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1. 发明申请

WO1992003574A1 CYTOKINE PRODUCTION 审中-公开
标题翻译：细菌生产
公开(公告)号：WO1992003574A1
公开(公告)日：1992-03-05
申请号：PCT/AU1991000358
申请日：1991-08-13
申请人： THE UNIVERSITY OF MELBOURNE , AUSTRALIAN WOOL CORPORATION , BRANDON, Malcolm, Roy , ANDREWS, Arna, Elizabeth , NASH, Andrew, Donald , MEEUSEN, Elsa, Nicole, Theresia
发明人： THE UNIVERSITY OF MELBOURNE , AUSTRALIAN WOOL CORPORATION
IPC分类号： C12Q01/68
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C12Q1/6876 , C12Q2600/158
摘要： A process for identifying nucleotide sequences coding for a polypeptide exhibiting specific ruminant cytokine or cytokine receptor activity or a fragment thereof, which process includes providing a vector including a complementary DNA (cDNA) sequence derived from ruminant cells or an extract thereof capable of being expressed in a unicellular organism; a unicellular organism; and a DNA probe for a homologous cytokine; introducing the vector into the said unicellular organism; culturing the organism to express a polypeptide encoded therein; probing the organism with the DNA probe; and isolating a vector containing a cDNA sequence encoding for a polypeptide exhibiting specific ruminant cytokine or cytokine receptor activity.
摘要翻译：用于鉴定编码表现出特异性反刍动物细胞因子或细胞因子受体活性或其片段的多肽的核苷酸序列的方法，该方法包括提供包含衍生自反刍动物细胞的互补DNA（cDNA）序列或其能够在单细胞生物单细胞生物和同源细胞因子的DNA探针; 将载体引入所述单细胞生物体; 培养生物体以表达其中编码的多肽; 用DNA探针探测生物体; 并分离含有编码显示特异性反刍动物细胞因子或细胞因子受体活性的多肽的cDNA序列的载体。

2. 发明申请

WO1994004174A1 CYTOKINE APPLICATIONS 审中-公开
标题翻译：细胞因子应用
公开(公告)号：WO1994004174A1
公开(公告)日：1994-03-03
申请号：PCT/AU1993000425
申请日：1993-08-20
申请人： THE UNIVERSITY OF MELBOURNE , WOOL RESEARCH AND DEVELOPMENT CORPORATION , ANDREWS, Arna, Elizabeth , NASH, Andrew, Donald , BRANDON, Malcolm, Roy
发明人： THE UNIVERSITY OF MELBOURNE , WOOL RESEARCH AND DEVELOPMENT CORPORATION
IPC分类号： A61K37/02
CPC分类号： A61K39/39 , A61K38/00 , A61K39/0003 , A61K2039/55505 , A61K2039/55527 , C07K14/545
摘要： A vaccine composition including an antigen against a disease of interest; a non-toxic adjuvant including a recombinant polypeptide having ovine cytokine or cytokine receptor activity, or mimotopes, derivatives or fragments thereof; and a non-toxic coadjuvant selected to stabilise and/or enhance the immune response to the recombinant polypeptide adjuvant.
摘要翻译：一种疫苗组合物，其包含针对目的疾病的抗原; 包括具有羊细胞因子或细胞因子受体活性的重组多肽的无毒佐剂，或模拟表位，其衍生物或片段; 和选择用于稳定和/或增强对重组多肽佐剂的免疫应答的无毒辅佐剂。

3. 发明申请

WO1995022603A1 VACCINE TO CONTROL ECTOPARASITES 审中-公开
标题翻译：疫苗来控制病毒
公开(公告)号：WO1995022603A1
公开(公告)日：1995-08-24
申请号：PCT/AU1995000078
申请日：1995-02-17
申请人： THE UNIVERSITY OF MELBOURNE , AUSTRALIAN WOOL RESEARCH AND PROMOTION ORGANISATION , BRANDON, Malcolm, Roy , BOWLES, Vernon, Morrison
发明人： THE UNIVERSITY OF MELBOURNE , AUSTRALIAN WOOL RESEARCH AND PROMOTION ORGANISATION
IPC分类号： C12N09/76
CPC分类号： A61K38/4826 , A61K39/00 , C07K14/435 , C12N9/6408 , A61K2300/00
摘要： An antigen or group of antigens for preventing or reducing ectoparasite infection or disease in an animal is described. The antigen(s) is such that when the animal is immunised with the antigen(s), immunity of the animal to the ectoparasite is boosted by natural challenge of the animal with the ectoparasite. Also described is a vaccine composition for prevention or reduction of ectoparasite infection or disease in an animal. The composition includes a prophylactically effective amount of an antigen or group of antigens against an ectoparasite, an adjuvant and a cytokine.
摘要翻译：描述了用于预防或减少动物体内外寄生虫感染或疾病的抗原或抗原组。抗原是这样的，当动物用抗原免疫时，通过用外寄生物的动物的天然攻击来促进动物对外寄生物的免疫。还描述了一种用于预防或减少动物体外寄生虫感染或疾病的疫苗组合物。组合物包含预防有效量的针对外寄生虫，佐剂和细胞因子的抗原或抗原组。

4. 发明申请

WO1995010599A1 EMBRYONIC STEM CELL-LIKE CELLS 审中-公开
标题翻译：胚胎干细胞样细胞
公开(公告)号：WO1995010599A1
公开(公告)日：1995-04-20
申请号：PCT/AU1994000624
申请日：1994-10-13
申请人： THE UNIVERSITY OF MELBOURNE , CHERNY, Robert, Alan , BRANDON, Malcolm, Roy , WILLIAMS, Robert, Lindsay
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C12N05/06
CPC分类号： C12N5/0606 , C12N2501/115 , C12N2501/125 , C12N2501/235 , C12N2502/13 , C12N2506/04 , G01N33/56966
摘要： A process for preparing embryonic stem cell-like cells ("ES-like cells") is described. The process includes providing a source of primordial germ ("PG") cells, and a source of feeder cells of a suitable type; contacting the PG cells with the feeder cells; culturing the PG cells in a culture medium; and identifying and isolating ES-like cells from the culture medium; wherein the culture step is performed in the absence of exogenous growth factors and/or exogenous cytokines.
摘要翻译：描述了制备胚胎干细胞样细胞（“ES样细胞”）的方法。该方法包括提供原始胚芽（“PG”）细胞源和合适类型的饲养细胞源; 使PG细胞与饲养细胞接触; 在培养基中培养PG细胞; 并从培养基中鉴定和分离ES样细胞; 其中所述培养步骤在不存在外源生长因子和/或外源性细胞因子的情况下进行。

5. 发明申请

WO1997045444A1 EBV CTL EPITOPES 审中-公开
标题翻译： EBV CTL抗体
公开(公告)号：WO1997045444A1
公开(公告)日：1997-12-04
申请号：PCT/AU1997000328
申请日：1997-05-23
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , KHANNA, Rajiv , KERR, Beverley, Mavis , MISKO, Ihor, Spephan , MOSS, Denis, James , BURROWS, Scott, Renton
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C12N2710/16222 , Y02A50/466
摘要： The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.
摘要翻译：本发明提供细胞毒性的爱泼斯坦 - 巴尔病毒T细胞表位。这些表位是QVKWRMTTL，VFSDGRVAC，VPAPAGPIV，TYSAGIVQI，LLDFVRFMGV，QNGALAINTF，VSSDGRVAC，VSSEGRVAC，VSSDGRVPC，VSSDGLVAC，VSSDGQVAC，VSSDGRVVC，VPAPPVGPIV，VEITPYEPTG，VEITPYEPTW，VELTPYKPTW，RRIYDLIKL，RKIYDLIEL和PYLFWLAGI。本发明进一步提供疫苗，其包括这些表位中的一个或多个，任选地具有另外的表位。

6. 发明申请

WO1997036923A1 PORPHYROMONAS GINGIVALIS ANTIGENS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTITIS 审中-公开
标题翻译：用于诊断和治疗周期性的PORPHYROMONAS GINGIVALIS抗原
公开(公告)号：WO1997036923A1
公开(公告)日：1997-10-09
申请号：PCT/AU1997000212
申请日：1997-04-01
申请人： THE UNIVERSITY OF MELBOURNE , VICTORIAN DAIRY INDUSTRY AUTHORITY , REYNOLDS, Eric, Charles , SLAKESKI, Nada , HENDTLASS, Anne
发明人： THE UNIVERSITY OF MELBOURNE , VICTORIAN DAIRY INDUSTRY AUTHORITY
IPC分类号： C07K14/195
CPC分类号： G01N33/56955 , A61K8/64 , A61K38/00 , A61K39/00 , A61K2039/51 , A61Q11/00 , C07K14/195 , C07K16/1203 , C07K2317/34 , C07K2319/00 , G01N2333/195 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： The present invention provides a composition for use in raising an immune response directed against Porphyromonas gingivalis. The composition includes a suitable adjuvant and/or acceptable carrier and one substantially purified P. gingivalis immunogen. The immunogen is selected from the group consisting of Antigen 1, Antigen 2, Antigen 3, Antigen 4 and epitope containing fragments thereof, in which: Antigen 1 is an antigen of P. gingivalis and has an internal amino acid sequence: DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; Antigen 2 is an antigen of P. gingivalis and has an internal amino acid sequence: DNPDENPLEGDITQTHTEKYVLAED; Antigen 3 is an antigen of P. gingivalis and has an internal amino acid sequence: DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK; Antigen 4 is an antigen of P. gingivalis and has an internal amino acid sequence: VYNASISAVGNTSAIDPVVQIIHHN.
摘要翻译：本发明提供了用于提高针对牙龈卟啉单胞菌的免疫应答的组合物。组合物包含合适的佐剂和/或可接受的载体和一种基本上纯化的牙龈卟啉单胞菌免疫原。免疫原选自抗原1，抗原2，抗原3，抗原4和含有其片段的表位，其中：抗原1是牙龈卟啉单胞菌的抗原，并具有内部氨基酸序列：DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; 抗原2是牙龈卟啉单胞菌的抗原，具有内部氨基酸序列：DNPDENPLEGDITQTHTEKYVLAED; 抗原3是牙龈卟啉菌的抗原，具有内部氨基酸序列：DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK; 抗原4是牙龈卟啉单胞菌的抗原，并具有内部氨基酸序列：VYNASISAVGNTSAIDPVVQIIHHN。

7. 发明申请

WO1997016542A1 DIAGNOSTICS AND TREATMENTS OF PERIODONTAL DISEASE 审中-公开
标题翻译：诊断和治疗周围疾病
公开(公告)号：WO1997016542A1
公开(公告)日：1997-05-09
申请号：PCT/AU1996000673
申请日：1996-10-30
申请人： THE UNIVERSITY OF MELBOURNE , VICTORIAN DAIRY INDUSTRY AUTHORITY , REYNOLDS, Eric, Charles , BHOGAL, Peter, Singh , SLAKESKI, Nada
发明人： THE UNIVERSITY OF MELBOURNE , VICTORIAN DAIRY INDUSTRY AUTHORITY
IPC分类号： C12N09/76
CPC分类号： C12N9/52 , A61K38/00
摘要： This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
摘要翻译：本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白，特别涉及包含PrtR和PrtK蛋白的多聚细胞相关蛋白复合物。因此，本发明提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。复合物包含精氨酸特异性和赖氨酸特异性硫醇内肽酶的至少一种多聚体蛋白质复合物，其各自含有至少一个粘附素结构域，所述复合物具有大于约200kDa的分子量。本发明还涉及基于用于检测，预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关试剂。

8. 发明申请

WO1996028472A1 ANTIGEN COMPOSITION AGAINST MYCOPLASMA 审中-公开
标题翻译：抗体组合物对MYCOPLASMA
公开(公告)号：WO1996028472A1
公开(公告)日：1996-09-19
申请号：PCT/AU1996000149
申请日：1996-03-15
申请人： THE UNIVERSITY OF MELBOURNE , WALKER, John , LEE, Rogan , DOUGHTY, Stephen, William
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C07K16/12
CPC分类号： C07K14/30 , A61K39/00 , C07K16/1253 , Y10S435/87 , Y10S530/806 , Y10S530/82 , Y10S530/821
摘要： The present invention relates to a putative protective antigen against a Mycoplasma, prepared by a method including a sample of a Mycoplasma; an antibody probe including at least one antibody against a Mycoplasma produced by a method including: providing a biological sample taken a short time after an immune animal has been challenged with a Mycoplasma or Mycoplasma extract taken from the infection site or an area of a lesion or an area close to the infection site or lesion; isolating cells from the biological sample; culturing cells in vitro in a suitable culture medium; and harvesting antibodies produced from said cells; probing the Mycoplasma sample with the antibody probe to detect at least one antigen; and isolating the antigen detected, also including diagnostic antigens, the preparation thereof, and their use in the formation of vaccine compositions, particularly vaccine compositions against Mycoplasma hyopneumoniae infections.
摘要翻译：本发明涉及通过包括支原体样品的方法制备的针对支原体的推定的保护性抗原; 一种抗体探针，其包含至少一种针对支原体的抗体，所述抗体通过以下方法产生，该方法包括：在免疫动物已用来自感染部位或病变区域的支原体或支原体提取物攻击之后提供短时间内的生物样品，或靠近感染部位或病变的区域; 从生物样品中分离细胞; 在合适的培养基中体外培养细胞; 并收获由所述细胞产生的抗体; 用抗体探针探测支原体样本以检测至少一种抗原; 并分离所检测的抗原，也包括诊断抗原，其制备及其在形成疫苗组合物，特别是针对猪肺炎支原体感染的疫苗组合物中的用途。

9. 发明申请

WO1993010472A1 DETECTING GAMMA RAYS 审中-公开
标题翻译：检测游戏
公开(公告)号：WO1993010472A1
公开(公告)日：1993-05-27
申请号：PCT/AU1992000620
申请日：1992-11-20
申请人： THE UNIVERSITY OF MELBOURNE , TAYLOR, Geoffrey, Norman , EGAN, Gary, Francis
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： G01T01/29
CPC分类号： G01T1/2985 , G01T1/2018
摘要： A method of, and apparatus for, detecting X-rays and gamma rays is provided in which scintillation crystals (12) are disposed around a source of X-rays or gamma rays in an annular or cylindrical array with light detectors (16, 18) to detect and measure the light emitted from both ends of each crystal (12) when it absorbs an X-ray or gamma ray, whereby the position (Z) of a scintillation point within the crystal (12) can be determined from a comparison of the measurement of the light emitted from each end of the crystal. An array of thin photodiodes (16) disposed on the inner end of each crystal (12) is used to measure the light emitted from the inner end of the crystal (12) to enable the apparatus to have a small ring diameter thereby reducing cost and complexity. The scintillation crystals of the array may be arranged in blocks with the apparatus including coincidence logic circuitry arranged to determine when a coincidence between X-rays or gamma rays is from opposed or nearly opposed blocks of the array.
摘要翻译：提供了一种用于检测X射线和γ射线的方法和装置，其中闪烁晶体（12）围绕具有光检测器（16,18）的环形或圆柱阵列中的X射线或γ射线源设置，以检测和测量当其吸收X射线或γ射线时从每个晶体（12）的两端发射的光，从而可以从晶体（12）内的闪烁点的位置（Z）从晶体的每一端发射的光的测量。设置在每个晶体（12）的内端上的薄光电二极管（16）的阵列用于测量从晶体（12）的内端发射的光，使得该装置具有小的环直径，从而降低成本，复杂。阵列的闪烁晶体可以以块为单位布置，其中装置包括重合逻辑电路，其布置成确定X射线或伽马射线之间的重合何时来自阵列的相对或几乎相对的块。

10. 发明申请

WO1992015136A1 SEMICONDUCTOR LASER 审中-公开
标题翻译：半导体激光器
公开(公告)号：WO1992015136A1
公开(公告)日：1992-09-03
申请号：PCT/AU1992000048
申请日：1992-02-12
申请人： THE UNIVERSITY OF MELBOURNE , TUCKER, Rodney, Stuart
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： H01S03/25
CPC分类号： H01S5/1021 , H01S5/0425 , H01S5/4006 , H01S5/4018 , H01S5/4031 , H01S5/4043 , H01S5/5027
摘要： A semiconductor laser comprises a plurality of laser sections (10, 11, 12) defined in a body and isolated electrically from one another. The active region (14) of each section are optically coupled together and electrical connections (9) connect the sections in series and provide connections to an external drive current source. In a practical embodiment the laser is constructed in planar form in a body (16) of semi-insulating material and wells (23a, 23b, 23c) are etched into the body and are provided with metallization (24) which forms the electrical connections. The active region (14) extends continuously through the body with separate p-type anodes thereabove and separate n-type cathodes beneath the active region and extending on either side thereof.
摘要翻译：半导体激光器包括限定在体内并彼此电隔离的多个激光部分（10,11,12）。每个部分的有源区域（14）光学耦合在一起，并且电连接（9）串联连接这些部分并且提供到外部驱动电流源的连接。在实际实施例中，激光器以半绝缘材料的主体（16）中的平面形式构造，并且将阱（23a，23b，23c）蚀刻到主体中并且设置有形成电连接的金属化（24）。有源区域（14）在其上方分开的p型阳极连续延伸穿过主体区域，并且在有源区域下方分开并在其任一侧上延伸的n型阴极。

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