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1. 发明申请

WO2008061628A2 ION TRANSFER ARRANGEMENT 审中-公开
标题翻译：离子转移装置
公开(公告)号：WO2008061628A2
公开(公告)日：2008-05-29
申请号：PCT/EP2007/009642
申请日：2007-11-07
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
发明人： MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

2. 发明申请

WO2008055668A3 ION TRANSFER ARRANGEMENT 审中-公开
公开(公告)号：WO2008055668A3
公开(公告)日：2008-05-15
申请号：PCT/EP2007/009641
申请日：2007-11-07
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
发明人： MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
IPC分类号： H01J49/06
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of a mass spectrometer includes an electrode assembly (120) with a first plurality of ring electrodes (205) arranged in alternating relation with a second plurality of ring electrodes (210). The first plurality of ring electrodes (205) are narrower than the second plurality of ring electrodes (210) in a longitudinal direction, but the first plurality of ring electrodes have a relatively high magnitude voltage of a first polarity applied to them whereas the second plurality of ring electrodes (210) have a relatively lower magnitude voltage applied to them, of opposing polarity to that applied to the first set of ring electrodes (205). In this manner, ions passing through the ion transfer arrangement experience spatially alternating asymmetric electric fields that tend to focus ions away from the inner surface of the channel wall and towards the channel plane or axis of symmetry.

3. 发明申请

WO2008055667A3 ION TRANSFER ARRANGEMENT 审中-公开
公开(公告)号：WO2008055667A3
公开(公告)日：2008-05-15
申请号：PCT/EP2007/009640
申请日：2007-11-07
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
发明人： MAKAROV, Alexander , PESCH, Reinhold , MALEK, Robert , KOZLOVSKIY, Viacheslav
IPC分类号： H01J49/06
摘要： A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 60 between the higher and lower pressure regions. The ion transfer conduit 60 includes an electrode assembly 300 which defines an ion transfer channel. The electrode assembly 300 has a first set of ring electrodes 305 of a first width D1, and a second set of ring electrodes of a second width D2 (≥D1) and interleaved with the first ring electrodes 305. A DC voltage of magnitude V 1 and a first polarity is supplied to the first ring electrodes 205 and a DC voltage of magnitude V 2 which may be less than or equal to the magnitude of V 1 but with an opposed polarity is applied to the second ring electrodes 310. The pressure of the ion transfer conduit 60 is controlled so as to maintain viscous flow of gas and ions within the ion transfer channel.

4. 发明申请

WO2009083242A1 SAMPLE EXCITATION APPARATUS AND METHOD FOR SPECTROSCOPIC ANALYSIS 审中-公开
标题翻译：样品激发装置和光谱分析方法
公开(公告)号：WO2009083242A1
公开(公告)日：2009-07-09
申请号：PCT/EP2008/011097
申请日：2008-12-23
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , SCHLÜTER, Hans-Jürgen , MALEK, Robert
发明人： SCHLÜTER, Hans-Jürgen , MALEK, Robert
IPC分类号： G01N21/67 , G01N21/73 , H01J49/04
CPC分类号： G01N21/714 , G01J3/443 , G01N21/72 , G01N21/73 , H01J49/105 , H01J49/165
摘要： Sample excitation apparatus for a spectrometric analyser, the apparatus comprising a sample introduction stage comprising an electrospray nebuliser for generating a nebulised sample; and a sample excitation stage arranged to operate in an atmospheric pressure environment and to receive and excite the nebulised sample in a sample excitation region for spectrometric analysis thereof. 'Excitation' includes ionisation in ICP and MIP, flame excitation in AES, and optical excitation in AAS. For example, analyte solution (38) is fed out of the outlet end of a capillary (30,40,60,96), to a plasma source. A potential difference is applied between the capillary, its outlet end or the analyte solution and an opposing effective (counter) electrode, which may comprise a tube (64), a grid (80), or the plasma (34) itself, to promote formation of smaller droplets (46). The pressure of the plasma source is similar to the pressure in the region of the capillary outlet end.
摘要翻译：用于光谱分析仪的样品激发装置，该装置包括样品引入级，其包括用于产生雾化样品的电喷雾雾化器; 以及样品激发级，被布置成在大气压力环境中操作并且接收和激发样品激发区域中的雾化样品用于其光谱分析。 “激发”包括ICP和MIP中的电离，AES中的火焰激发和AAS中的光激发。例如，将分析物溶液（38）从毛细管（30,40,60,96）的出口端送出到等离子体源。在毛细管，其出口端或分析物溶液之间施加电位差，以及可以包括管（64），格栅（80）或等离子体（34）本身的相对的有效（对置）电极，以促进形成较小的液滴（46）。等离子体源的压力类似于毛细管出口端的区域中的压力。

5. 发明申请

WO2005031290A2 METHOD AND APPARATUS FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于质谱分析的方法和设备
公开(公告)号：WO2005031290A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010735
申请日：2004-09-24
申请人： THERMO FINNIGAN LLC , MALEK, Robert , PESCH, Reinhold , HORNING, Stevan , LANGE, Oliver
发明人： MALEK, Robert , PESCH, Reinhold , HORNING, Stevan , LANGE, Oliver
IPC分类号： G01J3/00
CPC分类号： H01J49/0027
摘要： The present invention relates to mass spectrometry and, more particularly, to the scheduling of the steps involved in performing mass spectrometry. The present invention will be of particular benefit to types of mass spectrometry that generate large quantities of data and hence give rise to lengthy data-processing. The present invention provides a method of mass spectrometry comprising a plurality of cycles, each cycle comprising the steps of (a) preparing ions to be analysed by a mass spectrometer; (b) using a detector of the mass spectrometer to collect data from the ions prepared in step (a); and (c) processing the data collected in step (b) with processing means; wherein at least a part of step (a) and/or a part of step (b) of a cycle is performed concurrently with part (c) of a previous cycle.
摘要翻译：本发明涉及质谱法，并且更具体地涉及执行质谱法中涉及的步骤的调度。本发明将对产生大量数据并因此引起冗长的数据处理的质谱仪类型特别有益。本发明提供一种包括多个循环的质谱法，每个循环包括以下步骤：（a）制备待由质谱仪分析的离子; （b）使用质谱仪的检测器从步骤（a）中制备的离子收集数据; 和（c）用处理装置处理步骤（b）中收集的数据; 其中周期的步骤（a）的至少一部分和/或步骤（b）的一部分与前一周期的部分（c）同时执行。

6. 发明公开

EP3410109A1 SYSTEMS AND METHODS FOR EXTRACTING MASS TRACES 审中-公开
公开(公告)号：EP3410109A1
公开(公告)日：2018-12-05
申请号：EP17174385.9
申请日：2017-06-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： PFAFF, Hans , HENRICH, Christoph , MALEK, Robert , THAM, Katja
IPC分类号： G01N30/86 , H01J49/00 , G01N30/72
CPC分类号： H01J49/0036 , G01N30/72 , G01N30/8631 , G01N2030/8648 , H01J49/0004
摘要： A computer implemented method of extracting a mass trace from mass spectrometry data of a mass stream emitted from a separation device as a function of a separation parameter, wherein the mass spectrometry data are generated by analysis in a mass spectrometer, the method comprising, receiving the mass spectrometry data, wherein the mass spectrometry data comprise a plurality of mass spectra each obtained for respective values of the separation parameter; identifying, from the plurality of mass spectra, a sequence of three or more intensity peaks that are ordered according to the separation parameter, wherein said identifying the sequence of three or more intensity peaks comprises, selecting an initial intensity peak at an initial mass, and for each other intensity peak of the sequence of intensity peaks, selecting said intensity peak based on at least the mass of an adjacent intensity peak in the sequence of intensity peaks, the method further comprising, providing a mass trace, for a given emitted compound of the mass stream, from the identified sequence of intensity peaks.

7. 发明公开

EP3410110A1 SYSTEMS AND METHODS FOR EXTRACTING MASS TRACES 有权
公开(公告)号：EP3410110A1
公开(公告)日：2018-12-05
申请号：EP18170779.5
申请日：2018-05-04
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： PFAFF, Hans , HENRICH, Christoph , MALEK, Robert , THAM, Katja
IPC分类号： G01N30/86 , H01J49/00 , G01N30/72
CPC分类号： H01J49/0036 , G01N30/72 , G01N30/8631 , G01N2030/8648 , H01J49/0004
摘要： A computer implemented method of extracting a mass trace from mass spectrometry data of a mass stream emitted from a separation device as a function of a separation parameter, wherein the mass spectrometry data are generated by analysis in a mass spectrometer, the method comprising, receiving the mass spectrometry data, wherein the mass spectrometry data comprise a plurality of mass spectra each obtained for respective values of the separation parameter; identifying, from the plurality of mass spectra, a sequence of three or more intensity peaks that are ordered according to the separation parameter, wherein said identifying the sequence of three or more intensity peaks comprises, selecting an initial intensity peak at an initial mass, and for each other intensity peak of the sequence of intensity peaks, selecting said intensity peak based on at least the mass of an adjacent intensity peak in the sequence of intensity peaks, the method further comprising, providing a mass trace, for a given emitted compound of the mass stream, from the identified sequence of intensity peaks.

8. 发明公开

EP3745443A1 DECONVOLUTION OF MASS SPECTROMETRY DATA 审中-实审
公开(公告)号：EP3745443A1
公开(公告)日：2020-12-02
申请号：EP19189886.5
申请日：2019-08-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： MALEK, Robert , BERG, Frank , FRITZEMEIER, Kai
IPC分类号： H01J49/00
摘要： A method for deconvoluting measured mass spectrometry data, the method comprising: receiving measured mass spectrometry data representing at least two molecular moieties each having a respective isotopic pattern, wherein at least two of said isotopic patterns overlap; iteratively filling a set of mass channels to produce an approximated version of the mass spectrometry data, said iterative filling comprising a number of iterations, each iteration comprising filling one or more of the mass channels with a chunk of intensity data according to the isotopic pattern of a respective one of the two or more molecular moieties selected for said iteration; terminating said iterative filling when a fitness criterion is met indicating a fit of the approximated version of the mass spectrometry data to the measured mass spectrometry data; and determining the amount of each molecular moiety that produced the measured mass spectrometry data based on the total amount of fills according to the respective isotopic pattern of said molecular moiety.

9. 发明申请

WO2006103445A2 IMPROVEMENTS RELATING TO ION TRAPPING 审中-公开
标题翻译：关于离子捕获的改进
公开(公告)号：WO2006103445A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001170
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

10. 发明申请

WO2005031791A2 METHOD OF PROCESSING AND STORING MASS SPECTROMETRY DATA 审中-公开
标题翻译：处理和存储大量光谱数据的方法
公开(公告)号：WO2005031791A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010736
申请日：2004-09-23
申请人： THERMO FINNIGAN LLC , MALEK, Robert , LANGE, Oliver
发明人： MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H03M7/30
摘要： A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.
摘要翻译：公开了用于傅里叶变换质谱（FTMS）的数据压缩技术。对频域中的数据进行统计分析，因为这些数据大部分是随机分布的电子噪声的结果。将整个频率数据集合到分布上进行确定分布的初步时刻。然后删除该分布尾部的数据（主要是峰值数据），并将剩余的数据点重新拟合到分布中，以识别该剩余噪声数据的分布时刻。然后使用计算的时刻应用质谱的噪声阈值。保持阈值以上的数据。可以通过将分布的时刻与峰值数据一起存储，然后从那些时刻再生噪声并将其加到峰值数据来重构整个频谱。

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