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1. 发明申请

WO2005122939A1 ABLATION CATHETERS AND METHODS FOR THEIR USE 审中-公开
标题翻译：消除导管及其使用方法
公开(公告)号：WO2005122939A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020845
申请日：2005-06-13
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ORAL, Hakan , MORADY, Fred
发明人： ORAL, Hakan , MORADY, Fred
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/1435 , A61B2018/1467 , A61B2018/1475
摘要： The present invention relates generally to multifunctional catheters for performing ablation procedures, and more particularly to ablation catheters utilized in the treatment of atrial fibrillation and other cardiac disorders. The present invention eliminates many of the problems associated with previous ablation catheters by providing an ablation treatment not dependent upon continuous lesions.
摘要翻译：本发明一般涉及用于进行消融手术的多功能导管，更具体地涉及用于治疗房颤和其它心脏病的消融导管。本发明通过提供不依赖于连续病变的消融治疗来消除与先前消融导管相关的许多问题。

2. 发明申请

WO2013009872A1 MULTIMODALITY LEFT ATRIAL APPENDAGE OCCLUSION DEVICE 审中-公开
标题翻译：多方面的左侧附件附件设备
公开(公告)号：WO2013009872A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046256
申请日：2012-07-11
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ORAL, Hakan , MORADY, Fred
发明人： ORAL, Hakan , MORADY, Fred
IPC分类号： A61B5/00 , A61B17/12
CPC分类号： A61B5/0031 , A61B5/0006 , A61B5/0008 , A61B5/0215 , A61B17/0057 , A61B17/12122 , A61B17/12131 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/00022 , A61B2017/00084 , A61B2017/00579 , A61B2017/00588 , A61B2017/00597 , A61B2017/00606 , A61B2017/0061 , A61B2017/00615 , A61B2017/00632 , A61B2017/0065 , A61N1/057 , A61N1/37205 , A61N1/37258 , A61N1/37264
摘要： A left atrial appendage occlusion device is provided that acts in conjunction with a wireless transponder unit. The occlusion device provides a seal of the left atrial appendage opening, while the transponder is inserted into the left atrial appendage to sense one or more physiological conditions and relay the sensed information over wireless communication. Further, all or part of the left atrial appendage may be filled using a biocompatible inert filling material injected into the left atrial appendage as part of deployment of the transponder unit.
摘要翻译：提供了与无线应答器单元结合起作用的左心耳闭塞装置。闭塞装置提供左心耳开口的密封，同时将应答器插入左心耳以感测一个或多个生理条件并通过无线通信中继感测到的信息。此外，可以使用注射到左心耳中的生物相容惰性填充材料来填充左心耳的全部或部分，作为应答器单元的部署的一部分。

3. 发明申请

WO2009120694A2 NON-CONTACT INFRARED FIBER-OPTIC DEVICE FOR MONITORING ESOPHAGEAL TEMPERATURE TO PREVENT THERMAL INJURY DURING RADIOFREQUENCY CATHETER ABLATION OR CRYOABLATION 审中-公开
标题翻译：用于监测食道温度的非接触式红外光纤装置，以防止无线电导线管引起的热损伤或烧结
公开(公告)号：WO2009120694A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038101
申请日：2009-03-24
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANSFER , ORAL, Hakan , MORADY, Fred
发明人： ORAL, Hakan , MORADY, Fred
IPC分类号： A61B1/273
CPC分类号： A61B5/01 , A61B1/00096 , A61B1/273 , A61B5/015 , A61B5/412 , A61B5/7278 , A61B18/0218 , A61B18/12 , A61B18/1206 , A61B18/18 , A61B2017/00057 , A61B2017/00061 , A61B2017/00084 , A61B2018/00011 , A61B2018/00488 , A61B2018/0212 , A61B2562/0271 , G01J5/0022 , G01J5/0025 , G01J5/02 , G01J5/0215 , G01J5/04 , G01J5/047 , G01J5/08 , G01J5/0803 , G01J5/0806 , G01J5/0809 , G01J5/0818 , G01J5/0843 , G01J5/0846 , G01J2005/0081
摘要： An infrared fiber-optic device is able to monitor esophageal temperature during an ablation/cryoablation procedure over a volume of interest to sense whether the temperature is too high or too low. The device may include a plurality of optical fibers each with a wide angle lens collectively disposed circumferentially and longitudinally to cover the volume of interest, as the particular region over which undesirable temperature may not be known beforehand. In other examples, the device may include an embedded array of infrared sensors extending sufficiently to encompass a volume of interest. The device may be used as part of a feedback control to regulate and stop operation of the ablation/cryoablation procedure to prevent vessel damage.
摘要翻译：红外光纤设备能够在消融/冷冻消融过程中监测食管温度，以感兴趣的体积以感测温度是否太高或太低。该装置可以包括多个光纤，每个光纤具有沿着周向和纵向共同设置的广角透镜，以覆盖感兴趣的体积，作为预期不知道不期望的温度的特定区域。在其他示例中，该装置可以包括充分扩展以包含感兴趣体积的红外传感器的嵌入阵列。该装置可以用作反馈控制的一部分，以调节和停止消融/冷冻消融程序的操作以防止血管损伤。

4. 发明申请

WO2004037072A2 ABLATION CATHETERS 审中-公开
标题翻译：吸引力
公开(公告)号：WO2004037072A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/034091
申请日：2003-10-24
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ORAL, Hakan , MORADY, Fred
发明人： ORAL, Hakan , MORADY, Fred
IPC分类号： A61B
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/1435
摘要： The present invention relates generally to multifunctional catheters for performing ablation procedures, and more particularly to ablation catheters utilized in the treatment of atrial fibrillation and other cardiac disorders. The present invention eliminates many of the problems associated with previous ablation catheters by providing an ablation treatment not dependent upon continuous lesions.
摘要翻译：本发明一般涉及用于进行消融手术的多功能导管，更具体地涉及用于治疗房颤和其它心脏病的消融导管。本发明通过提供不依赖于连续病变的消融治疗来消除与先前消融导管相关的许多问题。

5. 发明申请

WO2013106559A2 ATRIAL FIBRILLATION CLASSIFICATION USING POWER MEASUREMENT 审中-公开
标题翻译：利用功率测量技术进行心房颤动分级
公开(公告)号：WO2013106559A2
公开(公告)日：2013-07-18
申请号：PCT/US2013/021017
申请日：2013-01-10
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ORAL, Hakan , BERENFELD, Omer , KRUGER, Grant
发明人： ORAL, Hakan , BERENFELD, Omer , KRUGER, Grant
IPC分类号： A61B5/04 , A61B5/046 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/04014 , A61B5/04017 , A61B5/0428 , A61B5/046 , A61B5/7257 , A61B5/7264 , A61N1/3956
摘要： An atrial fibrillation classification system collects celectrocardiogram signals and converts them to a frequency, time, or phase domain representation for analysis. An evaluation stage extracts energy density profile over a range of frequencies, time intervals, or phases, which is then summed and normalized to form dispersion metrics. The system then analyzes the dispersion metrics, in their respective domains, to determine whether a patient is experiencing an arrhythmia and then to classify the type of arrhythmia being experienced.
摘要翻译：心房颤动分类系统收集心电图信号并将它们转换为频率，时间或相位域表示以供分析。评估阶段提取一系列频率，时间间隔或阶段的能量密度分布，然后将其相加并归一化以形成分散度量。然后系统在各自的领域分析分散度量，以确定患者是否正在经历心律失常，然后分类正在经历的心律失常的类型。

6. 发明申请

WO2011150169A1 DEVICE SYSTEM FOR GASTRIC VOLUME REDUCTION TO FACILITATE WEIGHT LOSS 审中-公开
标题翻译：用于减少体积减少以减轻体重损失的装置系统
公开(公告)号：WO2011150169A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038080
申请日：2011-05-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ORAL, Elif, Arioglu , ORAL, Hakan
发明人： ORAL, Elif, Arioglu , ORAL, Hakan
IPC分类号： A61F5/00
CPC分类号： A61M29/02 , A61F5/0036 , A61F5/004 , A61F5/0046
摘要： An ingestible gastric volume reduction device (100) is provided that is controllably adjustable between an expanded state and a contracted state. A control subsystem within the device is able to selectively transition the device between both states. Such control can be by way of a biological or chemical sensor (102) in the device, a wireless (RF) receiver (104), or timer. Thus activation of the device whether to expand and fill a gastric volume or to contract to open up the gastric volume may be achieved from internal control (within device) or external control (to the device). The device may be used for patient treatment, by administering the device (e.g., through ingestion) to a gastric region and then controllably increasing and/or decreasing the volume of the device during treatment.
摘要翻译：提供了可扩张状态和收缩状态之间可控地调节的可摄入的胃容量减小装置（100）。设备内的控制子系统能够在两种状态之间选择性地转换设备。这种控制可以通过设备中的生物或化学传感器（102），无线（RF）接收器（104）或定时器来实现。因此，可以通过内部控制（在设备内部）或外部控制（到设备）来实现设备的激活，无论是扩张和填充胃体积还是收缩以打开胃体积。该装置可以通过将装置（例如，通过摄入）施用于胃区域，然后在治疗期间可控制地增加和/或减少装置的体积来用于患者治疗。

7. 发明申请

WO2009076461A1 RF ENERGY DELIVERY SYSTEM AND METHOD 审中-公开
标题翻译：射频能量输送系统及方法
公开(公告)号：WO2009076461A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086271
申请日：2008-12-10
申请人： ABLATION FRONTIERS, INC. , WERNETH, Randell, L. , ROMAN, Ricardo, David , KUNIS, Christopher, G. , ASCONEGUY, Alexander, J. , SOLEYMANI, Sadaf , TRINIDAD, Jeffrey , CHAMBERS, Martin , ORAL, Hakan , MORADY, Fred , COX, Jerald, L. , MORATORIO, Guillermo, W. , FU, Samuel , FLAHERTY, J., Christopher
发明人： WERNETH, Randell, L. , ROMAN, Ricardo, David , KUNIS, Christopher, G. , ASCONEGUY, Alexander, J. , SOLEYMANI, Sadaf , TRINIDAD, Jeffrey , CHAMBERS, Martin , ORAL, Hakan , MORADY, Fred , COX, Jerald, L. , MORATORIO, Guillermo, W. , FU, Samuel , FLAHERTY, J., Christopher
IPC分类号： A61F2/00
CPC分类号： A61B18/1492 , A61B17/00234 , A61B18/18 , A61B2017/00044 , A61B2017/003 , A61B2018/00184 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839
摘要： Devices, systems and methods are disclosed for the ablation of tissue. A steerable ablation catheter can include one or more ablation elements at its distal end and one or more ablation elements fixedly attached to its shaft. The distal end of the ablation catheter can be deflected to assume a number of different deflection geometries in at least one direction along the shaft. One feature of the ablation catheter is that its shaft can comprise materials of differing durometers or stiffnesses attached together at a joint. Methods associated with use of the ablation catheter are also covered.
摘要翻译：公开了用于组织消融的装置，系统和方法。可引导的消融导管可包括其远端处的一个或多个消融元件和固定地附接到其轴的一个或多个消融元件。消融导管的远端可以沿着轴在至少一个方向上被偏转以呈现多个不同的偏转几何形状。消融导管的一个特征是其轴可以包括在接头处附接在一起的不同硬度的刚度的材料。还涉及与使用消融导管相关的方法。

8. 发明申请

WO2016176009A1 METHOD AND SYSTEM FOR MAPPING AND ANALYZING CARDIAC ELECTRICAL ACTIVITY 审中-公开
标题翻译：用于摄影和分析心脏电活动的方法和系统
公开(公告)号：WO2016176009A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/026230
申请日：2016-04-06
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： BERENFELD, Omer , ORAL, Hakan
IPC分类号： A61B18/14 , A61B5/0215 , A61B5/053
CPC分类号： A61B5/6858 , A61B5/0422 , A61B5/046 , A61B5/068 , A61B5/7253 , A61B18/1492 , A61B34/20 , A61B2017/00044 , A61B2017/00048 , A61B2017/00053 , A61B2018/0016 , A61B2018/00267 , A61B2018/00351 , A61B2018/00839 , A61B2018/00892 , A61B2018/00898 , A61B2560/066 , A61B2562/04
摘要： A multiple-point basket-type or crown-shaped catheter device provides simultaneously mapping over a three-dimensional (3D) region of a subject, such as, one or more chambers of a subject's heart. The catheter device may include a series of splines each having a wave-like profile formed of a periodic series of peaks and troughs, with electrodes located at the peaks and troughs for mapping purposes.
摘要翻译：多点篮式或冠状导管装置同时提供对象的三维（3D）区域，例如受试者心脏的一个或多个腔室。导管装置可以包括一系列花键，每个花键具有由周期性的一系列峰和谷形成的波状轮廓，其中电极位于峰和谷以用于映射目的。

9. 发明申请

WO2022094248A1 INJECTOR DEVICE FOR ARRHYTHMIA CLASSIFICATION USING MEASUREMENT OF CARDIAC ACTIVITY AND POWER ANALYSIS 审中-公开
公开(公告)号：WO2022094248A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057308
申请日：2021-10-29
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： KRUGER, Grant , ORAL, Hakan , BERENFELD, Omer , FURNESS, Lindsey, Mei , NUNU, Nicola, Abraham , SALMERON, Anthony, William , SHRIFT, Samuel, James , VITTERT, Allison, Brooke , YANG, Jack, Lei
IPC分类号： A61B5/00 , A61B5/0215 , A61M25/00 , A61B5/02 , A61B5/0205 , A61B5/021
摘要： The following relates generally to an injector for injecting a cardiac monitor. In some embodiments, an injector includes: a push-rod configured to be inserted into a case at a first end of the case, where the case is configured to hold the injectable cardiac monitor. In some embodiments, the case includes: a first handle protruding from a first side of the case; a second handle protruding from a second side of the case; and a beveled needle configured to be attached to a second end of the case, and configured to be inserted into a mammal to inject the injectable cardiac monitor into the mammal.

10. 发明申请

WO2022094252A1 ARRHYTHMIA CLASSIFICATION USING MEASUREMENT OF CARDIAC ACTIVITY AND POWER ANALYSIS 审中-公开
公开(公告)号：WO2022094252A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057315
申请日：2021-10-29
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： KRUGER, Grant , ORAL, Hakan , BERENFELD, Omer
IPC分类号： A61B5/02 , A61B5/28 , A61B5/308 , A61B5/318 , A61M25/04
摘要： The following relates generally to an injectable cardiac monitor. In some embodiments, an injectable cardiac monitor includes: a sensor configured to detect a cardiac signal from a mammal; a processor configured to process the detected cardiac signal; a transmitter configured to transmit the processed signal to a computing device; and a capsule for injecting into the mammal. In some implementations, the capsule includes: a body configured to enclose all of the sensor, the processor, and the transmitter; and wings configured to, upon deployment into the mammal, deploy outwardly from the body of the capsule.

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