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1. 发明申请

WO2007044361A2 LDI/MALDI SOURCE FOR ENHANCED SPATIAL RESOLUTION 审中-公开
标题翻译： LDI / MALDI来源用于增强空间分辨率
公开(公告)号：WO2007044361A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/038701
申请日：2006-10-02
申请人： THERMO FINNIGAN LLC , IZGARIAN, Nicolae
发明人： IZGARIAN, Nicolae
IPC分类号： H01J27/24
CPC分类号： H01J27/24 , H01J49/164
摘要： A MALDI/LDI source is disclosed that includes an ion optical device and beam- focusing optics disposed on opposite sides of a sample support that is at least locally transparent in a region underlying the sample to allow transmission of a radiation beam therethrough. A laser or other radiation source, located adjacent a rear surface of the sample support, emits a beam of radiation that is focused by the beam focusing optics and traverses the transparent region of the sample support to impinge on the sample. Ions produced by irradiation of the sample are collected by an ion optical device located adjacent the front surface of the sample support. By locating the ion optical device and beam-focusing optics on opposite sides of the sample support, short focal length beam-focusing optics may be utilized, thereby facilitating smaller beam spot sizes. This may be particularly useful for mass spectral tissue imaging and other applications where high spatial resolution analysis of a differentiated sample is desirable.
摘要翻译：公开了一种MALDI / LDI源，其包括设置在样品支架的相对侧上的离子光学装置和光束聚焦光学元件，其在样品下方的区域中至少局部透明，以允许辐射束透过。邻近样品支架的后表面定位的激光或其他辐射源发射由光束聚焦光学元件聚焦并穿过样品支架的透明区域以照射在样品上的辐射束。通过照射样品产生的离子通过位于样品支撑体的前表面附近的离子光学装置收集。通过将离子光学器件和光束聚焦光学器件放置在样品支撑体的相对侧上，可以利用短焦距聚焦光学元件，从而有助于较小的束斑尺寸。这对于质谱图组织成像和其它需要分辨的样品的高空间分辨率分析的应用尤其有用。

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