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1. 发明专利

AU750760B2 Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient 未知
公开(公告)号：AU750760B2
公开(公告)日：2002-07-25
申请号：AU9648698
申请日：1998-10-27
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HAMAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HIROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07D401/04 , C07D215/32 , C07C311/04 , C07C311/17 , C07F5/02 , A61K31/47 , B01J23/44 , B01J31/24
摘要： This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula Ä1Ü which is useful as an antibacterial agent, and an intermediate thereof: wherein R represents a hydrogen atom or a carboxyl-protecting group; R represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R bonds; R represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C-R in which R represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula Ä1Ü, a hydrate thereof and a composition comprising them as an active ingredient.

2. 发明专利

UY25920A1 DERIVADO DE ÁCIDO 7-ISOINDOLINA-QUINOLONACARBOXÍLICO 未知
公开(公告)号：UY25920A1
公开(公告)日：2001-08-27
申请号：UY25920
申请日：2000-01-17
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HANAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HIROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： A61K20060101 , C07D20060101 , C07F20060101
摘要： Procesos para producir un derivado de ácido 7-isoindolina-quinolonacarboxílico representado por la fórmula general [1] y su producto intermedio, en donde: R1 respresenta un átomo de hidrógeno o un grupo protector de carboxilo; R2 representa un grupo alquilo, alquenilo, cicloalquilo, arilo o heterocíclico sustituido o no; R3 representa un grupo seleccionado entre átomo de hidrógeno, halógeno, grupo alquilo, alquenilo, cicloalquilo, arilo, alcoxi o alquiltio, nitro, ciano, acilo, grupos hidroxilo protegidos o no, y grupo amino protegido o no, sustituido o no; R4 representa un grupo seleccionado de hidrógeno, halógeno, alquilo, alquenilo, cicloalquilo, aralquilo, arilo, alcoxi o alquiltio, hidroxilo o imino portegidos sustituidos o no, alquilideno, oxo y grupos que forman anillo cicloalcano con el átomo de carbono al que R4 está unido; R5 representa un átomo de hidrógeno, un grupo protector de amino o alquilo, cicloalquilo, alquilsulfonilo, arilsulfonilo, acilo o arilo; R6 representa un átomo de hidrógeno, de halógeno, alquilo, alcoxi o alquiltio, hidroxilo o amino, nitro; A: CH o C-R7 en donde R7 representa un átomo de halógeno, alquilo, alcoxi o alquiltio, hidroxilo protegido o no. Por ejemplo: ácido 1-ciclopropil-7-(isoindolin-5-il)-1,4-dihidro-4-oxoquinolina-3-carboxílico. La presente invención es útil como agente antibacteriano.

3. 发明专利

AU9648698A Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient 未知
公开(公告)号：AU9648698A
公开(公告)日：1999-05-17
申请号：AU9648698
申请日：1998-10-27
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HAMAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HIROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07D401/04 , C07D215/32 , C07C311/04 , C07C311/17 , C07F5/02 , A61K31/47 , B01J23/44 , B01J31/24
摘要： This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula Ä1Ü which is useful as an antibacterial agent, and an intermediate thereof: wherein R represents a hydrogen atom or a carboxyl-protecting group; R represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R bonds; R represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C-R in which R represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula Ä1Ü, a hydrate thereof and a composition comprising them as an active ingredient.

4. 发明专利

GB2131428B AMINE DERIVATIVES HAVING HISTAMINE H2-BLOCKING ACTIVITY 未知
公开(公告)号：GB2131428B
公开(公告)日：1986-01-29
申请号：GB8330002
申请日：1983-11-10
申请人： TOYAMA CHEMICAL CO LTD
发明人： HIRAI SHIRO , HIRANO HIROSHI , ARAI HIROTOSHI , KIBA YASUO , SHIBATA HISANARI , KUSAYANAGI YOSHIKAZU , YOTSUJI MINAKO , HASHIBA KAZUHIKO , TANADA KIKUKO
IPC分类号： C07C323/25 , C07D209/48 , C07D211/42 , C07D213/40 , C07D233/54 , C07D263/10 , C07D263/14 , C07D263/28 , C07D277/28 , C07D277/42 , C07D277/48 , C07D295/096 , C07D307/52 , C07D317/58 , C07D333/20 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/18 , C07D307/38 , A61K31/00 , C07C91/02 , C07D233/64 , C07D263/08 , C07D277/32 , C07D295/04 , C07D333/06
摘要： This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compounds, a process for the preparation thereof and an anti-ulcer agent containing the same.

5. 发明公开

EP1031569A4 PROCESSES FOR PRODUCING 7-ISOINDOLINEQUINOLONECARBOXYLIC DERIVATIVES AND INTERMEDIATES THEREFOR, SALTS OF 7-ISOINDOLINEQUINOLONECARBOXYLIC ACIDS, HYDRATES THEREOF, AND COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：用于生产7-ISOINDOLINCHINOLONCARBONSÄUREDERIVATEN和中间产品，第7-ISOINDOLINCHINOLONCARBONSÄURENITS水盐和成分含有这些作为活性成分含
公开(公告)号：EP1031569A4
公开(公告)日：2003-04-23
申请号：EP98950405
申请日：1998-10-27
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HAMAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HIROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07D401/04 , A61K31/47 , B01J23/44 , B01J31/24 , C07C311/04 , C07C311/17 , C07D215/32 , C07F5/02
CPC分类号： C07D401/04 , A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07F5/025 , Y02P20/55
摘要： Processes for producing 7-isoindolinequinolonecarboxylic derivatives useful as antibacterials and represented by general formula (1) and intermediates therefor; salts of 7-isoindolinequinolonecarboxylic derivatives represented by formula (1) and hydrates thereof; and compositions containing the same as the active ingredient: (1) wherein R1 represents hydrogen or a carboxyl-protecting group; R2 represents cycloalkyl etc.; R3 represents at least one member selected among hydrogen, halogen, and the like; R4 represents at least one member selected among hydrogen, optionally substituted alkyl, and the like; R5 represents hydrogen, optionally substituted alkyl, etc.; R6 represents hydrogen etc.; and A represents CH or C-R7, wherein R7 represents alkoxy etc.

6. 发明专利

CY1110242T1 ΑΛΑΣ ΠΑΡΑΓΩΓΟΥ 7-ΙΣΟΪΝΔΟΛΙΝΟΚΙΝΟΛΟΝΟΚΑΡΒΟΞΥΛΙΚΟΥ ΟΞΕΟΣ, ΜΟΝΕΝΥΔΡΗ ΜΟΡΦΗ ΑΥΤΟΥ ΚΑΙ ΣΥΝΘΕΣΗ ΠΕΡΙΕΧΟΥΣΑ ΤΑ ΙΔΙΑ ΩΣ ΔΡΑΣΤΙΚΟ ΣΥΣΤΑΤΙΚΟ 未知
公开(公告)号：CY1110242T1
公开(公告)日：2015-01-14
申请号：CY101100540
申请日：2010-06-11
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HAMAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HIROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： C07D401/04 , A61K31/47 , A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56
摘要： Ηεφεύρεσησχετίζεταιμεμεθόδουςπαραγωγήςενόςπαραγώγου 7- ισοϊνδολινοκινοκαρβοξυλικούοξέοςπαρισταμένουαπότονγενικότύπο [1] τοοποίοείναιχρήσιμοωςαντιβακτηριακόμέσο, καιενόςενδιάμεσουαυτού,

9. 发明专利

CA2307824C PROCESSES FOR PRODUCING 7-ISOINDOLINEQUINOLONECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATES THEREFOR,SALTS OF 7-ISOINDOLINEQUINOLONECARBOXYLIC ACIDS, HYDRATES THEREOF, AND COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENT. 未知
公开(公告)号：CA2307824C
公开(公告)日：2008-02-19
申请号：CA2307824
申请日：1998-10-27
申请人： TOYAMA CHEMICAL CO LTD
发明人： TAKAOKA KAZUKO , KOTSUBO HIRONORI , OJIMA KATSUJI , MATSUKURA HIROKO , YONEZAWA KENJI , KIYOTO TARO , YAMAMOTO HIROHIKO , HAYASHI KAZUYA , YAMADA MINORU , TAYA KYOKO , HAMAMOTO SHOICHI , YOTSUJI MINAKO , TAKAMATSU TAMOTSU
IPC分类号： C07D401/04 , A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/32 , C07D215/56
摘要： This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1 represents a hydrogen atom or a carboxyl- protecting group; R2 represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R4 bonds; R5 represents a hydrogen atom, an amino- protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group;R6 represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C-R7 in which R7 represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7- isoindoline-quinolonecarboxylic acid represented by the general formula [1], a hydrate thereof and a composition comprising them as an active ingredient.

10. 发明专利

NO20002125D0 未知
公开(公告)号：NO20002125D0
公开(公告)日：2000-04-26
申请号：NO20002125
申请日：2000-04-26
申请人： TOYAMA CHEMICAL CO LTD
发明人： YAMADA MINORU , HAMAMOTO SHOICHI , HAYASHI KAZUYA , TAKAOKA KAZUKO , MATSUKURA HIROKO , YOTSUJI MINAKO , YONEZAWA KENJI , OJIMA KATSUJI , TAKAMATSU TAMOTSU , TAYA KYOKO , YAMAMOTO HOROHIKO , KIYOTO TARO , KOTSUBO HIRONORI
IPC分类号： A61K31/4709 , C07C217/48 , C07D209/44 , C07D215/56 , C07D401/04 , C07D
摘要： This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula Ä1Ü which is useful as an antibacterial agent, and an intermediate thereof: wherein R represents a hydrogen atom or a carboxyl-protecting group; R represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R bonds; R represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C-R in which R represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula Ä1Ü, a hydrate thereof and a composition comprising them as an active ingredient.

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