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1. 发明申请

WO2004001103A3 SILK BIOMATERIALS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2004001103A3
公开(公告)日：2003-12-31
申请号：PCT/US2003/019893
申请日：2003-06-24
申请人： TUFTS UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KAPLAN, David, L. , JIN, Hyoung-Joon , RUTLEDGE, Gregory , FRIDRIKH, Sergei
发明人： KAPLAN, David, L. , JIN, Hyoung-Joon , RUTLEDGE, Gregory , FRIDRIKH, Sergei
IPC分类号： D02G3/04
摘要： The present invention provides an all-aqueaous process for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (EPO)(a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the processed avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

2. 发明申请

WO2004000915A2 SILK BIOMATERIALS AND METHODS OF USE THEREOF 审中-公开
标题翻译：丝状生物材料及其使用方法
公开(公告)号：WO2004000915A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019968
申请日：2003-06-24
申请人： TUFTS UNIVERSITY , KAPLAN, David, L. , JIN, Hyoung-Joon
发明人： KAPLAN, David, L. , JIN, Hyoung-Joon
IPC分类号： C08J
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换相关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

3. 发明申请

WO2005012606A2 CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF 审中-公开
标题翻译：浓缩水性蚕丝蛋白溶液及其用途
公开(公告)号：WO2005012606A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/011199
申请日：2004-04-12
申请人： TUFTS UNIVERSITY , KAPLAN, David, L. , KIM, Ung-Jin , PARK, Jaehyung , JIN, Hyoung-Joon
发明人： KAPLAN, David, L. , KIM, Ung-Jin , PARK, Jaehyung , JIN, Hyoung-Joon
IPC分类号： D01F
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
摘要翻译：本发明提供浓缩的含水丝素蛋白溶液和用于制备浓缩含水丝心蛋白溶液的全水模式，其避免使用有机溶剂，直接添加剂或刺激性化学物质。本发明进一步提供了这些溶液在生产材料（例如纤维，薄膜，泡沫，网状物，支架和水凝胶）中的用途。

4. 发明申请

WO2005000483A1 METHOD FOR FORMING INORGANIC COATINGS 审中-公开
标题翻译：形成无机涂料的方法
公开(公告)号：WO2005000483A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/017661
申请日：2004-06-07
申请人： TUFTS UNIVERSITY , KAPLAN, David, L. , LI, Chunmei
发明人： KAPLAN, David, L. , LI, Chunmei
IPC分类号： B05D1/36
CPC分类号： A61L27/227 , A61L27/24 , A61L27/30 , A61L27/446 , A61L27/46 , Y10T428/24999 , Y10T428/2933 , Y10T428/31768 , Y10T442/10
摘要： The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an inorganic material for a sufficient period of time to allow mineralization of the inorganic material thus forming an inorganic coating on the template. Preferably, the coating is aligned.
摘要翻译：本发明涉及一种在蛋白质模板上形成无机涂层的方法。该方法包括使模板与阴离子聚合物界面接触，然后使无机材料接触足够的时间以允许无机材料的矿化，从而在模板上形成无机涂层。优选地，将涂层对准。

5. 发明申请

WO2012094436A2 ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES 审中-公开
标题翻译：基于纸张基板的电子元件
公开(公告)号：WO2012094436A2
公开(公告)日：2012-07-12
申请号：PCT/US2012/020244
申请日：2012-01-04
申请人： TUFTS UNIVERSITY/TRUSTEES OF TUFTS COLLEGE , OMENETTO, Fiorenzo , KAPLAN, David, L. , TAO, Hu
发明人： OMENETTO, Fiorenzo , KAPLAN, David, L. , TAO, Hu
IPC分类号： G06K19/06
CPC分类号： B01L3/502707 , C12Q1/54 , G01J1/02 , G01J5/02 , G01N21/3563 , G01N21/3581 , G01N22/00
摘要： The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
摘要翻译：本公开涉及基于纸的基板和包括这种基板的装置。该装置可以包括耦合到基于纸的基底的图案化导电结构，其中图案化导电结构响应于电磁辐射。

6. 发明申请

WO2004050795A2 ANTIOXIDANT-FUNCTIONALIZED POLYMERS 审中-公开
标题翻译：抗氧化剂官能化聚合物
公开(公告)号：WO2004050795A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/037775
申请日：2003-11-26
申请人： TUFTS UNIVERSITY , KAPLAN, David, L. , SINGH, Amarjit
发明人： KAPLAN, David, L. , SINGH, Amarjit
IPC分类号： C09K15/06
CPC分类号： A61L29/16 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/6957 , A61L17/005 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/40 , A61L2300/428 , A61L2300/442 , A61L2300/604 , C07D307/62 , C08F4/00 , C08F12/22 , C08F112/14 , C08F112/32 , C08F220/14 , C08G63/08 , C08G64/30 , C08G65/44 , C08G2650/64 , C08K5/005 , C08L71/126 , C12P7/62 , C12P17/04
摘要： Methods and compositions are disclosed for the preparation of free radical scavenging polymers and polymer films functionalized with antioxidants. Enzymatic and chemical tailoring of monomers with antioxidants followed by enzymatic polymerization is described. These antioxidant functionalized polymers can increase shelf life and quality of food products, as well as, increase effectiveness of pharmaceutical agents when used as packaging or as coatings on packaging for oxygen sensitive materials. The novel enzymatic covalent coupling of antioxidants to a polymer enhances the free radical scavenging ability of packaging while also inhibiting the escape of the antioxidants, and thus limiting exposure and/or absorption by an individual. In addition to its use in food or pharmaceutical packaging, methods are disclosed for using the antioxidant coupled polymers in a variety of applications including as coatings on the inside of medical devices, such as stents and catheters, which would substantially reduce free radical damage and/or oxygen depletion during medical procedures. Furthermore, through the coupling of antioxidants to biodegradable polymers, controlled delivery and sustained release of an antioxidant to a subject is possible.
摘要翻译：公开了用于制备用抗氧化剂官能化的自由基清除聚合物和聚合物薄膜的方法和组合物。描述了用抗氧化剂随后进行酶促聚合的单体的酶和化学剪裁。这些抗氧化官能化聚合物可以延长食品的保存期限和质量，以及当用作包装或用作氧敏感材料包装时的药剂的有效性。抗氧化剂与聚合物的新型酶共价偶联增强了包装的自由基清除能力，同时还抑制了抗氧化剂的逸出，并由此限制了个体的暴露和/或吸收。除了用于食品或药物包装之外，还公开了在各种应用中使用抗氧化剂偶联聚合物的方法，包括作为医疗装置内部的涂层，例如支架和导管，其将显着减少自由基损伤和/ 或医疗过程中的氧气消耗。此外，通过将抗氧化剂与生物可降解聚合物偶联，可以控制递送和持续释放抗氧化剂给受试者。

7. 发明申请

WO2004062697A2 SILK FIBROIN MATERIALS AND USE THEREOF 审中-公开
标题翻译：丝绸纤维材料及其用途
公开(公告)号：WO2004062697A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000255
申请日：2004-01-07
申请人： TUFTS UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KAPLAN, David, L. , NAZAROV, Rina , VUNJAK-NOVAKOVIC, Gordana , MEINEL, Lorenz
发明人： KAPLAN, David, L. , NAZAROV, Rina , VUNJAK-NOVAKOVIC, Gordana , MEINEL, Lorenz
IPC分类号： A61L
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

8. 发明申请

WO2012031282A2 PLASMONIC NANOPARTICLE-DOPED SILK MATERIALS 审中-公开
标题翻译：掺杂纳米颗粒的丝绸材料
公开(公告)号：WO2012031282A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050453
申请日：2011-09-03
申请人： TUFTS UNIVERSITY/TRUSTEES OF TUFTS COLLEGE , OMENETTO, Fiorenzo , KAPLAN, David, L. , TAO, Hu
发明人： OMENETTO, Fiorenzo , KAPLAN, David, L. , TAO, Hu
IPC分类号： A61M36/02 , A61F7/00 , A61M31/00 , A61F2/02 , A61L27/44 , A61L27/50 , A61L27/22 , A61L27/04 , A61L27/54
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供基于丝素蛋白的光热元件及其用途。基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体纳米颗粒，并且当等离子体纳米颗粒暴露于电磁辐射时可以产生热量。基于丝素蛋白的光热元件可以适合于适应性和生物可降解性，并且可以进一步与各种电子部件集成，例如用于将热转化为电的热电装置。本发明可用于各种体内应用，例如光热疗法，受控药物递送装置或植入式微型装置的无线供电。

9. 发明申请

WO2007100831A2 METHOD FOR POLYMER SYNTHESIS USING MICROFLUIDIC ENZYMATIC CASCADE 审中-公开
标题翻译：使用微流化酶催化合成聚合物的方法
公开(公告)号：WO2007100831A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/005107
申请日：2007-02-27
申请人： TUFTS UNIVERSITY , ZOU, Jin , WONG, Peter, Y. , KAPLAN, David, L.
发明人： ZOU, Jin , WONG, Peter, Y. , KAPLAN, David, L.
CPC分类号： C12P17/04
摘要： The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and reaction chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.
摘要翻译：本发明公开了一种在微型装置中制备聚合物的方法。该系统利用互连多个装载甲板和反应室的对称分支的微通道系统。通过放置毛细管止回阀，混合区域和微孔过滤器来操纵流体流动。该系统提供级联的酶生物合成途径，其中可以将任何多种酶和反应物引入系统以产生最终产物。

10. 发明申请

WO2012145594A2 MOLDED REGENERATED SILK GEOMETRIES USING TEMPERATURE CONTROL AND MECHANICAL PROCESSING 审中-公开
标题翻译：使用温度控制和机械加工的模制再生丝绸几何
公开(公告)号：WO2012145594A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/034401
申请日：2012-04-20
申请人： TRUSTEES OF TUFTS COLLEGE , LO, Tim Jia-Ching , LEISK, Gary, G. , LI, Lei , KAPLAN, David, L.
发明人： LO, Tim Jia-Ching , LEISK, Gary, G. , LI, Lei , KAPLAN, David, L.
IPC分类号： D01F4/02 , D01F1/10 , D01F1/02 , D01F11/02 , C08J5/18
CPC分类号： D01F4/02 , B05D3/007 , B05D7/24 , B29C39/003 , B29K2089/00 , B29K2105/04 , B29K2105/25 , B29K2883/00 , B29L2001/005 , B29L2001/007 , B29L2007/008 , B29L2031/7132 , D01F1/10 , D10B2211/22
摘要： The present disclosure provides methods for fabricating various regenerated silk geometries using temperature control. In addition to temperature control, mechanical processing can be used to enhance properties of the fabricated article. The present disclosure also provides silk foam and paper-like materials molded using freezer processing.
摘要翻译：本公开提供了使用温度控制来制造各种再生丝几何形状的方法。除了温度控制之外，还可以使用机械加工来增强制造物品的性能。本公开还提供了使用冷冻处理模制的丝绸泡沫和纸状材料。

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