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1. 发明申请

WO1997034614A1 PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 审中-公开
标题翻译：用于制备伤口愈合组合物的板生长因子提取方法
公开(公告)号：WO1997034614A1
公开(公告)日：1997-09-25
申请号：PCT/CA1997000188
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC.
发明人： THERATECHNOLOGIES INC. , BRAZEAU, Paul , ABRIBAT, Thierry , IBEA, Michel , BOUSHIRA, Michèle
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c) whereby causing lysis of the platelets and producing the platelet extract in optimal amount. Compositions comprising the platelet-extract are used for the promotion of wound healing.
摘要翻译：本发明涉及一种制备含有成熟生长因子的猪血小板提取物的方法，其包括以下步骤：a）将大约1000g至大约5000g的整个猪血液离心，从血小板富集的血清中分离出血小板，等离子体; b）将步骤a）的分离的血小板重悬于血浆 - 细胞A中并离心以浓缩血小板; c）洗涤步骤b）的浓缩血小板; d）冻干洗涤的步骤c）的血小板，由此引起血小板裂解并产生最佳量的血小板提取物。包含血小板提取物的组合物用于促进伤口愈合。

2. 发明授权

EP0828758B1 CHIMERIC FATTY BODY-PRO-GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY 失效
标题翻译： CHIMERA脂质体PRO-GRF与生物效价ERHÖHETERANALOG
公开(公告)号：EP0828758B1
公开(公告)日：2001-08-29
申请号：EP96914826.1
申请日：1996-05-22
申请人： THERATECHNOLOGIES INC.
发明人： IBEA, Michel , ABRIBAT, Thierry , BRAZEAU, Paul
IPC分类号： C07K14/60 , A61K38/25 , G01N33/68
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12

3. 发明授权

EP0784450B1 SUTURELESS WOUND CLOSING WITH HARNESS AND PLASTER ELEMENTS 失效
标题翻译：无缝伤口闭合使用鞋带固定在皮肤斑块元素
公开(公告)号：EP0784450B1
公开(公告)日：1999-01-13
申请号：EP95931116.8
申请日：1995-09-15
申请人： THERATECHNOLOGIES INC.
发明人： BRAZEAU, Paul
IPC分类号： A61B17/08
CPC分类号： A61B17/085 , A61B2017/086
摘要： The present invention relates to a device for closing cutaneous wounds without sutures, which comprises a pair of three-dimensionally flexible strips adopted to be positioned on each side of a wound and formed of a plurality of laterally spaced apart elongated anchoring members extending side-by-side in succession and transversely of the wound and being interconnected in a three-dimensionally flexible manner to follow the lips of an open wound. Each of the anchoring members has on the underside thereof an adhesive surface for adhesion directly or indirectly to the skin of a patient, and includes at an inner end thereof a thread receiving and retaining portion, whereby a thread can be engaged lace-wise through the anchoring members of both strips so as to draw the anchoring members of one strip towards the anchoring members of the other strip in such a way so as to close in a constant tensiometric way the open wound extending between the two strips with the lips of the wound being equidistant along the entire length thereof.

4. 发明授权

EP1007061B1 PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 失效
标题翻译：用于生产SLIDE生长因子筹备工作的提取物用于伤口愈合
公开(公告)号：EP1007061B1
公开(公告)日：2004-02-11
申请号：EP97908091.8
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC.
发明人： BRAZEAU, Paul , ABRIBAT, Thierry , IBEA, Michel , BOUSHIRA, Michèle
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.

5. 发明公开

EP0784450A1 SUTURELESS WOUND CLOSING WITH HARNESS AND PLASTER ELEMENTS 失效
标题翻译：无缝伤口闭合使用鞋带固定在皮肤斑块元素
公开(公告)号：EP0784450A1
公开(公告)日：1997-07-23
申请号：EP95931116.0
申请日：1995-09-15
申请人： THERATECHNOLOGIES INC.
发明人： BRAZEAU, Paul
IPC分类号： A61B17
CPC分类号： A61B17/085 , A61B2017/086
摘要： The present invention relates to a device for closing cutaneous wounds without sutures, which comprises a pair of three-dimensionally flexible strips adopted to be positioned on each side of a wound and formed of a plurality of laterally spaced apart elongated anchoring members extending side-by-side in succession and transversely of the wound and being interconnected in a three-dimensionally flexible manner to follow the lips of an open wound. Each of the anchoring members has on the underside thereof an adhesive surface for adhesion directly or indirectly to the skin of a patient, and includes at an inner end thereof a thread receiving and retaining portion, whereby a thread can be engaged lace-wise through the anchoring members of both strips so as to draw the anchoring members of one strip towards the anchoring members of the other strip in such a way so as to close in a constant tensiometric way the open wound extending between the two strips with the lips of the wound being equidistant along the entire length thereof.

6. 发明申请

WO1997017367A1 METHOD OF GRF PEPTIDES SYNTHESIS 审中-公开
标题翻译： GRF肽合成方法
公开(公告)号：WO1997017367A1
公开(公告)日：1997-05-15
申请号：PCT/CA1996000712
申请日：1996-10-28
申请人： THERATECHNOLOGIES INC.
发明人： THERATECHNOLOGIES INC. , IBEA, Michel , BRAZEAU, Paul
IPC分类号： C07K14/60
CPC分类号： C07K14/60 , A61K38/00
摘要： The present invention relates to a high yield manufacturing process of (Gly or Ala) or GRF containing peptide, resulting in GRF peptides synthesis at a yield averaging 65 to 68 %. The method comprises the steps of: a) synthesis of a 14 to 15 residues of the fully protected GRF peptide acidic segments (S1)-OH and (S2)-OH from sasrin resin, using sequential Fmoc chemistry; b) synthesis of a 12 to 15 residues of the side chain protected GRF peptide amide segments (S3)-NH-, (S4)-NH-, and/or (S5)-NH- on solid phase using any TFA sensitive resin; and c) one or two coupling steps of the synthesized GRF peptide segments of steps a) and b) on solid phase.
摘要翻译：本发明涉及（Gly或Ala）15或含GRF的肽的高产率制备方法，导致GRF肽合成，产率平均为65至68％。该方法包括以下步骤：a）使用顺序的Fmoc化学合成合成来自sasrin树脂的完全保护的GRF肽酸性片段（S1）-OH和（S2）-OH的14至15个残基; b）使用任何TFA敏感树脂在固相上合成侧链保护的GRF肽酰胺链段（S3）-NH-，（S4）-NH-和/或（S5）-NH-的12至15个残基; 和c）在固相上步骤a）和b）的合成的GRF肽片段的一个或两个偶联步骤。

7. 发明申请

WO1996037514A1 CHIMERIC FATTY BODY-PRO-GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY 审中-公开
标题翻译：具有增加的生物学意义的CHIMERIC FATTY BODY-PRO-GRF模拟
公开(公告)号：WO1996037514A1
公开(公告)日：1996-11-28
申请号：PCT/CA1996000327
申请日：1996-05-22
申请人： THERATECHNOLOGIES INC.
发明人： THERATECHNOLOGIES INC. , IBEA, Michel , ABRITAT, Thierry , BRAZEAU, Paul
IPC分类号： C07K14/60
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include a hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
摘要翻译：本发明涉及具有增加的生物学效力的嵌合脂肪体前GRF类似物，其作为合成代谢剂的应用以及生长激素缺陷的诊断和治疗。嵌合脂肪体前GRF类似物包括疏水部分（尾部），并且可以通过将一个或几个疏水尾部锚定到GRF或通过用化学物质中的假胶体残基取代一个或几个氨基酸来制备 GRF的合成。本发明的GRF类似物是可生物降解的，非免疫原性的，并且具有降低的剂量和延长的活性的改善的合成代谢功效。

8. 发明授权

EP1109909B1 GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY 有权
标题翻译： GRF具有增加的生物效价类似物
公开(公告)号：EP1109909B1
公开(公告)日：2005-11-30
申请号：EP99941349.5
申请日：1999-09-07
申请人： THERATECHNOLOGIES INC.
发明人： GRAVEL, Denis , HABI, Abdelkrim , BRAZEAU, Paul
IPC分类号： C12N15/16 , C07K14/60 , A61K38/25 , G01N33/68
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12

9. 发明公开

EP1109909A2 GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY 有权
标题翻译： GRF具有增加的生物效价类似物
公开(公告)号：EP1109909A2
公开(公告)日：2001-06-27
申请号：EP99941349.5
申请日：1999-09-07
申请人： THERATECHNOLOGIES INC.
发明人： GRAVEL, Denis , HABI, Abdelkrim , BRAZEAU, Paul
IPC分类号： C12N15/16 , C07K14/60 , A61K38/25 , G01N33/68
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include a hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

10. 发明公开

EP1007061A1 PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 失效
标题翻译：用于生产SLIDE生长因子筹备工作的提取物用于伤口愈合
公开(公告)号：EP1007061A1
公开(公告)日：2000-06-14
申请号：EP97908091.8
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC.
发明人： BRAZEAU, Paul , ABRIBAT, Thierry , IBEA, Michel , BOUSHIRA, Michèle
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.

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