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1. 发明申请

WO2009061369A2 DIRECTED EVOLUTION USING PROTEINS COMPRISING UNNATURAL AMINO ACIDS 审中-公开
标题翻译：用含有非天然氨基酸的蛋白质进行定向进化
公开(公告)号：WO2009061369A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/012363
申请日：2008-10-31
申请人： THE SCRIPPS RESEARCH INSTITUTE , LIU, Chang , TSAO, Meng-Lin , SMIDER, Vaughn , SCHULTZ, Peter, G.
发明人： LIU, Chang , TSAO, Meng-Lin , SMIDER, Vaughn , SCHULTZ, Peter, G.
IPC分类号： C12N15/10 , C12N15/12 , C12N15/09 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/1037 , C12N15/1058 , C12N15/67 , C40B40/08 , C40B40/10
摘要： The invention provides methods and compositions for screening polypeptide libraries that include variants comprising unnatural amino acids. In addition, the invention provides vector packaging systems and methods for packaging a nucleic acid in a vector. Compositions of vectors produced by the methods and systems are also provided
摘要翻译：本发明提供了用于筛选包括含有非天然氨基酸的变体的多肽文库的方法和组合物。另外，本发明提供了用于将核酸包装在载体中的载体包装系统和方法。也提供了由这些方法和系统产生的载体组合物

2. 发明公开

EP2217702A2 DIRECTED EVOLUTION USING PROTEINS COMPRISING UNNATURAL AMINO ACIDS 审中-公开
标题翻译：展望演化的蛋白非天然氨基酸
公开(公告)号：EP2217702A2
公开(公告)日：2010-08-18
申请号：EP08847822.7
申请日：2008-10-31
申请人： The Scripps Research Institute
发明人： LIU, Chang , TSAO, Meng-Lin , SMIDER, Vaughn , SCHULTZ, Peter, G.
IPC分类号： C12N15/10 , C12N15/12 , C12N15/09 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/1037 , C12N15/1058 , C12N15/67 , C40B40/08 , C40B40/10
摘要： The invention provides methods and compositions for screening polypeptide libraries that include variants comprising unnatural amino acids. In addition, the invention provides vector packaging systems and methods for packaging a nucleic acid in a vector. Compositions of vectors produced by the methods and systems are also provided

3. 发明申请

WO2008030284A2 SOFT MEMS 审中-公开
标题翻译：软MEMS
公开(公告)号：WO2008030284A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/012987
申请日：2007-06-01
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , LIU, Chang , ENGEL, Jonathan , CHEN, Nannan , RYU, Kee , LIU, Chang , TUCKER, Craig , YANG, Yingchen
发明人： LIU, Chang , ENGEL, Jonathan , CHEN, Nannan , RYU, Kee , LIU, Chang , TUCKER, Craig , YANG, Yingchen
IPC分类号： G11C17/00
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0887 , B01L2300/1827 , B81C99/0095 , B82Y10/00 , H01L51/0595
摘要： A microscale polymer-based apparatus comprises a substrate formed from a first polymer material and at least one active region integrated with the substrate. The at least one active region is patterned from a second polymer material that is modified to perform at least one function within the at least one active region.
摘要翻译：基于微型聚合物的装置包括由第一聚合物材料形成的基板和与基板结合的至少一个有源区。所述至少一个有源区域由第二聚合物材料图案化，所述第二聚合物材料被修改以在所述至少一个有源区域内执行至少一个功能。

4. 发明申请

WO2020056152A1 SINGLE CHAIN CONSTRUCTS 审中-公开
公开(公告)号：WO2020056152A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050837
申请日：2019-09-12
申请人： LIU, Chang , FREMONT, Daved, H. , EDELSON, Brian , NELSON, Christopher, A. , WANG, Xiaoli
发明人： LIU, Chang , FREMONT, Daved, H. , EDELSON, Brian , NELSON, Christopher, A. , WANG, Xiaoli
IPC分类号： A61K38/00 , C07K14/74 , C07K19/00 , C12N15/12
摘要： Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.

5. 发明申请

WO2010096602A1 OCCLUSION DETECTION SYSTEM 审中-公开
标题翻译： OCCLUSION检测系统
公开(公告)号：WO2010096602A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024645
申请日：2010-02-19
申请人： HOSPIRA, INC. , WANG, YiFei , LIU, Chang , NG, See Hai
发明人： WANG, YiFei , LIU, Chang , NG, See Hai
IPC分类号： G01M3/02 , A61M1/00
CPC分类号： A61M5/1456 , A61M5/16854 , A61M2005/16863 , A61M2205/18 , A61M2205/332
摘要： A method of monitoring pressure inside a fluid line and a system for implementing the method. The method is applicable to syringe pump systems. The method includes the steps of measuring a force value caused by a pressure inside the fluid line; collecting the measured force values during at least two consecutive moving time windows; calculating a slope of a best-fit line within each time window; calculating a slope difference of the slopes of the best-fit lines; comparing the slope difference with a pre-determined threshold gradient value; defining a baseline force as the detected force value when the slope difference is equal to the threshold gradient value; determining a relative force value by subtracting the baseline force from the detected force value; and, triggering an alarm if the relative force is greater than a pre-defined threshold force
摘要翻译：一种监测流体管线内压力的方法和一种用于实施该方法的系统。该方法适用于注射泵系统。该方法包括以下步骤：测量由流体管线内的压力引起的力值; 在至少两个连续移动时间窗口期间收集测量的力值; 计算每个时间窗内最佳拟合线的斜率; 计算最佳拟合线的斜率的斜率差; 将斜率差与预定阈值梯度值进行比较; 当所述斜率差等于所述阈值梯度值时，将基线力定义为所述检测到的力值; 通过从检测到的力值减去基准力来确定相对力值; 并且如果相对力大于预定义的阈值力，则触发报警

6. 发明申请

WO2007143123A2 MICROMACHINED ARTIFICIAL HAIRCELL 审中-公开
标题翻译： MICROMACHINED人造毛发
公开(公告)号：WO2007143123A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/012991
申请日：2007-06-01
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , LIU, Chang , ENGEL, Jonathan , CHEN, Nannan , CHEN, Jack
发明人： LIU, Chang , ENGEL, Jonathan , CHEN, Nannan , CHEN, Jack
IPC分类号： G01P15/12
CPC分类号： G01P15/123 , B81B3/0021 , B81B2201/0292 , B81B2203/0118 , G01P5/04 , G01P15/0802
摘要： A micromachined artificial sensor comprises a support coupled to and movable with respect to a substrate. A polymer, high-aspect ratio cilia-like structure is disposed on and extends out-of-plane from the support. A strain detector is disposed with respect to the support to detect movement of the support.
摘要翻译：微加工人造传感器包括耦合到基板并且可相对于基板移动的支撑件。聚合物，高纵横比的纤毛状结构从载体上设置在平面外并从其延伸。应变检测器相对于支撑件设置以检测支撑件的运动。

7. 发明申请

WO2023010347A1 ASSEMBLIES, CIRCUITS, AND METHODS OF TRANSMITTERS BETWEEN DIFFERENT EQUIPMENT PROTECTION LEVELS IN A HAZARDOUS ENVIRONMENT 审中-公开
公开(公告)号：WO2023010347A1
公开(公告)日：2023-02-09
申请号：PCT/CN2021/110618
申请日：2021-08-04
申请人： ABB SCHWEIZ AG , BALUJA, Wilfredo Fernando , LIU, Chang , YU, Yasong , JAROSLAWSKI, Andrzej , AERTS, Wouter Frans
发明人： BALUJA, Wilfredo Fernando , LIU, Chang , YU, Yasong , JAROSLAWSKI, Andrzej , AERTS, Wouter Frans
IPC分类号： G01F23/00 , G01L19/00
摘要： A transmitter assembly (100) for a hazardous environment is provided. The transmitter assembly (100) includes a transmitter (104) that includes a transmitting unit (106) and a probe (105). The transmitting unit (106) is configured to be positioned in a first area (103) and includes an intrinsically safe circuit (700). The probe (105) is configured to be positioned in a second area (101) that is more hazardous and has a higher equipment protection level than the first area (103). The probe (105) is electrically connected directly or indirectly to the intrinsically safe circuit (700). The transmitter assembly (100) also includes a separation assembly (111) positioned between the transmitting unit (106) and the probe (105) and including a hermetic seal (306) configured to be electrically connected to the transmitting unit (106) and the probe (105) and a nut (308) defining a tunnel (323) sized to receive the hermetic seal (306) therein. Exterior threads (328) of the nut (308) are complementary to threads (340) on a partition wall (102) positioned between the transmitting unit (106) and the probe (105).

8. 发明申请

WO2021240238A2 MASS ANALYSIS 审中-公开
公开(公告)号：WO2021240238A2
公开(公告)日：2021-12-02
申请号：PCT/IB2021/000352
申请日：2021-05-25
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , COVEY, Thomas, R. , LIU, Chang
发明人： COVEY, Thomas, R. , LIU, Chang
IPC分类号： G01N1/38 , G01N35/08 , G01N35/10 , G01N35/04 , H01J49/04
摘要： Technology for analyzing collections of substance samples. Systems in accordance with the disclosure can include one or more sample handlers, sample capture devices, mass analysis instruments, and controllers; the controllers being operative, in accordance with instructions received from at least one of an operator input device and machine- interpretable instructions stored in memory accessible by the controller, to generate signals configured to cause the sample handler to collectively retrieve from a sample source a plurality of samples of one or more substances, and deliver the plurality of collected samples to the at least one sample capture device; cause the sample capture device to independently capture at least one of the collectively retrieved samples delivered by the sample handler, and transfer the at least one captured sample to a mass analysis instrument; and cause the mass analysis instrument to ionize and detect one or more particles of the transferred treated sample.

9. 发明申请

WO2014117341A1 METHOD AND APPARATUS FOR CALIBRATING MULTIPLE ANTENNAS 审中-公开
标题翻译：用于校准多个天线的方法和装置
公开(公告)号：WO2014117341A1
公开(公告)日：2014-08-07
申请号：PCT/CN2013/071140
申请日：2013-01-30
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) , LIU, Chang
发明人： LIU, Chang
IPC分类号： H04B7/06 , H01Q3/26
CPC分类号： H04B7/04 , H01Q3/267 , H04B7/06 , H04B17/11 , H04B17/12 , H04B17/14 , H04B17/21 , H04L5/14
摘要： The embodiments disclose a method and apparatus for calibrating multiple antennas in a radio communication device. The radio communication device is configured with a TX circuit and a RX circuit for each of the multiple antennas, each pair of the TX circuit and the RX circuit are operably coupled to the corresponding antenna in normal antenna operation. The apparatus comprises a first TX oscillator and a first RX oscillator. The first TX oscillator is operably coupled to the respective TX circuits to supply them with a TX working frequency or a RX calibrating frequency, the TX working frequency is supplied in the normal antenna operation and an antenna TX calibration operation, and the RX calibrating frequency is supplied in an antenna RX calibration operation. The first RX oscillator is operably coupled to the respective RX circuits to supply them with a RX working frequency or a TX calibrating frequency, the RX working frequency is supplied in the normal antenna operation and an antenna RX calibration operation, and the TX calibrating frequency is supplied in an antenna TX calibration operation. In the apparatus, the TX working frequency is the same as TX calibrating frequency, and the RX working frequency is the same as the RX calibrating frequency.
摘要翻译：实施例公开了一种在无线电通信设备中校准多个天线的方法和装置。无线电通信装置配置有用于多个天线中的每一个的TX电路和RX电路，在正常天线操作中，每对TX电路和RX电路可操作地耦合到相应的天线。该装置包括第一TX振荡器和第一RX振荡器。第一TX振荡器可操作地耦合到相应的TX电路以向它们提供TX工作频率或RX校准频率，TX工作频率在正常天线操作和天线TX校准操作中提供，RX校准频率为在天线RX校准操作中提供。第一RX振荡器可操作地耦合到相应的RX电路以向它们提供RX工作频率或TX校准频率，RX工作频率在正常天线操作和天线RX校准操作中提供，TX校准频率为以天线TX校准操作提供。在该装置中，TX工作频率与TX校准频率相同，RX工作频率与RX校准频率相同。

10. 发明申请

WO2012032119A1 GRANULATED FOOD PRODUCT 审中-公开
标题翻译：颗粒食品
公开(公告)号：WO2012032119A1
公开(公告)日：2012-03-15
申请号：PCT/EP2011/065557
申请日：2011-09-08
申请人： NESTEC S.A. , LIAN, Rebecca Hwee Peng , SHEN, Dong , ULMER, Helge , LIU, Chang
发明人： LIAN, Rebecca Hwee Peng , SHEN, Dong , ULMER, Helge , LIU, Chang
IPC分类号： A23B4/03 , A23B7/02 , A23L1/00 , A23L1/212 , A23L1/311 , A23L1/40 , A23L2/08 , A23P1/02
CPC分类号： A23L1/223 , A23B7/026 , A23L2/08 , A23L2/38 , A23L13/10 , A23L13/30 , A23L13/428 , A23L13/52 , A23L13/67 , A23L23/00 , A23L23/10 , A23L27/10 , A23L27/14 , A23P10/20 , A23P10/25
摘要： A granulated food product comprising plant material from one or more aromatic plants, a meaty base and an osmotic agent, and a method for preparing a granulated food product comprising milling plant material from one or more aromatic plants together with a meaty base,mixing the milled material with an osmotic agent to form a viscous mixture,granulating the viscous mixture,and drying the granules.
摘要翻译：一种包含来自一种或多种芳族植物，肉质基质和渗透剂的植物材料的颗粒状食品，以及制备颗粒状食品的方法，包括将一种或多种芳香植物与肉质基料一起研磨植物材料，将经研磨的材料与渗透剂形成粘性混合物，造粒粘稠混合物，并干燥颗粒。

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