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2. 发明申请

WO2009099939A3 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 审中-公开
公开(公告)号：WO2009099939A3
公开(公告)日：2009-08-13
申请号：PCT/US2009/032619
申请日：2009-01-30
申请人： TRANSMEDICS, INC. , FISHMAN, Robert , HAVENER, Robert , FATTAH, Ihab Abdel , ABDELAZIM, Anas , NEWELL, Scott , BISHOP, Tom , KHAYAL, Tamer , KYI, Stanley , TAYLOR, Ronald , HARRIOTT, Doug , DE REMER, Matthew , MURRAY, Paul , SULLIVAN, John , ANDERSON, Mark , BRINGHAM, Richard , VAN DRIEL, Michael , HASSANEIN, Waleed
发明人： FISHMAN, Robert , HAVENER, Robert , FATTAH, Ihab Abdel , ABDELAZIM, Anas , NEWELL, Scott , BISHOP, Tom , KHAYAL, Tamer , KYI, Stanley , TAYLOR, Ronald , HARRIOTT, Doug , DE REMER, Matthew , MURRAY, Paul , SULLIVAN, John , ANDERSON, Mark , BRINGHAM, Richard , VAN DRIEL, Michael , HASSANEIN, Waleed
IPC分类号： A61M16/00
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

3. 发明申请

WO2008150587A3 SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR 审中-公开
公开(公告)号：WO2008150587A3
公开(公告)日：2008-12-11
申请号：PCT/US2008/061454
申请日：2008-04-24
申请人： TRANSMEDICS, INC. , HASSANEIN, Waleed , KHAYAL, Tamer , ELBETANONY, Ahmed , LEZBERG, Paul , CECERE, Giovanni , SOUSA, Dennis , HANSEN, Elizabeth
发明人： HASSANEIN, Waleed , KHAYAL, Tamer , ELBETANONY, Ahmed , LEZBERG, Paul , CECERE, Giovanni , SOUSA, Dennis , HANSEN, Elizabeth
IPC分类号： A01N1/02
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

4. 发明申请

WO2007124044A3 SYSTEMS AND METHODS FOR EX VIVO ORGAN CARE 审中-公开
公开(公告)号：WO2007124044A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/009652
申请日：2007-04-19
申请人： TRANSMEDICS, INC. , KYI, Stanley , HAVNER, Robert , HASSANEIN, Waleed , KHAYAL, Tamer , SALEH, Hesham , FATTAH, Ihab, Abdel , TRACHTENBERG, Jon
发明人： KYI, Stanley , HAVNER, Robert , HASSANEIN, Waleed , KHAYAL, Tamer , SALEH, Hesham , FATTAH, Ihab, Abdel , TRACHTENBERG, Jon
IPC分类号： A01N1/02 , A61M1/14 , A61M16/00
摘要： The invention provides systems, methods and solutions for perfusing a lung ex vivo. A method for perfusing a lung ex vivo comprises connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface.

5. 发明公开

EP3677118A1 SYSTEMS FOR EX VIVO ORGAN CARE 审中-实审
公开(公告)号：EP3677118A1
公开(公告)日：2020-07-08
申请号：EP19204566.4
申请日：2007-04-19
申请人： Transmedics, Inc.
发明人： KYI, Stanley , HAVNER, Robert , HASSANEIN, Waleed , KHAYAL, Tamer , SALEH, Hesham , FATTAH, Ihab Abdel , TRACHTENBERG, Jon
IPC分类号： A01N1/02 , A61M11/00 , A61M11/04 , A61M16/00 , A61M16/10 , G01N33/49
摘要： Claims relate to an organ care system for maintaining an ex vivo lung in a near physiologic functioning condition comprising:
a perfusion circuit for flowing fluid into and out of the ex vivo lung; a composition for use in the perfusion circuit to maintain the ex vivo lung in the near physiologic functioning condition, the composition comprising one or more carbohydrates that include dextran, and a plurality of amino acids that do not include asparagine, glutamine, or cysteine; and
a nutritional subsystem comprising an infusion pump.

6. 发明授权

EP2150105B1 METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR 有权
标题翻译：用乳酸作为指示物的体外护理方法
公开(公告)号：EP2150105B1
公开(公告)日：2017-11-01
申请号：EP08795820.3
申请日：2008-04-24
申请人： Transmedics, Inc.
发明人： HASSANEIN, Waleed , KHAYAL, Tamer , ELBETANONY, Ahmed , LEZBERG, Paul , CECERE, Giovanni , SOUSA, Dennis , HANSEN, Elizabeth
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/02

7. 发明公开

EP3178319A1 SYSTEMS FOR EX VIVO ORGAN CARE 有权
标题翻译：用于活体器官的系统
公开(公告)号：EP3178319A1
公开(公告)日：2017-06-14
申请号：EP16205395.3
申请日：2007-04-19
申请人： Transmedics, Inc.
发明人： KYI, Stanley , HAVNER, Robert , HASSANEIN, Waleed , KHAYAL, Tamer , SALEH, Hesham , FATTAH, Ihab, Abdel , TRACHTENBERG, Jon
IPC分类号： A01N1/02 , A61M16/00
CPC分类号： G01N33/4925 , A01N1/02 , A01N1/0226 , A01N1/0247 , A61M11/00 , A61M11/042 , A61M16/00 , A61M16/0078 , A61M16/024 , A61M16/10 , A61M2016/0027 , A61M2016/0033 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2202/025 , A61M2202/0468 , A61M2205/3368 , A61M2230/202 , A61M2230/205 , A61M2230/432 , A61M2230/005
摘要： The invention provides a system (1000) for perfusing a lung ex vivo. The system allows for connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface (1022) and away from the lung through a pulmonary vein interface (1026), providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface (1024).
摘要翻译：本发明提供了用于离体灌注肺的系统（1000）。该系统允许在流体灌注回路内连接肺，使灌注流体通过肺动脉界面（1022）流入肺并通过肺静脉界面（1026）离开肺，向肺提供呼吸气体用于用于肺代谢，呼吸气体具有预定的氧组成，并且通过气管接口使肺通气（1024）。

8. 发明公开

EP2244773A2 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 有权
标题翻译：系统和方法用于离体肺护理
公开(公告)号：EP2244773A2
公开(公告)日：2010-11-03
申请号：EP09707471.0
申请日：2009-01-30
申请人： Transmedics, Inc.
发明人： FISHMAN, Robert , HAVENER, Robert , FATTAH, Ihab Abdel , ABDELAZIM, Anas , NEWELL, Scott , BISHOP, Tom , KHAYAL, Tamer , KYI, Stanley , TAYLOR, Ronald , HARRIOTT, Doug , DE REMER, Matthew , MURRAY, Paul , SULLIVAN, John , ANDERSON, Mark , BRINGHAM, Richard , VAN DRIEL, Michael , HASSANEIN, Waleed
IPC分类号： A61M16/00
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

9. 发明公开

EP2150105A2 SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR 有权
标题翻译： VERFAHREN ZUR EX-VIVO-ORGAN-FUNKTIONSERHALTUNG MIT LAKTAT ALS INDIKATOR
公开(公告)号：EP2150105A2
公开(公告)日：2010-02-10
申请号：EP08795820.3
申请日：2008-04-24
申请人： Transmedics, Inc.
发明人： HASSANEIN, Waleed , KHAYAL, Tamer , ELBETANONY, Ahmed , LEZBERG, Paul , CECERE, Giovanni , SOUSA, Dennis , HANSEN, Elizabeth
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/02
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
摘要翻译：在各种实施例中，本发明提供了与离体器官护理有关的系统，装置和方法。在某些实施方案中，本发明涉及在近生理条件下离体维持器官。本申请描述了在器官护理系统心脏灌注装置的动脉和静脉血管中使用乳酸盐测量的方法，以评估：1）孤立心脏的总体灌注状态和2）孤立心脏的代谢状态和3）分离的供体心脏的整体血管通畅。本发明的这个方面使用心肌细胞在氧被氧气饥饿时产生/产生乳酸的独特能力的特性，并且当它们被氧充分灌注时代谢/利用乳酸进行能量产生。

10. 发明公开

EP4331362A3 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 审中-实审
公开(公告)号：EP4331362A3
公开(公告)日：2024-05-01
申请号：EP23209551.3
申请日：2009-01-30
申请人： TransMedics, Inc.
发明人： FISHMAN, Robert , HAVENER, Robert , FATTAH, Ihab Abdel , ABDELAZIM, Anas , NEWELL, Scott , BISHOP, Tom , KHAYAL, Tamer , KYI, Stanley , TAYLOR, Ronald , HARRIOTT, Doug , DE REMER, Matthew , MURRAY, Paul , SULLIVAN, John , ANDERSON, Mark , BRINGHAM, Richard , VAN DRIEL, Michael , HASSANEIN, Waleed
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/02 , A01N1/021
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

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