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1. 发明申请

WO2002094264A1 CCR4 ANTAGONISTS 审中-公开
公开(公告)号：WO2002094264A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/016393
申请日：2002-05-22
申请人： TULARIK INC. , MAHMUD, Hossen , COLLINS, Tassie , HOUZE, Jonathan, B. , HUANG, Alan, Xi , MEDINA, Julio , WANG, Xuemei , XU, Feng , XU, Qingge , ZHU, Liusheng
发明人： COLLINS, Tassie , HOUZE, Jonathan, B. , HUANG, Alan, Xi , MEDINA, Julio , WANG, Xuemei , XU, Feng , XU, Qingge , ZHU, Liusheng
IPC分类号： A61K31/421
CPC分类号： C07D417/12 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/426 , C07D277/42 , C07D277/82 , C07D513/04
摘要： Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
摘要翻译：提供了可用于治疗趋化因子受体介导的病症和疾病的化合物，组合物和方法。特别地，本发明提供调节CCR4功能或CCR4介导的应答的化合物。主题化合物和组合物可用于治疗或预防炎性疾病和疾病。

2. 发明申请

WO2010036520A1 MESOPOROUS METAL OXIDE MATERIALS FOR PHOSPHOPROTEOMICS 审中-公开
标题翻译： MOPOPOROUS金属氧化物材料的磷化学
公开(公告)号：WO2010036520A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/056632
申请日：2009-09-11
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , JIN, Song , GE, Ying , NELSON, Cory, Alexander , XU, Qingge
发明人： JIN, Song , GE, Ying , NELSON, Cory, Alexander , XU, Qingge
IPC分类号： C07K1/22
CPC分类号： C07K1/22
摘要： The present invention provides methods and materials for isolating, purifying, and/or enriching the concentration of compounds having one or more phosphate groups and/or derivatives thereof, including but not limited to phosphorylated peptides and/or phosphorylated proteins. In some aspects, the present invention provides nanostructured enrichment materials, such as metal oxide mesoporous materials, that selectively and reversibly bind with phosphorylated compounds with high specificity and are capable of controlled release of phosphorylated compounds bound to their active surfaces. Mesoporous materials of the present invention also provide enrichment materials having large active surface areas that provide for higher loading capacities for phosphorylated peptides and proteins relative to conventional affinity based methods. Nanostructured metal oxide mesoporous enrichment materials of the present invention are also compatible with implementation via a variety of separation platforms including flow through separation systems, elution based separation systems, column chromatography and affinity chromatography.
摘要翻译：本发明提供用于分离，纯化和/或富集具有一个或多个磷酸基团和/或其衍生物的化合物的浓度的方法和材料，包括但不限于磷酸化肽和/或磷酸化蛋白质。在一些方面，本发明提供纳米结构富集材料，例如金属氧化物介孔材料，其与高度特异性的磷酸化化合物选择性和可逆结合，并且能够控制释放与其活性表面结合的磷酸化化合物。本发明的介孔材料还提供具有大的活性表面积的富集材料，相对于常规的基于亲和力的方法，磷酸化肽和蛋白质具有更高的负载能力。本发明的纳米结构金属氧化物介孔富集材料还可通过各种分离平台实施，包括流通分离系统，基于洗脱的分离系统，柱色谱和亲和层析。

3. 发明申请

WO2004058164A2 ASTHMA AND ALLERGIC INFLAMMATION MODULATORS 审中-公开
标题翻译：哮喘和过敏性炎症调节剂
公开(公告)号：WO2004058164A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/040617
申请日：2003-12-19
申请人： TULARIK, INC.
发明人： FU, Zice , HUANG, Xi, Alan , LIU, Jiwen , MEDINA, Julio, C. , SCHMITT, Michael, J. , TANG, Lucy, H. , WANG, Yingcai , XU, Qingge
IPC分类号： A61K
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译：提供了可用于治疗炎症和免疫相关疾病和病症的化合物，药物组合物和方法。特别地，本发明提供了调节涉及特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。主题化合物是羧酸衍生物。

4. 发明公开

EP1585511A2 ASTHMA AND ALLERGIC INFLAMMATION MODULATORS 有权
标题翻译：过敏反应器ENTZÜNDUNGMODULATOREN VON ASTHMA
公开(公告)号：EP1585511A2
公开(公告)日：2005-10-19
申请号：EP03814219.6
申请日：2003-12-19
申请人： TULARIK, INC.
发明人： FU, Zice , HUANG, Xi, Alan , LIU, Jiwen , MEDINA, Julio, C. , SCHMITT, Michael, J. , TANG, Lucy, H. , WANG, Yingcai , XU, Qingge
IPC分类号： A61K31/18
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译：提供了可用于治疗炎症和免疫相关疾病和病症的化合物，药物组合物和方法。特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。主题化合物是羧酸衍生物。

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