专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996035446A1 TREATMENT OF ALZHEIMER DISEASE BY MODULATION OF SYNAPSINS 审中-公开
标题翻译：通过调节SYNPSINS治疗阿尔茨海默病
公开(公告)号：WO1996035446A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006835
申请日：1996-05-13
申请人： THE ROCKEFELLER UNIVERSITY , BRIGHAM AND WOMEN'S HOSPITAL
发明人： THE ROCKEFELLER UNIVERSITY , BRIGHAM AND WOMEN'S HOSPITAL , HAN, Hui-Quan , GREENGARD, Paul , KOSIK, Kenneth, S. , FERREIRA, Adriana
IPC分类号： A61K38/18
CPC分类号： A61K31/7076 , A61K38/185 , A61K38/1883
摘要： The role of synapsin II in both the reformation and the maintenance of synaptic connections in cultured hippocampal neurons can be the basis of therapy for neurodegenerative disorder, particularly Alzheimer disease, which involve the disruption of synapses. When synapsin II expression in neurons is blocked by antisense synapsin II oligonucleotides, the ability of hippocampal neurons to reform as well as to maintain synapses is severely disrupted. Antisense suppression of synapsin II after axon formation but immediately before synaptogenesis prevents synapse formation. Suppression of synapsin II after synaptogenesis disrupts the majority of existing synapses. Re-expression of synapsin II in synapsin deficient neurons achieved after removing the antisense oligonucleotides leads to the re-establishment of synaptic connections, providing direct evidence that synapsin II is required for the maintenance and/or restoration of synapses. Thus, therapeutic methods based on the reformation and the maintenance of synapses, including delivery of the synapsin cDNAS or proteins into the patient's nervous system, use of the synapsin cDNAS to promote the synapse forming ability of cells for grafting, and use of agents that increase the expression of, enhancing the activity of, or mimic the activity of, the endogenous synapsins, can provide treatment of neurodegenerative disorders.
摘要翻译：突触素II在培养的海马神经元的突触连接的重建和维持中的作用可以作为神经变性疾病，特别是涉及突触中断的阿尔茨海默氏病的治疗的基础。当突触素II在神经元中的表达被反义突触蛋白II寡核苷酸阻断时，海马神经元改变的能力以及维持突触的能力被严重地破坏。在突触形成之后但紧接在突触发生之前的突触体II的反义抑制阻止突触形成。突触后突触素II的抑制破坏了大多数现有的突触。在去除反义寡核苷酸后实现的突触素缺陷型神经元中突触素II的重新表达导致突触连接的重新建立，提供突触间质II用于维持和/或恢复突触所需的直接证据。因此，基于重建和维持突触的治疗方法，包括将突触素cDNAS或蛋白质递送到患者神经系统中，使用突触素cDNAS来促进细胞用于移植的突触形成能力，并且使用增加的试剂增强内源性突触素的活性或模拟活性的表达可提供治疗神经变性疾病。

2. 发明公开

EP0831883A1 TREATMENT OF ALZHEIMER DISEASE BY MODULATION OF SYNAPSINS 失效
标题翻译：方法对于疾病的按调制ALZHEIMISCHE SYNAPSINEN的治疗
公开(公告)号：EP0831883A1
公开(公告)日：1998-04-01
申请号：EP96915769.0
申请日：1996-05-13
申请人： THE ROCKEFELLER UNIVERSITY , BRIGHAM AND WOMEN'S HOSPITAL
发明人： HAN, Hui-Quan , GREENGARD, Paul , KOSIK, Kenneth, S. , FERREIRA, Adriana
IPC分类号： A61K45 , A61K31 , A61K38 , A61P25
CPC分类号： A61K31/7076 , A61K38/185 , A61K38/1883
摘要： The role of synapsin II in both the reformation and the maintenance of synaptic connections in cultured hippocampal neurons can be the basis of therapy for neurodegenerative disorder, particularly Alzheimer disease, which involve the disruption of synapses. When synapsin II expression in neurons is blocked by antisense synapsin II oligonucleotides, the ability of hippocampal neurons to reform as well as to maintain synapses is severely disrupted. Antisense suppression of synapsin II after axon formation but immediately before synaptogenesis prevents synapse formation. Suppression of synapsin II after synaptogenesis disrupts the majority of existing synapses. Re-expression of synapsin II in synapsin deficient neurons achieved after removing the antisense oligonucleotides leads to the re-establishment of synaptic connections, providing direct evidence that synapsin II is required for the maintenance and/or restoration of synapses. Thus, therapeutic methods based on the reformation and the maintenance of synapses, including delivery of the synapsin cDNAS or proteins into the patient's nervous system, use of the synapsin cDNAS to promote the synapse forming ability of cells for grafting, and use of agents that increase the expression of, enhancing the activity of, or mimic the activity of, the endogenous synapsins, can provide treatment of neurodegenerative disorders.

3. 发明申请

WO2005014815A1 siRNA BASED METHODS FOR TREATING ALZHEIMER’S DISEASE 审中-公开
标题翻译：基于siRNA的治疗阿尔茨海默病的方法
公开(公告)号：WO2005014815A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/025633
申请日：2004-08-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TSAI, Li-Huei , KOSIK, Kenneth, S.
发明人： TSAI, Li-Huei , KOSIK, Kenneth, S.
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/14
摘要： The present invention relates to siRNA molecules derived from BACE1 and BACE2 genes. Accordingly, provided herein are siRNA molecules comprising a nucleotide sequence consisting essentially of a BACE1 or BACE2 gene. Also provided are methods for reducing the level of BACE1 protein in a cell. Further provided are methods for preparing a pharmaceutical composition comprising an siRNA with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及衍生自BACE1和BACE2基因的siRNA分子。因此，本文提供了包含基本上由BACE1或BACE2基因组成的核苷酸序列的siRNA分子。还提供了降低细胞中BACE1蛋白水平的方法。还提供了制备包含具有药学上可接受的载体的siRNA的药物组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式