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1. 发明申请

WO2007077256A1 AVIAN TELOMERASE REVERSE TRANSCRIPTASE 审中-公开
标题翻译： AVIAN端粒酶逆转录酶
公开(公告)号：WO2007077256A1
公开(公告)日：2007-07-12
申请号：PCT/EP2007/050120
申请日：2007-01-05
申请人： TRANSGENE S.A. , ERBS, Philippe , BALLOUL, Jean-Marc , KAPFER, Marina , SILVESTRE, Nathalie
发明人： ERBS, Philippe , BALLOUL, Jean-Marc , KAPFER, Marina , SILVESTRE, Nathalie
IPC分类号： C12N9/12
CPC分类号： C12N9/1276
摘要： The present invention notably relates to novel recombinant telomerase reverse transcriptases, nucleic acid molecules coding them, cells comprising said nucleic acid molecule and use of these cells for the production of substance of interest.
摘要翻译：本发明特别涉及新的重组端粒酶逆转录酶，编码它们的核酸分子，包含所述核酸分子的细胞以及这些细胞用于产生感兴趣物质的用途。

2. 发明申请

WO2009004016A1 IMMORTALIZED AVIAN CELL LINES 审中-公开
标题翻译：完全免费的AVIAN细胞线
公开(公告)号：WO2009004016A1
公开(公告)日：2009-01-08
申请号：PCT/EP2008/058472
申请日：2008-07-02
申请人： TRANSGENE S.A. , ERBS, Philippe , KAPFER, Marina , SILVESTRE, Nathalie
发明人： ERBS, Philippe , KAPFER, Marina , SILVESTRE, Nathalie
IPC分类号： C12N5/06
CPC分类号： C12N15/907 , C12N7/00 , C12N15/902 , C12N2710/24152 , C12N2800/80
摘要： This invention relates to immortalized avian cells, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.
摘要翻译：本发明涉及永生化鸟类细胞，以及这些细胞用于生产病毒的用途。根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。

3. 发明申请

WO2012001075A2 IMMORTALIZED AVIAN CELL LINES 审中-公开
标题翻译：完全免费的AVIAN细胞线
公开(公告)号：WO2012001075A2
公开(公告)日：2012-01-05
申请号：PCT/EP2011/060952
申请日：2011-06-29
申请人： TRANSGENE , ERBS, Philippe , KAPFER, Marina , SILVESTRE, Nathalie
发明人： ERBS, Philippe , KAPFER, Marina , SILVESTRE, Nathalie
IPC分类号： C12N7/02
CPC分类号： C12N5/0018 , C12N5/0602 , C12N7/00 , C12N15/907 , C12N2510/02 , C12N2510/04 , C12N2710/24052 , C12N2710/24152 , C12N2760/16152 , C12N2760/16252 , C12N2800/80
摘要： This invention relates to immortalized avian cells, including those deposited under accession numbers 09070701, 09070702, and 09070703 at the ECACC, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.
摘要翻译：本发明涉及永生化禽类细胞，包括在ECACC登录号为09070701,09070702和09070703的那些，以及这些细胞用于生产病毒的用途。根据本发明的细胞特别可用于生产重组病毒载体，所述重组病毒载体可用于制备用于治疗动物，更特别是人的治疗和/或预防组合物。

4. 发明申请

WO2008138648A1 VECTORS FOR MULTIPLE GENE EXPRESSION 审中-公开
标题翻译：多基因表达载体
公开(公告)号：WO2008138648A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/051031
申请日：2008-01-29
申请人： TRANSGENE S.A. , SILVESTRE, Nathalie , SCHMITT, Doris
发明人： SILVESTRE, Nathalie , SCHMITT, Doris
IPC分类号： C12N15/86
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/24143 , C12N2840/20
摘要： The present invention provides a vector for expressing at least a first and a second nucleic acid molecules which exhibit a percentage of homology of approximately 80% or greater than 80% over a portion of 40 or more continuous nucleotides and wherein said first nucleic acid molecule and/or said second nucleic acid molecule is modified so as to reduce said percentage of homology to less than 75%. The present invention also relates to substantially isolated nucleic acid molecules comprising a nucleotide sequence as defined in any of SEQ ID NO: 9-15 and 66-69. It also provides a host cell and a pharmaceutical composition comprising such a nucleic acid molecule or vector as well as their use for therapeutic or preventive purposes.
摘要翻译：本发明提供了用于表达至少第一和第二核酸分子的载体，其在40个或更多个连续核苷酸的一部分上表现出大约80％或大于80％的同源性百分比，并且其中所述第一核酸分子和 /或所述第二核酸分子被修饰以便将所述同源性百分比降低到小于75％。本发明还涉及包含SEQ ID NO：9-15和66-69中任一项所定义的核苷酸序列的基本上分离的核酸分子。它还提供了宿主细胞和包含这种核酸分子或载体的药物组合物以及它们用于治疗或预防目的的用途。

5. 发明申请

WO2008138649A3 SIGNALING PEPTIDES 审中-公开
公开(公告)号：WO2008138649A3
公开(公告)日：2008-11-20
申请号：PCT/EP2008/051035
申请日：2008-01-29
申请人： TRANSGENE S.A. , SILVESTRE, Nathalie , JACOBS, Eric
发明人： SILVESTRE, Nathalie , JACOBS, Eric
IPC分类号： C07K14/145 , C12N15/85
摘要： The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecule, vectors, infectious viral particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recombinantly producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.

6. 发明申请

WO2008092854A2 PAPILLOMAVIRUS VACCINE 审中-公开
标题翻译：斑马鱼疫苗
公开(公告)号：WO2008092854A2
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051032
申请日：2008-01-29
申请人： TRANSGENE S.A. , BAUDIN, Martine , BALLOUL, Jean-Marc , SILVESTRE, Nathalie
发明人： BAUDIN, Martine , BALLOUL, Jean-Marc , SILVESTRE, Nathalie
IPC分类号： C12N15/86 , C12N15/863 , C12N7/04 , C07K14/025 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2710/20022
摘要： The present invention relates to the use of a nucleic acid molecule encoding at least one papillomavirus E2 polypeptide, or a vector, an infectious viral particle or a composition thereof for the preparation of a drug intended for treating a patient suffering from a persistent papillomavirus infection caused by at least one papillomavirus. The present invention also provides a vector comprising a nucleic acid molecule comprising a first nucleotide sequence encoding a papillomavirus E1 polypeptide and a second nucleotide sequence encoding a papillomavirus E2 polypeptide wherein the 3' portion of the first nucleotide which in the natural context is 100% identical to the 5' portion of the second nucleotide is modified so as to exhibit a percentage of identity between said portions of at most 75%.
摘要翻译：本发明涉及编码至少一种乳头状瘤病毒E2多肽或载体，感染性病毒颗粒或其组合物的核酸分子用于制备用于治疗患有持续性乳头瘤病毒感染的患者的药物的用途由至少一种乳头瘤病毒。本发明还提供了包含核酸分子的载体，所述核酸分子包含编码乳头瘤病毒E1多肽的第一核苷酸序列和编码乳头瘤病毒E2多肽的第二核苷酸序列，其中第一核苷酸的3'部分在天然环境中为100％对第二核苷酸的5'部分进行修饰，以使所述部分之间的同一性百分比至多为75％。

7. 发明申请

WO2013007772A1 HBV POLYMERASE MUTANTS 审中-公开
标题翻译： HBV聚合酶突变体
公开(公告)号：WO2013007772A1
公开(公告)日：2013-01-17
申请号：PCT/EP2012/063640
申请日：2012-07-12
申请人： TRANSGENE SA , MARTIN, Perrine , SILVESTRE, Nathalie , MARCHAND, Jean-Baptiste
发明人： MARTIN, Perrine , SILVESTRE, Nathalie , MARCHAND, Jean-Baptiste
IPC分类号： C12N9/22 , A61K38/16 , C07K14/02 , C12N5/10 , A61K39/29 , A61P31/12
CPC分类号： C12N9/1252 , A61K38/00 , A61K39/292 , A61K2039/53 , C07K14/005 , C07K2319/02 , C07K2319/03 , C07K2319/40 , C12N7/00 , C12N9/1276 , C12N9/22 , C12N2730/10122 , C12N2730/10134 , C12N2799/022 , C12N2799/023 , C12P21/02 , C12Y207/07007 , C12Y301/26004
摘要： The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
摘要翻译：本发明涉及聚合酶HBV突变体多肽，其包含功能性地破坏聚合酶活性的突变聚合酶结构域和包含该聚合酶突变体多肽的融合蛋白。本发明还涉及用于表达所述聚合酶突变体多肽的核酸分子和表达载体以及可用于引发对HBV的免疫应答的组合物，目的是提供对HBV感染的保护或治疗作用。

8. 发明申请

WO2011015656A2 COMPOSITION FOR TREATING HBV INFECTION 审中-公开
标题翻译：用于治疗HBV感染的组合物
公开(公告)号：WO2011015656A2
公开(公告)日：2011-02-10
申请号：PCT/EP2010/061492
申请日：2010-08-06
申请人： TRANSGENE SA , MARTIN, Perrine , INCHAUSPE, Geneviève , SILVESTRE, Nathalie , SCHMITT, Doris
发明人： MARTIN, Perrine , INCHAUSPE, Geneviève , SILVESTRE, Nathalie , SCHMITT, Doris
IPC分类号： A61K39/29 , A61P31/12
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N9/1252 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2730/10134 , C12Y207/07007
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译：本发明提供包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的核酸分子以及编码这样的HBV组分的载体。它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。它还提供包含这种核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及用于预防或治疗HBV感染的治疗用途。

9. 发明申请

WO2003074711A1 EXPRESSION CASSETTE FOR PERSISTENCE OF EXPRESSION OF A GENE OF INTEREST IN MUSCLE CELLS 审中-公开
标题翻译：在肌肉细胞中表达兴趣基因的表达表达的表达
公开(公告)号：WO2003074711A1
公开(公告)日：2003-09-12
申请号：PCT/IB2003/001360
申请日：2003-03-04
申请人： TRANSGENE S.A.
发明人： ANTONIOU, Michael , RAGUZ, Selina , JACOBS, Eric , SILVESTRE, Nathalie
IPC分类号： C12N15/67
CPC分类号： C07K14/4708 , A61K48/00 , C12N2799/022
摘要： The present invention concerns the use of a nucleic acid fragment comprising a portion of at least 100 contigous nucleotide bases which portion has a sequence the same as, or homologous to a portion of corresponding length of the sequence as set out in SEQ ID NO: 1 starting at nucleotide approximately 1 and ending at nucleotide approximately 16879 or the same as, or homologous to a portion of the corresponding length of the sequence complementary to said SEQ ID NO: 1 within the specified positions, for improving the persistence of transfected cells expressing one or more gene(s) of interest operably linked to said acid nucleic fragment. The invention also relates to an expression cassette for the expression of one or more gene(s) of interest which expression is controlled by one or more control sequence(s) and a nucleic acid fragment as defined above. The present invention also provides a vector containing said expression cassette and a eukaryotic host cell containing said expression cassette or vector as well as a 15 composition comprising said expression cassette, vector or eukaryotic host cell for therapeutic or prophylactic purposes. The present invention is useful for many applications including the the construction of transgenic animal models and somatic gehe therapy, especially for treating or preventing muscle-affecting diseases.
摘要翻译：本发明涉及包含至少100个连续核苷酸碱基的一部分的核酸片段的用途，该部分具有与SEQ ID NO：1所示的序列的相应长度的一部分相同或同源的序列从核苷酸大约1开始，以与指定位置内与所述SEQ ID NO：1互补的序列的相应长度的一部分相同或相同的核苷酸为16879，以改善表达一个的转染细胞的持续性或更多的可操作地连接到所述酸性核酸片段的基因。本发明还涉及用于表达一种或多种感兴趣的基因的表达盒，其表达受一个或多个控制序列和如上定义的核酸片段的控制。本发明还提供含有所述表达盒和含有所述表达盒或载体的真核宿主细胞的载体以及包含所述表达盒，载体或真核宿主细胞用于治疗或预防目的的组合物。本发明可用于许多应用，包括构建转基因动物模型和体细胞地球疗法，特别是用于治疗或预防肌肉疾病的疾病。

10. 发明公开

EP1979474A1 AVIAN TELOMERASE REVERSE TRANSCRIPTASE 失效转让
标题翻译：禽端粒酶逆转录酶
公开(公告)号：EP1979474A1
公开(公告)日：2008-10-15
申请号：EP07703676.2
申请日：2007-01-05
申请人： TRANSGENE S.A.
发明人： ERBS, Philippe , BALLOUL, Jean-Marc , KAPFER, Marina , SILVESTRE, Nathalie
IPC分类号： C12N9/12
CPC分类号： C12N9/1276
摘要： The present invention notably relates to novel recombinant telomerase reverse transcriptases, nucleic acid molecules coding them, cells comprising said nucleic acid molecule and use of these cells for the production of substance of interest.

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