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1. 发明申请

WO2005031792A2 MEASURING CELL FOR ION CYCLOTRON RESONANCE SPECTROMETER 审中-公开
标题翻译：用于离子循环共振光谱仪的测量单元
公开(公告)号：WO2005031792A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010839
申请日：2004-09-24
申请人： THERMO FINNIGAN LLC , MALEK, Robert , CZEMPER, Frank
发明人： MALEK, Robert , CZEMPER, Frank
IPC分类号： H01J49/00
CPC分类号： H01J49/38
摘要： This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extends in a direction generally parallel to the field direction of an applied homogeneous magnetic field; and a trapping electrode arrangement, also positioned about the said longitudinal axis, for trapping ions longitudinally in the cell within a trapping region defined by the trapping electrode arrangement; wherein at least a part of the excitation electrode arrangement extends axially outwardly of the trapping region defined by the trapping electrode arrangement.
摘要翻译：本发明涉及用于离子回旋共振（ICR）光谱仪的测量池。本发明提供了一种用于FTMS光谱仪的测量单元，其包括围绕纵向轴线定位的激励电极装置，所述纵向轴线在大致平行于所施加的均匀磁场的场方向的方向上延伸; 以及还围绕所述纵向轴线定位的捕获电极装置，用于在由所述捕获电极装置限定的捕获区域内纵向俘获所述电池中的离子; 其中所述激励电极装置的至少一部分沿着由所述捕获电极装置限定的捕获区域轴向向外延伸。

2. 发明申请

WO2006045393A2 MEASUREMENT CELL FOR ION CYCLOTRON RESONANCE SPECTROMETER 审中-公开
标题翻译：离子循环共振谱仪的测量元件
公开(公告)号：WO2006045393A2
公开(公告)日：2006-05-04
申请号：PCT/EP2005/010439
申请日：2005-09-26
申请人： THERMO FINNIGAN LLC , MALEK, Robert , CZEMPER, Frank
发明人： MALEK, Robert , CZEMPER, Frank
IPC分类号： H01J49/42
CPC分类号： H01J49/38
摘要： This invention relates to a measurement cell for a FTMS spectrometer. The measurement cell comprises a longitudinal axis and comprising five or more electrodes arranged about the longitudinal axis including two or more excitation electrodes operable to excite ions in the measurement cell into cyclotron motion and two or more dedicated detection electrodes operable to detect ions within the measurement cell, wherein a plane orthogonal to the longitudinal axis meets the five or more electrodes to define the perimeter of a cross-section, the two or more detection electrodes occupying at least 50% of that perimeter.
摘要翻译：本发明涉及用于FTMS光谱仪的测量单元。测量单元包括纵轴并且包括围绕纵轴布置的五个或更多个电极，所述五个或更多个电极包括两个或更多个激励电极，所述激励电极可操作以激励测量单元中的离子进入回旋加速运动，以及两个或更多个专用检测电极，其中与所述纵轴正交的平面与所述五个或更多个电极相遇以限定横截面的周边，所述两个或更多个检测电极占据所述周边的至少50％。

3. 发明申请

WO2005031791A2 METHOD OF PROCESSING AND STORING MASS SPECTROMETRY DATA 审中-公开
标题翻译：处理和存储大量光谱数据的方法
公开(公告)号：WO2005031791A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010736
申请日：2004-09-23
申请人： THERMO FINNIGAN LLC , MALEK, Robert , LANGE, Oliver
发明人： MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H03M7/30
摘要： A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.
摘要翻译：公开了用于傅里叶变换质谱（FTMS）的数据压缩技术。对频域中的数据进行统计分析，因为这些数据大部分是随机分布的电子噪声的结果。将整个频率数据集合到分布上进行确定分布的初步时刻。然后删除该分布尾部的数据（主要是峰值数据），并将剩余的数据点重新拟合到分布中，以识别该剩余噪声数据的分布时刻。然后使用计算的时刻应用质谱的噪声阈值。保持阈值以上的数据。可以通过将分布的时刻与峰值数据一起存储，然后从那些时刻再生噪声并将其加到峰值数据来重构整个频谱。

4. 发明申请

WO2005093782A2 A METHOD OF IMPROVING A MASS SPECTRUM 审中-公开
标题翻译：改进质谱的方法
公开(公告)号：WO2005093782A2
公开(公告)日：2005-10-06
申请号：PCT/EP2005/003367
申请日：2005-03-24
申请人： THERMO FINNIGAN LLC , HORNING, Stevan, Roy , LANGE, Oliver , MALEK, Robert , WIEGHAUS, Andreas
发明人： HORNING, Stevan, Roy , LANGE, Oliver , MALEK, Robert , WIEGHAUS, Andreas
IPC分类号： H01J49/00
CPC分类号： H01J49/38 , H01J49/0009
摘要： The present invention provides a method of improving a mass spectrum collected from a mass spectrometer comprising a detector for collecting a mass spectrum from ions stored in or released from an ion trapping volume, wherein assignment of masses to peaks appearing in the mass spectrum is sensitive to an experimental parameter related to the mass spectrometer or the operation thereof, such as ion abundance, the method comprising: determining a positional value of a peak; determining the experimental parameter associated with the mass spectrum; comparing the determined positional value with positional values of peaks contained in a calibration dataset; and improving the determined positional value of the peak from adjacent peak positional values by interpolation thereby to provide a corrected mass assignment for the peak. The present invention also provides a method of calibrating such a mass spectrometer.
摘要翻译：本发明提供了一种改进从质谱仪收集的质谱的方法，该质谱仪包括用于从离子捕获体积存储或释放的离子中收集质谱的检测器，其中质谱对质谱中出现的峰的分配对与质谱仪或其操作相关的实验参数，例如离子丰度，该方法包括：确定峰的位置值; 确定与质谱相关的实验参数; 将确定的位置值与校准数据集中包含的峰的位置值进行比较; 并且通过内插从相邻的峰值位置值改善确定的峰值的位置值，从而为峰值提供校正的质量分配。本发明还提供了一种校准这种质谱仪的方法。

5. 发明申请

WO2004068523A2 CONTROLLING ION POPULATIONS IN A MASS ANALYZER 审中-公开
标题翻译：在大众分析仪中控制离子人口
公开(公告)号：WO2004068523A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001810
申请日：2004-01-23
申请人： THERMO FINNIGAN LLC , HORNING, Stevan , MALEK, Robert , SYKA, John, E. , WEIGHAUS, Andreas
发明人： HORNING, Stevan , MALEK, Robert , SYKA, John, E. , WEIGHAUS, Andreas
IPC分类号： H01J
CPC分类号： H01J49/4265
摘要： Method and apparatus of controlling an ion population to be analyzed in a mass analyzer. Ions are accumulated for an injection time interval determined as a function of an ion accumulation rate and a predetermined desired population of ions. The accumulation rate represents a flow rate of ions from a source of ions into an ion accumulator. Ions derived form the accumulated ions are introduced into the mass analyzer for analysis.
摘要翻译：控制在质量分析仪中分析离子群体的方法和装置。以作为离子累积速率和预定的期望离子群的函数确定的注射时间间隔累积离子。累积速率表示离子从离子源到离子蓄能器的流速。将离子积聚的离子引入质量分析器进行分析。

6. 发明申请

WO2005031290A2 METHOD AND APPARATUS FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于质谱分析的方法和设备
公开(公告)号：WO2005031290A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010735
申请日：2004-09-24
申请人： THERMO FINNIGAN LLC , MALEK, Robert , PESCH, Reinhold , HORNING, Stevan , LANGE, Oliver
发明人： MALEK, Robert , PESCH, Reinhold , HORNING, Stevan , LANGE, Oliver
IPC分类号： G01J3/00
CPC分类号： H01J49/0027
摘要： The present invention relates to mass spectrometry and, more particularly, to the scheduling of the steps involved in performing mass spectrometry. The present invention will be of particular benefit to types of mass spectrometry that generate large quantities of data and hence give rise to lengthy data-processing. The present invention provides a method of mass spectrometry comprising a plurality of cycles, each cycle comprising the steps of (a) preparing ions to be analysed by a mass spectrometer; (b) using a detector of the mass spectrometer to collect data from the ions prepared in step (a); and (c) processing the data collected in step (b) with processing means; wherein at least a part of step (a) and/or a part of step (b) of a cycle is performed concurrently with part (c) of a previous cycle.
摘要翻译：本发明涉及质谱法，并且更具体地涉及执行质谱法中涉及的步骤的调度。本发明将对产生大量数据并因此引起冗长的数据处理的质谱仪类型特别有益。本发明提供一种包括多个循环的质谱法，每个循环包括以下步骤：（a）制备待由质谱仪分析的离子; （b）使用质谱仪的检测器从步骤（a）中制备的离子收集数据; 和（c）用处理装置处理步骤（b）中收集的数据; 其中周期的步骤（a）的至少一部分和/或步骤（b）的一部分与前一周期的部分（c）同时执行。

7. 发明申请

WO2006103445A2 IMPROVEMENTS RELATING TO ION TRAPPING 审中-公开
标题翻译：关于离子捕获的改进
公开(公告)号：WO2006103445A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001170
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

8. 发明公开

EP1586104A3 CONTROLLING ION POPULATIONS IN A MASS ANALYZER 审中-公开
标题翻译：用质量分析仪控制离子群体
公开(公告)号：EP1586104A3
公开(公告)日：2005-12-14
申请号：EP04704854.1
申请日：2004-01-23
申请人： THERMO FINNIGAN LLC
发明人： HORNING, Stevan , MALEK, Robert , SYKA, John, E. , WEIGHAUS, Andreas
IPC分类号： H01J1/00

9. 发明授权

EP1866948B1 METHODS AND APPARATUS OF ION TRAPPING 有权
公开(公告)号：EP1866948B1
公开(公告)日：2018-11-07
申请号：EP06726576.9
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC
发明人： LANGE, Oliver C/O Thermo Fischer Scientific (Bremen)GmbH, , MALEK, Robert , JUNG, Gerhard , DENISOV, Eduard , MAKAROV, Alexander, Alekseevich C/O Thermo Fischer Scientific (Bremen)GmbH
IPC分类号： H01J49/00 , H01J49/02 , H01J49/04 , B01D59/44
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

10. 发明公开

EP1866948A2 METHOD AND APPARATUS OF ION TRAPPING 有权
标题翻译： ION事件的方法和装置
公开(公告)号：EP1866948A2
公开(公告)日：2007-12-19
申请号：EP06726576.9
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC
发明人： LANGE, Oliver , MALEK, Robert , JUNG, Gerhard , DENISOV, Eduard , MAKAROV, Alexander, Alekseevich
IPC分类号： H01J49/00 , H01J49/02 , H01J49/04 , B01D59/44
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

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