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    • 10. 发明公开
    • WHOLE MOUTH MALODOR CONTROL BY A COMBINATION OF ANTIBACTERIAL AND DEODORIZING AGENTS
    • FIGHT口臭抗菌和除臭剂的组合
    • EP2553444A2
    • 2013-02-06
    • EP11713951.9
    • 2011-03-31
    • The Procter & Gamble Company
    • RAMJI, NiranjanSNIDER, Ann, GilliganWITTE, Lina, AuroraBECKER, Beverly, D.STATT, Beth, HansellNOLAND, Andrea, L.MCKINNEY, Kristi
    • G01N33/00A61K8/37A61K8/368A61K8/35A61K8/33A61K8/34A61K8/41A61K8/49A61Q11/00
    • A61K8/347A61K8/33A61K8/35A61K8/368A61K8/37A61K8/41A61Q11/00
    • Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure wherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, —OH or —ORa; R4 is —OH, —ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from α-damascenone, α-isomethylionone, α-ionone, &bgr;-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde. The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.
    • 本发明公开了口腔护理组合物有效地控制口和呼吸恶臭在药学上可接受的载体,包括,抗菌剂的组合和除臭或气味中和剂,其包含具有以下结构的化合物worin R1,R2,R3和R5可以是 相同或不同的,每个代表H,直链或支链的C1-C6烷基或烯基,苯基,-OH或-ORa; R 4为-OH,-ORa,苯基,或直链或支链的C1-C6烷基或烯基; 且R a是苯基或直链或支链的C1-C6烷基或烯基。 气味中和剂可以进一步包含一种或多种选自α大马酮,α-isomethyl ionomes,α紫罗兰酮,β-紫罗兰酮,胡薄荷酮,胡椒酮,carvones,辅酶Q10或肉桂醛中选择的额外的气味中和化合物。 抗菌剂可以包括一种或季铵化合物的从西吡氯铵,十四烷基氯化选择的混合物,N-十四烷基-4-乙基吡啶鎓氯化物或溴化物度米芬; 金属离子:如亚锡,锌或铜; 洗必泰; 三氯生; 三氯生单磷酸; 或选择的精油。