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1. 发明公开

EP1960748A2 METHOD AND SYSTEM OF ARRAY IMAGING 审中-公开
标题翻译：方法和系统阵成像
公开(公告)号：EP1960748A2
公开(公告)日：2008-08-27
申请号：EP06851638.4
申请日：2006-08-21
申请人： TUFTS UNIVERSITY , Bencic-Nagale, Sandra
发明人： WALT, David R.
IPC分类号： G01J1/32 , H01J40/14
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/0213 , G01J3/0229 , G01J3/10 , G01J3/4406 , G01J2001/0276 , G01N21/6428 , G01N21/6458 , G01N2021/6441 , G01N2021/6484 , G01N2201/08 , G01N2201/088
摘要： The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array b minimizing the effects of photobleaching. The imaging system has a light source (12), a variable exposure aperture (14), and a varia filter system (16). The system extends the longevity of sensors (28) by 1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or 2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing intensity over time as necessary to counteract the effects of photobleaching.

2. 发明申请

WO2008051189A2 METHOD AND SYSTEM OF ARRAY IMAGING 审中-公开
标题翻译：阵列成像的方法与系统
公开(公告)号：WO2008051189A2
公开(公告)日：2008-05-02
申请号：PCT/US2006/032608
申请日：2006-08-21
申请人： TUFTS UNIVERSITY , BENCIC-NAGALE, Sandra , WALT, David R.
发明人： WALT, David R.
IPC分类号： G01J1/32 , H01J40/14
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/0213 , G01J3/0229 , G01J3/10 , G01J3/4406 , G01J2001/0276 , G01N21/6428 , G01N21/6458 , G01N2021/6441 , G01N2021/6484 , G01N2201/08 , G01N2201/088
摘要： The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.
摘要翻译：本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。成像系统具有光源，可变曝光孔径和可变过滤器系统。该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度激发光，仅提供诱导适当激发所需的强度，并随时间增加强度以抵消光漂白的影响。

3. 发明申请

WO2014160432A1 FRAGMENT COMPLEMENTATION BASED ASSAYS 审中-公开
标题翻译：基于片段补充的测试
公开(公告)号：WO2014160432A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/026592
申请日：2014-03-13
申请人： TUFTS UNIVERSITY
发明人： BENITO-PENA, Elena , WALT, David R.
IPC分类号： C12Q1/68 , C12Q1/34 , C12Q1/66 , C12N9/38 , C12N9/02
CPC分类号： C12Q1/6834 , C12N9/2468 , C12Q1/6816 , C12Q2561/107 , G01N33/581 , Y02A50/57
摘要： The present disclosure provides, among other things, methods and compositions for detecting and/or quantifying analytes using fragment complementation technologies. In accordance with various embodiments of the present disclosure, a kit can include a) a capture probe immobilized on a surface, wherein the capture probe can associate with an analyte in a sample, thereby forming at least one captured analyte; b) a detection element including a target interacting probe associated with a first subunit of a detectable entity, wherein the target interacting probe can associate with the captured analyte so that a first complex is formed; and c) a second subunit that can complement the first subunit and generate a detectable entity, wherein the presence and/or amount of the analyte is indicated by detecting level or activity of the detectable entity.
摘要翻译：本公开尤其提供了使用片段互补技术检测和/或定量分析物的方法和组合物。根据本公开的各种实施方案，试剂盒可以包括：a）固定在表面上的捕获探针，其中捕获探针可以与样品中的分析物结合，从而形成至少一种捕获的分析物; b）包括与可检测实体的第一亚基相关联的靶相互作用探针的检测元件，其中所述靶相互作用探针可以与所捕获的分析物结合，从而形成第一复合物; 和c）可补充第一亚基并产生可检测实体的第二亚基，其中通过检测可检测实体的水平或活性来指示分析物的存在和/或量。

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