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1. 发明申请

WO2011028674A3 LOW-POWER AREA-EFFICIENT SAR ADC USING DUAL CAPACITOR ARRAYS 审中-公开
公开(公告)号：WO2011028674A3
公开(公告)日：2011-03-10
申请号：PCT/US2010/047218
申请日：2010-08-31
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , CHANG, Sun-II
发明人： YOON, Euisik , CHANG, Sun-II
IPC分类号： H03M1/38 , H03M1/12
摘要： An analog to digital converter that comprises a successive approximation register (SAR) having an n bit binary output, a first capacitor array connected to receive some of the bits of the binary output, a second capacitor array connected to receive the remaining bits of the binary output, and a comparator including an output connected to the SAR. The first and second capacitor arrays each have an analog output indicative of the charge stored by capacitors of that array. The comparator includes a pair of inputs, one of which is connected to the analog output of the first capacitor array and the other of which is connected to the analog output of the second capacitor array.

2. 发明申请

WO2010048107A2 BIOAMPLIFIER FOR NEURAL INTERFACES 审中-公开
标题翻译：用于神经接口的补偿器
公开(公告)号：WO2010048107A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/061221
申请日：2009-10-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , CHANG, Sun-II
发明人： YOON, Euisik , CHANG, Sun-II
IPC分类号： A61B5/0476 , A61B5/0478 , A61B5/0484
CPC分类号： A61B5/048 , A61B5/6846
摘要： A bioamplifier that includes a high pass filter, open-loop amplifier, and low pass filter in an area efficient design that can be used in implantable neural interfaces. The high pass filter can be implemented by using a switch-capacitance resistor coupled with parasitic capacitance of the electrode. The amplifier can be chopper stabilized and can include a high gain, current-ratio first stage followed by one or more dimension-ratio stages. The low pass filter utilizes the output impedance of the open- loop amplifier to form an embedded g m -C low pass filter.
摘要翻译：生物放大器，其包括可用于可植入神经接口的区域高效设计中的高通滤波器，开环放大器和低通滤波器。高通滤波器可以通过使用与电极的寄生电容耦合的开关电容电阻来实现。放大器可以被斩波稳定，并且可以包括高增益，电流比第一级，之后是一个或多个尺寸比级。低通滤波器利用开环放大器的输出阻抗形成嵌入式gm-C低通滤波器。

3. 发明申请

WO2011123150A2 DISTRIBUTED, MINIMALLY-INVASIVE NEURAL INTERFACE FOR WIRELESS EPIDURAL RECORDING 审中-公开
标题翻译：用于无线硬式记录的分布式，微量入侵式神经接口
公开(公告)号：WO2011123150A2
公开(公告)日：2011-10-06
申请号：PCT/US2010/053449
申请日：2010-10-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CHANG, Sun-II , YOON, Euisik
发明人： CHANG, Sun-II , YOON, Euisik
IPC分类号： A61B5/0476 , A61B5/0478 , A61B5/048
CPC分类号： A61B5/0478 , A61B5/0028 , A61B5/7232
摘要： A neural interface for measuring or stimulating brain neural activity, either as a standalone unit or as a part of a larger system of similar neural interfaces. The neural interface includes a bolt-shaped housing having a tool-engaging head and threaded shank with internal circuitry and at least one electrode. In use, the housing is threaded into a cranial bore such that the electrode contacts the outer surface of the meninges. The neural interface circuitry includes an SAR ADC that provides at least rail-to-rail operation to convert received signals from the electrode(s) into digital data that can be modulated and wirelessly transmitted by intra-skin or other suitable communication.
摘要翻译：用于测量或刺激大脑神经活动的神经接口，既可以作为独立的单元，也可以作为类似神经接口的较大系统的一部分。神经接口包括具有工具接合头部的螺栓形壳体以及具有内部电路和至少一个电极的螺纹杆。在使用中，壳体被拧入颅孔中，使得电极接触脑膜的外表面。神经接口电路包括SAR ADC，其至少提供轨到轨操作以将来自电极的接收信号转换成数字数据，该数字数据可以通过皮内或其他合适的通信进行调制和无线传输。

4. 发明申请

WO2011068696A2 NEURAL PROBE WITH OPTICAL STIMULATION CAPABILITY 审中-公开
标题翻译：具有光刺激能力的神经探针
公开(公告)号：WO2011068696A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/057377
申请日：2010-11-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , CHO, Il-joo
发明人： YOON, Euisik , CHO, Il-joo
IPC分类号： A61N5/06 , A61N1/04
CPC分类号： A61B5/04001 , A61B5/0048 , A61N1/0529 , A61N1/0551 , A61N5/0601 , A61N5/0622 , A61N2005/0612 , A61N2005/063 , A61N2005/0651 , A61N2005/0653
摘要： A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure.
摘要翻译：公开了用于光学刺激或沉默神经元并记录对刺激的电响应的神经探针。使用图案化技术，可以在探针上制造整体光波导，用于将从光源到探针尖端的影响影响的影响神经元的光发射。探针尖端可以包括一个或多个电极，以接收来自被刺激的神经元的用于记录或进一步处理的电响应。根据各种实施例，所公开的神经探针可以同时利用多个光源，在多个光源之间切换，或利用单个光源同时经由多个探针尖端刺激或沉默多个神经元位置，或经由多个发光部位沿着探头的长度。从而提供了具有足够的空间分辨率的神经探针，以利用纤细的紧凑结构精确地靶向，刺激和记录神经元或单个神经元的反应。

5. 发明申请

WO2011056643A2 MICROFLUIDIC PLATFORM FOR DISCRETE CELL ASSAY 审中-公开
标题翻译：用于离散细胞分析的微流体平台
公开(公告)号：WO2011056643A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/054257
申请日：2010-10-27
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , YOUNG-JI, Kim
发明人： YOON, Euisik , YOUNG-JI, Kim
IPC分类号： G01N35/00 , G01N33/48 , C12M3/00 , C12Q1/04 , G01N1/28
CPC分类号： C12Q1/24 , B01L3/502738 , B01L3/502761 , B01L2200/0647 , B01L2400/0655 , B01L2400/086 , C12M23/16 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0086
摘要： A microfluidic chamber for use in individual cell assays. The microfluidic chamber includes a cell microchamber having an interior region and front and rear valves, each of which are separately controllable so that they can be selectively opened and closed to thereby permit the transference of an individual cell into and out of the interior region. Cell secretion and contact interaction studies can be carried out using the microchambers, with the valves permitting either complete isolation or perfusion media flow through the microchambers. An internal perfusion wall can be included to partition the microchamber for non-contact perfusion studies of secretion interactions between cells.
摘要翻译：用于单个细胞测定的微流体室。微流体腔室包括具有内部区域和前后阀门的细胞微型腔室，其中每一个都是可单独控制的，使得它们可以选择性地打开和关闭，从而允许单个细胞移入和移出内部区域。可以使用微室进行细胞分泌和接触相互作用研究，其中阀允许完全隔离或灌注介质流过微室。可以包括内部灌注壁来分隔微室以进行细胞间分泌相互作用的非接触灌注研究。

6. 发明申请

WO2012170340A3 INSERTABLE NEURAL PROBE WITH FLEXIBLE STRUCTURE 审中-公开
公开(公告)号：WO2012170340A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/040709
申请日：2012-06-04
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YOON, Euisik , WU, Fan
发明人： YOON, Euisik , WU, Fan
IPC分类号： A61N1/05 , A61N1/36 , A61L27/54 , A61L27/58
摘要： A neural probe (10) is provided for in vivo communication with biological tissue, including stimulating neurons and/or recording neural electrical activity. The probe (10) may be constructed so that the immune response by the biological tissue in which the device is implanted is reduced over known implantable probes. The probe (10) can be constructed with a tip (16) that has a branched configuration, with electrodes (24) located along each of the branches (20). A biodegradable coating (18) is disposed over at least the tip (16) of the probe (10) to provide the probe (10) with sufficient integrity for insertion into the biological tissue and to degrade after insertion. The biodegradable coating (18) can have an anti-inflammatory drug or other bioagent distributed therein for localized release of the bioagent to further reduce the immune response.

7. 发明申请

WO2018140302A1 SYSTEMS AND METHODS FOR WHOLE CELL ANALYSIS 审中-公开
公开(公告)号：WO2018140302A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/014353
申请日：2018-01-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： YOON, Euisik , CHENG, Yu-Heng , CHEN, Yu-Chih , BRIEN, Riley
IPC分类号： B01L3/00 , C12M1/00 , G01N1/02 , G01N1/28
摘要： The present disclosure relates to systems and methods for whole cell analysis. In particular, the present disclosure relates to single cell genomic analysis (e.g., gene expression analysis.

8. 发明申请

WO2018067802A1 SYSTEMS AND METHODS FOR HIGH THROUGHPUT SCREENING 审中-公开
标题翻译：用于高通量筛选的系统和方法
公开(公告)号：WO2018067802A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055315
申请日：2017-10-05
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： YOON, Euisik , ZHANG, Zhixiong , CHEN, Yu-Chih
IPC分类号： B01L3/00 , G01N1/18 , G01N33/50
摘要： Provided herein are compositions, systems, and methods for high throughput screening. In particular, provided herein are microfluidic devices for high throughput analysis of multiplex chemical (e.g., drug interactions) across a wide range of concentrations.
摘要翻译：本文提供了用于高通量筛选的组合物，系统和方法。具体而言，本文提供了用于跨越宽范围浓度的多重化学（例如，药物相互作用）的高通量分析的微流体装置。

9. 发明申请

WO2016149701A1 SYSTEM FOR ANALYZING TISSUE 审中-公开
标题翻译：用于分析组织的系统
公开(公告)号：WO2016149701A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/023437
申请日：2016-03-21
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： MYCEK, Mary-Ann , WU, Fan , SCHEIMAN, James, M. , YOON, Euisik , LLOYD, William , LEE, Seung, Yup
IPC分类号： G01N21/17 , G01N21/63 , G02B21/00
CPC分类号： A61B5/1455 , A61B5/0084 , A61B5/0261 , G01N33/54366 , G06T2207/30004
摘要： A system for analyzing tissue includes a platform and an optical sensing unit coupled to the platform. The optical sensing unit has a detector and a plurality of light sources surrounding and electrically isolated from the detector. The optical sensing units obtain optical data for tissue analysis.
摘要翻译：用于分析组织的系统包括平台和耦合到平台的光学感测单元。光学感测单元具有检测器和围绕检测器电隔离的多个光源。光学单元获得用于组织分析的光学数据。

10. 发明申请

WO2010042750A3 SYSTEM AND METHOD FOR MINIATURE WIRELESS IMPLANTABLE PROBE 审中-公开
公开(公告)号：WO2010042750A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060048
申请日：2009-10-08
申请人： REDISH, Aaron David , YOON, Euisik , ERDMAN, Arthur G. , AL-ASHMOUNY, Khaled M. , FERGUSON, John, E. , BOLDT, Christopher J.
发明人： REDISH, Aaron David , YOON, Euisik , ERDMAN, Arthur G. , AL-ASHMOUNY, Khaled M. , FERGUSON, John, E. , BOLDT, Christopher J.
IPC分类号： A61B5/0408 , A61B5/048
摘要： A system includes a neural probe and an intracorporeal module. The probe, such as a nanoprobe, is configured to detect physiological activity and to wirelessly transmit a first signal based on the physiological activity. The intracorporeal module is communicatively coupled to the neural probe, the intracorporeal module configured to receive the first signal from the neural probe.

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