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1. 发明申请

WO0158904A9 APOPTOSIS-INDUCING COMPOUNDS 审中-公开
标题翻译：杀虫剂诱导化合物
公开(公告)号：WO0158904A9
公开(公告)日：2002-02-21
申请号：PCT/IE0100020
申请日：2001-02-09
申请人： TRINITY COLLEGE DUBLIN , UNI DI SIENA , WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61P35/00 , C07D498/04 , C07D498/14 , C07D513/04 , A61K31/554
CPC分类号： C07D513/04
摘要： The invention relates to a pharmaceutical composition comprising an apoptosis-inducing amount of a compound having general formula (I), wherein: (i) R1 represents an unsubstituted C6 or C10 aryl group; or a C6 aryl group substituted with Me or OMe; (ii) A represents O, S or S partially oxidized to sulfoxide; (iii) the cyclic group labelled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused system substituted with ethoxycarbonyl function; (iv) and Y represents the group (A) wherein R2 and R3 are independently hydrogen; or methyl; or Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom). The compositions may be used for the treatment of tumours or other cancerous conditions, such as CML (chronic myeloid leukaemia), AML, in AIDS-related lymphomas (such as Karpowski's sarcoma, a sub-cutaneous lymphoma) and used as apoptotic agents in the treatment of cancers generally.
摘要翻译：本发明涉及包含细胞凋亡诱导剂量的具有通式（I）的化合物的药物组合物，其中：（i）R 1表示未取代的C 6或C 10芳基; 或被Me或OMe取代的C6芳基; （ii）A表示O，S或S部分氧化成亚砜; （iii）标记为F的环状基团表示未取代的C6或C10芳基稠合基团或C5杂芳基稠合基团（氮作为杂原子）或被乙氧基羰基官能团取代的苯并稠合体系; （ⅳ），Y表示其中R2和R3独立地为氢的基团（A）; 或甲基; 或Y表示基团CH 3或（CH 2）2 CH 3基团; 或未取代的C5杂芳基（氮作为杂原子）。组合物可用于治疗肿瘤或其它癌症病症，例如艾滋病相关淋巴瘤（如卡尔波夫斯基氏肉瘤，亚皮肤淋巴瘤）中的CML（慢性骨髓性白血病），AML，并用作细胞凋亡剂一般治疗癌症。

2. 发明申请

WO9956736A2 APOPTOSIS-INDUCING COMPOUNDS 审中-公开
标题翻译：细胞凋亡诱导化合物
公开(公告)号：WO9956736A2
公开(公告)日：1999-11-11
申请号：PCT/IE9900030
申请日：1999-05-06
申请人： TRINITY COLLEGE DUBLIN , UNI DI SIENA , WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61K31/472 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/675 , A61K31/00
CPC分类号： A61K31/675 , A61K31/472 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554
摘要： The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.
摘要翻译：本发明涉及具有诱导细胞凋亡能力的吡咯并苯并氧杂吖庚因，吡咯并苯并噻唑类和相关化合物，涉及包含这些化合物的药物组合物以及它们作为抗肿瘤剂的用途。

3. 发明专利

CA2400102A1 APOPTOSIS-INDUCING COMPOUNDS 未知
公开(公告)号：CA2400102A1
公开(公告)日：2001-08-16
申请号：CA2400102
申请日：2001-02-09
申请人： TRINITY COLLEGE DUBLIN , UNI DI SIENA
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , CAMPIANI GIUSEPPE , NACCI VITO
IPC分类号： A61P35/00 , C07D498/04 , C07D498/14 , C07D513/04 , A61K31/554
摘要： The invention relates to a pharmaceutical composition comprising an apoptosi s- inducing amount of a compound having general formula (I), wherein: (i) R1 represents an unsubstituted C6 or C10 aryl group; or a C6 aryl group substituted with Me or OMe; (ii) A represents O, S or S partially oxidized t o sulfoxide; (iii) the cyclic group labelled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused system substituted with ethoxycarbonyl function; (iv) and Y represents the group (A) wherein R2 and R3 are independently hydrogen; or methyl; or Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom). The compositions may be used for the treatment of tumours or other cancerous conditions, such as CML (chronic myeloid leukaemia), AML, in AIDS-related lymphomas (such as Karpowski's sarcoma, a sub-cutaneous lymphoma) and used as apoptotic agents in the treatment of cancers generally.

4. 发明专利

NZ520884A Apoptosis-inducing compounds 未知
公开(公告)号：NZ520884A
公开(公告)日：2004-05-28
申请号：NZ52088401
申请日：2001-02-09
申请人： TRINITY COLLEGE DUBLIN , NIVERSITA DI SIENA
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61P35/00 , C07D498/04 , C07D498/14 , C07D513/04 , A61K31/554
摘要： A pharmaceutical composition comprising an apoptosis-inducing amount of a compound having the general formula (I) for the treatment of tumours or other cancerous conditions, where: - R1 represents a 1-naphthyl group; - A represents O, S or S partially oxidized to sulfoxide; - The cyclic group labeled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused substituted with ethoxycarbonyl function; - Y presents the group of formula (II), where R2 and R3 are independently hydrogen or methyl. Alternatively, Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom).

5. 发明专利

AU3218501A Apoptosis-inducing compounds 未知
公开(公告)号：AU3218501A
公开(公告)日：2001-08-20
申请号：AU3218501
申请日：2001-02-09
申请人： PROVOST FELLOWS , UNI DI SIENA
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61P35/00 , C07D498/04 , C07D498/14 , C07D513/04 , A61K31/554

6. 发明专利

AU3843899A Apoptosis-inducing compounds 未知
公开(公告)号：AU3843899A
公开(公告)日：1999-11-23
申请号：AU3843899
申请日：1999-05-06
申请人： PROVOST FELLOWS , UNI DI SIENA
发明人： WILLIAMS DAVID CLIVE , ZISTERER DANIELA M , NACCI VITO , CAMPIANI GIUSEPPE
IPC分类号： A61K31/472 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/675 , A61K31/00
摘要： The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.

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