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1. 发明申请

WO03083079A8 BONE GENERATION BY GENE THERAPY 审中-公开
标题翻译：骨生成基因治疗
公开(公告)号：WO03083079A8
公开(公告)日：2004-12-02
申请号：PCT/US0309718
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
IPC分类号： A61K38/18 , A61K48/00 , C07K14/495 , C07K14/51 , C12N15/74 , A01N43/04 , C12N15/85
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/00 , A61L2430/02 , C07K14/495 , C07K14/51 , C12N2799/027
摘要： The application discloses a method for making bone at a bone defect site for a person suffering from low bone mass which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone.
摘要翻译：该申请公开了一种在低骨量的人的骨缺损部位处制造骨的方法，其包括将编码具有骨再生功能的蛋白质的基因插入可操作地连接到启动子的结缔组织细胞中，并将哺乳动物细胞移植到骨缺损部位，并使骨缺损部位形成骨。

2. 发明申请

WO03083079A9 BONE GENERATION BY GENE THERAPY 审中-公开
标题翻译：骨生成基因治疗
公开(公告)号：WO03083079A9
公开(公告)日：2005-02-10
申请号：PCT/US0309718
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
IPC分类号： A61K38/18 , A61K48/00 , C07K14/495 , C07K14/51 , C12N15/74 , A01N43/04 , C12N15/85
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/00 , A61L2430/02 , C07K14/495 , C07K14/51 , C12N2799/027
摘要： The application discloses a method for making bone at a bone defect site for a person suffering from low bone mass which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone.
摘要翻译：该申请公开了一种在低骨量的人的骨缺损部位处制造骨的方法，其包括将编码具有骨再生功能的蛋白质的基因插入可操作地连接到启动子的结缔组织细胞中，并将哺乳动物细胞移植到骨缺损部位，并使骨缺损部位形成骨。

3. 发明申请

WO03083079A2 BONE GENERATION BY GENE THERAPY 审中-公开
标题翻译：骨生成基因治疗
公开(公告)号：WO03083079A2
公开(公告)日：2003-10-09
申请号：PCT/US0309718
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
IPC分类号： A61K38/18 , A61K48/00 , C07K14/495 , C07K14/51 , C12N
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/00 , A61L2430/02 , C07K14/495 , C07K14/51 , C12N2799/027
摘要： The application discloses a method for making bone at a bone defect site for a person suffering from low bone mass which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone.
摘要翻译：该申请公开了一种在低骨量的人的骨缺损部位处制造骨的方法，其包括将编码具有骨再生功能的蛋白质的基因插入可操作地连接到启动子的结缔组织细胞中，并将哺乳动物细胞移植到骨缺损部位，并使骨缺损部位形成骨。

4. 发明申请

WO03083080A3 MIXED- CELL GENE THERAPY 审中-公开
标题翻译：混合细胞基因治疗
公开(公告)号：WO03083080A3
公开(公告)日：2003-12-24
申请号：PCT/US0309720
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P19/02 , C12N5/02 , C12N5/077 , C12N5/10 , A61K31/70 , C12N5/00
CPC分类号： C12N5/0656 , A61K35/12 , A61K35/32 , A61K35/33 , A61K48/00 , A61K48/0008 , C12N5/0655 , C12N2501/15 , C12N2501/155 , C12N2502/13 , C12N2502/1317 , C12N2502/99 , C12N2510/02
摘要： The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mammalian cells that have not been transfected or transduced with the gene, wherein endogenously existing forms of the second population of mammalian cells are decreased at the target site, and wherein generation of the therapeutic protein by the first population of mammalian cells at the target site stimulates the second population cells to induce a therapeutic effect.
摘要翻译：本发明涉及一种混合细胞组合物，其通过提供用寻求表达的基因转染或转导的哺乳动物细胞的第一群体和未寻靶的哺乳动物细胞的第二群体被转染或用基因转导，其中内源存在形式的第二哺乳动物细胞群在靶位点处减少，并且其中靶位点处哺乳动物细胞的第一群体产生的治疗性蛋白质刺激第二群细胞至诱导治疗效果。

5. 发明申请

WO03082302A9 BIOADHESIVE DIRECTED SOMATIC CELL THERAPY 审中-公开
标题翻译： BIOADHESIVE指导的SOMATIC CELL THERAPY
公开(公告)号：WO03082302A9
公开(公告)日：2005-01-20
申请号：PCT/US0309719
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
IPC分类号： A61K48/00 , A61K9/00 , A61K31/715 , A61K35/16 , A61K38/00 , A61K38/18 , A61K38/19 , A61P19/00 , A61P19/02 , A61P19/04 , A01N61/00
CPC分类号： A61K9/0024 , A61K31/715 , A61K38/1841 , A61K38/1875 , A61K48/0041 , A61K48/005
摘要： The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized delivery of therapeutic somatic cells to the site of interest.
摘要翻译：本发明涉及使用包括生物粘附材料的细胞组合物的细胞介导的基因治疗治疗。生物粘附材料允许治疗性体细胞靶向和局部递送到感兴趣的部位。

6. 发明申请

WO03077852A8 CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-beta 审中-公开
标题翻译：使用CHONDROCYTE和TGF-β的功能再生
公开(公告)号：WO03077852A8
公开(公告)日：2004-12-23
申请号：PCT/US0307486
申请日：2003-03-12
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , LEE DUG KEUN
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , LEE DUG KEUN
IPC分类号： C12N15/09 , A61K35/32 , A61K38/18 , A61K48/00 , A61L27/00 , C12N5/06 , C12N5/08 , C12N5/16 , C12N15/63 , C12N15/85
CPC分类号： A61K38/1875 , A61K35/32 , A61K38/1841 , A61K48/00 , A61K2300/00
摘要： The present application is directed to a method of treating osteoarthritis, which includes obtaining a member of a transforming growth factor superfamily of proteins; obtaining a population of cultured connective tissue cells that may contain vector encoding a gene, or a population of cultured connective tissue cells that do not contain any vector encoding a gene; and then transferring the protein and the connective tissue cells into an arthritic joint space of a mammalian host, such that the activity of the combination within the joint space results in regenerating connective tissue.
摘要翻译：本申请涉及一种治疗骨关节炎的方法，其包括获得蛋白质的转化生长因子超家族的成员; 获得可以含有编码基因的载体的培养的结缔组织细胞群，或不含任何编码基因的载体的培养的结缔组织细胞群; 然后将蛋白质和结缔组织细胞转移到哺乳动物宿主的关节炎关节间隙中，使得联合空间内的组合的活性导致再生结缔组织。

7. 发明申请

WO03082302A2 BIOADHESIVE DIRECTED SOMATIC CELL THERAPY 审中-公开
标题翻译： BIOADHESIVE直接体外细胞疗法
公开(公告)号：WO03082302A2
公开(公告)日：2003-10-09
申请号：PCT/US0309719
申请日：2003-03-28
申请人： TISSUEGENE INC , SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
IPC分类号： A61K48/00 , A61K9/00 , A61K31/715 , A61K35/16 , A61K38/00 , A61K38/18 , A61K38/19 , A61P19/00 , A61P19/02 , A61P19/04 , A01N61/00
CPC分类号： A61K9/0024 , A61K31/715 , A61K38/1841 , A61K38/1875 , A61K48/0041 , A61K48/005
摘要： The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized delivery of therapeutic somatic cells to the site of interest.
摘要翻译：本发明涉及使用包含生物粘附材料的细胞组合物的细胞介导的基因治疗处理。生物粘附材料允许将治疗性体细胞定向和局部递送至感兴趣的部位。

8. 发明申请

WO2007002512A3 NEUROPROTECTIVE EFFECTIVE COMPOUND 审中-公开
标题翻译：神经保护有效的化合物
公开(公告)号：WO2007002512A3
公开(公告)日：2007-07-05
申请号：PCT/US2006024656
申请日：2006-06-23
申请人： TISSUEGENE INC , LEE KWAN HEE , LEE DUK KEUN , YI YOUNGSUK , NOH MOON JONG , KIM HYOUNG CHUN
发明人： LEE KWAN HEE , LEE DUK KEUN , YI YOUNGSUK , NOH MOON JONG , KIM HYOUNG CHUN
IPC分类号： A61K48/00
CPC分类号： A61K48/005 , A61K38/1875
摘要： The present application discloses a method of preventing degeneration of nerve, which includes: a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; b) transfecting in vitro a population o cultured cells with the recombinant vector, resulting in a population of the cultured cells; and c) transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes prevention o degeneration of the nerve.
摘要翻译：本发明公开了一种预防神经变性的方法，其包括：a）产生包含编码转化生长因子超家族成员的DNA序列的重组病毒或质粒载体或可操作地连接至启动子的神经营养因子蛋白; b）用重组载体体外转染培养细胞群体，产生培养细胞群体; 和c）将转染的细胞移植到受损神经附近的区域，使得在受损神经附近区域内的DNA序列表达导致神经变性的预防。

9. 发明申请

WO2009117740A2 TREATMENT OF INTERVERTEBRAL DISC DEGENERATION 审中-公开
标题翻译：治疗椎间盘突出症
公开(公告)号：WO2009117740A2
公开(公告)日：2009-09-24
申请号：PCT/US2009037987
申请日：2009-03-23
申请人： TISSUEGENE INC , NOH MOON JONG , KANG SUNG WOO , BAE HYUN , LEE KWAN HEE
发明人： NOH MOON JONG , KANG SUNG WOO , BAE HYUN , LEE KWAN HEE
IPC分类号： A61K35/12 , A61P19/04
CPC分类号： A61K38/1841 , A61K35/12 , C12N5/0655 , C12N2501/15 , C12N2510/02
摘要： The present application discloses a method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site, which includes injecting a mammalian connective tissue cell into the intervertebral disc defect site.
摘要翻译：本申请公开了一种在椎间盘缺损部位预防或延缓椎间盘退变的方法，其包括将哺乳动物结缔组织细胞注射入椎间盘缺损部位。

10. 发明申请

WO02055656A3 GENE THERAPY USING TGF- beta 审中-公开
标题翻译：使用TGF-β进行基因治疗
公开(公告)号：WO02055656A3
公开(公告)日：2003-01-30
申请号：PCT/US0147588
申请日：2001-11-07
申请人： TISSUEGENE INC , NOH MOON JONG , KANG KYOUNG AE , LEE KWAN HEE
发明人： NOH MOON JONG , KANG KYOUNG AE , LEE KWAN HEE
IPC分类号： A61K48/00 , A61K35/00 , C12N15/85
CPC分类号： A61K48/00
摘要： The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor- beta (TGF- beta ) superfamily. TGF- beta gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF- beta cDNA expression vectors into fibroblasts (NIH 3T3-TGF- beta 1), the cells were injected into rabbit achilles tendon and knee joints with artificaslly-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration of in vivo expression. Partially defected cartilage model was made to stimulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.
摘要翻译：本发明涉及使用属于转化生长因子-β（TGF-β）超家族的成员的骨科疾病的细胞介导的基因治疗治疗。证实了TGF-β基因治疗作为退行性关节炎的新治疗方法。将TGF-βcDNA表达载体转染到成纤维细胞（NIH 3T3-TGF-β1）后，将细胞注射到兔子跟腱和膝关节与人造软骨缺损。进行Intratendinous注射以确定体内表达的最佳浓度。部分缺损的软骨模型被用来刺激膝关节退行性关节炎。用细胞介导的基因治疗方法处理的部分软骨缺损被新形成的透明软骨覆盖，表明细胞存活并刺激该区域的基质形成。完全剥落的软骨区域被纤维胶原覆盖。

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