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1. 发明申请

WO2006010077A3 PRODRUGS OF LONIDAMINE AND LONIDAMINE ANALOGS 审中-公开
公开(公告)号：WO2006010077A3
公开(公告)日：2006-01-26
申请号：PCT/US2005/024434
申请日：2005-07-08
申请人： THRESHOLD PHARMACEUTICALS, INC. , MATTEUCCI, Mark , SELICK, Harold, E. , RAO, Photon
发明人： MATTEUCCI, Mark , SELICK, Harold, E. , RAO, Photon
IPC分类号： A61K31/5377 , C07D413/12
摘要： The invention provides prodrugs of lonidamine and lonidamine analogs as well as methods of using such prodrugs.

2. 发明申请

WO2006015191A2 MULTICYCLIC LONIDAMINE ANALOGS 审中-公开
标题翻译：多元兰辛胺类似物
公开(公告)号：WO2006015191A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/026929
申请日：2005-07-29
申请人： THRESHOLD PHARMACEUTICALS, INC. , MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
发明人： MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
IPC分类号： A01N43/52
CPC分类号： C07D235/24 , C07D209/52 , C07D231/56 , C07D403/04 , C07D405/04 , C07D409/04 , C07D498/04
摘要： The invention provides lonidamine analogs as well as methods of treating cancer and BPH.
摘要翻译：本发明提供了罗丹明胺类似物以及治疗癌症和BPH的方法。

3. 发明申请

WO2006015263A3 LONIDAMINE ANALOGS 审中-公开
公开(公告)号：WO2006015263A3
公开(公告)日：2006-02-09
申请号：PCT/US2005/027092
申请日：2005-07-29
申请人： THRESHOLD PHARMACEUTICALS, INC. , MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
发明人： MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
IPC分类号： C07D231/56 , A61K31/416
摘要： Lonidamine analogs are useful in the treatment of cancer and BPH.

4. 发明申请

WO2006065448A2 TOPOISOMERASE INHIBITORS AND PRODRUGS 审中-公开
标题翻译： TOPOISOMERASE抑制剂和PRODRUGS
公开(公告)号：WO2006065448A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/041959
申请日：2005-11-17
申请人： THRESHOLD PHARMACEUTICALS, INC. , MATTEUCCI, Mark , DUAN, Jian-Xin , RAO, Photon
发明人： MATTEUCCI, Mark , DUAN, Jian-Xin , RAO, Photon
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D471/04 , C07D221/18 , C07D487/04 , C07D491/147 , C07D495/04
摘要： Compositions and methods for treating cancer and other hyperproliferatice disease conditions with topoisomerase inhibitors and their prodrugs are disclosed.
摘要翻译：公开了用拓扑异构酶抑制剂及其前体药物治疗癌症和其它过度增生症病症的组合物和方法。

5. 发明申请

WO2004087075A3 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2004087075A3
公开(公告)日：2004-10-14
申请号：PCT/US2004/009667
申请日：2004-03-29
申请人： THRESHOLD PHARMACEUTICALS, INC. , MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
发明人： MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
IPC分类号： A61K31/415
摘要： Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.

6. 发明申请

WO2003082301A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2003082301A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/009492
申请日：2003-03-28
申请人： THRESHOLD PHARMACEUTICALS, INC.
发明人： TIDMARSH, George , MATTEUCCI, Mark , RAO, Photon
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K47/549
摘要： Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells.
摘要翻译：提供了用于治疗癌症的方法和组合物，其利用癌细胞中相对于正常细胞增加的葡萄糖 - 抗肿瘤剂缀合物的摄取。

7. 发明公开

EP1622608A2 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：EP1622608A2
公开(公告)日：2006-02-08
申请号：EP04749522.1
申请日：2004-03-29
申请人： Threshold Pharmaceuticals, Inc.
发明人： MATTEUCCI, Mark , RAO, Photon , DUAN, Jian-Xin
IPC分类号： A61K31/415 , A61K31/44 , C07D233/02 , C07D401/00
CPC分类号： A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/5377 , A61K47/54 , A61K47/559 , A61K47/6899 , B82Y5/00
摘要： Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
摘要翻译：当单独施用或与一种或多种抗肿瘤剂组合施用时，缺氧激活的前药可用于治疗癌症。

8. 发明申请

WO2013090682A1 TRISUBSTITUTED METHYL ALCOHOLS AND THEIR POLYMERIZABLE DERIVATIVES 审中-公开
标题翻译：三氯甲烷醇及其可聚合衍生物
公开(公告)号：WO2013090682A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069686
申请日：2012-12-14
申请人： INDICATOR SYSTEMS INTERNATIONAL, INC. , SWISS, Gerald F. , RAO, Photon , SABNIS, Ram W.
发明人： SWISS, Gerald F. , RAO, Photon , SABNIS, Ram W.
IPC分类号： C07C43/20 , C07C41/34 , C07C41/58
CPC分类号： C07C43/23 , C07C69/54 , C07C69/738 , C07C265/08 , C07C331/24 , C09B11/06 , C09B69/103
摘要： Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.
摘要翻译：本文提供三取代甲醇，优选用任选取代的芳基和/或任选取代的杂芳基取代的pH指示剂，并任选地包括一个或多个可聚合取代基。

9. 发明申请

WO2012047495A2 METHODS FOR PREPARING SYNTHETIC BILE ACIDS AND COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：制备合成胆汁酸的方法和包含其的组合物
公开(公告)号：WO2012047495A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/052204
申请日：2011-09-19
申请人： KYTHERA BIOPHARMACEUTICALS, INC. , MORIARTY, Robert M. , RAO, Photon
发明人： MORIARTY, Robert M. , RAO, Photon
IPC分类号： C07J21/00 , C07J75/00 , C07J9/00 , C07J41/00 , A61K31/56 , A61P3/04
CPC分类号： C07J41/0061 , A61K31/56 , A61K45/06 , C07J1/0011 , C07J5/0053 , C07J9/005 , C07J13/005 , C07J13/007 , C07J21/006 , C07J43/003 , A61K2300/00
摘要： This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.
摘要翻译：本发明一般涉及从非哺乳动物来源的起始材料以及合成胆汁酸和包含这些酸的组合物制备某些胆汁酸的方法，其中所述酸的特征在于不同的C ^{14群体比天然存在的胆汁酸以及没有任何哺乳动物病原体。本发明还涉及用于合成这种胆汁酸的中间体的合成。因此，类固醇支架的C环被氧化以提供合成途径和DCA的中间体。本发明还提供从芳香族类固醇如雌激素，equilenin及其衍生物开始制备脱氧胆酸或其盐的合成方法。本发明还涉及中间体如12-氧代或δ-9,11-烯类固醇以及其制备新方法。在优选的实施方案中，本文提供了在B-环和/或D-环侧链上以及任选地在A-环的羟基上具有取代基的胆汁酸。}

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