专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003092633A2 DIFFUSION-CONTROLLED DOSAGE FORM AND METHOD OF FABRICATION INCLUDING THREE DIMENSIONAL PRINTING 审中-公开
标题翻译：扩散控制剂型及其制备方法，包括三维印刷
公开(公告)号：WO2003092633A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/014376
申请日：2003-05-06
申请人： THERICS, INC. , WANG, Chen-Chao , YOO, Jaedeok , BORNANCINI, Esteban , ROACH, Willie, J. , MOTWANI, Monica, Rewachand
发明人： WANG, Chen-Chao , YOO, Jaedeok , BORNANCINI, Esteban , ROACH, Willie, J. , MOTWANI, Monica, Rewachand
IPC分类号： A61K
CPC分类号： A61K9/00 , A61K9/2027 , A61K9/2077 , A61K9/2086 , A61K9/2095 , A61K31/137 , B29C64/153 , B33Y70/00 , B33Y80/00
摘要： The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
摘要翻译：本发明包括核 - 壳剂型或单位，其中核包含API，并且其中壳基本上控制释放，例如通过控制API通过壳的扩散。壳可以包含释放阻断聚合物和释放调节聚合物的颗粒。壳可以是基本上不可渗透的，但是释放调节聚合物可能变得适合于在被激活时允许通过其扩散。核心可以包括在壳体和核心的含API部分之间的缓冲区域。剂型可以包括多个单位。本发明的剂型能够提供释放曲线，其时间尺度可以通过调节粉末组成来调节，并且其可以大致零级释放。本发明还包括制造这种剂型的方法，例如三维印刷。

2. 发明申请

WO2003092633A3 DIFFUSION-CONTROLLED DOSAGE FORM AND METHOD OF FABRICATION INCLUDING THREE DIMENSIONAL PRINTING 审中-公开
公开(公告)号：WO2003092633A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/014376
申请日：2003-05-06
申请人： THERICS, INC. , WANG, Chen-Chao , YOO, Jaedeok , BORNANCINI, Esteban , ROACH, Willie, J. , MOTWANI, Monica, Rewachand
发明人： WANG, Chen-Chao , YOO, Jaedeok , BORNANCINI, Esteban , ROACH, Willie, J. , MOTWANI, Monica, Rewachand
IPC分类号： A61K9/26
摘要： The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.

3. 发明申请

WO2003041690A3 THREE-DIMENSIONAL SUSPENSION PRINTING OF DOSAGE FORMS 审中-公开
公开(公告)号：WO2003041690A3
公开(公告)日：2003-05-22
申请号：PCT/US2001/043722
申请日：2001-11-21
申请人： THERICS, INC. , ROWE, Charles, W. , PRYCE LEWIS, Wendy, E. , CIMA, Michael, J. , BORNANCINI, Esteban, R., N. , SHERWOOD, Jill, K. , WANG, Chen-Chao , GAYLO, Christopher, M. , FAIRWEATHER, James, A.
发明人： ROWE, Charles, W. , PRYCE LEWIS, Wendy, E. , CIMA, Michael, J. , BORNANCINI, Esteban, R., N. , SHERWOOD, Jill, K. , WANG, Chen-Chao , GAYLO, Christopher, M. , FAIRWEATHER, James, A.
IPC分类号： A61K9/20
摘要： The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.

4. 发明申请

WO2008030385A3 LOCAL TOPICAL ADMINISTRATION FORMULATIONS CONTAINING INDOXACARB 审中-公开
公开(公告)号：WO2008030385A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/019096
申请日：2007-08-30
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , GUERINO, Frank , FREEHAUF, Keith, Alan , SARGENT, Roger, Mervyn , O'NEIL, Peter, Andrew , SIMMONS, Robert, D. , WANG, Chen-Chao
发明人： GUERINO, Frank , FREEHAUF, Keith, Alan , SARGENT, Roger, Mervyn , O'NEIL, Peter, Andrew , SIMMONS, Robert, D. , WANG, Chen-Chao
IPC分类号： A01N47/38 , A01N25/02 , A01P7/00
摘要： The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.

5. 发明公开

EP1286663A2 ENCAPSULATING A TOXIC CORE WITHIN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM 有权
标题翻译：封装有毒芯无毒区一个口服药物剂型
公开(公告)号：EP1286663A2
公开(公告)日：2003-03-05
申请号：EP01937808.2
申请日：2001-05-18
申请人： Therics, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： PAYUMO, Francis, C. , WANG, Chen-Chao , SHERWOOD, Jill, K. , CIMA, Michael, J. , GAYLO, Christopher, M. , MONKHOUSE, Donald, C. , YOO, Jaedeok
IPC分类号： A61K9/28
CPC分类号： A61K9/2893 , A61K9/209 , A61K9/2886 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

6. 发明授权

EP1286663B1 ENCAPSULATING A TOXIC CORE WITHIN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM 有权
标题翻译： EINKAPSELUNG EINES臭氧叮咬在EINEN NICHT-TOXISCHEN BEREICH IN EINER ORALEN DARREICHUNGSFORM
公开(公告)号：EP1286663B1
公开(公告)日：2006-01-18
申请号：EP01937808.2
申请日：2001-05-18
申请人： Therics, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： PAYUMO, Francis, C. , WANG, Chen-Chao , SHERWOOD, Jill, K. , CIMA, Michael, J. , GAYLO, Christopher, M. , MONKHOUSE, Donald, C. , YOO, Jaedeok
IPC分类号： A61K9/28
CPC分类号： A61K9/2893 , A61K9/209 , A61K9/2886 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.
摘要翻译：药物递送装置，例如口服剂型（ODF），其具有由无毒区域包裹的毒性或有效核心。无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对毒性或有效核心的保护和分离。毒性或有效核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。这最小化在制造过程中产生有毒药物的空气中颗粒的可能性，从而控制和最小化制造人员暴露于有害物质。有毒或有效药物的湿分配进一步提供药物对患者更大的生物利用度。

7. 发明公开

EP1439824A2 THREE-DIMENSIONAL SUSPENSION PRINTING OF DOSAGE FORMS 审中-公开
标题翻译： DREIDIMENSIONALES暂停停牌DARREICHUNGSFORMEN
公开(公告)号：EP1439824A2
公开(公告)日：2004-07-28
申请号：EP01989744.6
申请日：2001-11-21
申请人： Therics, Inc.
发明人： ROWE, Charles, W. , PRYCE LEWIS, Wendy, E. , CIMA, Michael, J. , BORNANCINI, Esteban, R., N. , SHERWOOD, Jill, K. , WANG, Chen-Chao , GAYLO, Christopher, M. , FAIRWEATHER, James, A.
IPC分类号： A61K9/20 , A61L27/12
CPC分类号： A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , A61K9/2893 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.
摘要翻译：本发明包括分配含有固体颗粒的悬浮液，用于通过3DP制造剂型或其它生物医学制品。悬浮液含有悬浮在液体中的固体颗粒。固体颗粒可以是一种或多种活性药物成分。固体颗粒可以是不溶于液体的材料颗粒，或者它们可以是已经溶解在液体中的物质的颗粒直到饱和水平并且以超过可溶解的浓度存在。除了固体颗粒外，液体还可能含有溶解在其中的其他物质，含有活性药物成分（API）或不含API的物质。本发明的一个方面包括通过向悬浮液中加入几种类型的添加剂中的一种或多种来防止附聚。本发明的另一方面包括操作API悬浮液中颗粒的表面电荷以防止颗粒附聚。本发明的另一方面包括具有比相应的结晶材料更大的生物利用度的无定形API。本发明的另一方面包括一种用于提供悬浮液的连续循环使得固体颗粒保持分散在悬浮液中的系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式