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1. 发明专利

DE69328605D1 未知
公开(公告)号：DE69328605D1
公开(公告)日：2000-06-15
申请号：DE69328605
申请日：1993-08-13
申请人： TOSOH CORP
发明人： HONDA MITSUO , YAMAZAKI SHUDO , HORIE RYUICHI , SAITO TAKASHI , SHIGETA KATSUYOSHI , OTA NORIYUKI
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P31/12 , A61P31/18 , C07K16/18 , C12P21/08 , G01N33/53
摘要： A pharmaceutical composition against AIDS, which contains, as an active ingredient, an antibody capable of recognizing glycolipid derived from Echinoidea.

2. 发明专利

DE69328605T2 未知
公开(公告)号：DE69328605T2
公开(公告)日：2001-01-11
申请号：DE69328605
申请日：1993-08-13
申请人： TOSOH CORP
发明人： HONDA MITSUO , YAMAZAKI SHUDO , HORIE RYUICHI , SAITO TAKASHI , SHIGETA KATSUYOSHI , OTA NORIYUKI
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P31/12 , A61P31/18 , C07K16/18 , C12P21/08 , G01N33/53
摘要： A pharmaceutical composition against AIDS, which contains, as an active ingredient, an antibody capable of recognizing glycolipid derived from Echinoidea.

3. 发明专利

JPH0665098A MEDICINE COMPOSITION FOR AIDS 失效
公开(公告)号：JPH0665098A
公开(公告)日：1994-03-08
申请号：JP23759492
申请日：1992-08-14
申请人： TOSOH CORP
发明人： HONDA MITSUO , YAMAZAKI OSAMICHI , HORIE RYUICHI , SAITO TAKASHI , SHIGETA KATSUMI , OTA NORIYUKI
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P31/12 , A61P31/18 , C07K16/18 , C12P21/08
摘要： PURPOSE:To provide a composition reactive with the sugar chain developed on cell surface due to human immunodeficiency virus(HIV) infection, thus useful as a diagnostic or medicine for AIDS, containing, as active ingredient, an antibody capable of recognizing the glycolipids derived from sea urchin. CONSTITUTION:The glycolipids derived from sea urchin are prepared by the established method, and administered to BALB/c mice to effect immunization. The splenocytes are then taken from the resulting mice and fused with established mouse myeloma cells using e.g. ethylene glycol as fusing agent, and the clones capable of producing antibody reactive with the above glycolipids are selected through screening, and the resulting hybridoma is provided with monoclonality through cloning using limiting dilution method, methyl cellulose method or soft agarose method. The resultant hybridoma is implanted into e.g. mice to produce monoclonal antibody in the ascites; the monoclonal antibody is purified to obtain the monoclonal antibody capable of recognizing the above glycolipids. This monoclonal antibody is made, as active ingredient, into a pharmaceutical to obtain the objective medicine composition for AIDS.

4. 发明专利

JPH05304984A 失效
公开(公告)号：JPH05304984A
公开(公告)日：1993-11-19
申请号：JP13141592
申请日：1992-04-27
申请人： TOSOH CORP
发明人： OTA NORIYUKI , SHIGETA KATSUMI , HOSHI MOTONORI
IPC分类号： A61B10/00 , A61K39/395 , A61P35/00 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574 , G01N33/577
摘要： PURPOSE:To provide the monoclonal antibody against a tumor-related sugar chain antigen useful for the detection and treatment of tumors, and further to provide the method for producing the same. CONSTITUTION:The monoclonal antibody is produced, while using a glucolipid and/or a glucoprotein originated from the sperm of an echinoid as an antigen. The monoclonal antibody is an IgM isotype having the cross reactivity with a glucolipid and/or a glucoprotein originated from human tumor cells.

5. 发明专利

JPH06102275A MEASURING METHOD OF STEROID HORMONE 失效
公开(公告)号：JPH06102275A
公开(公告)日：1994-04-15
申请号：JP27341192
申请日：1992-09-18
申请人： TOSOH CORP
发明人： MORIMOTO KOICHI , KAWAKAMI NAMI , FUJII TATSUSHI , OTA NORIYUKI
IPC分类号： G01N33/53 , G01N33/74
摘要： PURPOSE:To allow accurate measurement of the concentration of steroid hormone in a sample by allowing coexistence of other steroid hormones in the sample thereby blocking bonding of steroid hormone to be measured and a binding protein. CONSTITUTION:Steroid hormone to be measured includes estradiol, estriol, testosterone, progesterone, cortisol, dihydroepiantrosterone sulfuric acid, and the like. Since these hormones bond with a binding protein in the blood, a steroid hormone other than that to be measured is added in order to block bonding. Such steroid hormone is added by 10-500ng/ml into the sample. When the sample is heated at 10-40 deg.C for 5 min-5 hours, bonding of hormone and binding protein can be blocked. Hormone is measured after anti-bonding reaction.

6. 发明专利

JPH0662889A ANTOBODY, CELL SYSTEM AND MEDICINE 失效
公开(公告)号：JPH0662889A
公开(公告)日：1994-03-08
申请号：JP23759892
申请日：1992-08-14
申请人： TOSOH CORP
发明人： SHIGETA KATSUMI , KAWAI NOBUYUKI , OTA NORIYUKI
IPC分类号： A61K39/395 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
摘要： PURPOSE:To provide a monoclonal antibody which is an antibody against neutral saccharide chain and has reactivity especially to carcinoma of the stomach. CONSTITUTION:A monoclonal antibody produced from cell line MKN74 of carcinoma of the stomach as an immunogen shows reactivity to saccharide chain of glycoprotein having >=1,000,000 Da molecular weight especially of cell line MKN74 of carcinoma of the stomach and has an Ig class of IgM(kappa).

7. 发明专利

JPH0634636A MEASURING METHOD FOR STEROID HORMONE 失效
公开(公告)号：JPH0634636A
公开(公告)日：1994-02-10
申请号：JP21228392
申请日：1992-07-17
申请人： TOSOH CORP
发明人： MORIMOTO KOICHI , KAWAKAMI NAMI , FUJII TATSUSHI , OTA NORIYUKI
IPC分类号： G01N33/74 , G01N33/76
摘要： PURPOSE:To exactly measure hormone concentration of a specimen by checking the combination of steroid hormone and binding protein with salicylic acid or its salt. CONSTITUTION:Androgen, estrogen and the like, for instance, estradiol, oestriol, progesterone and the like are mentioned as steroid hormone to be measured. Since a such hormone is bound to binding protein in blood, salicylic acid or its salt is added because its combination is checked. The salt of salicylic acid, for instance, sodium salicylate, calcium salicylate and the like are mentioned. These salicylic acid or its salt is preferably 0.1-2 % in a specimen to be measured and added so as to be furthermore preferably 0.2-1.0%. And it is reacted at about 4-5 deg.C for about 5 minutes-several hours in proportion to temperature and the combination of hormone and binding protein is checked. The check reaction may as well be performed before hormone measurement, at the same time as measurement or in either may.

8. 发明专利

JPH07128336A CARRIER FOR IMMUNOASSAY AND PRODUCTION THEREOF 失效
公开(公告)号：JPH07128336A
公开(公告)日：1995-05-19
申请号：JP27184293
申请日：1993-10-29
申请人： TOSOH CORP
发明人： OTA NORIYUKI , MORIMOTO KOICHI
IPC分类号： G01N33/543
摘要： PURPOSE:To make it possible to inhibit nonspecific adsorption of a labeled substance by bonding polylysine covalently or noncovalently to the surface of an insoluble substance thereby covering the surface. CONSTITUTION:An antigen or an antibody is not bonded directly or indirectly to a carrier but the surface of the carrier is covered with polylysine by bonding the polylysine covalrntly or noncovalently thereto thus inhibiting the surface properties of the carrier itself causing nonspecific bonding. The carrier includes polystyrene, vinyl chloride resin, alumina, metal, for example. The labeled substance includes a radioisotope, an enzyme, a fluorescent substance, for example. When polylysine is bonded to a carrier and blocking is conducted using a protein which does not participate in the immunoreaction, a carrier having lower nonspecific adsorption can be obtained. The protein includes bovine serum albumin gelatin, casein, for example. In other words, nonspecific adsorption can be inhibited by improving the properties on the surface of the carrier.

9. 发明专利

JPH07128335A PRODUCTION OF CARRIER FOR IMMUNOASSAY 失效
公开(公告)号：JPH07128335A
公开(公告)日：1995-05-19
申请号：JP27184193
申请日：1993-10-29
申请人： TOSOH CORP
发明人： OTA NORIYUKI , MORIMOTO KOICHI
IPC分类号： G01N33/543
摘要： PURPOSE:To make it possible to blocking effect in a short time by treating a carrier for antibody or antigen for a specified time in a solution of phthalic acid and/or citric acid containing a protein and the like which do not participate in the immunoreaction. CONSTITUTION:Carrier for antibody or antigen is polystyrene, PVC resin, alumina, metal, etc., to which an antibody or an antigen is bonded by physical adsorption. Blood serum albumin, gelatin, or casein, for example, is employed as a protein which does not participate in the immunoreaction. Phthalic acid, citric acid or succinic acid having concentration in the range of 20-150mM and pH in the range of 2-4 is employed as an acid solution. The carrier is treated in the acidic solution for about 1 to 30min to cause acidic modification of proteins which do not participate in the immunoreaction and to increase the adsorption rate of the carrier thus realizing efficient blocking.

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