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1. 发明申请

US20100280398A1 LASER DOPPLER BLOOD FLOW MEASURING METHOD AND DEVICE 有权
标题翻译：激光多普勒血液流量测量方法和装置
公开(公告)号：US20100280398A1
公开(公告)日：2010-11-04
申请号：US12809738
申请日：2008-12-19
申请人： Tadashi Hachiga , Hiroki Ishida , Shunsuke Akiguchi , Hiroki Shirakawa , Tsugunobu Andoh , Yasushi Kuraishi
发明人： Tadashi Hachiga , Hiroki Ishida , Shunsuke Akiguchi , Hiroki Shirakawa , Tsugunobu Andoh , Yasushi Kuraishi
IPC分类号： A61B5/026
CPC分类号： A61B5/0285 , A61B5/0261 , A61B5/411
摘要： [Subject] To provide laser Doppler blood flow measuring method and device which achieve multi-dimensional measurement efficiently at a high degree of accuracy over a wide range with a simple optical system and device.[Solving Means] Laser light from a semiconductor laser 12 is split and formed into sheet lights Ls using a cylindrical lens 22, and the sheet lights Ls are crossed with each other at a predetermined position. A lens system 30 configured to form an image of scattered lights into a linear shape at a linear irradiation site Lx where the sheet lights Ls cross with each other is provided. An optical fiber array 32 having a plurality of optical fibers 34 is provided at an image-forming position of the lens system 30. Avalanche photodiodes 42 configured to convert the scattered lights which are shifted in frequency by the Doppler effect caused by the blood flow into electric signals for the each optical fiber 34 are provided. The blood flow velocity in a tissue of a biological body at the linear irradiation site Lx is calculated from the scattered lights transformed from the laser light by being shifted in frequency by the Doppler effect and is scanned for the each optical fiber 34, whereby the blood flow velocity in the blood vessel in a predetermined area in the biological body is calculated.
摘要翻译： [主题]提供使用简单的光学系统和装置，在宽范围内以高精度实现多维度测量的激光多普勒血流测量方法和装置。 [解决方案]使用柱面透镜22将来自半导体激光器12的激光分割并形成为片状光Ls，并且片状光Ls在预定位置彼此交叉。提供了一种透镜系统30，其被配置为在片状光Ls彼此交叉的线性照射位置Lx处形成散射光的图像成线状。具有多个光纤34的光纤阵列32设置在透镜系统30的图像形成位置。雪崩光电二极管42被配置为将频率偏移的散射光转换成由血流引起的多普勒效应提供每个光纤34的电信号。通过以多普勒效应使频率偏移从激光变换的散射光计算线状照射部位Lx处的生物体的组织中的血流速度，并扫描各光纤34，由此血液计算生物体中预定区域中血管中的流速。

2. 发明授权

US09031640B2 Laser doppler blood flow measuring method and device 有权
标题翻译：激光多普勒血流测量方法及装置
公开(公告)号：US09031640B2
公开(公告)日：2015-05-12
申请号：US12809738
申请日：2008-12-19
申请人： Tadashi Hachiga , Hiroki Ishida , Shunsuke Akiguchi , Hiroki Shirakawa , Tsugunobu Andoh , Yasushi Kuraishi
发明人： Tadashi Hachiga , Hiroki Ishida , Shunsuke Akiguchi , Hiroki Shirakawa , Tsugunobu Andoh , Yasushi Kuraishi
IPC分类号： A61B5/02 , A61B5/0285 , A61B5/00 , A61B5/026
CPC分类号： A61B5/0285 , A61B5/0261 , A61B5/411
摘要： [Subject] To provide laser Doppler blood flow measuring method and device which achieve multi-dimensional measurement efficiently at a high degree of accuracy over a wide range with a simple optical system and device.[Solving Means] Laser light from a semiconductor laser 12 is split and formed into sheet lights Ls using a cylindrical lens 22, and the sheet lights Ls are crossed with each other at a predetermined position. A lens system 30 configured to form an image of scattered lights into a linear shape at a linear irradiation site Lx where the sheet lights Ls cross with each other is provided. An optical fiber array 32 having a plurality of optical fibers 34 is provided at an image-forming position of the lens system 30. Avalanche photodiodes 42 configured to convert the scattered lights which are shifted in frequency by the Doppler effect caused by the blood flow into electric signals for the each optical fiber 34 are provided. The blood flow velocity in a tissue of a biological body at the linear irradiation site Lx is calculated from the scattered lights transformed from the laser light by being shifted in frequency by the Doppler effect and is scanned for the each optical fiber 34, whereby the blood flow velocity in the blood vessel in a predetermined area in the biological body is calculated.
摘要翻译： [主题]提供使用简单的光学系统和装置，在宽范围内以高精度实现多维度测量的激光多普勒血流测量方法和装置。 [解决方案]使用柱面透镜22将来自半导体激光器12的激光分割并形成为片状光Ls，并且片状光Ls在预定位置彼此交叉。提供了一种透镜系统30，其被配置为在片状光Ls彼此交叉的线性照射位置Lx处形成散射光的图像成线状。具有多个光纤34的光纤阵列32设置在透镜系统30的图像形成位置。雪崩光电二极管42被配置为将频率偏移的散射光转换成由血流引起的多普勒效应提供每个光纤34的电信号。通过以多普勒效应使频率偏移从激光变换的散射光计算线状照射部位Lx处的生物体的组织中的血流速度，并扫描各光纤34，由此血液计算生物体中预定区域中血管中的流速。

3. 发明申请

US20100221733A1 BIOMARKER OF ALLERGIC DISEASE AND USE OF THE SAME 审中-公开
标题翻译：过敏性疾病的生物标志物及其使用
公开(公告)号：US20100221733A1
公开(公告)日：2010-09-02
申请号：US12713802
申请日：2010-02-26
申请人： Tsugunobu Andoh , Yasushi Kuraishi , Tasuku Nakano
发明人： Tsugunobu Andoh , Yasushi Kuraishi , Tasuku Nakano
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/37 , C07K16/40 , C07H21/04 , C12N15/63
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/573 , G01N33/6893 , G01N2333/96436 , G01N2800/24
摘要： A biomarker is provided for an allergic disease caused by an allergic reaction that is caused not exclusively by histamine release, such as pruritus, and use of the same. Use of Granzyme A as a biomarker makes it possible to provide an indication for chronic itching skin disease, for which existing antiallergic drugs have little effect, and easily and adequately allow diagnosis of the disease. It is possible to, for example, make a diagnosis of an allergic disease with an IV type allergy-like reaction not depending on the antigen-antibody reaction system. Screening with the use of Granzyme A enables the development of novel remedies for allergic diseases. Moreover, a drug capable of specifically controlling the action of a granzyme enables treatment of allergic disease with little side effect.
摘要翻译：提供了一种生物标志物，用于由不仅仅由组胺释放引起的过敏反应引起的过敏性疾病，例如瘙痒和使用它们。使用粒酶A作为生物标志物可以提供慢性瘙痒皮肤病的适应症，其中现有的抗过敏药物几乎没有效果，并且容易且充分地允许诊断该疾病。例如，可以用不依赖于抗原 - 抗体反应系统的IV型过敏样反应来诊断过敏性疾病。使用Granzyme A进行筛选可以开发出针对过敏性疾病的新疗法。此外，能够特异性控制颗粒酶的作用的药物能够治疗过敏性疾病，副作用很小。

4. 发明申请

US20060094741A1 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US20060094741A1
公开(公告)日：2006-05-04
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A61K31/4745 , A61K49/00 , C07D471/04
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R 1，R 2， R 2，R 3，R 4，R 5，R 6，R 6， A +和B B具有与说明书中描述的那些相同的定义）和通过给予（+） - 4a-（3- 羟基苯基）-2-甲基-1,2,3,4,4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗作用。

5. 发明授权

US08637539B2 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US08637539B2
公开(公告)日：2014-01-28
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R1，R2，R3，R4，R5，R6， R7，R8，A和B具有与说明书中描述的定义相同的定义）和通过给予（+） - 4a-（3-羟基苯基）-2-甲基-1,2,3,4 ，4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗效果。

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