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1. 发明申请

WO1997038697A1 SENSITIZATION OF CELLS TO RADIATION AND CHEMOTHERAPY 审中-公开
标题翻译：细胞对辐射和化疗的敏感性
公开(公告)号：WO1997038697A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006314
申请日：1997-04-15
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH OF PENNSYLVANIA
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH OF PENNSYLVANIA , MCKENNA, W., Gilles , MUSCHEL, Ruth, J. , BERNHARD, Eric, J. , SEBTI, Said, M. , HAMILTON, Andrew, D.
IPC分类号： A61K31/70
CPC分类号： G01N33/57407 , A61K31/198 , A61K31/216 , A61K41/0038 , G01N33/573 , G01N33/5748
摘要： The invention relates to a method of conferring radiation sensitivity on a tumor cell comprising administering to the cell an inhibitor of a protein product which participates in the ras signalling pathway, whereby inhibition of the protein product confers radiation sensitivity on the cell.
摘要翻译：本发明涉及赋予肿瘤细胞辐射敏感性的方法，包括向细胞施用参与ras信号通路的蛋白质产物的抑制剂，由此蛋白质产物的抑制赋予细胞辐射敏感性。

2. 发明申请

WO1998005274A1 COMPOSITIONS AND METHODS FOR INTERVERTEBRAL DISC REFORMATION 审中-公开
标题翻译：用于椎间盘突变的组合物和方法
公开(公告)号：WO1998005274A1
公开(公告)日：1998-02-12
申请号：PCT/US1997013854
申请日：1997-08-06
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , GAN, Jean, Chin, Chin , DUCHEYNE, Paul , VRESILOVIC, Edward , SHAPIRO, Irving
IPC分类号： A61F02/44
CPC分类号： A61L27/3817 , A61F2/30767 , A61F2/442 , A61F2002/30062 , A61F2002/30187 , A61F2210/0004 , A61F2230/0034 , A61L27/025 , A61L27/18 , A61L27/306 , A61L27/3856 , A61L27/3895 , A61L27/44 , A61L27/56 , A61L2430/38 , C08L67/04
摘要： Methods of reforming degenerated intervertebral discs are provided in accordance with methods of the invention. Hybrid materials useful in methods of the present invention are also provided.
摘要翻译：根据本发明的方法提供重建退化椎间盘的方法。还提供了可用于本发明方法的混合材料。

3. 发明申请

WO1997025982A1 DICARBONYL-CONTAINING COMPOUNDS 审中-公开
标题翻译：含有DICARBONYL的化合物
公开(公告)号：WO1997025982A1
公开(公告)日：1997-07-24
申请号：PCT/US1997001212
申请日：1997-01-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , HIRSCHMANN, Ralph, F. , SMITH, Amos, B., III , SPRENGELER, Paul , YAO, Wenqing , ANDERSON, Paul
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： A61K31/165
CPC分类号： C07C237/20 , C07C235/36 , C07C271/22 , C07C2602/08
摘要： This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other medicinally-significant proteins. In particular, the invention relates to dicarbonyl compounds that are capable of acting as enzyme inhibitors, including irreversible inhibitors of HIV-1 protease.
摘要翻译：本发明涉及含有相邻羰基的化学化合物，其有效抑制酶和其它医学上重要的蛋白质的生物，化学和/或物理性质。特别地，本发明涉及能够作为酶抑制剂的二羰基化合物，包括HIV-1蛋白酶的不可逆抑制剂。

4. 发明申请

WO1997025961A1 BOWMAN-BIRK INHIBITOR FOR MALE SEXUAL DYSFUNCTION 审中-公开
标题翻译： BOWMAN-BIRK抑制剂用于男性性功能障碍
公开(公告)号：WO1997025961A1
公开(公告)日：1997-07-24
申请号：PCT/US1997000643
申请日：1997-01-16
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , KENNEDY, Ann, R. , CLARK, Larry, C.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： A61K07/035
CPC分类号： A61K38/56
摘要： A composition containing a Bowman-Birk Inhibitor for the treatment of abnormal conditions or diseases of the genitourinary tract/pelvic region is provided. Methods of using this composition in the treatment of such conditions and diseases are also provided.
摘要翻译：提供了含有用于治疗泌尿生殖道/骨盆区域的异常状况或疾病的Bowman-Birk抑制剂的组合物。还提供了使用该组合物治疗这些病症和疾病的方法。

5. 发明申请

WO1997015679A1 RECOMBINANT VIRUSES CONTAINING MOBILE GENETIC ELEMENTS AND METHODS OF USE IN GENE THERAPY 审中-公开
标题翻译：含有移植遗传因素的重组病毒及其在基因治疗中的使用方法
公开(公告)号：WO1997015679A1
公开(公告)日：1997-05-01
申请号：PCT/US1996017176
申请日：1996-10-24
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , KELLEY, William, Mark , WILSON, James, M.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N15/00 , C12N15/90 , C12N2710/10343 , C12N2710/10352 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2830/42 , C12N2840/44
摘要： Recombinant E1-deleted adenoviruses are provided that contain a transgene associated with the elements of a recombinant transposon sequence, e.g., from Moloney murine leukemia virus (Mo-MLV), necessary to achieve specific retrotransposition of the transgene from the recombinant adenovirus into the target cell chromatin. Also provided are methods for generating the recombinant adenoviruses and methods of use thereof.
摘要翻译：提供了重组E1缺失的腺病毒，其含有与重组转座子序列的元件相关的转基因，例如来自莫洛尼鼠白血病病毒（Mo-MLV），其是实现转基因从重组腺病毒特异性逆转录入靶细胞所必需的染色质。还提供了用于产生重组腺病毒的方法及其使用方法。

6. 发明申请

WO1997000498A1 APPARATUS AND METHOD FOR DYNAMIC MODELING OF AN OBJECT 审中-公开
标题翻译：一种物体动态建模的装置和方法
公开(公告)号：WO1997000498A1
公开(公告)日：1997-01-03
申请号：PCT/US1996010413
申请日：1996-06-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , METAXAS, Dimitri
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： G06T17/40
CPC分类号： G06T17/20 , G06T17/00
摘要： A method and apparatus for dynamic modeling of an object having material points. The method includes receiving signals from a sensor (403) which correspond to respective material points; providing a volumetric model, having functions as parameters, representative of the object; and adapting the parameters to fit a changing model shape. This method of dynamic shape modeling, dynamic motion modeling or both includes shape estimation and motion analysis. The apparatus includes a signal processor (405) for receiving signals from a sensor, a second signal processor (407) for providing a volumetric model having functions as parameters representative of the object and a third signal processor (409) for receiving sensed signals and adapting the model and providing a dynamic representation.
摘要翻译：一种用于具有材料点的物体的动态建模的方法和装置。该方法包括从传感器（403）接收与各个物料点对应的信号; 提供具有代表对象的功能作为参数的体积模型; 并调整参数以适应不断变化的模型形状。动态形状建模，动态运动建模或二者的这种方法包括形状估计和运动分析。该装置包括用于从传感器接收信号的信号处理器（405），用于提供具有作为表示物体的参数的功能的体积模型的第二信号处理器（407）和用于接收感测信号并适应的第三信号处理器该模型并提供动态表示。

7. 发明申请

WO1996032127A1 METHODS OF ENHANCING EPITHELIAL CELL PROLIFERATION 审中-公开
标题翻译：增强上皮细胞增殖的方法
公开(公告)号：WO1996032127A1
公开(公告)日：1996-10-17
申请号：PCT/US1996004994
申请日：1996-04-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , GREENE, Mark, I. , COTSARELIS, George
IPC分类号： A61K38/04
CPC分类号： C07K7/08 , A61K38/00 , C07K14/005 , C07K16/28 , C12N2720/12022
摘要： Methods of enhancing epithelial cell proliferation are disclosed.The methods comprise the step of contacting epithelial cells with a compound that binds to reovirus type 3 receptor. Methods of treating an individual susceptible to or suffering from a condition, disease or disorder characterized by insufficient proliferation of epithelial cells are disclosed. The methods comprise the steps of identifying such individuals and administering to them a therapeutically effect amount of compound that binds to reovirus type 3 receptor and thereby enhances proliferation of ephithelial cells. Methods of treating individuals suffering from wounds that involve epithelial cells are disclosed. The methods comprise the steps of identifying such individuals and administering to them a therapeutically effect amount of compound that binds to reovirus type 3 receptor and thereby enhances proliferation of ephithelial cells.
摘要翻译：公开了增强上皮细胞增殖的方法。该方法包括使上皮细胞与结合呼肠孤病毒3型受体的化合物接触的步骤。公开了治疗易感或患有以上皮细胞增殖不足为特征的疾病或病症的个体的方法。所述方法包括鉴定这些个体并向其施用治疗有效量的结合呼肠孤病毒3型受体并从而增强ephithelial细胞增殖的步骤。公开了治疗患有涉及上皮细胞的伤口的个体的方法。所述方法包括鉴定这些个体并向其施用治疗有效量的结合呼肠孤病毒3型受体并从而增强ephithelial细胞增殖的步骤。

8. 发明申请

WO1996029345A1 NOVEL INOTROPIC AGENTS 审中-公开
标题翻译：新颖的非对称剂
公开(公告)号：WO1996029345A1
公开(公告)日：1996-09-26
申请号：PCT/US1996003911
申请日：1996-03-22
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LIANG, Bruce, T.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： C07K14/705
CPC分类号： C07H19/20 , C07F9/65586 , C07F9/6561 , C07K14/705
摘要： Purine-containing compounds that modulate cardiac muscle contractility and possess vasodilator activity are provided, as well as methods for modulating cardiac muscle contractility, and for causing vasodilation. Receptors that bind the coumpounds are also provided.
摘要翻译：提供了调节心肌收缩力并具有血管扩张剂活性的含嘌呤化合物，以及调节心肌收缩力和引起血管舒张的方法。还提供了结合固体的受体。

9. 发明申请

WO1996028756A1 CONDUCTING SUBSTRATE, LIQUID CRYSTAL DEVICE MADE THEREFROM AND LIQUID CRYSTALLINE COMPOSITION IN CONTACT THEREWITH 审中-公开
标题翻译：导电基板，液晶晶体装置及其接触液晶组合物
公开(公告)号：WO1996028756A1
公开(公告)日：1996-09-19
申请号：PCT/US1995016400
申请日：1995-12-29
申请人： GEO-CENTERS, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY OF THE NAVY
发明人： GEO-CENTERS, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY OF THE NAVY , SHASHIDHAR, Ranganathan , CALVERT, Jeffrey, M. , CRAWFORD, Renate, J. , WYNNE, Kenneth, J. , VARGO, Terrence, G. , MACDIARMID, Alan, G. , AVLYANOV, Jamshid, K.
IPC分类号： G02F01/1343
CPC分类号： G02F1/13439 , G02F1/133305
摘要： Conducting substrate (1) for use in display device having a conducting polymer on the surface of a rigid or flexible, flat, curved or bent substrate.
摘要翻译：导电基板（1）用于在刚性或柔性，平坦，弯曲或弯曲基板的表面上具有导电聚合物的显示装置中。

10. 发明申请

WO1996022087A1 SULFONAMIDE-BASED COMPOSITIONS AND METHODS 审中-公开
标题翻译：基于磺酰胺的组合物和方法
公开(公告)号：WO1996022087A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000501
申请日：1996-01-16
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SPRENGELER, Paul , SMITH, Amos, B., III , HIRSCHMANN, Ralph, F. , YOKOYAMA, Akihisa
IPC分类号： A61K31/18
CPC分类号： A61K31/496 , A61K31/18
摘要： Methods are provided for using 2-hydroxy-3-aminopropylsulfonamides to mimic peptides and to modulate the chemical and/or biological activity of enzymes, particularly proteolytic enzymes. Also provided are compositions comprising the sulfonamides in admixture with a pharmaceutically acceptable carrier, adjuvant, or vehicle.
摘要翻译：提供了使用2-羟基-3-氨基丙基磺酰胺模拟肽并调节酶，特别是蛋白水解酶的化学和/或生物活性的方法。还提供了包含与药学上可接受的载体，佐剂或载体混合的磺酰胺的组合物。

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