专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2010065044A Method and composition for peptide synthesis 有权
标题翻译：肽合成的方法和组合
公开(公告)号：JP2010065044A
公开(公告)日：2010-03-25
申请号：JP2009247579
申请日：2009-10-28
申请人： Trimeris Inc , トリメリス,インコーポレーテッド
发明人： KANG MYUNG-CHOL , BRAY BRIAN , LICHTY MAYNARD , MADER CATHERINE , CHESLA SCOTT
IPC分类号： C07K1/02 , C07K1/06 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/16
CPC分类号： C07K14/005 , C12N2740/16122
摘要： PROBLEM TO BE SOLVED: To provide methods and compositions for peptide synthesis. SOLUTION: First, methods for the synthesis of peptide, in particular T-20 (also referred to as "DP-178") and T-20-like peptide are provided. Such methods utilize solid and liquid phase synthesis methods to synthesize groups of specific peptide fragments and to combine them so as to yield the peptide of interest. Further, individual peptide fragments which act as intermediates in the synthesis of the peptide of interest (e.g., T-20) are provided. Still further, groups of such peptide fragment intermediates which can be utilized together to produce full length T-20 and T-20-like peptide are provided. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供肽合成的方法和组合物。解决方案：首先，提供了合成肽的方法，特别是T-20（也称为“DP-178”）和T-20样肽。这种方法利用固相和液相合成方法来合成特定肽片段的组合并将其组合以产生目的肽。此外，提供了在合成感兴趣的肽（例如T-20）中充当中间体的单个肽片段。此外，提供可以一起用于产生全长T-20和T-20样肽的这些肽片段中间体的基团。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2004029073A3 CONJUGATES COMPRISED OF POLYMER AND HIV GP41-DERIVED PEPTIDES AND THEIR USE IN THERAPY 审中-公开
标题翻译：由聚合物和HIV GP41衍生肽组成的缀合物及其在治疗中的用途
公开(公告)号：WO2004029073A3
公开(公告)日：2004-08-12
申请号：PCT/US0330285
申请日：2003-09-26
申请人： TRIMERIS INC
发明人： BRAY BRIAN , KANG MYUNG-CHOL , TVERMOES NICOLAI , KINDER DANIEL , LACKEY JOHN WILLIAM
IPC分类号： C07K7/00 , A61K38/00 , A61K47/48 , C07K14/16 , A61K39/21 , A61K39/385
CPC分类号： C07K14/005 , A61K38/00 , A61K47/60 , C12N2740/16122
摘要： Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.
摘要翻译：提供了包含与其可操作结合的聚合物不少于两个分子的衍生自HIV gp41的合成肽的缀合物; 通过加入一定量的有效抑制病毒对细胞的感染来使用这些缀合物来抑制HIV向靶细胞的传播的方法; 以及通过经由反应性官能团将每个合成肽分子可操作地结合到聚合物来产生缀合物的方法。

3. 发明申请

WO0134635A9 METHODS AND COMPOSITIONS FOR PEPTIDE SYNTHESIS 审中-公开
标题翻译：肽合成的方法和组合物
公开(公告)号：WO0134635A9
公开(公告)日：2002-08-01
申请号：PCT/US0035725
申请日：2000-07-05
申请人： TRIMERIS INC
发明人： BRAY BRIAN , ANDERSEN MARC , FRIEDRICH PAUL E , KANG MYUNG-CHOL
IPC分类号： C07K7/08 , C07K1/06 , C07K14/00 , C07K14/16 , C07K17/08 , C07K
CPC分类号： C07K14/005 , C12N2740/16122
摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.
摘要翻译：本发明首先涉及用于合成被称为T-1249和T-1249样肽的肽的方法。这些方法利用固相和液相合成方法来合成和组合特定肽片段的组合以产生感兴趣的肽。本发明还涉及在合成感兴趣的肽（例如T-1249）中充当中间体的单个肽片段。本发明还涉及可以一起用于产生全长T-1249和T-1249样肽的这种肽中间体片段的基团。

4. 发明申请

WO0137896A3 METHODS AND COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC REAGENTS 审中-公开
标题翻译：治疗药物管理的方法和组合
公开(公告)号：WO0137896A3
公开(公告)日：2002-01-10
申请号：PCT/US0035724
申请日：2000-07-05
申请人： TRIMERIS INC
发明人： DING SHIULIN , KANG MYUNG-CHOL , VENETTA THOMAS MICHAEL
IPC分类号： A61K9/00 , A61K38/00 , A61K38/16 , A61K47/10 , C07K14/16 , A01N37/18 , A01N43/04 , A61F2/00 , A61F13/00 , A61K31/715 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61F9/14 , A61F9/50
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/162 , A61K47/10 , C07K14/005 , C12N2740/16122
摘要： Methods and compositions are taught that may be used to administer specific bioactive polypeptides, known as T20 and T1249 to a patient, e.g. , as a method of treating a disease or disease state. In particular, the invention teaches carrier hydrogel composition that contain (a) a polymer material and (b) an effective dose of T20, T1249 or a derivative thereof. The polymer materials used in the carrier hydrogel composition preferably have reverse gelation properties and exist as a liquid, aqueous solution at temperatures below physiological temperatures ( e.g. , below the body temperature of a patient) but form hydrogels under physiological conditions ( e.g. , at temperature at or near the body temperature of a patient). The carrier hydrogel compositions may thus be administered to a patient by injection while they are in a liquid state. Upon administration the carrier hydrogel compositions then form hydrogels with the T20 and/or T1249 polypeptides embedded therein. The T20 and/or T1249 polypeptides are thereby released with improved pharmacokinetic properties and bioavailability. The invention thus provides methods for administering T20 and T1249 polypeptides to a patient by administering the T20 and/or T1249 polypeptides in the carrier hydrogel composition of the invention. Methods of treating various diseases and disease states, particularly HIV infection, are also provided that involve administering an effective dose of T20 and/or T1249 polypeptides to a patient in the carrier hydrogel composition of the invention.
摘要翻译：教导了可用于向患者（例如，作为治疗疾病或疾病状态的方法）向特定生物活性多肽（称为T20和T1249）施用的方法和组合物。特别地，本发明教导了含有（a）聚合物材料和（b）有效剂量的T20，T1249或其衍生物的载体水凝胶组合物。在载体水凝胶组合物中使用的聚合物材料优选具有反向凝胶化性质并且在低于生理温度（例如，低于患者体温））的温度下以液体，水溶液形式存在，但在生理学上形成水凝胶条件（例如，，在患者体温或接近体温的温度）。因此，载体水凝胶组合物可以在液体状态下通过注射施用于患者。给药后，载体水凝胶组合物然后形成水凝胶，其中嵌入有T20和/或T1249多肽。由此释放T20和/或T1249多肽，并具有改善的药代动力学性质和生物利用度。因此，本发明提供了通过在本发明的载体水凝胶组合物中施用T20和/或T1249多肽来向患者施用T20和T1249多肽的方法。还提供了治疗各种疾病和疾病状态，特别是HIV感染的方法，其涉及向本发明的载体水凝胶组合物中的患者施用有效剂量的T20和/或T1249多肽。

5. 发明申请

WO0134635A3 METHODS AND COMPOSITIONS FOR PEPTIDE SYNTHESIS 审中-公开
标题翻译：肽合成的方法和组合物
公开(公告)号：WO0134635A3
公开(公告)日：2003-10-16
申请号：PCT/US0035725
申请日：2000-07-05
申请人： TRIMERIS INC
发明人： BRAY BRIAN , ANDERSEN MARC , FRIEDRICH PAUL E , KANG MYUNG-CHOL
IPC分类号： C07K7/08 , C07K1/06 , C07K14/00 , C07K14/16 , C07K17/08 , A61K38/00 , C07K1/00
CPC分类号： C07K14/005 , C12N2740/16122
摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.
摘要翻译：本发明首先涉及用于合成被称为T-1249和T-1249样肽的肽的方法。这些方法利用固相和液相合成方法来合成和组合特定肽片段的组合以产生感兴趣的肽。本发明还涉及在合成感兴趣的肽（例如T-1249）中充当中间体的单个肽片段。本发明还涉及可以一起用于产生全长T-1249和T-1249样肽的这种肽中间体片段的基团。

6. 发明公开

EP1554306A4 CONJUGATES COMPRISED OF POLYMER AND HIV GP41-DERIVED PEPTIDES AND THEIR USE IN THERAPY 审中-公开
标题翻译：聚合物和HIV GP41衍生肽含结合物以及它们在治疗中
公开(公告)号：EP1554306A4
公开(公告)日：2009-01-21
申请号：EP03770450
申请日：2003-09-26
申请人： TRIMERIS INC
发明人： BRAY BRIAN , KANG MYUNG-CHOL , TVERMOES NICOLAI , KINDER DANIEL , LACKEY JOHN WILLIAM , ZHANG YUI
IPC分类号： C07K7/00 , A61K38/00 , A61K47/48 , C07K14/16 , A61K39/21 , A61K39/385
CPC分类号： C07K14/005 , A61K38/00 , A61K47/60 , C12N2740/16122

7. 发明公开

EP1372686A4 METHODS AND COMPOSITIONS FOR PEPTIDE SYNTHESIS 有权
标题翻译：方法和组合物的肽合成
公开(公告)号：EP1372686A4
公开(公告)日：2004-01-02
申请号：EP00992116
申请日：2000-07-05
申请人： TRIMERIS INC
发明人： BRAY BRIAN , ANDERSEN MARC , FRIEDRICH PAUL E , KANG MYUNG-CHOL
IPC分类号： C07K7/08 , C07K1/06 , C07K14/00 , C07K14/16 , C07K17/08 , A61K38/00 , C07K1/00
CPC分类号： C07K14/005 , C12N2740/16122
摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.

8. 发明公开

EP1071442A4 METHODS AND COMPOSITIONS FOR PEPTIDE SYNTHESIS 有权
标题翻译：方法和组合物的肽合成
公开(公告)号：EP1071442A4
公开(公告)日：2002-06-05
申请号：EP99912802
申请日：1999-03-22
申请人： TRIMERIS INC
发明人： KANG MYUNG-CHOL , BRAY BRIAN , LICHTY MAYNARD , MADER CATHERINE , MERUTKA GENE
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K14/16 , C07K16/00 , C07K17/00
CPC分类号： C07K14/005 , C12N2740/16122 , Y02P20/582
摘要： The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

9. 发明专利

AT299029T 未知
公开(公告)号：AT299029T
公开(公告)日：2005-07-15
申请号：AT99912802
申请日：1999-03-22
申请人： TRIMERIS INC
发明人： KANG MYUNG-CHOL , BRAY BRIAN , LICHTY MAYNARD , MADER CATHERINE , MERUTKA GENE
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K14/16 , C07K16/00 , C07K17/00

10. 发明专利

DK1372686T3 未知
公开(公告)号：DK1372686T3
公开(公告)日：2005-05-30
申请号：DK00992116
申请日：2000-07-05
申请人： TRIMERIS INC
发明人： BRAY BRIAN , KANG MYUNG-CHOL , ANDERSEN MARC , FRIEDRICH PAUL E
IPC分类号： C07K7/08 , C07K1/06 , C07K14/00 , C07K14/16 , C07K17/08 , A61K38/00 , C07K1/00
摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式