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1. 发明申请

WO2010065957A3 VASCULARIZED LIVING SKIN CONSTRUCTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：血液生化皮肤结构及其使用方法
公开(公告)号：WO2010065957A3
公开(公告)日：2010-09-23
申请号：PCT/US2009067006
申请日：2009-12-07
申请人： TUFTS COLLEGE , DRAPER LAB CHARLES S , KAPLAN DAVID L , HERMAN IRA M , BORENSTEIN JEFFREY T , GARLICK JONATHAN
发明人： KAPLAN DAVID L , HERMAN IRA M , BORENSTEIN JEFFREY T , GARLICK JONATHAN
IPC分类号： C12N11/02 , A61L27/56 , C12N5/071
CPC分类号： A61L27/60 , A61L27/3604 , A61L27/38
摘要： While several devices and living skin substitutes have been developed over the past few years, none possess an integrated vasculature. Accordingly, the invention described herein provides, in part, controllable, three-dimensional human skin equivalents constructed using biodegradable microfluidic systems that encompass a variety of properties, including biodegradeability, bioactivity and full functionality, and a complete microcirculation.
摘要翻译：虽然在过去几年中已经开发了几种装置和活体皮肤替代品，但没有一种具有集成的脉管系统。因此，本文描述的本发明部分地提供使用可生物降解的微流体系统构建的可控的三维人体皮肤等同物，其包括生物降解性，生物活性和全功能性以及完整的微循环。

2. 发明申请

WO2011109691A3 SILK-BASED IONOMERIC COMPOSITIONS 审中-公开
标题翻译：基于SILK的离子组合物
公开(公告)号：WO2011109691A3
公开(公告)日：2012-02-09
申请号：PCT/US2011027153
申请日：2011-03-04
申请人： TUFTS COLLEGE , KAPLAN DAVID L , SERBAN MONICA A
发明人： KAPLAN DAVID L , SERBAN MONICA A
IPC分类号： C08L89/00 , C07K19/00 , C08H1/00 , C08L101/12
CPC分类号： A61L27/52 , A61K9/5063 , A61L15/26 , A61L15/32 , A61L15/42 , A61L27/18 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/00 , Y10T428/2982 , C08L77/04
摘要： Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.
摘要翻译：本文公开了基于pH的丝心蛋白基离聚物组合物和胶体及其制备方法。丝素蛋白离聚物组合物的状态是可逆的，并且可以在诸如pH的环境刺激下从凝胶状胶体转化为更流体状的溶液，或反之亦然。因此，基于丝的离聚物组合物和胶体可以应用于各种行业，从电子应用到生物医学应用，例如传感器，凝胶二极管，吸收材料，药物递送系统，组织植入物和造影剂。

3. 发明申请

WO2011008842A2 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING 审中-公开
标题翻译： ELECTROSPUN丝绸材料系统用于创伤治疗
公开(公告)号：WO2011008842A2
公开(公告)日：2011-01-20
申请号：PCT/US2010041953
申请日：2010-07-14
申请人： TUFTS COLLEGE , UNIV MASSACHUSETTS FOUNDATION INC , ZHANG XIAOHUI , KAPLAN DAVID L , WHARRAM SCOTT E , MCCARTHY STEPHEN
发明人： ZHANG XIAOHUI , KAPLAN DAVID L , WHARRAM SCOTT E , MCCARTHY STEPHEN
IPC分类号： A61L15/22 , A61L15/32 , A61L15/36 , A61L15/44 , D01D5/00
CPC分类号： A61L15/40 , A61L15/225 , A61L15/44 , A61L2300/406 , A61L2300/62 , A61L2300/64 , D01D5/003 , D01F4/02 , D04H1/09 , D04H1/4266 , D04H1/728 , C08L71/02
摘要： The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.
摘要翻译：本发明涉及制备丝纤蛋白/聚环氧乙烷共混材料的方法及其所得材料，其适用于生物医学应用如伤口愈合。特别地，具有丝绸：PEO混合比为2:1至4:1的电纺丝丝素/ PEO垫，用受控蒸发，约束干燥技术和/或醇处理和/或PEO提取处理，显示出合适的与用于伤口敷料的生物材料系统相关的物理和生物功能性质，例如纤维结构，形貌，吸收，水蒸汽透过率，氧渗透和生物降解性。

4. 发明申请

WO2006028996A2 EMULSAN-ALGINATE MICROSPHERES AND METHODS OF USE THEREOF 审中-公开
标题翻译：微乳化微球及其使用方法
公开(公告)号：WO2006028996A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031372
申请日：2005-09-02
申请人： TUFTS COLLEGE , KAPLAN DAVID L , CASTRO GUILLERMO R , PANILAITIS BRUCE
发明人： KAPLAN DAVID L , CASTRO GUILLERMO R , PANILAITIS BRUCE
IPC分类号： A61K9/50
CPC分类号： A61K9/167
摘要： The present invention relates generally to emulsan-alginate compositions and to methods of use. Methods are provided for use of emulsan-alginate compositions as drug delivery vehicles. In addition, methods are provided for use of emulsan-alginate compositions in applications requiring protein adsorption (e.g removal of protein toxins from food products or other products and solutions). The compositions of the invention avoid some of the problems seen in the art with alginate microspheres or particles.
摘要翻译：本发明一般涉及藻酸 - 海藻酸盐组合物和使用方法。提供了用作乳剂 - 藻酸盐组合物作为药物递送载体的方法。此外，提供了在需要蛋白质吸附的应用（例如从食品或其他产品和溶液中除去蛋白质毒素）的情况下使用乳藻 - 藻酸盐组合物的方法。本发明的组合物避免了藻酸盐微球或颗粒在本领域中看到的一些问题。

5. 发明申请

WO2011041395A3 SILK NANOSPHERES AND MICROSPHERES AND METHODS OF MAKING SAME 审中-公开
标题翻译：丝绸纳米球和微球及其制备方法
公开(公告)号：WO2011041395A3
公开(公告)日：2011-08-25
申请号：PCT/US2010050698
申请日：2010-09-29
申请人： TUFTS COLLEGE , WANG XIAOQIN , KAPLAN DAVID L
发明人： WANG XIAOQIN , KAPLAN DAVID L
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： A61K9/5169 , A61K9/14 , A61K9/1605 , A61K9/1647 , A61K9/5052 , A61K9/5089 , A61K9/5192 , A61K31/352 , Y10T428/2982
摘要： The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped. The silk nano- and microparticles of the present invention are thus suitable for a variety of biomedical and pharmaceutical applications, such as drug delivery or tissue engineering.
摘要翻译：本发明提供制备丝纳米颗粒和微颗粒的方法，将活性剂包封到丝纳米颗粒和微颗粒中的方法以及包含这些丝颗粒的组合物。特别地，丝球由丝和聚乙烯醇（PVA）的相分离制备，而不暴露于有机溶剂。该方法使用化学药品PVA，它是药物制剂中FDA批准的成分。可以调整不同的参数来控制制造过程中丝球的尺寸和形状。本发明的丝粒组合物也可以包封活性剂或化学品。这样的组合物允许活性剂可控地并且可持续地释放到靶器官或组织。捕获活性剂的丝组合物也为这种包埋的活性剂提供了长期存储介质。因此，本发明的蚕丝纳米颗粒和微米颗粒适用于各种生物医学和药物应用，例如药物递送或组织工程。

6. 发明申请

WO2010126640A3 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 审中-公开
标题翻译：用于生物医学和生物医学应用的丝素纤维结构的纳米生物
公开(公告)号：WO2010126640A3
公开(公告)日：2011-01-13
申请号：PCT/US2010024004
申请日：2010-02-12
申请人： TUFTS COLLEGE , AMSDEN JASON J , KAPLAN DAVID L , OMENETTO FIORENZO
发明人： AMSDEN JASON J , KAPLAN DAVID L , OMENETTO FIORENZO
IPC分类号： B82B3/00 , B29C59/02 , B29D7/01
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译：本发明提供了一种基于光子纳米压印丝素蛋白的材料及其制备方法，其包括用光子纳米尺度图案压花丝素蛋白基膜。此外，本发明提供了通过局部降低丝膜的玻璃化转变温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印工艺增加了高通量，并且提高了将丝基光子学结合到生物医学和其它光学器件中的潜力。

7. 发明申请

WO2010036992A3 ACTIVE SILK MUCO-ADHESIVES, SILK ELECTROGELATION PROCESS, AND DEVICES 审中-公开
标题翻译：主动丝光胶粘剂，丝光电镀工艺和器件
公开(公告)号：WO2010036992A3
公开(公告)日：2010-05-20
申请号：PCT/US2009058534
申请日：2009-09-28
申请人： TUFTS COLLEGE , BERNHARD NICOLAI N , LO TIM JIA-CHING , LEISK GARY G , KAPLAN DAVID L
发明人： BERNHARD NICOLAI N , LO TIM JIA-CHING , LEISK GARY G , KAPLAN DAVID L
IPC分类号： A61L27/36 , A61F2/02
CPC分类号： H01L41/193 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/38 , A61L27/52 , C08L89/00
摘要： The present invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ß-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for a variety of medical applications. The electrogelated silk exists as a piezoelectric silk material comprising a mixture of silk fibroin proteins having silk I conformation and silk ß-sheet structure. Silk electrogelation process of the present invention is useful in variety of applications such as tissue engineering, medical device or implants, drug delivery, soft robotics or motion associated technology.
摘要翻译：本发明提供了在称为电凝胶的方法中使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物，方法和装置。丝素蛋白凝胶可以通过施加反向电压而被可逆地转换成液体形式，或者可以通过施加剪切力或其它处理而进一步转化成β片结构。电致凝胶丝可以用作提取的体积凝胶，喷雾或凝胶流加工成材料或装置，或者可以用作设备的丝凝胶涂层。活性剂可以嵌入丝绸凝胶中用于各种医疗应用。电致凝胶丝作为压电丝材料存在，其包含具有丝绸构象和丝绸ß片材结构的丝素蛋白的混合物。本发明的丝网印刷方法可用于组织工程，医疗装置或植入物，药物递送，软机器人或运动相关技术等各种应用。

8. 发明申请

WO2009100280A3 3-DIMENSIONAL SILK HYDROXYAPATITE COMPOSITIONS 审中-公开
标题翻译：三维丝素羟基磷酸酯组合物
公开(公告)号：WO2009100280A3
公开(公告)日：2009-10-08
申请号：PCT/US2009033309
申请日：2009-02-06
申请人： TUFTS COLLEGE , KAPLAN DAVID L , KIM HYEON JOO , KUGEL GERARD
发明人： KAPLAN DAVID L , KIM HYEON JOO , KUGEL GERARD
IPC分类号： A61L27/14 , A61F2/28 , A61L27/12 , A61L27/54
CPC分类号： A61F2/2846 , A61F2002/2817 , A61F2310/00293 , A61F2310/00365 , A61L27/46 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/64 , A61L2430/02 , C08L89/00
摘要： Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.
摘要翻译：本文描述了包含丝聚合物和羟基磷灰石的混合物的方法和组合物。本文所述的方法可用于制备丝聚合物和羟基磷灰石的混合物，并进一步提供可模塑成所需形状的混合物。本文还包括包含丝状聚合物和具有所需形状的羟基磷灰石的混合物的组合物，其可以进一步植入，例如以促进骨愈合或牙齿结构或支撑。这样的组合物还可以包括试剂，例如治疗剂或细胞。

9. 发明申请

WO2008118133A3 SILK MICROSPHERES FOR ENCAPSULATION AND CONTROLLED RELEASE 审中-公开
标题翻译：用于封装和控制释放的SILK微孔
公开(公告)号：WO2008118133A3
公开(公告)日：2009-01-08
申请号：PCT/US2007020789
申请日：2007-09-26
申请人： TUFTS COLLEGE , KAPLAN DAVID L , WANG XIAOQIN
发明人： KAPLAN DAVID L , WANG XIAOQIN
IPC分类号： A61K9/16 , A61K47/34 , A61K47/42
CPC分类号： A61K38/44 , A61K9/127 , A61K9/16 , A61K9/1658 , A61K9/19 , A61K9/5052 , A61K31/7076 , A61K47/34 , A61K47/42
摘要： A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ß-sheet structure dominant silk microsphere structures having about 2 µm in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
摘要翻译：开发了一种使用脂质囊泡作为模板来制备丝素蛋白微球的方法，以有效地加载活性形式的治疗剂用于控制释放。随后通过使用脱水剂如甲醇或氯化钠除去脂质，得到具有约2μm直径的β片结构优势的丝微球结构。治疗剂可以包埋在丝微球中并用于药物制剂中用于控制释放处理。

10. 发明申请

WO2012145594A3 MOLDED REGENERATED SILK GEOMETRIES USING TEMPERATURE CONTROL AND MECHANICAL PROCESSING 审中-公开
标题翻译：使用温度控制和机械加工的模制再生丝绸几何形状
公开(公告)号：WO2012145594A3
公开(公告)日：2012-12-20
申请号：PCT/US2012034401
申请日：2012-04-20
申请人： TUFTS COLLEGE , LO TIM JIA-CHING , LEISK GARY G , LI LEI , KAPLAN DAVID L
发明人： LO TIM JIA-CHING , LEISK GARY G , LI LEI , KAPLAN DAVID L
IPC分类号： D01F4/02 , C08G101/00 , C08J5/18 , D01F1/02 , D01F1/10 , D01F11/02
CPC分类号： D01F4/02 , B05D3/007 , B05D7/24 , B29C39/003 , B29K2089/00 , B29K2105/04 , B29K2105/25 , B29K2883/00 , B29L2001/005 , B29L2001/007 , B29L2007/008 , B29L2031/7132 , D01F1/10 , D10B2211/22
摘要： The present disclosure provides methods for fabricating various regenerated silk geometries using temperature control. In addition to temperature control, mechanical processing can be used to enhance properties of the fabricated article. The present disclosure also provides silk foam and paper-like materials molded using freezer processing.
摘要翻译：本公开提供了使用温度控制来制造各种再生丝线几何形状的方法。除了温度控制之外，可以使用机械加工来提高制造物品的性能。本公开还提供使用冷冻加工模制的丝状泡沫和纸状材料。

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