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1. 发明申请

WO2005050235A1 ARBITRARY SHAPED GRADIENT COILS FOR MRI 审中-公开
标题翻译：用于MRI的ARBITRARY形状梯度线圈
公开(公告)号：WO2005050235A1
公开(公告)日：2005-06-02
申请号：PCT/AU2004/001641
申请日：2004-11-24
申请人： THE UNIVERSITY OF QUEENSLAND , ZHAO, Huawei , DODDRELL, David, Michael , ROFFMANN, Wolfgang, Udo
发明人： ZHAO, Huawei , DODDRELL, David, Michael , ROFFMANN, Wolfgang, Udo
IPC分类号： G01R33/20
CPC分类号： G01R33/385
摘要： Gradient coils of arbitrary shape, suitable for use in magnetic resonance imaging, are designed by first calculating a two dimensional wire pattern, and then mapping the two dimensional wire pattern to a three dimensional shape. To calculate the two dimensional wire pattern, a two dimensional domain is defined and a two dimensional base function is selected. A two dimensional current stream function distribution is then obtained, such that the contour of the current stream function distribution gives a two dimensional wire pattern. A suitable three dimensional mapping function with geometric control parameters is selected, and is used to map the two dimensional wire pattern to a three dimensional real wire set. The magnetic field generated by the wire set is calculated by using the Biot-Savart Law, and an optimization procedure is used to determine the best parameter set that gives a three dimensional wire set which produces the desired field.
摘要翻译：通过首先计算二维线图，然后将二维线图映射到三维形状，设计适用于磁共振成像的任意形状的渐变线圈。为了计算二维线图，定义了二维域并且选择了二维基函数。然后获得二维电流流函数分布，使得当前流函数分布的轮廓给出二维有线图案。选择具有几何控制参数的合适的三维映射函数，并将二维线图映射到三维实线组合。通过使用Biot-Savart定律计算由线组产生的磁场，并且使用优化程序来确定产生产生所需场的三维线组的最佳参数集。

2. 发明申请

WO2004059335A1 CORRECTION OF MAGNETIC RESONANCE IMAGES 审中-公开
标题翻译：磁共振图像校正
公开(公告)号：WO2004059335A1
公开(公告)日：2004-07-15
申请号：PCT/AU2003/001707
申请日：2003-12-22
申请人： THE UNIVERSITY OF QUEENSLAND , DODDRELL, David, Michael , ZHAO, Huawei
发明人： DODDRELL, David, Michael , ZHAO, Huawei
IPC分类号： G01R33/20
CPC分类号： A61B5/7257 , A61B5/055 , G01R33/56518 , G01R33/56572
摘要： Spatial encoding in magnetic resonance imaging (MRI) techniques is achieved by sampling the signal as a function of time in the presence of magnetic field gradients, e.g. , X, Y, and Z gradients. The gradient magnets have in the past been assumed to generate a linear gradient, and typical image reconstruction techniques have relied upon this assumption. However, to achieve high speed performance, gradient magnets often sacrifice linearity for speed. This non-linearity, in turn, results in distorted images, the distortion often being sufficiently large to compromise the usefulness of MRI images for stereotaxy or longitudinal studies, where precise volumetric information is required. The disclosure provides practical methods for correcting distorted images resulting from such non-linearity in the gradient fields, as well as distortions resulting from translational, rotational, and/or winding/design errors in the field generating devices. The methods employ spherical harmonic expansions of the gradient fields and fast Fourier transform techniques to provide well-corrected images without undue computational burdens.
摘要翻译：在磁共振成像（MRI）技术中的空间编码通过在存在磁场梯度例如X，Y和Z梯度的情况下将信号作为时间的函数进行采样来实现。过去已经假设梯度磁体产生线性梯度，典型的图像重建技术依赖于这一假设。然而，为了实现高速性能，梯度磁体通常牺牲线速度的速度。这种非线性反过来导致图像失真，失真通常足够大以损害用于立体定向或纵向研究的MRI图像的有用性，其中需要精确的体积信息。本公开提供了用于校正由梯度场中的这种非线性导致的失真图像以及由场产生装置中的平移，旋转和/或绕组/设计误差引起的失真的实用方法。该方法采用梯度场和快速傅立叶变换技术的球面谐波扩展，以提供良好校正的图像，而不会造成不必要的计算负担。

3. 发明公开

EP1583978A1 CORRECTION OF MAGNETIC RESONANCE IMAGES 审中-公开
标题翻译：修正用磁IMAGES OF
公开(公告)号：EP1583978A1
公开(公告)日：2005-10-12
申请号：EP03767302.7
申请日：2003-12-22
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： DODDRELL, David, Michael , ZHAO, Huawei
IPC分类号： G01R33/20 , A61B5/055
CPC分类号： A61B5/7257 , A61B5/055 , G01R33/56518 , G01R33/56572
摘要： Spatial encoding in magnetic resonance imaging (MRI) techniques is achieved by sampling the signal as a function of time in the presence of magnetic field gradients, e.g., X, Y, and Z gradients. The gradient magnets have in the past been assumed to generate a linear gradient, and typical image reconstruction techniques have relied upon this assumption. However, to achieve high speed performance, gradient magnets often sacrifice linearity for speed. This non-linearity, in turn, results in distorted images, the distortion often being sufficiently large to compromise the usefulness of MRI images for stereotaxy or longitudinal studies, where precise volumetric information is required. The disclosure provides practical methods for correcting distorted images resulting from such non-linearity in the gradient fields, as well as distortions resulting from translational, rotational, and/or winding/design errors in the field generating devices. The methods employ spherical harmonic expansions of the gradient fields and fast Fourier transform techniques to provide well-corrected images without undue computational burdens.

4. 发明申请

WO2013166308A1 INTRAOCULAR LENS WITH SHAPE CHANGING CAPABILTIY TO PROVIDE ENHANCED ACCOMODATION AND VISUAL ACUITY 审中-公开
标题翻译：具有形状改变能力的内窥镜提供增强的摄影和视觉功能
公开(公告)号：WO2013166308A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039302
申请日：2013-05-02
申请人： ABBOTT MEDICAL OPTICS INC. , BRADY, Daniel, G. , ZHAO, Huawei , GERAGHTY, Edward , CATLIN, Scott, J.
发明人： BRADY, Daniel, G. , ZHAO, Huawei , GERAGHTY, Edward , CATLIN, Scott, J.
IPC分类号： A61F2/16
CPC分类号： A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2002/1681 , A61F2002/1682 , A61F2002/1689 , A61F2250/0018
摘要： An intraocular lens for providing a range of accommodative vision, an extended depth of focus, or enhanced performance through the asymmetric transfer of ocular forces to the lens. The intraocular lens contains an optic and a haptic. The shape and/or material of the haptic results in the transmission of ocular forces to particular regions in the optic. Greater forces applied to particular regions result in deformation of that region and increased power.
摘要翻译：一种眼内透镜，用于通过对眼镜的不对称转移提供一定范围的调节视力，扩大的焦点深度或增强的性能。眼内透镜包含视神经和触觉。触觉的形状和/或材料导致眼力传递到光学元件中的特定区域。施加到特定区域的更大的力导致该区域的变形并增加功率。

5. 发明申请

WO2012078763A1 PUPIL DEPENDENT DIFFRACTIVE LENS FOR NEAR, INTERMEDIATE, AND FAR VISION 审中-公开
标题翻译：用于近旁，中间和远景的镜头相关透镜
公开(公告)号：WO2012078763A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063752
申请日：2011-12-07
申请人： ABBOTT MEDICAL OPTICS INC. , ZHAO, Huawei
发明人： ZHAO, Huawei
IPC分类号： G02C7/04 , A61F2/16 , G02C7/06 , G02B5/18
CPC分类号： G02C7/06 , A61F2/16 , A61F2/1613 , A61F2/1618 , A61F2/1654 , A61F2230/0006 , G02B5/1895 , G02C7/041 , G02C7/044 , G02C2202/20 , G02C2202/22
摘要： A multifocal diffractive lens comprises a multifocal diffractive structure coupled to a refractive component. The refractive component comprises at least one curved surface. The multifocal diffractive structure comprises a first plurality of substantially monofocal echellettes having a first optical power for near vision correction and a second plurality of substantially monofocal echellettes for far vision correction. The first plurality of substantially monofocal echellettes combined with the second plurality of substantially monofocal echellettes can provide a multifocal diffractive profile having decreased light scatter, chromatic aberration, and diffraction to non- viewing orders such that dysphotopsia is substantially inhibited. A third plurality of substantially monofocal echellettes having an intermediate optical power can be combined with the first plurality of substantially monofocal echellettes and the second plurality of substantially monofocal echellettes.
摘要翻译：多焦点衍射透镜包括耦合到折射分量的多焦点衍射结构。折射分量包括至少一个曲面。多焦点衍射结构包括具有用于近视矫正的第一光焦度和用于远视矫正的第二多个基本单焦点的第一组多个基本上单焦点的电子表格。与第二组多个基本上单一的聚焦片组合的第一组多个基本上单焦点的电子表格可以提供具有减少的光散射，色差和衍射到非观看次数的多焦点衍射轮廓，从而基本上抑制了摄像斑。具有中间光焦度的第三组多个基本单焦点的电子表格可以与第一组多个基本上单焦点的电子表格和第二组多个基本单焦点的电子表格组合。

6. 发明申请

WO2012031211A1 MICROINCISION LENS 审中-公开
标题翻译：微型镜头
公开(公告)号：WO2012031211A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050342
申请日：2011-09-02
申请人： ABBOTT MEDICAL OPTICS INC. , ZHAO, Huawei
发明人： ZHAO, Huawei
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1637 , A61F2/1654 , A61F2/1656 , A61F2002/169053 , A61F2250/0036
摘要： A foldable lens comprises an outer refractive surface portion comprising a first plurality of convexly curved refractive profile regions having positive optical power to converge light energy with refraction toward a focus on the retina. The convexly curved refractive profile regions of the outer region may correspond to at least about a quarter of the refractive power of the lens, such that the lens thickness is decreased substantially and the folded lens can fit through a small incision. The outer refractive surface portion focuses light with refraction, in focus images viewed through the outer portion of the lens can appear sharp to the patient. The outer refractive surface portion also comprises a second plurality of concavely curved refractive profile regions having negative optical power disposed between the first plurality, so as to diverge the light energy substantially away from the focus on the retina, such that visual artifacts are inhibited.
摘要翻译：可折叠透镜包括外折射表面部分，该外折射表面部分包括具有正光焦度的第一多个凸曲面折射轮廓区域，以将具有折射的光能聚焦到视网膜上的焦点。外部区域的凸曲面的折射轮廓区域可以对应于透镜的折射力的至少约四分之一，使得透镜厚度基本上减小，并且折叠的透镜可以通过小切口装配。外折射表面部分聚焦具有折射的光，通过透镜的外部部分观看的焦点图像对于患者可能显得锋利。外折射表面部分还包括设置在第一多个之间的具有负光焦度的第二多个凹曲面的折射轮廓区域，以便将光能基本上远离焦点在视网膜上分离，使得视觉伪影被禁止。

7. 发明申请

WO2015021115A1 SYSTEM AND METHOD FOR DETERMINING OCULAR SCATTERING 审中-公开
标题翻译：用于确定OCULAR散射的系统和方法
公开(公告)号：WO2015021115A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049886
申请日：2014-08-06
申请人： ABBOTT MEDICAL OPTICS INC. , ZHAO, Huawei , CHEN, Li
发明人： ZHAO, Huawei , CHEN, Li
IPC分类号： A61B3/10
CPC分类号： A61B3/10 , A61B3/0008
摘要： Improved systems and methods for determining ocular scattering are provided. These systems and methods can be used to quantify ocular scattering before and/or after a wide variety of different ophthalmic diagnostic procedures, and various surgical and non-surgical treatments. One embodiment provides a system and method for determining ocular scattering that uses two light detectors, with one detector configured to detect light over a relatively narrow angular range, and the other detector configured to detect light over a relatively large angular range. The data from the narrow angular range and the large angular range can then be analyzed to determine a measurement of ocular scattering.
摘要翻译：提供了用于确定眼睛散射的改进的系统和方法。这些系统和方法可用于在各种不同的眼科诊断程序和各种手术和非手术治疗之前和/或之后量化眼部散射。一个实施例提供了一种用于确定使用两个光检测器的眼睛散射的系统和方法，其中一个检测器被配置为在相对较窄的角度范围内检测光，而另一个检测器被配置为在相对较大的角度范围内检测光。然后可以分析来自窄角度范围和大角度范围的数据，以确定眼睛散射的测量。

8. 发明申请

WO2012006385A2 TORIC LENS WITH DECREASED SENSITIVITY TO CYLINDER POWER AND ROTATION AND METHOD OF USING THE SAME 审中-公开
标题翻译：降低圆筒动力和旋转灵敏度的TORIC镜片及其使用方法
公开(公告)号：WO2012006385A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043119
申请日：2011-07-07
申请人： ABBOTT MEDICAL OPTICS INC. , BOGAERT, Theophilus , WEEBER, Hendrik, A. , ZHAO, Huawei
发明人： BOGAERT, Theophilus , WEEBER, Hendrik, A. , ZHAO, Huawei
IPC分类号： A61F2/16
CPC分类号： A61F2/1654 , A61B3/0025 , A61F2/1645 , A61F9/013 , A61F2002/1699 , G02B3/06 , G02B27/0075 , G02C7/02 , G02C7/027 , G02C7/041 , G02C7/06 , G02C2202/02 , G02C2202/06 , G02C2202/20
摘要： A method, system and apparatus for vision correction are disclosed. The method, system and apparatus include a toric intraocular element for correcting astigmatism and having a cylinder power, and a depth of focus extender coupled to the toric intraocular element, the depth of focus extender extending a depth of focus. The extended depth of focus may reduce sensitivity of the toric intraocular element to at least one of rotation and selected cylinder power.
摘要翻译：公开了一种用于视力矫正的方法，系统和设备。该方法，系统和设备包括用于校正散光并具有柱面光焦度的复曲面眼内元件以及耦合到复曲面眼内元件的焦深扩展器，焦深扩展器延伸焦点深度。扩大的焦点深度可以降低复曲面眼内元件对旋转和选择的柱面能量中的至少一种的灵敏度。

9. 发明申请

WO2005046527A2 MULTI-ZONAL MONOFOCAL INTRAOCULAR LENS FOR CORRECTING OPTICAL ABERRATIONS 审中-公开
标题翻译：用于校正光学异常的多区单眼内窥镜
公开(公告)号：WO2005046527A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037684
申请日：2004-11-10
申请人： ADVANCED MEDICAL OPTICS, INC. , LANG, Alan, J. , ZHAO, Huawei
发明人： LANG, Alan, J. , ZHAO, Huawei
IPC分类号： A61F2/16
CPC分类号： A61F2/1616 , A61F2/1637 , A61F2240/002 , A61F2250/0053
摘要： A multi-zonal monofocal opthalmic lens comprises an inner zone, an intermediate zone, and an outer zone. The inner zone has a first optical power. The intermediate zone surrounds the inner zone and has' a second optical power that is different from the first power by a magnitude that is less than at least about 0.75 Diopter. The outer zone surrounds the intermediate zone and has a third optical power different from the second optical power. In certain embodiments, the third optical power is equal to the first optical power.
摘要翻译：多区域单焦点眼镜包括内部区域，中间区域和外部区域。内区具有第一光功率。中间区域围绕内部区域并且具有与第一功率不同的小于至少约0.75屈光度的量值的第二光学功率。外部区域围绕中间区域并且具有与第二光学功率不同的第三光学功率。在某些实施例中，第三光功率等于第一光功率。

10. 发明申请

WO2014008343A1 HIGH EFFICIENCY OPTIC 审中-公开
标题翻译：高效光学
公开(公告)号：WO2014008343A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/049227
申请日：2013-07-03
申请人： ABBOTT MEDICAL OPTICS INC. , ZHAO, Huawei
发明人： ZHAO, Huawei
IPC分类号： G02C7/02 , G02C7/04 , A61F2/16
CPC分类号： G02C7/022 , A61F2/1654 , A61F2002/1699 , G02C7/024 , G02C7/028 , G02C7/041 , G02C7/06 , G02C2202/20
摘要： Ophthalmic lenses and methods for their design and use involve displacement functions based on the sum of a continuous cosine function and a continuous sine function, optionally over a plurality of echelettes. Exemplary monofocal and multifocal diffractive ophthalmic lenses provide reduced light scatter and/or improved light energy distribution properties. Such properties can be provided by diffractive profiles, often having subtlety shaped echelettes with appropriately curving profiles. Light scatter may be generated by the sharp corners associated with vertical steps between adjacent conventional diffractive echelettes. Smooth diffractive profiles of the invention reduce light scatter. Light energy directed toward non- viewing diffractive orders may have a unwanted effects on vision quality. Diffractive profiles as described herein may limit the light energy in certain, selected orders, thereby improving viewing quality and mitigating unwanted effects such as dysphotopsia. Diffractive profiles may also vary the light energy distributed between individual echelettes, providing additional advantages in various viewing situations.
摘要翻译：眼科镜片及其设计和使用的方法涉及基于连续余弦函数和连续正弦函数之和的位移函数，可选地在多个小阶梯上。示例性单焦点和多焦点衍射眼镜片提供减少的光散射和/或改善的光能分布特性。这种性质可以由衍射轮廓提供，通常具有具有适当弯曲轮廓的细微形状的小阶梯。光散射可以通过与相邻常规衍射小阶梯之间的垂直台阶相关联的尖角产生。本发明的平滑衍射轮廓减少光散射。针对非观看衍射指令的光能可能对视觉质量产生不良影响。如本文所述的衍射轮廓可以以特定的选定次序限制光能，从而提高观看质量并减轻不期望的影响，例如失调。衍射轮廓也可以改变在各个小阶梯之间分配的光能，在各种观看情况下提供额外的优点。

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