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1. 发明申请

WO2002100332A2 ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有MIF拮抗剂活性的ISOXAZOLINE化合物
公开(公告)号：WO2002100332A2
公开(公告)日：2002-12-19
申请号：PCT/US2002/017898
申请日：2002-06-10
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： AL-ABED, Yousef
IPC分类号： A61K
CPC分类号： A61K31/421 , C07D261/04
摘要： Methods of use and pharmaceutical compositions for a genus of low molecular weight compounds comprising optionally substituted isoxazoline ring system that act as inhibitors of MIF (macrophage migration inhibitory factor) are disclosed. Specifically, the compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases (including rheumatiod arthritis, insulin-dependent diabetes, multiple sclerosis, graft versus host disease, lupus syndromes), asthma, arthritis, ARDS, psoriasis, interleukin-2 toxicity, proliferative vascular disease, and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization (angiogenesis).
摘要翻译：公开了用作低分子量化合物属的药物组合物，其包含用作MIF抑制剂（巨噬细胞迁移抑制因子）的任选取代的异恶唑啉环体系。具体地说，该化合物可用于治疗涉及炎症活性或促炎细胞因子应答的各种疾病，例如自身免疫性疾病（包括风湿性关节炎，胰岛素依赖性糖尿病，多发性硬化，移植物抗宿主病，狼疮综合征），哮喘，关节炎，ARDS，牛皮癣，白细胞介素-2毒性，增殖性血管疾病和各种形式的败血症和败血性休克，以及其他基本MIF反应特征的病症，包括例如肿瘤生长和新生血管形成（血管生成）。

2. 发明公开

EP1018005A1 METHODS FOR MEASURING AND ELIMINATING ADVANCED GLYCATION ENDPRODUCTS 审中-公开
标题翻译：方法用于测量和成品消除晚期糖化
公开(公告)号：EP1018005A1
公开(公告)日：2000-07-12
申请号：EP98948350.8
申请日：1998-09-18
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： AL-ABED, Yousef , BUCALA, Richard
IPC分类号： G01N31/00 , G01N33/00 , G01N33/53
CPC分类号： G01N33/6842 , G01N33/68 , G01N33/6893
摘要： There is disclosed a means for standardizing a kit that provides a means for measuring the formation of advanced glycosylation endproducts (AGEs). The present invention further provides a novel isolate AGE that is antigenic and useful for forming antibodies having utility in diagnostic assays and for standardizing diagnostic assays.

3. 发明公开

EP1098647A1 COMPOUNDS AND COMPOSITIONS FOR TREATING TISSUE ISCHEMIA 有权
标题翻译：化合物和筹备缺血织物的处理
公开(公告)号：EP1098647A1
公开(公告)日：2001-05-16
申请号：EP99934082.1
申请日：1999-07-16
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： TRACEY, Kevin, J. , AL-ABED, Yousef , IVANOVA, Svetlana , BUCALA, Richard, J.
IPC分类号： A61K31/435
CPC分类号： G01N33/5044 , A61K31/197 , A61K31/426 , A61K31/4425 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5058 , G01N33/5088
摘要： There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia of the myocardium. The present invention further provides a method for treating tissue damage caused by ischemia. Lastly, the present invention provides a method for treating tissue damage caused by providing a compound that inhibits the cytotoxic activity of 3-aminopropanal.

4. 发明公开

EP1311255A1 COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有拮抗活性CONNECTION
公开(公告)号：EP1311255A1
公开(公告)日：2003-05-21
申请号：EP01957247.8
申请日：2001-07-26
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： AL-ABED, Yousef , BUCALA, Richard, J. , MITCHELL, Robert, A. , SENTER, Peter
IPC分类号： A61K31/17 , A61K31/12
CPC分类号： A61K31/122 , A61K31/167
摘要： There are disclosed methods of use and pharmaceutical compositions for two related fenera of low molecular weight compounds comprising optionally substituted iminoquinone or orthoquinone ring systems. The compounds have MIF (macrophage migration inhibitory factor) antagonist activity and find utility as such. For example, the compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases (including rheumatiod arthritis, insulin-dependent diabetes, multiple sclerosis, graft versus host disease, lupus syndromes), asthma, arthritis, EAE, ARDS, psoriasis, interleukin-2 toxicity, proliferative vascular diseases, and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization (angiogenesis).

5. 发明公开

EP1228037A1 COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY 审中-公开
标题翻译： CONNECTIONS MIF拮抗作用
公开(公告)号：EP1228037A1
公开(公告)日：2002-08-07
申请号：EP00973908.7
申请日：2000-10-27
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： AL-ABED, Yousef , BUCALA, Richard
IPC分类号： C07C249/00 , C07C229/00 , C07C211/00 , C07F9/02
CPC分类号： C07D209/20 , C07C251/24 , C07C323/58
摘要： There is disclosed a genus of optionally substituted Schiff base condensation products (and the carba analogs thereof) comprising an amino acid component and a benzaldehyde component, that have MIF (macrophage migration inhibitory factor) antagonist activity. The compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases, asthma, arthritis, EAE, ARDS and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization.

6. 发明公开

EP1178998A1 SYNTHETIC PROCESS FOR HIGHLY FUNCTIONALIZED CARBOCYCLIC POLYOLS AND SUBSTITUTED SUGAR ANALOGS 审中-公开
标题翻译：合成方法用于生产循环高功能卡博POLYOLS和取代糖类似物
公开(公告)号：EP1178998A1
公开(公告)日：2002-02-13
申请号：EP00928308.6
申请日：2000-04-19
申请人： THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
发明人： AL-ABED, Yousef , SEEPERSAUD, Mohindra
IPC分类号： C07H1/00 , C07C41/00
CPC分类号： C07H1/00 , C07C29/132 , C07C43/188 , C07C45/29 , C07C45/49 , C07C45/78 , C07C49/597 , C07C2601/10 , C07C49/255 , C07C49/753 , C07C31/205 , C07C31/274 , C07C31/276
摘要： Chemical processes for more efficient synthesis of carbocyclic polyols and substituted sugar analogs are disclosed, together with a novel class of cyclopentene polyol intermediate products and anhydro derivatives thereof.

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