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1. 发明申请

WO2006124234A3 SENSE OPTIMIZED MRI RF COIL DESIGNED WITH A TARGET FIELD METHOD 审中-公开
公开(公告)号：WO2006124234A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/016167
申请日：2006-04-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MUFTULER, Lutfi , CHEN, Gang , NALCIOGLU, Orhan
发明人： MUFTULER, Lutfi , CHEN, Gang , NALCIOGLU, Orhan
IPC分类号： G01V3/00 , H01Q17/00
摘要： An MRI RF coil that is optimized for SENSE imaging is used in a method where the surface current density distribution on a coil former was calculated to maximize the SNR sense within a volume of interest. An analytic relationship was formulated between the SNR sense and surface current density on the coil former. The SNR at pixel p in a SENSE-MR image, SNR sense , p , is inversely proportional to the g - factor. The g-factor was formulated in terms of the B1 distribution of the coils. By specifying the geometry of the desired coil former and using a finite element mesh, the surface current distribution was calculated to maximize the SNR sense , by minimizing (1 /SNR sense ) in the volume of interest using a least squares procedure. A simple two-coil array was tested and phantom images were collected. The results show that the new coil design method yielded better uniformity and SNR compared to standard coils.

2. 发明申请

WO2018191557A1 HUMAN RESISTIN COMPOSITIONS AND METHODS OF TREATING TLR4-MEDIATED DISEASE AND INFECTION 审中-公开
公开(公告)号：WO2018191557A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027387
申请日：2018-04-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： NAIR, Meera, G. , JANG, Jessica , CHEN, Gang
IPC分类号： A61K38/00 , C07K14/575 , C07K19/00 , C12N15/09 , C12N15/62
摘要： Compositions and methods for treating, mitigating, or preventing a Toll-like receptor (4) (TLR4)-mediated infection or disease in a host cell or a subject include administration of a resistin protein composition selected from full length resistin protein, a resistin protein fragment, or a fusion protein of resistin and an immunoglobulin G protein to the host cell or the subject having or likely to be exposed to a TLR4-mediated infection or disease.

3. 发明申请

WO2022109741A1 CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF 审中-公开
公开(公告)号：WO2022109741A1
公开(公告)日：2022-06-02
申请号：PCT/CA2021/051688
申请日：2021-11-25
申请人： RISEN (SUZHOU) PHARMA TECH CO., LTD. , LU, Jiasheng , CHEN, Gang , ZHANG, Qiguo , KONG, Xianqi , CHEN, Dawei , HUANG, Chuanhao , ZHU, Xingwu , ZHANG, Yuhua
发明人： LU, Jiasheng , CHEN, Gang , ZHANG, Qiguo , KONG, Xianqi , CHEN, Dawei , HUANG, Chuanhao , ZHU, Xingwu , ZHANG, Yuhua
IPC分类号： C07H19/20 , A61K31/7076 , A61P35/00
摘要： CD73 (also known as ecto-5´-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I': (I') and pharmaceutically acceptable esters or salts thereof.

4. 发明申请

WO2020258219A1 KIT FOR CARING FOR THE SKIN 审中-公开
公开(公告)号：WO2020258219A1
公开(公告)日：2020-12-30
申请号：PCT/CN2019/093592
申请日：2019-06-28
申请人： L'OREAL , CHEN, Gang , YOSHIOKA, Nariyoshi , YU, Jing , DENG, Yi
发明人： CHEN, Gang , YOSHIOKA, Nariyoshi , YU, Jing , DENG, Yi
IPC分类号： A61K8/73 , A61K8/9706 , A61K8/97 , A61Q19/00
摘要： A kit for caring for keratin materials comprises 1) at least one anhydrous substrate, comprising: -a) at least one tremella polyssacharide; -b) at least one gel-forming agent that is a water soluble salt; -c) at least one reinforcement agent that is able to reinforce the anhydrous substrate; 2) at least one aqueous composition comprising at least one water soluble gelatinizing agent, which is gelatinizable with the gel-forming agent; wherein the anhydrous substrate and the aqueous composition are separately placed from one another.

5. 发明申请

WO2018069851A2 C-MET ANTIBODY DRUG CONJUGATE 审中-公开
标题翻译： C-MET抗体药物共轭物
公开(公告)号：WO2018069851A2
公开(公告)日：2018-04-19
申请号：PCT/IB2017/056295
申请日：2017-10-11
申请人： SORRENTO THERAPEUTICS, INC. , ZHU, Tong , CHEN, Gang , KHASANOV, Alisher
发明人： ZHU, Tong , CHEN, Gang , KHASANOV, Alisher
IPC分类号： A61K47/68 , C07K19/00
CPC分类号： A61K47/6809 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2863 , C07K2317/24
摘要： Described are antibody drug conjugates (ADCs) having an IgG antibody (A) that binds to a c-Met target, conjugated through a conjugation component at both Cys sites in the hinge region of the IgG antibody and to disulfide bonds linking heavy and light chains of the IgG class human antibody, to a drug (D). More specifically, the present disclosure relates to the drug component (D) of the ADC.
摘要翻译：描述了具有IgG抗体（A）的抗体药物缀合物（ADCs），其结合c-Met靶标，通过IgG抗体铰链区域中两个Cys位点处的缀合组分偶联和连接IgG类人抗体的重链和轻链的二硫键连接到药物（D）上。更具体地说，本公开涉及ADC的药物组分（D）。

6. 发明申请

WO2014205378A1 FABRICATION OF STABLE ELECTRODE/DIFFUSION BARRIER LAYERS FOR THERMOELECTRIC FILLED SKUTTERUDITE DEVICES 审中-公开
标题翻译：稳定电极/扩散障碍层的制造用于热电填充的SKUTTERUDITE设备
公开(公告)号：WO2014205378A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/043461
申请日：2014-06-20
申请人： UNIVERSITY OF HOUSTON SYSTEM , JIE, Qing , REN, Zhifeng , CHEN, Gang , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JIE, Qing , REN, Zhifeng , CHEN, Gang
IPC分类号： H01L35/12 , H01L35/34
CPC分类号： H01L35/34 , H01L35/08 , H01L35/14 , H01L35/20 , H01L35/22
摘要： Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of CoSi 2 and a dopant are ball-milled to form a first powder which is thermo-mechanically processed with a second powder of n-type skutterudite to form a n-type skutterudite layer disposed between a first layer and a third layer of the doped-CoSi 2 . In addition, a plurality of components such as iron, and nickel, and at least one of cobalt or chromium are ball-milled form a first powder that is thermo-mechanically processed with a p-type skutterudite layer to form a p-type skutterudite layer "second layer" disposed between a first and a third layer of the first powder. The specific contact resistance between the first layer and the skutterudite layer for both the n-type and the p-type skutterudites subsequent to hot-pressing is less than about 10.0 µΩ•cm 2 .
摘要翻译：公开了用于制造电触头的n型和p型填充方钴矿热电腿的方法。将CoSi 2和掺杂剂的第一材料球磨以形成用n型方钴矿的第二粉末热机械加工的第一粉末，以形成设置在第一层和第三层之间的n型方钴矿层掺杂CoSi2。此外，将多种组分如铁和镍以及至少一种钴或铬球磨成形成第一粉末，其用p型方钴矿层热机械加工以形成p型方钴矿层“第二层”设置在第一和第三层之间。在热压之后的n型和p型方钴矿的第一层和方钴矿层之间的比接触电阻小于约10.0μΩ·cmgr·cm 2。

7. 发明申请

WO2010065635A2 SUB-WAVELENGTH METALLIC CONE STRUCTURES AS SELECTIVE SOLAR ABSORBER 审中-公开
标题翻译：亚波长金属结构作为选择性太阳能吸收器
公开(公告)号：WO2010065635A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/066408
申请日：2009-12-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHEN, Gang , HU, Lu , CHEN, Xiaoyuan , CHIESA, Matteo
发明人： CHEN, Gang , HU, Lu , CHEN, Xiaoyuan , CHIESA, Matteo
IPC分类号： F24J2/46 , F24J2/48 , B32B15/04
CPC分类号： G02B1/118 , C25D5/34 , C25D5/44 , C25D11/02 , C25D11/04 , C25D11/24 , F24S70/25 , F24S70/30 , F24S70/60 , G02B1/005 , H01L31/02168 , H01L35/30 , Y02E10/44 , Y02E10/50
摘要： In one aspect, the present invention provides a radiation-absorbing structure, which includes a metallic layer and a plurality of protuberances formed in the metallic layer. The protuberances are configured to selectively enhance radiation absorptance at wavelengths less than a cut-off wavelength, for example, for incident radiation wavelengths less than about 2500 nm (2.5 microns), hi some cases, the cut-off wavelength below which the protuberance provide enhanced radiation absorptance can be about 2000 nm or 1800 nm. For example, the protuberances can enhance radiation absorptance for wavelengths in a range of about 300 nm to about 2500 nm, or in a range of about 300 nm to about 2000 nm, or in a range of about 300 nm to about 1800 nm. Further, in many embodiments the radiation absorbing structure exhibits a low emissivity at longer wavelengths, e.g., at wavelengths greater than about 3000 nm.
摘要翻译：一方面，本发明提供了一种辐射吸收结构，其包括金属层和形成在金属层中的多个突起。突起被配置成选择性地增强在小于截止波长的波长处的辐射吸收率，例如，对于小于约2500nm（2.5微米）的入射辐射波长，在一些情况下，突起提供的截止波长增强的辐射吸收率可以是约2000nm或1800nm。例如，突起可以增强在约300nm至约2500nm的范围内或在约300nm至约2000nm的范围内或在约300nm至约1800nm的范围内的波长的辐射吸收率。此外，在许多实施例中，辐射吸收结构在较长波长处表现出低发射率，例如在大于约3000nm的波长处。

8. 发明申请

WO2009148554A1 ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT 审中-公开
标题翻译：通过分子成像指导的药物治疗实现高效治疗指标
公开(公告)号：WO2009148554A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003309
申请日：2009-06-01
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , KASI, Dhanalakshmi , GANGADHARMATH, Umesh, B. , SCOTT, Peter, J.h. , CHEN, Gang , MOCHARLA, Vani, P.
发明人： KOLB, Hartmuth, C. , WALSH, Joseph, C. , CHEN, Kai , KASI, Dhanalakshmi , GANGADHARMATH, Umesh, B. , SCOTT, Peter, J.h. , CHEN, Gang , MOCHARLA, Vani, P.
IPC分类号： A61K51/08 , A61P35/00
CPC分类号： A61K51/088 , A61K51/082
摘要： The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.
摘要翻译：本公开提供了在需要这种治疗的患者中治疗癌症的方法，所述方法包括通过使用在肿瘤部位对癌症靶标特异的标记的生物标志物向患者进行分子成像程序来资格评估患者的治疗性治疗; 以及施用治疗有效量的包含连接于与抗体连接的化学治疗剂或靶向剂的靶向剂的化合物。本发明的实施方案还包括使用这些方法的化合物和组合物。

9. 发明申请

WO2009094133A1 MULTI-COLOR LIGHT SOURCE 审中-公开
标题翻译：多色光源
公开(公告)号：WO2009094133A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/000349
申请日：2009-01-21
申请人： ALCATEL-LUCENT USA INC. , CHEN, Gang , RYF, Roland
发明人： CHEN, Gang , RYF, Roland
IPC分类号： G03B21/14 , H04N9/31
CPC分类号： H04N9/3164 , G03B21/2013 , G03B21/2053 , H04N9/3111 , H04N9/3155
摘要： System including first and second light sources and controller. First light source is configured to generate first light beam of first perceived color. Second light source is configured to generate second light beam of different second perceived color. Controller is configured to direct light from first light beam to an image projector during first time intervals and to direct light from second light beam to an image projector during second time intervals. First light source generates first light beam with first intensity. Second light source generates second light beam with different second intensity. Controller is configured to temporally interleave first and second time intervals such that second time intervals are longer than first time intervals. Method also provided.
摘要翻译：系统包括第一和第二光源和控制器。第一光源被配置为产生第一感知颜色的第一光束。第二光源被配置为产生不同的第二感知颜色的第二光束。控制器被配置为在第一时间间隔期间将光从第一光束引导到图像投影仪，并且在第二时间间隔期间将来自第二光束的光引导到图像投影仪。第一光源产生具有第一强度的第一光束。第二光源产生具有不同第二强度的第二光束。控制器被配置为在时间上交织第一和第二时间间隔，使得第二时间间隔长于第一时间间隔。方法也提供。

10. 发明申请

WO2008151219A1 ENHANCED EXPRESSION AND STABILITY REGIONS 审中-公开
标题翻译：增强表达和稳定性领域
公开(公告)号：WO2008151219A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065733
申请日：2008-06-04
申请人： REGENERON PHARMACEUTICALS, INC. , CHEN, Gang , BABB, Robert , FANDL, James, P.
发明人： CHEN, Gang , BABB, Robert , FANDL, James, P.
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C07K16/00 , C07K2319/30 , C12N15/86 , C12N2740/10043 , C12N2800/30 , C12N2840/203 , C12P21/02
摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.
摘要翻译：提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

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