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1. 发明申请

WO2008074175A3 BIOACTIVE IMPLANT COATING 审中-公开
标题翻译：生物活性涂层种植体
公开(公告)号：WO2008074175A3
公开(公告)日：2009-03-26
申请号：PCT/CH2007000637
申请日：2007-12-17
申请人： THOMMEN MEDICAL AG , BAYER ULRICH , SCHMIDT JUERGEN , HENNING ANGELIKA , KAUTZ ARMIN REX , WEISSER JUERGEN , SCHNABELRAUCH MATTHIAS , SCHLOTTIG FALKO
发明人： BAYER ULRICH , SCHMIDT JUERGEN , HENNING ANGELIKA , KAUTZ ARMIN REX , WEISSER JUERGEN , SCHNABELRAUCH MATTHIAS , SCHLOTTIG FALKO
IPC分类号： A61L27/30 , A61C8/00 , A61F2/28 , A61L27/06 , A61L27/54
CPC分类号： A61C8/0012 , A61F2/30767 , A61F2/3094 , A61F2002/3092 , A61F2310/00598 , A61F2310/00796 , A61L27/06 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/414 , A61L2400/18
摘要： Disclosed is a method for coating a medical implant, particularly a metal-based dental implant, as well as an implant that can be produced by means of said method. The disclosed method is characterized in that the implant is dipped into an (aqueous) (electrolyte) solution comprising strontium ions at least in an area exposed to the bone in the implanted state, and the coating is formed in a plasma-chemical preferably electrolytic oxidation process.
摘要翻译：公开了一种用于涂覆医疗植入物，特别是方法的牙科植入物的基于金属的，以及与该方法中，植入物的帮助下生产。该方法的特征在于，所述植入物是至少在植入状态的暴露骨的范围（水溶液）（电解质）浸入用锶离子的溶液，并形成为优选的化合物的等离子体化学阳极氧化涂层。

2. 发明申请

WO2009106502A3 IMPLANT AND METHOD FOR THE MANUFACTURE THEREOF 审中-公开
标题翻译：植入物和方法及其
公开(公告)号：WO2009106502A3
公开(公告)日：2010-07-01
申请号：PCT/EP2009052112
申请日：2009-02-23
申请人： THOMMEN MEDICAL AG , SCHNABELRAUCH MATTHIAS , KAUTZ ARMIN REX , SCHLOTTIG FALKO
发明人： SCHNABELRAUCH MATTHIAS , KAUTZ ARMIN REX , SCHLOTTIG FALKO
IPC分类号： A61L27/34 , A61K31/366 , A61K47/48
CPC分类号： A61L27/34 , A61K31/366 , A61K47/61
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
摘要翻译：描述了一种至少部分地在植入状态中的表面区域，其与硬和/或软组织的至少间接地相接触具有涂层的植入物。优选的植入物，其特征在于，两个他汀类药物如辛伐他汀的包衣，在选自支链或直链的，取代或未取代的选择的水解或未水解形式或药学上可接受的盐，和至少一种另外的组分，饱和或部分不饱和的 C10-C30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，Alkylcycloaryl胺或它们的混合物和/或含有至少一种水溶性离子聚合物组分。此外，制造这种植入物的方法被描述，以及其可以在这样的方法中使用的组合物。

3. 发明申请

WO2007048263A3 IMPLANT AND PRODUCTION METHOD FOR SAID IMPLANT 审中-公开
标题翻译：植入物及其制造方法
公开(公告)号：WO2007048263A3
公开(公告)日：2007-06-28
申请号：PCT/CH2006000576
申请日：2006-10-17
申请人： NEXILIS AG , SCHLOTTIG FALKO , SCHNABELRAUCH MATTHIAS , KAUTZ ARMIN REX
发明人： SCHLOTTIG FALKO , SCHNABELRAUCH MATTHIAS , KAUTZ ARMIN REX
IPC分类号： A61L27/32 , A61L27/54
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/112 , A61L2300/606
摘要： The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing an implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译：描述的是植入物，例如血管移植物，骨替代物，假体，支架O.A.，其具有涂层至少部分地在植入状态与硬和/或软组织的表面区域接触。该涂层是用于控制在其中的药物的双膦酸盐，并且可以在正确的速度分别被递送到周围组织中后者采取行动，其特征在于，该涂层同时含有二膦酸盐，分别，药学上可接受的盐或酯，以及至少一种选自支链或直链的，取代或未取代的选择的两亲性组分，饱和或部分不饱和的C10-C30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，Alkylcycloaryl - 羧酸盐， - 磷酸盐或硫酸盐，或它们的混合物和/或水溶性离子聚合物组分。此外，描述了用于制造这种植入物的方法以及可用于生产这种涂层的特定组合物。

4. 发明专利

CA2716671A1 IMPLANT AND METHOD FOR THE MANUFACTURE THEREOF 未知
公开(公告)号：CA2716671A1
公开(公告)日：2009-09-03
申请号：CA2716671
申请日：2009-02-23
申请人： THOMMEN MEDICAL AG
发明人： SCHNABELRAUCH MATTHIAS , KAUTZ ARMIN REX , SCHLOTTIG FALKO
IPC分类号： A61L27/34 , A61K31/366 , A61K47/48
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating compri-ses both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, satura-ted or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.

5. 发明专利

CA2625975A1 DENTAL IMPLANT AND PRODUCTION METHOD FOR SAID IMPLANT 未知
公开(公告)号：CA2625975A1
公开(公告)日：2007-05-03
申请号：CA2625975
申请日：2006-10-17
申请人： THOMMEN MEDICAL AG
发明人： SCHLOTTIG FALKO , KAUTZ ARMIN REX , SCHNABELRAUCH MATTHIAS
IPC分类号： A61K6/00 , A61K9/00
摘要： The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing a dental implant of this type and to a specific composition, which can be used to produce a coating of this type.

6. 发明专利

ES2435433T3 Recubrimiento bioactivo para implantes 未知
公开(公告)号：ES2435433T3
公开(公告)日：2013-12-19
申请号：ES07845634
申请日：2007-12-17
申请人： THOMMEN MEDICAL AG
发明人： BAYER ULRICH , SCHMIDT JUERGEN , HENNING ANGELIKA , KAUTZ ARMIN REX , WEISSER JUERGEN , SCHNABELRAUCH MATTHIAS , SCHLOTTIG FALKO
IPC分类号： A61F2/30 , A61C8/00 , A61L27/06 , A61L27/30 , A61L27/54
摘要： Procedimiento para recubrir un implante dental médico a base de metal, caracterizado porque el implante,al menos en una zona expuesta al hueso en el estado implantado, se sumerge en una disolución acuosacon iones estroncio, y el recubrimiento se forma en una oxidación anódica plasmoquímica, encontrándosela densidad de corriente por encima de 5 mA/cm2 y modulándose la tensión aplicada con una frecuencia deal menos 500 Hz.

7. 发明专利

AU2009218573A1 Implant and method for the manufacture thereof 未知
公开(公告)号：AU2009218573A1
公开(公告)日：2009-09-03
申请号：AU2009218573
申请日：2009-02-23
申请人： THOMMEN MEDICAL AG
发明人： KAUTZ ARMIN REX , SCHLOTTIG FALKO , SCHNABELRAUCH MATTHIAS
IPC分类号： A61L27/34 , A61K31/366 , A61K47/48
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.

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