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1. 发明申请

WO2019018238A1 AN OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE OF CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION 审中-公开
公开(公告)号：WO2019018238A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/042132
申请日：2018-07-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： NISHIMURA, Ichiro , HOKUGO, Akishige , MORINAGA, Kenzo , MCKENNA, Charles, E. , KASHEMIROV, Boris, A. , RICHARD, Eric, T.
IPC分类号： A61P19/10 , C07F9/38 , C07K2/00 , C12Q1/37
摘要： In certain embodiments osteoadsorptive fluorogenic substrates of cathepsin K (or other proteases) are provided. Utilizing a bisphosphonate targeting moiety, the fluorogenic substrates provide effective bone-targeted protease sensor(s). In certain embodiments the "probes" comprise cleavable fluorophore-quencher pair linked by a cathepsin K (or other protease) peptide substrate and tethered to a bisphosphonate. Unlike existing probes that are cleared within a few days in vivo, the probes described herein (e.g., OFS-1) allow for monitoring resorption over the course of longer time periods with a single dose.

2. 发明申请

WO2022246264A1 COMPOSITIONS AND METHODS OF TISSUE REGENERATION THERAPY 审中-公开
公开(公告)号：WO2022246264A1
公开(公告)日：2022-11-24
申请号：PCT/US2022/030357
申请日：2022-05-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： NISHIMURA, Ichiro , HOKUGO, Akishige , KONDO, Takeru , SHIBUYA, Yoichiro
IPC分类号： A61P17/02 , A61P17/00 , A61L24/0015
摘要： The present disclosure provides methods for improving or accelerating wound healing and/or preventing scarring during skin wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of neuronal PAS domain protein 2 (Npas2), wherein the agent is a serotonin receptor antagonist, e.g., a serotonin receptor 1B antagonist or a serotonin receptor 2B antagonist. The methods can be used to regenerate alveolar bone, regenerate connective tissue at a wound site, decrease wound area size and/or promote scarless healing of a skin wound.

3. 发明申请

WO2004000867A1 DIAGNOSTIC PHENOTYPE ASSAY FOR ENGINEERED CELLS AND TISSUES 审中-公开
标题翻译：用于工程细胞和组织的诊断性PHENOTYPE测定
公开(公告)号：WO2004000867A1
公开(公告)日：2003-12-31
申请号：PCT/US2002/019705
申请日：2002-07-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NISHIMURA, Ichiro , IIDA, Keisuke
发明人： NISHIMURA, Ichiro , IIDA, Keisuke
IPC分类号： C07H21/02
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides an improved method for assessing, monitoring and/or determining the phenotype of cells and tissues. One aspect of the present invention is a method of fabricating phenotype specific gene (PSGs) and house keeping gene (HKGs) targets onto a microarray. Another aspect of the present invention provides a composition PSGs and HKGs as targets for high throughput assays including microarray analyses. Another aspect of the present invention is accessing, monitoring and/or determining the phenotype of tissue engineered cells derived from stem cells including embryonic stem cells, embryonic germ cells, fetal stem cells and adult stem cells by hybridizing cDNA probes to either PSG or HKG targets. These methods employ at least 25 PSG targets and no greater than 5000 HKG targets.
摘要翻译：本发明提供用于评估，监测和/或确定细胞和组织表型的改进方法。本发明的一个方面是将表型特异性基因（PSG）和家族保持基因（HKG）靶标制造到微阵列上的方法。本发明的另一方面提供组合物PSG和HKG作为包括微阵列分析的高通量测定的靶标。本发明的另一方面是通过将cDNA探针与PSG或HKG靶物杂交来获取，监测和/或确定衍生自干细胞的组织工程细胞的表型，包括胚胎干细胞，胚胎生殖细胞，胎儿干细胞和成体干细胞。这些方法使用至少25个PSG目标和不超过5000个HKG目标。

5. 发明申请

WO2021046438A1 REGENERATING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION 审中-公开
公开(公告)号：WO2021046438A1
公开(公告)日：2021-03-11
申请号：PCT/US2020/049529
申请日：2020-09-04
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： NISHIMURA, Ichiro , HOKUGO, Akishige , SASAKI, Hodaka , OKAWA, Hiroko , WANG, Lixin , DAMOISEAUX, Robert D.
IPC分类号： A61P17/02 , A61P19/08 , C07K14/47 , C12N15/113
摘要： The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

6. 发明申请

WO2017087685A1 DEFORMABLE NANO-SCALE VEHICLES (DNVS) FOR TRANS-BLOOD BRAIN BARRIER, TRANS-MUCOSAL, AND TRANSDERMAL DRUG DELIVERY 审中-公开
标题翻译：可变形的纳米级车辆（DNVS）用于反式血脑屏障，反式粘膜和透皮药物递送
公开(公告)号：WO2017087685A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062552
申请日：2016-11-17
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： JOHN, Varghese , NISHIMURA, Ichiro , SUBBIAH, Naren , CAMPAGNA, Jesus , SPILMAN, Patricia R. , ALAM, Mohammad Parvez
IPC分类号： A61K9/107 , A61K47/24 , A61K47/28 , A61K9/127 , A61K47/48 , A61K9/70 , A61K9/00
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/0019 , A61K9/006 , A61K9/0085 , A61K9/1271 , A61K9/19 , A61K9/70 , A61K47/644 , A61K47/6911
摘要： In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.
摘要翻译：在各种实施方案中，提供了可用于递送治疗剂的可变形纳米级载体（DNV）。在某些实施方案中，DNV能够透皮递送并且可以另外穿过血脑屏障。

7. 发明申请

WO2002100250A2 WIT 3.0, NOVEL GENE TO CONTROL SOFT TISSUE WOUND HEALING 审中-公开
标题翻译： WIT 3.0，新基因控制软组织治疗
公开(公告)号：WO2002100250A2
公开(公告)日：2002-12-19
申请号：PCT/US2002/018828
申请日：2002-06-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NISHIMURA, Ichiro , SUKOTJO, Cortino
发明人： NISHIMURA, Ichiro , SUKOTJO, Cortino
IPC分类号： A61B
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a method of treatment to improve wound healing and to minimize/prevent abnormal scarring caused by tissue contraction and fibrosis formation by providing a specific gene, Wit 3.0 alpha and beta sequences that is differentially expressed in wounded oral mucosa cells, relative to their decreased expression in non-wounded oral mucosa cells. One aspect of the invention is a method to treat soft tissue wound using anti-sense nucleic acid technologies. Another aspect of the present invention is a method to treat soft tissue wound using sense nucleic acid technologies. These methods can employ a complimentary nucleic acid sequence that is greater than 85% identity to Wit 3.0 alpha and/or beta sequences or greater than 90% identity to the deduced amino acids thereof.
摘要翻译：本发明提供了一种治疗方法，其通过提供在受伤的口腔粘膜细胞中差异表达的特异性基因Wit3.0α和β序列，来改善伤口愈合并且最小化/预防由组织收缩和纤维化形成引起的异常瘢痕形成其在非伤口口腔粘膜细胞中的表达降低。本发明的一个方面是使用反义核酸技术治疗软组织伤口的方法。本发明的另一方面是使用有义核酸技术治疗软组织伤口的方法。这些方法可以使用与Wit3.0α和/或β序列大于85％同一性或与其推导的氨基酸大于90％同一性的互补核酸序列。

8. 发明申请

WO2020096975A1 SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION 审中-公开
公开(公告)号：WO2020096975A1
公开(公告)日：2020-05-14
申请号：PCT/US2019/059693
申请日：2019-11-04
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： NISHIMURA, Ichiro , HOKUGO, Akishige , MORINAGA, Kenzo , SASAKI, Hodaka
IPC分类号： A61F2/28
摘要： Methods for enhancing or accelerating osseointegration of an implant into bone marrow of a subject, the methods comprising increasing expression of peripheral clock neuronal PAS domain protein 2 (NPAS2) in the bone marrow, are provided. Expression of NPAS2 is increased by administration of a Npas2 modulating compound to the subject.

9. 发明申请

WO2018187240A1 DEFORMABLE NANO-SCALE VEHICLES (DNVS) FOR TRANS-BLOOD BRAIN BARRIER, TRANS-MUCOSAL, AND TRANSDERMAL DRUG DELIVERY 审中-公开
公开(公告)号：WO2018187240A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/025749
申请日：2018-04-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： JOHN, Varghese , NISHIMURA, Ichiro , SUBBIAH, Naren , CAMPAGNA, Jesus , SPILMAN, Patricia, R. , ALAM, Mohammad, Parvez
IPC分类号： A61K47/24 , A61K47/28 , A61K47/48
摘要： In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.

10. 发明申请

WO2017210272A1 SKELETAL REMOVAL OF BISPHOSPHONATES 审中-公开
标题翻译：双膦酸盐的骨架去除
公开(公告)号：WO2017210272A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035169
申请日：2017-05-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BIOVINC LLC
发明人： EBETINO, Frank Hallock , NISHIMURA, Ichiro , SUN, Shuting , LUNDY, Mark Walden , HOKUGO, Akishige , MCKENNA, Charles , SADRERAFI, Keivan
IPC分类号： A61K31/663 , A61K31/675 , C07F9/38 , C07F9/40
摘要： Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.
摘要翻译：本文公开了用于去除或替代骨骼组织中的双膦酸盐的方法和组合物。

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