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1. 发明申请

WO2018005335A1 METHOD FOR SAMPLING GINGIVAL METABOLITES 审中-公开
标题翻译：采样牙龈代谢物的方法
公开(公告)号：WO2018005335A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039226
申请日：2017-06-26
申请人： THE PROCTER & GAMBLE COMPANY
发明人： XIE, Sancai , HAUGHT, John, Christian , TANSKY, Cheryl, Sue , HUGGINS, Thomas, Glenn , WHITE, Donald, James , LI, Lijuan , KLUKOWSKA, Malgorzata , FIENO, Angela, Marie , KHAMBE, Deepa, Ashok
IPC分类号： A46B15/00 , A61Q11/00
CPC分类号： G01N1/28 , A46B15/00 , A46B2200/108 , A61B10/0051 , A61B10/02 , A61B2010/0216 , A61B2010/0225 , A61C19/00 , A61Q11/00 , G01N2800/18
摘要： One or more methods for sampling gingival metabolites and biomarkers.
摘要翻译：一种或多种取样牙龈代谢物和生物标志物的方法。

2. 发明申请

WO2014144223A3 A NONINVASIVE METHOD FOR MEASURING METABOLITES FOR SKIN HEALTH 审中-公开
公开(公告)号：WO2014144223A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/028537
申请日：2014-03-14
申请人： THE PROCTER & GAMBLE COMPANY
发明人： KERR, Kathleen, Marie , WEHMEYER, Kenneth, Robert , WANG, Feng , FIENO, Angela, Marie , MILLS, Kevin, John
IPC分类号： G01N33/50
摘要： A noninvasive method for diagnosing skin health in a subject comprising collecting a skin sample from the subject; detecting a level of one or more small molecule biomarkers in the epithelial cell sample/skin cell sample; diagnosing the subject as having a skin condition based on the level of a detected small molecule biomarker, wherein the detected small molecule is at least one compound chosen from: a compound generated by metabolism of amino acids, a compound generated by dipeptides metabolism, a compound generated by nucleic acids, a compound generated by metabolism of lipids, a compound generated by metabolism of carbohydrates, and mixtures thereof and further small molecule biomarkers as listed in Table 1. Further, a noninvasive method for evaluating the efficacy of products for skin health.

3. 发明申请

WO2011034766A1 A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH 审中-公开
标题翻译：用于从皮肤测量组胺的非侵入性方法作为其目的测量
公开(公告)号：WO2011034766A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/048185
申请日：2010-09-09
申请人： THE PROCTER & GAMBLE COMPANY , SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
发明人： SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
IPC分类号： G01N33/68 , G01N1/28
CPC分类号： G01N33/6881 , G01N2001/2833 , G01N2001/4061
摘要： A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.
摘要翻译：一种用于测量表皮中组胺的方法，包括将粘合剂制品施用于哺乳动物的上皮; 允许上皮细胞粘附到粘合剂制品上; 从哺乳动物的上皮移除粘合剂制品; 使用标准实验室方法制备粘合剂制品; 从附着于所述粘合剂制品的上皮细胞中提取组胺; 从附着于所述粘合剂制品的上皮细胞测量组胺; 与基线样品相比，确定上皮细胞中组胺的量。此外，一种客观地测量哺乳动物中瘙痒感觉的方法，其中组胺从基线水平降低，其与瘙痒感觉的减少成正比。

4. 发明申请

WO2022132864A1 AZOXYSTROBIN EFFICACY IN SCALP HEALTH 审中-公开
公开(公告)号：WO2022132864A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/063453
申请日：2021-12-15
申请人： THE PROCTER & GAMBLE COMPANY
发明人： RICHARDS, Jeanette, Anthea , KERR, Kathleen, Marie , FIENO, Angela, Marie
IPC分类号： A61K8/49 , A61Q5/00 , A61Q5/02 , A61Q5/12
摘要： The present invention is directed to use of azoxystrobin to decrease the number of flakes on a surface; the use of azoxystrobin to decrease itch on a surface as perceived by a user; the use of azoxystrobin to decrease the level of myeloperoxidase on a surface as an indicator of decrease of oxidative stress and damage. The present invention is directed to the use of azoxystrobin wherein the azoxystrobin is applied from a personal care composition such as a shampoo, conditioner or leave on treatment.

5. 发明申请

WO2014144289A2 A NONINVASIVE METHOD FOR MEASURING ANTIMICROBIAL PEPTIDES FROM SKIN AS AN OBJECTIVE MEASUREMENT OF NATURAL PROTECTION FROM MICROBES 审中-公开
标题翻译：用于从皮肤测量抗微生物肽的非侵入性方法，作为微生物自然保护的目标测量
公开(公告)号：WO2014144289A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028631
申请日：2014-03-14
申请人： THE PROCTER & GAMBLE COMPANY
发明人： KERR, Kathleen, Marie , FIENO, Angela, Marie , SUN, Yiping , CHAUDHARY, Tanuja , GRANT, Raymond, Alan , MILLS, Kevin, John
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , G01N33/6881
摘要： A noninvasive method for measuring skin health in a subject comprising collecting an epithelial cell /skin cell sample from the subject; detecting a level of one or more antimicrobial peptide biomarkers in the epithelial cell sample/skin cell sample; diagnosing the subject as having a defense mechanism due to microbial attack on skin or a measure of the system being in balance with environment homeostasis based on the level of one or more antimicrobial peptide biomarkers selected from the group consisting of Histone H2B type 1-M, Histone H2A, Histone H4, Protein S100-A7, Protein S100-A8, Protein S100-A9, Cathepsin G, Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3), Dermcidin, Ribonuclease 7 (RNase 7), human beta-defensin -2 (nBD-2) and Beta-defensin 103 (hBD-3) and listed in Table 1 wherein the AMP families include bactericidal permeability-increasing protein (BPI), Defensin, Histone, Pore-forming toxin, S100 protein, Cytotoxin, Serine Protease S1, Dual Oxidase, transcription regulation, and mixtures thereof. Further, a noninvasive method for evaluating the efficacy of products for skin health.
摘要翻译：一种用于测量受试者皮肤健康的非侵入性方法，包括从受试者收集上皮细胞/皮肤细胞样品; 检测上皮细胞样品/皮肤细胞样品中一种或多种抗微生物肽生物标志物的水平; 基于一种或多种选自组蛋白H2B型1-M的抗微生物肽生物标志物的水平，诊断受试者具有由于微生物对皮肤的侵袭而产生的防御机制或与体内环境平衡的测量，组蛋白H2A，组蛋白H4，蛋白质S100-A7，蛋白质S100-A8，蛋白质S100-A9，组织蛋白酶G，嗜中性粒细胞防御素3（防御素，α3）（HNP-3），皮肤抑制素，核糖核酸酶7（RNase 7） - 防御素-2（nBD-2）和β-防御素103（hBD-3），并列于表1中，其中AMP家族包括杀菌通透性增加蛋白（BPI），防御素，组蛋白，形成孔蛋白的S100蛋白，细胞毒素，丝氨酸蛋白酶S1，双重氧化酶，转录调控及其混合物。此外，用于评估产品对皮肤健康的功效的非侵入性方法。

6. 发明申请

WO2014144265A1 A NONINVASIVE METHOD FOR MEASURING OXIDATIVE STRESS AND OXIDATIVE DAMAGE FROM SKIN 审中-公开
标题翻译：用于测量氧化应激和氧化皮肤损伤的非侵入性方法
公开(公告)号：WO2014144265A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028598
申请日：2014-03-14
申请人： THE PROCTER & GAMBLE COMPANY
发明人： KERR, Kathleen, Marie , FIENO, Angela, Marie , WEHMEYER, Kenneth, Robert , LI, Lijuan , SCHWARTZ, James, Robert , GRANT, Raymond, Alan
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , C12Q1/28 , G01N33/5064 , G01N33/92 , G01N2800/20
摘要： A noninvasive method for diagnosing skin health in a subject comprising collecting a skin sample/epithelial cell sample from the subject; detecting a level of one or more biomarkers selected from the group consisting of Myeloperoxidase and oxidized lipids in the epithelial cell sample/skin cell sample; diagnosing the subject as having oxidative stress and/or oxidative damage based on the level of a detected biomarker. Further, a noninvasive method for evaluating the efficacy of products for skin health.
摘要翻译：用于诊断受试者皮肤健康的非侵入性方法，包括从受试者收集皮肤样品/上皮细胞样品; 检测在上皮细胞样品/皮肤细胞样品中选自由髓过氧化物酶和氧化脂质组成的组中的一种或多种生物标志物的水平; 基于检测到的生物标志物的水平将受试者诊断为具有氧化应激和/或氧化损伤。此外，用于评估产品对皮肤健康的功效的非侵入性方法。

7. 发明公开

EP2478376A1 A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH 有权
标题翻译： FROM AS LENSES瘙痒测量皮肤测量组胺的非侵入性方法
公开(公告)号：EP2478376A1
公开(公告)日：2012-07-25
申请号：EP10755273.9
申请日：2010-09-09
申请人： The Procter & Gamble Company
发明人： SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
IPC分类号： G01N33/68 , G01N1/28
CPC分类号： G01N33/6881 , G01N2001/2833 , G01N2001/4061
摘要： A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.

8. 发明公开

EP3478121A1 METHOD FOR SAMPLING GINGIVAL METABOLITES 审中-公开
公开(公告)号：EP3478121A1
公开(公告)日：2019-05-08
申请号：EP17735742.3
申请日：2017-06-26
申请人： The Procter & Gamble Company
发明人： XIE, Sancai , HAUGHT, John, Christian , TANSKY, Cheryl, Sue , HUGGINS, Thomas, Glenn , WHITE, Donald, James , LI, Lijuan , KLUKOWSKA, Malgorzata , FIENO, Angela, Marie , KHAMBE, Deepa, Ashok
IPC分类号： A46B15/00 , A61Q11/00

9. 发明授权

EP2478376B1 A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH 有权
标题翻译： FROM AS LENSES瘙痒测量皮肤测量组胺的非侵入性方法
公开(公告)号：EP2478376B1
公开(公告)日：2015-06-17
申请号：EP10755273.9
申请日：2010-09-09
申请人： The Procter & Gamble Company
发明人： SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
IPC分类号： G01N33/68 , G01N1/28
CPC分类号： G01N33/6881 , G01N2001/2833 , G01N2001/4061

10. 发明公开

EP2972324A1 A NONINVASIVE METHOD FOR MEASURING OXIDATIVE STRESS AND OXIDATIVE DAMAGE FROM SKIN 有权
标题翻译：耐腐蚀VERFAHREN ZUR MESSUNG VON氧化剂应力UND OIAIDATIVERSCHÄDIGUNGDER HAUT
公开(公告)号：EP2972324A1
公开(公告)日：2016-01-20
申请号：EP14717367.8
申请日：2014-03-14
申请人： The Procter & Gamble Company
发明人： KERR, Kathleen, Marie , FIENO, Angela, Marie , WEHMEYER, Kenneth, Robert , LI, Lijuan , SCHWARTZ, James, Robert , GRANT, Raymond, Alan
IPC分类号： G01N33/50
摘要： A noninvasive method for diagnosing skin health in a subject comprising collecting a skin sample/epithelial cell sample from the subject; detecting a level of one or more biomarkers selected from the group consisting of Myeloperoxidase and oxidized lipids in the epithelial cell sample/skin cell sample; diagnosing the subject as having oxidative stress and/or oxidative damage based on the level of a detected biomarker. Further, a noninvasive method for evaluating the efficacy of products for skin health.
摘要翻译：用于诊断受试者皮肤健康的非侵入性方法，包括从受试者收集皮肤样品/上皮细胞样品; 检测在上皮细胞样品/皮肤细胞样品中选自由髓过氧化物酶和氧化脂质组成的组中的一种或多种生物标志物的水平; 基于检测到的生物标志物的水平将受试者诊断为具有氧化应激和/或氧化损伤。此外，用于评估产品对皮肤健康的功效的非侵入性方法。

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