专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010141133A2 SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY 审中-公开
标题翻译： SILK FIBROIN系统用于抗生素递送
公开(公告)号：WO2010141133A2
公开(公告)日：2010-12-09
申请号：PCT/US2010026190
申请日：2010-03-04
申请人： TUFTS COLLEGE , KAPLAN DAVID L , PANILAITIS BRUCE , PRITCHARD ELEANOR M , OMENETTO FIORENZO , AXELRAD JORDAN
发明人： KAPLAN DAVID L , PANILAITIS BRUCE , PRITCHARD ELEANOR M , OMENETTO FIORENZO , AXELRAD JORDAN
IPC分类号： A61L27/40 , A61L27/36 , A61L27/54 , A61P31/00 , C07K14/435
CPC分类号： A61L27/227 , A61K9/0019 , A61K9/1617 , A61K9/1664 , A61K9/7007 , A61K31/43 , A61K31/546 , A61K31/7036 , A61K45/06 , A61K47/42 , A61K47/46 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/54 , A61L2300/406 , A61L2300/45 , A61L2300/622 , C07K14/43586 , A61K2300/00
摘要： The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.
摘要翻译：本发明提供了包含一种或多种用于预防或治疗微生物污染的抗生素的丝素蛋白基组合物，制备含抗生素的丝支架的方法，在丝支架中稳定抗生素的方法，以及用于预防或治疗微生物污染的方法含有抗生素的组合物。可以使用各种方法将抗生素包埋在基于丝素蛋白的组合物中。本发明的含抗生素的组合物特别可用于稳定抗生素，防止细菌感染，以及用于医疗植入物，组织工程，药物递送系统或其它药物或医疗应用。

2. 发明申请

WO2012094436A3 ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES 审中-公开
标题翻译：电子元件在纸基基片上
公开(公告)号：WO2012094436A3
公开(公告)日：2012-09-27
申请号：PCT/US2012020244
申请日：2012-01-04
申请人： TUFTS UNIVERSITY TRUSTEES OF TUFTS COLLEGE , OMENETTO FIORENZO , KAPLAN DAVID L , TAO HU
发明人： OMENETTO FIORENZO , KAPLAN DAVID L , TAO HU
IPC分类号： G06K19/06
CPC分类号： B01L3/502707 , C12Q1/54 , G01J1/02 , G01J5/02 , G01N21/3563 , G01N21/3581 , G01N22/00
摘要： The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
摘要翻译：本公开涉及纸基衬底和包含这种衬底的设备。该设备可以包括耦合到纸基衬底的图案化导电结构，其中图案化导电结构响应电磁辐射。

3. 发明申请

WO2010126640A3 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 审中-公开
标题翻译：用于生物医学和生物医学应用的丝素纤维结构的纳米生物
公开(公告)号：WO2010126640A3
公开(公告)日：2011-01-13
申请号：PCT/US2010024004
申请日：2010-02-12
申请人： TUFTS COLLEGE , AMSDEN JASON J , KAPLAN DAVID L , OMENETTO FIORENZO
发明人： AMSDEN JASON J , KAPLAN DAVID L , OMENETTO FIORENZO
IPC分类号： B82B3/00 , B29C59/02 , B29D7/01
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译：本发明提供了一种基于光子纳米压印丝素蛋白的材料及其制备方法，其包括用光子纳米尺度图案压花丝素蛋白基膜。此外，本发明提供了通过局部降低丝膜的玻璃化转变温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印工艺增加了高通量，并且提高了将丝基光子学结合到生物医学和其它光学器件中的潜力。

4. 发明申请

WO2011026101A3 SILK TRANSISTOR DEVICES 审中-公开
标题翻译：丝光晶体管器件
公开(公告)号：WO2011026101A3
公开(公告)日：2011-06-16
申请号：PCT/US2010047307
申请日：2010-08-31
申请人： TUFTS COLLEGE , OMENETTO FIORENZO , KAPLAN DAVID L , AMSDEN JASON , CAPELLI RAFFAELLA , TOFFANIN STEFANO , BENFENATI VALENTINA , MUCCINI MICHELE , ZAMBONI ROBERTO
发明人： OMENETTO FIORENZO , KAPLAN DAVID L , AMSDEN JASON , CAPELLI RAFFAELLA , TOFFANIN STEFANO , BENFENATI VALENTINA , MUCCINI MICHELE , ZAMBONI ROBERTO
IPC分类号： H01L51/10 , H01L51/30
CPC分类号： H01L51/0093 , B82Y5/00 , B82Y10/00 , C07K14/43586 , G01N33/502 , H01L51/0036 , H01L51/0053 , H01L51/052 , H01L51/0545 , H01L51/0562 , H01L51/0566 , H01L51/5296
摘要： The invention relates to ecosustainable and biocompatible, low cost, ambient friendly electronic and optoelectronic devices, such as transistors and light-emitting transistors, made with silk fibroin or blended with other biopolymers, methods for fabrication and methods of using the silk-based electronics and optoelectronics. The silk-based electronics and optoelectronics can be implanted in vivo and in vitro for biomedical applications, such as for drug discovery or drug screening assays and devices. The silk-based devices may be used in the food industry and embedded in packaging for tracking and sensing, for security purposes or exploited as disposable not harmful for the environment efficient general electronic and optoelectronic devices.
摘要翻译：本发明涉及用丝素蛋白制成或与其他生物聚合物混合的生物可降解和生物兼容，低成本，环境友好的电子和光电器件，例如晶体管和发光晶体管，其制造方法和使用丝基电子学的方法以及光电。基于丝的电子和光电子可以植入体内和体外用于生物医学应用，例如用于药物发现或药物筛选测定和装置。基于丝绸的设备可以用于食品工业，并且为了安全目的而被嵌入到用于跟踪和感测的包装中，或者被开发为一次性对环境有效的通用电子和光电子器件无害的。

5. 发明申请

WO2010042798A3 MODIFIED SILK FILMS CONTAINING GLYCEROL 审中-公开
标题翻译：含有GLYCEROL的改性丝状膜
公开(公告)号：WO2010042798A3
公开(公告)日：2010-07-22
申请号：PCT/US2009060135
申请日：2009-10-09
申请人： TUFTS COLLEGE , LU SHENZHOU , WANG XIAOQIN , OMENETTO FIORENZO , KAPLAN DAVID L
发明人： LU SHENZHOU , WANG XIAOQIN , OMENETTO FIORENZO , KAPLAN DAVID L
IPC分类号： A61L27/36 , A23L19/00 , A61F2/02 , A61L27/54
CPC分类号： A61L27/3604 , A61L27/3804 , A61L27/50 , A61L27/54 , A61L2420/06 , B05D1/30 , B05D3/0254 , B05D3/107 , C08J3/18 , C08J5/18 , C08J2389/00 , C08K5/053 , C12N11/02 , C08L89/00
摘要： The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
摘要翻译：本发明提供了制备水不溶性，韧性，柔韧性丝素蛋白膜的组合物和方法。丝膜包括丝素蛋白和约10％至约50％（w / w）甘油，并且通过完全水性方法制备。可以通过从丝膜中提取甘油并重新干燥来进一步处理延性丝膜。活性剂可以嵌入或沉积在甘油改性丝膜上用于各种医疗应用。膜可以成形为3维结构，或者作为标签或涂层放置在支撑表面上。本发明的甘油改性丝膜可用于组织工程，医疗装置或植入物，药物递送，食用药物或食品标签等各种应用。

6. 发明申请

WO2009155397A2 EDIBLE HOLOGRAPHIC SILK PRODUCTS 审中-公开
标题翻译：可食用硅胶产品
公开(公告)号：WO2009155397A2
公开(公告)日：2009-12-23
申请号：PCT/US2009047751
申请日：2009-06-18
申请人： TUFTS COLLEGE , OMENETTO FIORENZO , KAPLAN DAVID L
发明人： OMENETTO FIORENZO , KAPLAN DAVID L
IPC分类号： A61K47/00 , A23L1/212 , A61K9/20 , A61K9/48 , G03H1/04
CPC分类号： G03H1/02 , A61J3/007 , A61J2200/30 , A61J2200/60 , A61J2205/20 , A61J2205/30 , A61K9/2893 , A61K9/4883 , G03H1/0011 , G03H1/0244 , G03H1/0272 , G03H2001/0044 , Y10T428/24802
摘要： The present invention relates to edible silk holographic elements and methods for making the same. Edible silk holographic elements are used to label pharmaceuticals and foods, or may be formulated to deliver pharmaceuticals.
摘要翻译：本发明涉及食用丝全息元件及其制造方法。食用丝全息元件用于标签药品和食品，或者可以配制成用于递送药物。

7. 发明申请

WO2008106485A3 TISSUE-ENGINEERED SILK ORGANS 审中-公开
标题翻译：组织工程丝织品
公开(公告)号：WO2008106485A3
公开(公告)日：2008-11-06
申请号：PCT/US2008055072
申请日：2008-02-27
申请人： TUFTS COLLEGE , KAPLAN DAVID L , OMENETTO FIORENZO , MARCHANT JEFFREY , PANJWANI NOORJAHAN , LAWRENCE BRIAN
发明人： KAPLAN DAVID L , OMENETTO FIORENZO , MARCHANT JEFFREY , PANJWANI NOORJAHAN , LAWRENCE BRIAN
IPC分类号： A61L27/38 , C12N5/071
CPC分类号： A61L27/3604 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3839 , A61L27/3891 , A61L27/56 , A61L2300/412 , C12N5/0068 , C12N5/0621 , C12N2533/50 , G01N33/5044
摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
摘要翻译：本发明涉及薄片组织层，其包含含有组织特异性细胞的开槽丝素蛋白基质。丝素蛋白底物提供了控制和培养细胞和细胞外基质发育的极好手段。许多薄层组织层可用于创建组织工程器官，如组织工程角膜。组织工程器官是非免疫原性和生物相容性的。

8. 发明申请

WO2012031282A3 PLASMONIC NANOPARTICLE-DOPED SILK MATERIALS 审中-公开
标题翻译： PLASMONIC NANOPARTICLE DOPED SILK MATERIALS
公开(公告)号：WO2012031282A3
公开(公告)日：2012-06-21
申请号：PCT/US2011050453
申请日：2011-09-03
申请人： TUFTS UNIVERSITY TRUSTEES OF TUFTS COLLEGE , OMENETTO FIORENZO , KAPLAN DAVID L , TAO HU
发明人： OMENETTO FIORENZO , KAPLAN DAVID L , TAO HU
IPC分类号： A61M36/02 , A61F2/02 , A61F7/00 , A61L27/04 , A61L27/22 , A61L27/44 , A61L27/50 , A61L27/54 , A61M31/00
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供了基于丝素蛋白的光热元件及其用途。基于丝心蛋白的光热元件包括分布在丝心蛋白基质中的多个等离子体纳米颗粒，并且当等离子体激元纳米颗粒暴露于电磁辐射时可产生热量。丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与诸如用于将热量转换成电的热电装置的各种电子部件集成。本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

9. 发明申请

WO2011046652A2 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS 审中-公开
标题翻译：全蛋白可植入，可折叠的反射器
公开(公告)号：WO2011046652A2
公开(公告)日：2011-04-21
申请号：PCT/US2010042585
申请日：2010-07-20
申请人： TUFTS COLLEGE , OMENETTO FIORENZO , KAPLAN DAVID L
发明人： OMENETTO FIORENZO , KAPLAN DAVID L
IPC分类号： G01N33/48 , A61B5/00 , G01N33/68
CPC分类号： A61B5/0059 , A61K49/0004 , A61L27/227
摘要： The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.
摘要翻译：本发明提供了用于制造由生物相容性和生物可再吸收的丝素蛋白构成的光学反射体的组合物和方法。例如，丝绸后向反射器可以基于毫米尺寸的微棱镜阵列构建，以旋转成像的皮质层的图像平面，从而增加当插入待分析的样品中时在反射方向上可检测的光子的量，并且最终增加在多光子显微镜中的对比度。这种装置可用作用于各种应用的无标签，生物相容性，生物可吸收的可植入装置，从医学成像/诊断，药物/治疗递送，食品链安全和环境监测。

10. 发明申请

WO2012054121A9 SILK-BASED BIOPHOTONIC SENSORS 审中-公开
标题翻译：基于SILK的生物传感器
公开(公告)号：WO2012054121A9
公开(公告)日：2012-06-14
申请号：PCT/US2011046060
申请日：2011-07-30
申请人： TUFTS UNIVERSITY TRUSTEES OF TUFTS COLLEGE , UNIV BOSTON , OMENETTO FIORENZO , KAPLAN DAVID , AMSDEN JASON , DAL NEGRO LUCA
发明人： OMENETTO FIORENZO , KAPLAN DAVID , AMSDEN JASON , DAL NEGRO LUCA
IPC分类号： G01N33/53 , B82Y15/00 , G01N21/25 , G01N33/52
CPC分类号： G01N21/25 , B82Y30/00 , G01N21/4788 , G01N33/54373
摘要： The present disclosure relates to biophotonic sensors. An example of a biophotonic sensor may be an apparatus for analyzing a sample. The apparatus may include a substrate, aperiodic nanostructured protrusions disposed on the substrate, and a silk material deposited between the protrusions.
摘要翻译：本发明涉及生物光子传感器。生物光子传感器的实例可以是用于分析样品的装置。该装置可以包括衬底，设置在衬底上的非周期纳米结构化突起和沉积在突起之间的丝材料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式