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    • 7. 发明申请
    • COMPOSITIONS AND METHODS FOR IMPROVING OVERALL TOOTH HEALTH AND APPEARANCE
    • 提高整体牙齿健康和外观的组合物和方法
    • WO2010004361A2
    • 2010-01-14
    • PCT/IB2008/052562
    • 2008-06-25
    • THE PROCTER & GAMBLE COMPANYBAIG, Arif, AliFALLER, Robert, VincentDECKNER, George, Endel
    • BAIG, Arif, AliFALLER, Robert, VincentDECKNER, George, Endel
    • A61Q11/00A61K8/86
    • A61K8/55A61K6/0067A61K8/19A61K8/21A61K8/24A61K8/416A61K8/4926A61K8/556A61K8/81A61K8/8147A61Q11/00C08G65/3355C08L71/02A61K6/0017C08L33/08C08L33/10
    • Disclosed are oral care compositions comprising selected surface-active organophosphate compounds and methods of use to provide protection of teeth from erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active organophosphate compounds are substantive to teeth, the phosphate groups binding the calcium in teeth and thus preventing loss of calcium from dissolution when contacted with acids. The organophosphate compound may also deposit a protective surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more phosphate groups and are combined in the oral care composition with one or more of a fluoride ion agent, an antimicrobial agent preferably selected from quaternary ammonium compounds and polyvalent metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-erosion, anticaries, antiplaque and anti-staining as demonstrated by enhanced fluoride uptake, remineralization, resistance to acid demineralization and antimicrobial activities, resulting in improved overall tooth health, structural integrity and appearance.
    • 公开了包含选择的表面活性有机磷酸酯化合物的口腔护理组合物以及用于保护牙齿免受由化学物质如苛刻研磨剂和酸的作用引起的侵蚀的方法。 表面活性有机磷酸酯化合物对牙齿是实质性的,磷酸盐基团结合牙齿中的钙,因此当与酸接触时防止钙从溶解中损失。 有机磷酸酯化合物也可以沉积保护性表面涂层,以防止牙齿与腐蚀性挑战接触。 选定的有机磷酸酯化合物含有一个或多个磷酸酯基团并且在口腔护理组合物中与一种或多种氟离子试剂,优选选自季铵化合物和多价金属盐的抗微生物剂,防牙垢剂和附加表面活性剂组合以提供 通过提高氟化物吸收,再矿化,抗酸脱矿质作用和抗微生物活性,从而改善整体牙齿健康状况,结构完整性和外观,证明其具有优异的抗侵蚀,防龋齿,抗牙斑和抗沾污性。
    • 10. 发明申请
    • METHODS AND COMPOSITIONS FOR HYDROPHOBIC MODIFICATION OF ORAL CAVITY SURFACES
    • 口腔修复表面的疏水性修饰方法及组合物
    • WO2011031807A2
    • 2011-03-17
    • PCT/US2010/048186
    • 2010-09-09
    • THE PROCTER & GAMBLE COMPANYBAIG, Arif, AliRAJAIAH, JayanthDECKNER, George, EndelGLANDORF, William, Michael
    • BAIG, Arif, AliRAJAIAH, JayanthDECKNER, George, EndelGLANDORF, William, Michael
    • A61Q11/00
    • A61Q11/00A61K8/24A61K8/55A61K8/556A61Q11/02
    • Oral care compositions containing agents that are effective for treating and modifying teeth and mucosal surfaces to be hydrophobic are disclosed. Hydrophobic modification of teeth and other oral cavity surfaces imparts a variety of end use benefits including prevention of caries, erosion, wear, staining, sensitivity and desquamation as well as providing shine, smoothness and positive tooth feel benefits. The compositions contain selected surface active organophosphate compounds that deposit and adhere to teeth and other oral cavity surfaces forming a hydrophobic coating having prolonged retention thereon. By forming a "hydrophobic coating" on the oral cavity surface is meant that the hydrophobic character of the surface is increased as measured, for example, by an increase of at least about 10 degrees in the water contact angle of the surface after treatment. The increased hydrophobic character of the surface is maintained for a period of at least about 5 minutes and desirably longer such as at least about 10, at least about 20 or at least about 30 minutes. The compositions may contain additional hydrophobic materials to further increase hydrophobicity of the surface and/or functionality of the coating to provide surface protection and many other benefits.
    • 公开了含有有效治疗和改变牙齿和粘膜表面是疏水性的试剂的口腔护理组合物。 牙齿和其他口腔表面的疏水改性赋予各种最终用途的优点,包括预防龋齿,侵蚀,磨损,染色,敏感性和脱屑,以及提供光泽,平滑度和积极的牙齿感受益处。 组合物含有选择的表面活性有机磷酸酯化合物,其沉积并粘附到牙齿和其它口腔表面,形成其上具有延长保留性的疏水涂层。 通过在口腔表面上形成“疏水性涂层”是指表面的疏水特性例如通过在处理后表面的水接触角增加至少约10度来测量而增加。 表面增加的疏水特性保持至少约5分钟,期望更长,例如至少约10,至少约20或至少约30分钟。 组合物可以含有另外的疏水材料以进一步增加涂层的表面和/或功能性的疏水性,以提供表面保护和许多其它益处。