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1. 发明申请

WO2015027164A1 HISTOTRIPSY USING VERY SHORT ULTRASOUND PULSES 审中-公开
标题翻译：使用非常短的超声波脉冲的感觉
公开(公告)号：WO2015027164A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/052310
申请日：2014-08-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： CAIN, Charles, A. , MAXWELL, Adam , XU, Zhen , LIN, Kuang-Wei
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N2007/0039 , A61N2007/0065
摘要： Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P-) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud.. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
摘要翻译：提供了用于将超声脉冲施加到组织或介质中的装置和方法，其中超声脉冲的一个或多个负半周的峰值负压（P-）超过组织或介质的固有阈值直接在组织或介质中形成致密的气泡云而不产生冲击散射。在一个实施例中，组织切除术治疗的微切术方法包括将超声波脉冲从超声治疗换能器输送到组织中，所述超声脉冲具有超过组织中的固有阈值的至少一部分峰值负压半周期以产生组织中至少有一个气泡的气泡云，并且在气泡云中产生组织中的病变。本征阈值可以根据待治疗组织的类型而变化。在一些实施方案中，组织中的固有阈值可以在15-30MPa的范围内。

2. 发明申请

WO2015138781A1 FREQUENCY COMPOUNDING ULTRASOUND PULSES FOR IMAGING AND THERAPY 审中-公开
标题翻译：用于成像和治疗的频率复合超声波脉冲
公开(公告)号：WO2015138781A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020258
申请日：2015-03-12
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： LIN, Kuang-Wei , CAIN, Charles, A.
IPC分类号： A61N7/02
CPC分类号： A61B17/22004 , A61B2017/22008 , A61N7/02 , A61N7/022 , A61N2007/0039 , A61N2007/0052 , A61N2007/0073 , A61N2007/0078
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a low-frequency ultrasound pulse is transmitted into tissue, a high-frequency ultrasound pulse is transmitted into tissue, and a composite waveform is formed in the tissue that has a peak negative pressure value that exceeds an intrinsic threshold for cavitation in the tissue. In some embodiments, the peak negative pressures of the individual ultrasound pulses do not exceed the intrinsic threshold for cavitation. In another embodiment, a plurality of ultrasound pulses at various resonant frequencies are transmitted into tissue, and the time delays between these transmissions are adjusted to allow the ultrasound pulses to align temporally and form a monopolar pulse having a compound peak negative pressure that exceeds an intrinsic threshold for cavitation in the tissue. Systems for performing Histotripsy therapy are also discussed.
摘要翻译：提供了用于在组织中产生空化的方法和装置。在一个实施例中，将低频超声脉冲传输到组织中，将高频超声脉冲传输到组织中，并且在组织中形成复合波形，该组合具有超过空化的固有阈值的峰值负压值组织。在一些实施例中，各个超声脉冲的峰值负压不超过空化的固有阈值。在另一个实施例中，将多个谐振频率的多个超声脉冲传输到组织中，并且调整这些传输之间的时间延迟以允许超声脉冲在时间上对准并形成具有超过内在的复合峰值负压的单极脉冲组织中空化的阈值。还讨论了用于进行组织切除术治疗的系统。

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