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1. 发明申请

WO2018027102A1 SYSTEMS, APPARATUS, AND METHODS FOR DELIVERY OF THERAPEUTIC SUBSTANCE TO THE MIDDLE AND/OR INNER EAR 审中-公开
标题翻译：用于将治疗物质递送至中耳和/或内耳的系统，装置和方法
公开(公告)号：WO2018027102A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045438
申请日：2017-08-04
申请人： TUSKER MEDICAL, INC. , GOLDFARB, Eric , GIROTRA, Rohit , ABOLFATHI, Amir
发明人： GOLDFARB, Eric , GIROTRA, Rohit , ABOLFATHI, Amir
IPC分类号： A61F11/00
摘要： Systems (300), apparatus, and methods are described for delivering a therapeutic substance to an ear of a subject, including a reservoir (300) configured to contain the therapeutic substance and an outlet (320) configured to transport the therapeutic substance from the reservoir to a lumen of a tympanostomy tube disposed within a tympanic membrane bordering the tympanic cavity and/or the tympanic cavity via the lumen of the tympanostomy tube, such that the therapeutic substance can be delivered to the tympanic cavity and/or a round window to an inner ear bordering the tympanic cavity.
摘要翻译：描述了用于将治疗物质递送至受试者的耳朵的系统（300），装置和方法，所述系统（300），设备和方法包括被配置为容纳治疗物质的储存器（300）和被配置为以将治疗物质从储存器输送到设置在与鼓膜腔和/或鼓室腔接界的鼓膜内的鼓膜造口管的管腔，所述鼓膜通过鼓膜造口管的管腔，使得治疗物质可被输送到鼓室和/或与鼓室邻接的内耳的圆窗。

2. 发明申请

WO2019152866A1 SYSTEMS, APPARATUS, AND METHODS FOR TRANSPORT AND DELIVERY OF THERAPEUTIC SUBSTANCE TO MIDDLE EAR 审中-公开
公开(公告)号：WO2019152866A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016389
申请日：2019-02-01
申请人： TUSKER MEDICAL, INC.
发明人： GOLDFARB, Eric , KERMANI, Mahyar Z. , GIROTRA, Rohit
IPC分类号： A61F11/00
摘要： Systems, apparatus, and methods are described for transporting and delivering a therapeutic substance to an ear of a subject, including a tubular element (216) configured for deployment in a tympanic membrane (TM) and a fluid transport element (230). The fluid transport element can be configured to transport the therapeutic substance from a proximal side to a distal side of the tubular element. Systems, apparatus, and methods further can include a fluid dispenser including a reservoir configured to contain a therapeutic substance, and a tubular element defining a lumen in fluid communication with an outlet in which the lumen and the outlet are configured to deliver the therapeutic substance from the reservoir to a region proximal to the tympanic membrane. Systems, apparatus, and methods further can include an electrode device.

3. 发明申请

WO2019089537A1 SYSTEMS, APPARATUS, AND METHODS FOR DELIVERY OF THERAPEUTIC SUBSTANCE TO NASAL CAVITY 审中-公开
公开(公告)号：WO2019089537A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058138
申请日：2018-10-30
申请人： TUSKER MEDICAL, INC.
发明人： GOLDFARB, Eric , GIROTRA, Rohit , KERMANI, Mahyar Z.
IPC分类号： A61K9/00 , A61M31/00 , A61M37/00 , A61N1/30
摘要： Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

4. 发明申请

WO2019143587A1 VISUALIZATION DEVICES AND METHODS FOR OTOLOGIC PROCEDURES 审中-公开
公开(公告)号：WO2019143587A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/013568
申请日：2019-01-15
申请人： TUSKER MEDICAL, INC.
发明人： GOLDFARB, Eric , KERMANI, Mahyar Z. , GIROTRA, Rohit
IPC分类号： A61B1/227 , A61B1/00 , A61B1/018
CPC分类号： A61B1/227 , A61B1/00052 , A61B1/00105 , A61B1/0014 , A61B1/00154 , A61B1/018
摘要： Systems, apparatuses, and methods are described for providing visualization inside an ear of a subject before, during, or after an otologic procedure. An apparatus (100) includes a light source (140), a sensor (130), a processor (152, 170), and a display (154, 172, 972). The light source (140) can be configured to provide incident light to a target area (TM), and the sensor (130) can be configured to capture reflected light from the target area (TM) to generate image data based on the reflected light. The processor (152, 170) can process the image data to produce an image of the target area (TM), and the display (154, 172, 972) can display the image of the target area (TM).

5. 发明申请

WO2021011855A1 SYSTEMS, DEVICES, AND METHODS FOR VISUALIZATION DURING MEDICAL PROCEDURES 审中-公开
公开(公告)号：WO2021011855A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042484
申请日：2020-07-17
申请人： TUSKER MEDICAL, INC.
发明人： DOMECUS, Brian , KERMANI, Mahyar Z. , GIROTRA, Rohit , GOLDFARB, Eric , LANTZ, Andrew , SCHNEIDER, Robert Edwin , BIGHAM, Tyler Bennett
IPC分类号： A61B1/00 , A61B1/227
摘要： Visualization during medical procedures is provided using a visualization system comprising: a control device defining an upper surface and a lower surface; a display visible through the upper surface of the control device; a handle coupled to the lower surface and extending away from the lower surface; a knob coupled to the control device, the knob configured to rotate about a rotational axis; an imaging assembly mechanically coupled to the knob and communicatively coupled to the control device, the imaging assembly configured to rotate around the rotational axis based on rotation of the knob; and the control device configured to display an image on the display, the image captured by the imaging assembly.

6. 发明公开

EP3998930A1 SYSTEMS, DEVICES, AND METHODS FOR VISUALIZATION DURING MEDICAL PROCEDURES 审中-公开
公开(公告)号：EP3998930A1
公开(公告)日：2022-05-25
申请号：EP20753579.0
申请日：2020-07-17
申请人： Tusker Medical, Inc.
发明人： DOMECUS, Brian , KERMANI, Mahyar Z. , GIROTRA, Rohit , GOLDFARB, Eric , LANTZ, Andrew , SCHNEIDER, Robert Edwin , BIGHAM, Tyler Bennett
IPC分类号： A61B1/00 , A61B1/227

7. 发明公开

EP3493779A1 SYSTEMS, APPARATUS, AND METHODS FOR DELIVERY OF THERAPEUTIC SUBSTANCE TO THE MIDDLE AND/OR INNER EAR 审中-公开
公开(公告)号：EP3493779A1
公开(公告)日：2019-06-12
申请号：EP17752253.9
申请日：2017-08-04
申请人： Tusker Medical, Inc.
发明人： GOLDFARB, Eric , GIROTRA, Rohit , ABOLFATHI, Amir
IPC分类号： A61F11/00

8. 发明公开

EP3300707A1 SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL TREATMENT OF TARGET TISSUES WITHIN THE EARS 审中-公开
标题翻译：系统和方法同时双边治疗目标组织中的耳朵
公开(公告)号：EP3300707A1
公开(公告)日：2018-04-04
申请号：EP17187372.2
申请日：2008-04-18
申请人： Tusker Medical, Inc.
发明人： CLIFFORD, Anton , LIU, Greg , MORRISS, John , MAKOWER, Joshua , FACTEAU, William , GOLDFARB, Eric , CHANG, John Y. , SHAHOIAN, Erik James
IPC分类号： A61F11/00 , A61N1/30 , A61B5/00 , A61M31/00 , A61B17/00
CPC分类号： A61M31/00 , A61B5/0077 , A61B2017/00787 , A61F11/002 , A61F2230/0039 , A61F2230/0052 , A61F2250/0039 , A61M2210/0662 , A61N1/30 , A61N1/306
摘要： A) Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear; aligning a second device with a target tissue of the second ear; and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively. B) Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. C) Systems and methods for treating a patient having an ear canal and a target tissue function by positioning a fluid or gel in the ear canal, the fluid or gel comprising a therapeutic agent; retaining the fluid or gel with a support structure, the support structure supporting an electrode and a battery; and applying the agent from the fluid or gel to the target tissue by energizing the electrode with an iontophoresis potential from the battery. D) Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. E) Systems and methods for treating a patient having a head with a first ear and a second ear, function by aligning a first device with a tympanic membrane of the first ear; inputting a command to an input device operatively coupled to the first device to generate a signal; and actuating the first device in response to the signal so as to drive a penetrator of the device through the tympanic membrane.
摘要翻译： A）通过将第一装置与第一耳朵的目标组织对准，用于对具有第一耳朵和第二耳朵的头部的患者进行双边治疗的系统和方法; 将第二装置与第二耳朵的目标组织对准; 并且同步地分别用第一和第二对准装置对第一和第二耳朵的目标组织进行治疗性重塑。 B）用于通过将支撑系统安装到患者头部以使支撑系统与第一耳朵的目标组织对齐来治疗具有第一耳朵和第二耳朵的头部的患者的系统和方法; 通过激励由支撑系统支撑的离子电渗疗法电极来将治疗剂施加到第一耳朵; 以及在所述装置由所述支撑系统支撑的同时致动装置，使得所述装置在治疗上重塑所述第一耳朵的所述目标组织。 C）通过将流体或凝胶布置在耳道中来治疗具有耳道和目标组织功能的患者的系统和方法，所述流体或凝胶包含治疗剂; 用支撑结构保持流体或凝胶，支撑结构支撑电极和电池; 以及通过用来自电池的离子电渗电位激励电极将来自流体或凝胶的试剂施加到目标组织。 D）用于治疗具有第一耳朵和第二耳朵的头部的患者的系统和方法，其通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳朵的耳道中的目标组织对准; 通过将材料注入管道中并使材料硬化来使支撑结构相对于目标组织稳定; 以及在所述装置由所述支撑系统支撑的同时致动装置，使得所述装置在治疗上重塑所述第一耳朵的所述目标组织。 E）用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法，其通过将第一装置与第一耳朵的鼓膜对准而起作用; 向可操作地耦合到第一设备的输入设备输入命令以生成信号; 以及响应于所述信号致动所述第一装置，以便驱动所述装置的穿透器穿过鼓膜。

9. 发明申请

WO2008134288A2 MECHANICAL DILATION OF THE OSTIA OF PARANASAL SINUSES AND OTHER PASSAGEWAYS OF THE EAR, NOSE AND THROAT 审中-公开
标题翻译：豚耳，鼻及喉的鼻旁及其他传播途径的机械性D裂
公开(公告)号：WO2008134288A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/061048
申请日：2008-04-21
申请人： ACCLARENT, INC. , MORRISS, John, H. , JENKINS, Thomas, R. , GOLDFARB, Eric , BARON, Scott, J. , MUNI, Ketan, P. , CHANG, John, Y. , VRANY, Julia, D. , HARFE, Daniel, T. , SWEI, Serena , WOOD, Robert, N. , CHAN, Randy, S. , HA, Hung, V.
发明人： MORRISS, John, H. , JENKINS, Thomas, R. , GOLDFARB, Eric , BARON, Scott, J. , MUNI, Ketan, P. , CHANG, John, Y. , VRANY, Julia, D. , HARFE, Daniel, T. , SWEI, Serena , WOOD, Robert, N. , CHAN, Randy, S. , HA, Hung, V.
IPC分类号： A61M29/00 , A61M1/00 , A61B17/24
CPC分类号： A61B17/24 , A61B17/0218 , A61M29/02
摘要： Devices and methods for dilating the ostia of paranasal sinuses and other passageways within the ear, nose and throat. A mechanical dilator is inserted through a nostril and used to dilate an ostium or a paranasal sinus or other passageway within the ear, nose or throat (e.g., a Eustachian tube or nasolacrimal duct). The mechanical dilator may be an expandable dilators that comprises one or more non-balloon structures with or without an accompanying balloon or a members of varying diameter or cross dimension (e.g., a tapered member) that may be advanced into the ostium or other passageway to cause dilation of that passageway.
摘要翻译：用于扩张鼻窦和其他通道，在耳朵，鼻子和喉咙内的通道的设备和方法。机械扩张器通过鼻孔插入并用于扩张耳，鼻或咽喉内的口或鼻旁窦或其他通道（例如咽鼓管或鼻泪管）。机械扩张器可以是可扩张扩张器，其包括可带入或不带有伴随气囊的一个或多个非气囊结构或者可以推进到开口或其他通道中的不同直径或横向尺寸的构件（例如，锥形构件）以导致通道扩张。

10. 发明公开

EP3740111A1 VISUALIZATION DEVICES AND METHODS FOR OTOLOGIC PROCEDURES 审中-实审
公开(公告)号：EP3740111A1
公开(公告)日：2020-11-25
申请号：EP19703486.1
申请日：2019-01-15
申请人： Tusker Medical, Inc.
发明人： GOLDFARB, Eric , KERMANI, Mahyar Z. , GIROTRA, Rohit
IPC分类号： A61B1/227 , A61B1/00 , A61B1/018

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