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1. 发明申请

WO2005002606A1 USE OF A SINGLE-CELL PROTEIN MATERIAL 审中-公开
标题翻译：使用单细胞蛋白质材料
公开(公告)号：WO2005002606A1
公开(公告)日：2005-01-13
申请号：PCT/NO2004/000204
申请日：2004-07-02
申请人： THIA MEDICA AS , NORFERM DA , BERGE, Rolf , KLEPPE, Gunnar
发明人： BERGE, Rolf , KLEPPE, Gunnar
IPC分类号： A61K35/74
CPC分类号： A23K10/18 , A23L33/135 , A23L33/195 , A23V2002/00 , A61K35/74 , A23V2200/326 , A23V2200/3262 , A23V2250/546
摘要： The present invention relates to the use of a single-cell protein material (SCP). The SCP material lowers the concentration of cholesterol in plasma, and triglycerides in the liver. SCP also induces a favourable change in the fatty acid pattern, and lowers the concentration of homocysteine in plasma. A preferable embodiment of the invention relates to the use of SCP as an anti-atherogenic and cardio protective agent, either given as a pharmaceutical or as nutritional composition, e.g. as a functional food.
摘要翻译：本发明涉及单细胞蛋白质材料（SCP）的使用。 SCP物质降低血浆中的胆固醇浓度，降低肝脏中的甘油三酯。 SCP也引起脂肪酸模式的有利变化，降低血浆中同型半胱氨酸的浓度。本发明的优选实施方案涉及SCP作为抗动脉粥样硬化和心脏保护剂的用途，其作为药物或营养组合物给予，例如作为抗动脉粥样硬化和心脏保护剂。作为功能性食品。

2. 发明申请

WO2003072133A3 IMMUNOSTIMULATORY AGENT COMPRISING A BIOMASS OF METHANOTROPHIC BACTERIUM 审中-公开
公开(公告)号：WO2003072133A3
公开(公告)日：2003-09-04
申请号：PCT/GB2002/002555
申请日：2002-05-31
申请人： NORFERM DA , GOLDING, Louise , JØRGENSEN, Lars , JOHANNESSEN, Arild , JENSEN, Karen, Møller , KLEPPE, Gunnar
发明人： JØRGENSEN, Lars , JOHANNESSEN, Arild , JENSEN, Karen, Møller , KLEPPE, Gunnar
IPC分类号： A61K35/74
摘要： The invention relates to the use as an immunostimulant of a composition comprising biomass derived from a methanotrophic bacterium-containing culture. The immunostimulatory effect of this biomass material renders this particularly suitable for use in preventing diseases or conditions in an animal body which are associated with, caused by, or otherwise contributed to by any exogenous foreign material, e.g. a pathogenic microorganism. A preferred biomass for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB 11132), DB3 (strain NCIMB 13287) and DB5 (strain NCIMB 13289), optionally in combination with DB4 (strain NCIMB 13288).

3. 发明申请

WO2003015534A1 USE OF SINGLE-CELL PROTEIN AS FEED FOR FISH AND SHELLFISH 审中-公开
标题翻译：使用单细胞蛋白作为鱼和虾粉饲料
公开(公告)号：WO2003015534A1
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003795
申请日：2002-08-16
申请人： NORFERM DA , GOLDING, Louise , KLEPPE, Gunnar
发明人： KLEPPE, Gunnar
IPC分类号： A23K1/16
CPC分类号： A23K50/80 , A23K10/16
摘要： The invention relates to a feed material for fish and shellfish, for example a feed material for molluscs such as mussels. In particular, the invention relates to the use of single-cell protein materials and their derivatives (especially homogenized and/or autolysed derivatives) as a feed for fish and shellfish. A preferred single-cell material for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB 11132), Ralstonia sp. DB3 (strain NCIMB 13287) and Brevibacillus agri DB5 (strain NCIMB 13289), optionally in combination with Aneurinibacillus sp. DB4 (strain NCIMB 13288).
摘要翻译：本发明涉及用于鱼和贝类的饲料，例如用于软体动物例如贻贝的饲料。特别地，本发明涉及单细胞蛋白质材料及其衍生物（特别是均质和/或自动衍生的衍生物）作为鱼和贝类的饲料的用途。用于本发明的优选单细胞材料是衍生自微生物培养物的微生物培养物，其包括荚膜甲酸癣菌（Bath）（菌株NCIMB 11132），Ralstonia sp。 DB3（菌株NCIMB 13287）和农杆菌DB5（菌株NCIMB 13289），任选与Aneurinibacillus sp。 DB4（菌株NCIMB 13288）。

4. 发明申请

WO2005004888A1 LIPIDS FROM METHANOTROPHIC BACTERIA FOR CHOLESTEROL REDUCTION 审中-公开
标题翻译：来自甲醇细菌的脂质减少胆固醇
公开(公告)号：WO2005004888A1
公开(公告)日：2005-01-20
申请号：PCT/GB2004/002866
申请日：2004-07-02
申请人： NORFERM DA , COCKBAIN, Julian , MÜLLER, Hanne , SKREDE, Anders , KLEPPE, Gunnar
发明人： MÜLLER, Hanne , SKREDE, Anders , KLEPPE, Gunnar
IPC分类号： A61K35/74
CPC分类号： A61K31/685 , A23J7/00 , A23L33/12 , A23V2002/00 , A23V2250/1848 , A23V2200/3262
摘要： The present invention provides the use of lipids from methanotrophic bacteria for the manufacture of a composition for oral administration for use in the treatment of animal subjects to reduce plasma cholesterol levels therein or to reduce the ratio of LDL to HDL cholesterol in the plasma thereof. The composition is also useful for increasing plasma docosahexaenoic acid and as immuno-protectant.
摘要翻译：本发明提供了来自甲酸营养细菌的脂质用于制造用于治疗动物受试者的口服给药组合物以降低其中的血浆胆固醇水平或降低其血浆中LDL与HDL胆固醇的比例的用途。该组合物也可用于增加血浆二十二碳六烯酸和作为免疫保护剂。

5. 发明申请

WO2003072133A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2003072133A2
公开(公告)日：2003-09-04
申请号：PCT/GB2002/002555
申请日：2002-05-31
申请人： NORFERM DA , GOLDING, Louise , JØRGENSEN, Lars , JOHANNESSEN, Arild , JENSEN, Karen, Møller , KLEPPE, Gunnar
发明人： JØRGENSEN, Lars , JOHANNESSEN, Arild , JENSEN, Karen, Møller , KLEPPE, Gunnar
IPC分类号： A61K39/39
CPC分类号： A61K35/74 , A23K10/12 , A23K50/30 , A23K50/75 , A23K50/80 , C12N1/20
摘要： The invention relates to the use as an immunostimulant of a composition comprising biomass derived from a methanotrophic bacterium-containing culture. The immunostimulatory effect of this biomass material renders this particularly suitable for use in preventing diseases or conditions in an animal body which are associated with, caused by, or otherwise contributed to by any exogenous foreign material, e.g. a pathogenic microorganism. A preferred biomass for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB 11132), DB3 (strain NCIMB 13287) and DB5 (strain NCIMB 13289), optionally in combination with DB4 (strain NCIMB 13288).
摘要翻译：本发明涉及用作包含衍生自含甲烷营养细菌的培养物的生物质的组合物的免疫刺激剂的用途。该生物质材料的免疫刺激作用使其特别适用于预防与任何外源性外来物质相关，由其引起或以其他方式促成的动物体内的疾病或病症，例如，一种致病微生物。用于本发明的优选的生物质源自包含荚膜甲基球菌（Bath）（菌株NCIMB 11132），DB3（菌株NCIMB 13287）和DB5（菌株NCIMB 13289）的微生物培养物，任选地与DB4（菌株NCIMB 13288）组合。

6. 发明公开

EP1416808A1 USE OF SINGLE-CELL PROTEIN AS FEED FOR FISH AND SHELLFISH 有权
标题翻译：单细胞蛋白材料作为食品使用的鱼类和贝类
公开(公告)号：EP1416808A1
公开(公告)日：2004-05-12
申请号：EP02751441.3
申请日：2002-08-16
申请人： Norferm DA , Golding, Louise
发明人： KLEPPE, Gunnar
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K50/80 , A23K10/16
摘要： The invention relates to a feed material for fish and shellfish, for example a feed material for molluscs such as mussels. In particular, the invention relates to the use of single-cell protein materials and their derivatives (especially homogenized and/or autolysed derivatives) as a feed for fish and shellfish. A preferred single-cell material for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB 11132), Ralstonia sp. DB3 (strain NCIMB 13287) and Brevibacillus agri DB5 (strain NCIMB 13289), optionally in combination with Aneurinibacillus sp. DB4 (strain NCIMB 13288).

7. 发明授权

EP1416808B1 USE OF SINGLE-CELL PROTEIN AS FEED FOR FISH AND SHELLFISH 有权
标题翻译：单细胞蛋白材料作为食品使用的鱼类和贝类
公开(公告)号：EP1416808B1
公开(公告)日：2006-10-04
申请号：EP02751441.3
申请日：2002-08-16
申请人： Norferm DA
发明人： KLEPPE, Gunnar
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K50/80 , A23K10/16
摘要： The invention relates to a feed material for fish and shellfish, for example a feed material for molluscs such as mussels. In particular, the invention relates to the use of single-cell protein materials and their derivatives (especially homogenized and/or autolysed derivatives) as a feed for fish and shellfish. A preferred single-cell material for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB 11132), Ralstonia sp. DB3 (strain NCIMB 13287) and Brevibacillus agri DB5 (strain NCIMB 13289), optionally in combination with Aneurinibacillus sp. DB4 (strain NCIMB 13288).

8. 发明授权

EP1265982B1 METHOD FOR THE EXTRACTION OF PROTEINS FROM A SINGLE CELL 有权
标题翻译： FOR蛋白质的方法，从单细胞TO EXTRACT
公开(公告)号：EP1265982B1
公开(公告)日：2004-09-29
申请号：EP01904208.4
申请日：2001-02-15
申请人： Norferm DA
发明人： JOHANNESSEN, Arild , KLEPPE, Gunnar , LARSEN, Jan , MOEN, Einar
IPC分类号： C12N1/00
CPC分类号： C12N1/00 , A23J3/20 , A23K10/16 , A23K50/40 , A23L29/065 , A23L29/269 , A23V2002/00 , A23V2200/228 , A23V2300/26 , A23V2300/46
摘要： The present invention provides a process for imparting improved functional properties to a single-cell protein material, said process comprising the step of homogenizing an aqueous slurry of the single-cell protein, e.g. a single-cell protein material derived from fermentation on natural gas. The resulting homogenized protein material has excellent functional properties and finds particular use in the preparation of food products, for example as a gelling agent or emulsifier.

9. 发明公开

EP1478376A2 IMMUNOSTIMULATORY AGENT COMPRISING A BIOMASS OF METHANOTROPHIC BACTERIUM 有权
标题翻译：含有细菌methanotrophem的生物质免疫刺激剂
公开(公告)号：EP1478376A2
公开(公告)日：2004-11-24
申请号：EP02727769.8
申请日：2002-05-31
申请人： Norferm DA
发明人： JORGENSEN, Lars,Norferm Danmark AS , JOHANNESSEN, Arild , JENSEN, Karen Moller,Norferm Danmark AS , KLEPPE, Gunnar
IPC分类号： A61K35/74 , C12N1/02 , C12N1/20
CPC分类号： A61K35/74 , A23K10/12 , A23K50/30 , A23K50/75 , A23K50/80 , C12N1/20
摘要： The invention relates to the use as an immunostimulant of a composition comprising biomass derived from a methanotrophic bacterium-containing culture. The immunostimulatory effect of this biomass material renders this particularly suitable for use in preventing disease or conditions in an animal body which are associated with, caused by, or otherwise contributed to by any exogenous foreign material, e.g. a pathogenic microorganism. A preferred biomass for use in the invention is that derived from a microbial culture comprising Methylococcus capsulatus (Bath) (strain NCIMB11132), DB3 (strain NCIMB 13287) and DB5 (strain NCIMB13289), optionally in combination with DB4 (strain NCIMB13288).

10. 发明公开

EP1265982A2 METHOD FOR THE EXTRACTION OF PROTEINS FROM A SINGLE CELL 有权
标题翻译： FOR蛋白质的方法，从单细胞TO EXTRACT
公开(公告)号：EP1265982A2
公开(公告)日：2002-12-18
申请号：EP01904208.4
申请日：2001-02-15
申请人： Norferm DA , Golding, Louise
发明人： JOHANNESSEN, Arild , KLEPPE, Gunnar , LARSEN, Jan , MOEN, Einar
IPC分类号： C12N1/00
CPC分类号： C12N1/00 , A23J3/20 , A23K10/16 , A23K50/40 , A23L29/065 , A23L29/269 , A23V2002/00 , A23V2200/228 , A23V2300/26 , A23V2300/46
摘要： The present invention provides a process for imparting improved functional properties to a single-cell protein material, said process comprising the step of homogenizing an aqueous slurry of the single-cell protein, e.g. a single-cell protein material derived from fermentation on natural gas. The resulting homogenized protein material has excellent functional properties and finds particular use in the preparation of food products, for example as a gelling agent or emulsifier.

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