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1. 发明申请

WO2002069704A3 DEVICES AND METHODS FOR ELIMINATING TERMITE COLONIES 审中-公开
公开(公告)号：WO2002069704A3
公开(公告)日：2002-09-12
申请号：PCT/US2002/006200
申请日：2002-03-01
申请人： THE PROCTER & GAMBLE COMPANY
发明人： BRODE, Philip, Frederick, III , GARRETT, Garry, Steven , LAUGHLIN, Leo, Timothy , MATTHEWS, Randall, Stryker , BARKER, Dale, Edwin , KINNE, Daniel, James , MILLER, Christopher, Miles , PROBST, Timothy, Robert , MCKIBBEN, Gary, Eugene
IPC分类号： A01N25/02
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containinga) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide,b) a cellulose containing material, andc) water.The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

2. 发明申请

WO1998008827A1 HETEROCYCLIC METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：杂环金属蛋白酶抑制剂
公开(公告)号：WO1998008827A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014551
申请日：1997-08-22
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D243/08
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
摘要翻译：本发明提供了如权利要求中所述的式（I）化合物或其旋光异构体，非对映异构体或其对映异构体或其药学上可接受的盐或可生物水解的酰胺，酯或酰亚胺是金属蛋白酶的有用抑制剂。还公开了使用这些化合物或含有它们的药物组合物治疗以金属蛋白酶活性为特征的疾病，病症和病症的药物组合物和方法。

3. 发明申请

WO1998008825A1 1,4-HETEROCYCLIC METALLPROTEASE INHIBITORS 审中-公开
标题翻译： 1,4-杂环金属催化剂抑制剂
公开(公告)号：WO1998008825A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014552
申请日：1997-08-22
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabist , CHENG, Menyan
IPC分类号： C07D241/04
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
摘要翻译：本发明提供了如权利要求中所述的式（I）化合物或其旋光异构体，非对映异构体或其对映异构体或其药学上可接受的盐或可生物水解的酰胺，酯或酰亚胺可用作金属蛋白酶抑制剂。还公开了使用这些化合物或含有它们的药物组合物治疗以金属蛋白酶活性为特征的疾病，病症和病症的药物组合物和方法。

4. 发明申请

WO1997018191A1 SULFUR CONTAINING DI-TERT-BUTYLPHENOL COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：含有二叔丁基酚化合物的硫磺作为抗炎药物有用
公开(公告)号：WO1997018191A1
公开(公告)日：1997-05-22
申请号：PCT/US1996018016
申请日：1996-11-08
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , MATTHEWS, Randall, Stryker
IPC分类号： C07C317/24
CPC分类号： C07C317/24
摘要： The subject invention relates to compounds having structure (I), wherein (a) x is from 1 to 5; (b) y is from 1 to 2; and (c) z is from 0 to 5. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.
摘要翻译：本发明涉及具有结构（I）的化合物，其中（a）x为1至5; （b）y为1至2; 本发明还涉及包含上述化合物的药物组合物和使用该化合物治疗炎症的方法。

5. 发明申请

WO1996003396A1 DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：二氢苯并呋喃及相关化合物作为抗炎药物有用
公开(公告)号：WO1996003396A1
公开(公告)日：1996-02-08
申请号：PCT/US1995009109
申请日：1995-07-19
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , SCHERZ, Michael, Wiard , MATTHEWS, Randall, Stryker
IPC分类号： C07D307/79
CPC分类号： C07D307/79 , C07D333/54
摘要： A compound having structure (1) wherein (a) X is oxygen or sulfur; (b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen; (d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
摘要翻译：具有结构（1）的化合物，其中（a）X是氧或硫; （b）每个Y独立地为氢或未取代的具有1至约3个碳原子的直链，支链或环状烷基，或两个Y键合以形成具有3至约7个碳原子的烷基环; （c）Z为氢或未取代的支链或环状烷基，或未取代或烷基取代的苯基，具有除氢以外的3至约10个原子; （d）W是直链，支链或环状的烷基或芳基，未取代或取代的，饱和的或单或二不饱和的双键，除了W的末端碳原子不是双键的一部分; W具有除氢以外的1至约15个原子; 包含这些化合物的药物组合物，以及使用这些化合物治疗炎症或疼痛的方法。

6. 发明申请

WO1991013057A1 CO-SULFATION OF ETHOXYLATED ALCOHOLS AND UNSATURATED FATTY ALCOHOLS 审中-公开
标题翻译：乙氧基化醇和不饱和脂肪醇的共同硫化
公开(公告)号：WO1991013057A1
公开(公告)日：1991-09-05
申请号：PCT/US1991001111
申请日：1991-02-25
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , MATTHEWS, Randall, Stryker , WARD, James, Frank
IPC分类号： C07C305/10
CPC分类号： C07C303/24 , C07C305/14 , C07C305/10
摘要： The present invention is directed to a process for co-sulfating alkyl ethoxylated alcohols and unsaturated fatty alcohols to prepare a mixed product system which can be neutralized to form a mixed surfactant system. This process comprises sulfating together both an unsaturated alcohol of the formula R-OH, wherein R is a C8-C22 alkenyl group, and an alkyl ethoxylated alcohol of the formula R (OCH2CH2)nOH, wherein R is a C8-C20 alkyl group and n is an integer from 1 to 10, inclusive. The mole ratio of unsaturated alcohol plus alkyl ethoxylated alcohol to sulfating agent in the process of the present invention ranges from about 1:1 to about 5:1. The final product resulting from the process of the present invention is a mixed product system comprising an unsaturated fatty acid sulfate of the formula R-OSO3H, wherein R is as hereinbefore defined, and an alkyl ethoxylated acid sulfate of the formula R (OCH2CH2)nOSO3H, wherein R and n are as hereinbefore defined. This mixed product system can be neutralized to form a mixed surfactant system comprising the neutralized salts of said acid sulfates.
摘要翻译：本发明涉及一种使烷基乙氧基化醇和不饱和脂肪醇共硫酸化以制备可中和以形成混合表面活性剂体系的混合产物体系的方法。该方法包括将式R-OH的不饱和醇（其中R是C 8 -C 22烯基）和式R 1（OCH 2 CH 2）n OH的烷基乙氧基化醇同时硫酸化，其中R 1是 C8-C20烷基，n为1-10的整数，包括1和10。本发明方法中不饱和醇加烷基乙氧基化醇与硫酸化剂的摩尔比为约1:1至约5:1。由本发明方法得到的最终产物是包含式R-OSO 3 H的不饱和脂肪酸硫酸盐（其中R如上所定义）和式R 1的烷基乙氧基化酸式硫酸酯的混合产物体系（ OCH 2 CH 2）nOSO 3 H，其中R 1和n如上文所定义。该混合产物体系可被中和以形成包含所述酸式硫酸盐的中和盐的混合表面活性剂体系。

7. 发明公开

EP0923563A1 1,4-HETEROCYCLIC METALLPROTEASE INHIBITORS 失效
标题翻译： 1,4杂环金属蛋白酶
公开(公告)号：EP0923563A1
公开(公告)日：1999-06-23
申请号：EP97938410.0
申请日：1997-08-22
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabist , CHENG, Menyan
IPC分类号： C07D243 , A61K31 , A61P1 , A61P9 , A61P11 , A61P15 , A61P17 , A61P19 , A61P27 , A61P29 , A61P31 , A61P35 , A61P37 , A61P39 , A61P43 , C07D223 , C07D241 , C07D265 , C07D279 , C07D281 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

8. 发明授权

EP0925287B1 HETEROCYCLIC METALLOPROTEASE INHIBITORS 失效
标题翻译：杂环金属蛋白酶抑制剂
公开(公告)号：EP0925287B1
公开(公告)日：2003-01-15
申请号：EP97939442.6
申请日：1997-08-22
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D243/08 , C07D267/10 , C07D281/04 , C07D281/18 , A61K31/53 , A61K31/54
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

9. 发明公开

EP0925287A1 HETEROCYCLIC METALLOPROTEASE INHIBITORS 失效
标题翻译：杂环金属蛋白酶抑制剂
公开(公告)号：EP0925287A1
公开(公告)日：1999-06-30
申请号：EP97939442.0
申请日：1997-08-22
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D243 , A61K31 , A61P1 , A61P9 , A61P11 , A61P15 , A61P17 , A61P19 , A61P27 , A61P29 , A61P31 , A61P35 , A61P37 , A61P39 , A61P43 , C07D223 , C07D241 , C07D265 , C07D279 , C07D281 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

10. 发明公开

EP0863870A1 SULFUR CONTAINING DI-TERT-BUTYLPHENOL COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS 失效
标题翻译：含S DI-TER丁基苯酚连接是非常有用的消炎药
公开(公告)号：EP0863870A1
公开(公告)日：1998-09-16
申请号：EP96939627.0
申请日：1996-11-08
申请人： THE PROCTER & GAMBLE COMPANY
发明人： MATTHEWS, Randall, Stryker
IPC分类号： A61K31 , A61P25 , A61P29 , A61P37 , C07C317 , C07C323
CPC分类号： C07C317/24
摘要： The subject invention relates to compounds having structure (I), wherein (a) x is from 1 to 5; (b) y is from 1 to 2; and (c) z is from 0 to 5. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.

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