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1. 发明专利

AU1655192A ANTIVIZAL DIBENZOTHIAZEPINONE DERIVATIVES 未知
公开(公告)号：AU1655192A
公开(公告)日：1992-12-21
申请号：AU1655192
申请日：1992-05-01
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： ROBIN HAMISH NICOL , MARTIN JOHN SLATER , SIMON TEANBY HODGSON
IPC分类号： A61K31/55 , A61K31/554 , A61P31/12 , C07D281/16
摘要： PCT No. PCT/GB92/00805 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19277 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6alkyl, C3-6cycloalkyl or C1-6alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); -NR4R5 where R4 and R5, which may be the same or different, each represent hydrogen or C1-6alkyl; -S(O)mR6, where m is 0, 1, 2 or 3 and R6 represents hydrogen, C1-6alkyl or C3-6cycloakyl; -SO2NR4R5 where R4 et R5 are each as defined above; phenyl, phenylC1-3alkoxy or phenylC1-3alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6alkyl, C1-6alkoxy, hydroxy, nitro, halogen and amino; and -CO2H or -COR7 where R7 is C1-6alkyl or C3-6cycloalkyl; R3 represents hydrogen or C1-4alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.

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