主范围的变化。该方法适用于病毒监控。

4. 发明申请

US20060104985A1 Dengue virus infection inhibitor 审中-公开
标题翻译：登革热病毒感染抑制剂
公开(公告)号：US20060104985A1
公开(公告)日：2006-05-18
申请号：US10532211
申请日：2003-10-22
申请人： Yasuo Suzuki , Ilpal Jwa
发明人： Yasuo Suzuki , Ilpal Jwa
IPC分类号： A61K39/40 , A61K31/737
CPC分类号： A61K31/7024 , C07H15/10 , Y02A50/385
摘要： A dengue virus infection inhibitor, as a drug effectively inhibiting the infection with dengue virus, which is characterized by containing, as the active ingredient, at least a carbohydrate molecule having as an essential constituent an oligosaccharide chain represented by the following formula (I): Hex1NAcβ1-3Hex2β1-4Hex1β1- (I) (wherein Hex1 and Hex2 represent a hexose) is provided.
摘要翻译：登革热病毒感染抑制剂作为有效抑制登革热病毒感染的药物，其特征在于含有作为活性成分的至少一种作为必需成分的碳水化合物分子，由下式（I）表示的寡糖链：六价<！ - SIPO - > 1 NAcbeta1-3Hex β1-4Hex1β1-（I）（其中Hex＆lt; 1＆ SUP> 2 表示己糖）。

5. 发明申请

US20050234010A1 Novel branched sialo-sugar molecules and antiviral agents using the same 审中-公开
标题翻译：新型支链唾液酸糖分子和使用其的抗病毒剂
公开(公告)号：US20050234010A1
公开(公告)日：2005-10-20
申请号：US10506469
申请日：2003-02-28
申请人： Yasuo Suzuki , Ilpal Jwa
发明人： Yasuo Suzuki , Ilpal Jwa
IPC分类号： A61K31/739 , A61K39/00 , C08B37/00
CPC分类号： C07H15/04 , C07H7/027
摘要： A novel branched sialo-sugar molecule represented by the following formula (I) which is a substance which responds to a variation in the host range of an influenza virus or a variation in antigenicity and is useful as a drug or an adsorbent in a virus removal filter or the like capable of preventing the infection with a type A influenza virus and a type B influenza virus originating in any animals including humans: (wherein NeuAc represents N-acetylneuraminic acid in which the hydroxyl group, the carboxyl group and the amido group may be chemically modified with a halogen group, an alkyl group or an acyl group, either the same group or separate groups, Hex represents hexose, HexNAc represents N-acetylhexosamine and R represents a substrate selected from among a hydrogen atom, a hydrocarbon chain, a sugar chain, a lipid, a protein and a synthetic polymer, R may have a substituent, and the linkage between N-acetylneuraminic acid and hexose may be either an O-glycoside linkage occurring in nature or a chemically converted linkage such as an S-glycoside or a Se-glycoside linkage) is provided.
摘要翻译：由下式（I）表示的新型支链唾液酸糖分子，其是对流感病毒的宿主范围的变化或抗原性变化作出反应的物质，并且可用作病毒去除剂中的药物或吸附剂过滤器等能够防止A型流感病毒和源自任何动物（包括人）的B型流感病毒的感染：（其中NeuAc表示N-乙酰神经氨酸，其中羟基，羧基和酰胺基可以用卤素基团，烷基或酰基进行化学修饰，相同基团或单独的基团，Hex表示己糖，HexNAc表示N-乙酰基己糖胺，R表示选自氢原子，烃链，糖链，脂质，蛋白质和合成聚合物，R可以具有取代基，并且N-乙酰神经氨酸和己糖之间的连接可以是发生于其中的O-糖苷键 n性质或化学转化的连接如S-糖苷或Se-糖苷键）。

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