专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018195380A1 VERTEBRAL BODY MANIPULATION DEVICE AND METHODS 审中-公开
公开(公告)号：WO2018195380A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028491
申请日：2018-04-20
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , WOLINSKY, Jean-Paul
IPC分类号： A61B17/70 , A61B17/68 , A61B17/56
摘要： Featured is a vertebral body manipulation instrument or vertebral body manipulation device being configured and arranged to allow correction of vertebral translation. Such a vertebral body manipulation device embodies one or more identical modules that are configured as needed for correcting the deformity. Such a vertebral body manipulation device also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are known to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a vertebral body manipulation device.

2. 发明公开

EP4051926A1 HARMONIC DRIVE ACTUATOR GEARHEAD 审中-实审
公开(公告)号：EP4051926A1
公开(公告)日：2022-09-07
申请号：EP20881600.9
申请日：2020-11-02
申请人： The Johns Hopkins University
发明人： STOIANOVICI, Dan , PETRISOR, Doru
IPC分类号： F16H1/00 , F16H49/00

3. 发明授权

EP2836133B1 COHESIVE ROBOT-ULTRASOUND PROBE FOR PROSTATE BIOPSY 有权
公开(公告)号：EP2836133B1
公开(公告)日：2018-08-29
申请号：EP13775721.7
申请日：2013-04-10
申请人： The Johns Hopkins University
发明人： STOIANOVICI, Dan , HAN, Misop , PETRISOR, Doru , KIM, Chunwoo
IPC分类号： A61B10/02 , A61B8/08 , A61B8/12 , A61B8/00 , A61B34/30 , A61B18/00 , A61B17/34 , A61B17/00 , A61B90/00
CPC分类号： A61B10/0241 , A61B8/0841 , A61B8/12 , A61B8/4245 , A61B34/30 , A61B2017/00274 , A61B2017/3413 , A61B2018/00547 , A61B2090/3782 , F04C2270/0421
摘要： An embodiment in accordance with the present invention provides a device and method for a transrectal ultrasound (TRUS) guided prostate biopsy. The device includes an ultrasound wand equipped with a lateral fire ultrasound sensor. The ultrasound wand also defines a channel having an oblique path though the wand. The channel accommodates a biopsy needle, which can be pivoted as well inserted through the channel to different depths in order to perform a biopsy of the prostate. The device therefore uses only three degrees-of-freedom of movement in order to obtain the biopsy samples. Additionally, the ultrasound wand can be used to generate a three-dimensional image of the prostate.

4. 发明公开

EP2637571A2 REMOTE CENTER OF MOTION ROBOT FOR MEDICAL IMAGE SCANNING AND IMAGE-GUIDED TARGETING 有权
标题翻译： FERNZENTRALE EINES BEWEGUNGSROBOTERS ZUM SCANNEN MEDISINISCHER BILDER UNDFÜRBILDGESTEUERTE ANZIELUNGEN
公开(公告)号：EP2637571A2
公开(公告)日：2013-09-18
申请号：EP11840646.1
申请日：2011-11-11
申请人： The Johns Hopkins University
发明人： STOIANOVICI, Dan , PETRISOR, Doru , SCHAFER, Felix , KIM, Chunwoo , HAN, Misop
IPC分类号： A61B8/14 , A61N7/00
摘要： The present invention pertains to a remote center of motion robot for medical image scanning and image-guided targeting, hereinafter referred to as the "Euler" robot. The Euler robot allows for ultrasound scanning for 3-Dimensional (3-D) image reconstruction and enables a variety of robot-assisted image-guided procedures, such as needle biopsy, percutaneous therapy delivery, image-guided navigation, and facilitates image-fusion with other imaging modalities. The Euler robot can also be used with other handheld medical imaging probes, such as gamma cameras for nuclear imaging, or for targeted delivery of therapy such as high-intensity focused ultrasound (HIFU). 3-D ultrasound probes may also be used with the Euler robot to provide automated image-based targeting for biopsy or therapy delivery. In addition, the Euler robot enables the application of special motion-based imaging modalities, such as ultrasound elastography.
摘要翻译：本发明涉及用于医学图像扫描和图像引导瞄准的远程运动机器人中心，以下称为“欧拉”机器人。欧拉机器人可以进行三维（3-D）图像重建的超声波扫描，并实现各种机器人辅助图像引导程序，如针刺活检，经皮治疗传递，图像引导导航和促进图像融合与其他成像方式。欧拉机器人还可以与其他手持式医学成像探头一起使用，例如用于核成像的伽马照相机，或用于靶向递送治疗如高强度聚焦超声（HIFU）。 3-D超声探头也可以与欧拉机器人一起使用，以提供基于图像的定向靶向活检或治疗。此外，欧拉机器人能够应用特殊的基于运动的成像方式，如超声弹性成像。

5. 发明申请

WO2017192796A1 REMOTE CENTER OF MOTION ROBOT 审中-公开
标题翻译：远程运动机器人中心
公开(公告)号：WO2017192796A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030958
申请日：2017-05-04
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , PETRISOR, Doru , JUN, Changhan , LIM, Sunghwan
IPC分类号： A61B34/35 , A61B34/30 , A61B90/11
摘要： An embodiment in accordance with the present invention provides a remote center of motion robot. The RCM here is a parallelogram bar type RCM mechanism with a novel joint arrangement. The novel joint arrangement facilitates the mounting of the medical instrument and offers improved clearance relative to the patient. Moreover, the robot was built to guide a bone biopsy cannula, needle, or drill. Even though exact interventional values are unknown, it is expected that the forces exerted laterally on the needle-guide are higher than those encountered for slender needle insertion into soft tissue. For this, the RCM has been built with novel structure to enhance stiffness.
摘要翻译：根据本发明的实施例提供了一种远程运动机器人中心。这里的RCM是一种平行四边形条形RCM机构，带有一种新颖的连接装置。新颖的关节布置方便了医疗器械的安装并提供了相对于患者更好的间隙。此外，机器人的建立是为了引导骨活检套管，针头或钻头。尽管确切的介入值是未知的，但可以预期横向施加在导针上的力高于细针插入软组织时遇到的力。为此，RCM采用新颖结构构建，以增强刚度。

6. 发明申请

WO2007065013A2 MULTI IMAGER COMPATIBLE ROBOT FOR IMAGE-GUIDED INTERVENTIONS, AUTOMATED BRACHYTHERAPY SEED DELIVERY APPARATUS AND METHODS AND SYSTEMS RELATED THERETO 审中-公开
标题翻译：用于图像导向干预的多图像兼容机器人，自动化BRACHYTHERAPY种子传送装置及其相关方法和系统
公开(公告)号：WO2007065013A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/046278
申请日：2006-12-04
申请人： THE JOHNS HOPKINS UNIVERSITY , STOIANOVICI, Dan , PATRICUI, Alexandru , MAZILU, Dumitru , PETRISOR, Doru , KAVOUSSI, Louis, R.
发明人： STOIANOVICI, Dan , PATRICUI, Alexandru , MAZILU, Dumitru , PETRISOR, Doru , KAVOUSSI, Louis, R.
IPC分类号： A61B5/103
CPC分类号： A61N5/1007 , A61B10/0233 , A61B17/3468 , A61B34/30 , A61B2017/00544 , A61B2034/304 , A61B2090/062 , A61N2005/101 , A61N2005/1011
摘要： Featured is a robot and a needle delivery apparatus. Such a robot comprises a plurality of actuators coupled to control locating any of number of intervention specific medical devices such as intervention specific needle injectors. Such a robot is usable with image guided interventions using any of a number of types of medical imaging devices or apparatuses including MRI. The end-effector can include an automated low needle delivery apparatus that is configured for dose radiation seed brachytherapy injection. Also featured is an automated seed magazine for delivering seeds to such an needle delivery apparatus adapted for brachytherapy seed injection.
摘要翻译：特色是一个机器人和一个针送出装置。这样的机器人包括多个致动器，其耦合以控制定位任意数量的干预特定医疗装置，例如干预专用针注射器。这样的机器人可用于使用多种类型的医学成像装置或包括MRI的装置中的任何一种的图像引导干预。末端执行器可以包括被配置用于剂量辐射种子近距离放射治疗注射的自动化低针递送装置。还有一种自动种子杂志，用于将种子输送到适于近距离放射治疗种子注射的针式输送装置中。

7. 发明申请

WO2007021743A2 PNEUMATIC STEPPER MOTOR 审中-公开
标题翻译：气动步进电机
公开(公告)号：WO2007021743A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031030
申请日：2006-08-09
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , PATRICIU, Alexandru , MAZILU, Dumitru , PETRISOR, Doru , KAVOUSSI, Louis, R.
IPC分类号： F16H1/32 , F16H49/00
CPC分类号： F01C1/10 , F16H1/32 , F16H35/00 , F16H2001/325 , F16H2001/327 , Y10T74/19
摘要： A stepper motor suitable for use in a medical imaging environment has (a) a cylindrical central gear (10) having two ends (11a, 11b) with a center line (12) extending between these ends, and an external surface (13) with circumferentially distributed and radially directed teeth (14), (b) a means for mounting the central gear (10) such that it is constrained to move in rotational motion about its centerline (12), (c) a cylindrical hoop gear (20) having a bore (22) with an internal surface (24) having circumferentially distributed and radially directed teeth (26), (d) a means for mounting (40) the hoop gear such that it is constrained to move in translational-circular motion about the central gear's centerline (12), wherein this central gear (10) is further configured to fit within the hoop gear's bore (22) in such a manner that a plurality of the central gear (14) and hoop gear (26) teeth intermesh, and wherein these hoop gear teeth (26) are further configured so as to cooperate with the central gear teeth (14) so that the planetary movement of the hoop gear teeth causes the central gear (10) to rotate, and (e) a means for applying a fluid pressure driven force to specified points on the hoop gear (20) so as to cause its movement.
摘要翻译：适用于医学成像环境的步进电机具有（a）圆柱形中心齿轮（10），其具有两端（11a，11b），中心线（12）在这些端部之间延伸，和具有圆周分布且径向定向的齿（14）的外表面（13），（b）用于安装中心齿轮（10）的装置，使得它被限制围绕其中心线（12）旋转运动，（c））具有孔（22）的圆柱形环形齿轮（20），所述孔具有内表面（24），所述内表面具有周向分布且径向定向的齿（26），（d）用于将所述环形齿轮安装（40）以围绕中心齿轮的中心线（12）进行平移 - 圆周运动，其中该中心齿轮（10）进一步构造成以这样的方式配合在箍齿轮的孔（22）内，使得多个中心齿轮（14）和环形齿轮（26）的齿互相啮合，并且其中这些环形齿轮齿（26）进一步构造成冷却与中心齿轮齿（14）磨合，使得环形齿轮齿的行星运动导致中心齿轮（10）旋转，以及（e）用于将流体压力驱动力施加到环形齿轮上的指定点的装置 20）以便引起它的移动。

8. 发明申请

WO2019160595A1 LIQUID BIOPSY METHOD AND DEVICE 审中-公开
公开(公告)号：WO2019160595A1
公开(公告)日：2019-08-22
申请号：PCT/US2018/062963
申请日：2018-11-29
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , PETRISOR, Doru , JUN, Changhan , PIENTA, Kenneth J.
IPC分类号： A61B10/02 , C12M1/26 , B01D43/00 , C12Q1/24 , G01N33/49
摘要： An embodiment in accordance with the present invention provides a method and device that leverages a controlled scanning process for CTC-antibody binding, rather than classic random mixing. Magnetophoretic direct extraction is used to extract the CTCs onto a standard microscope slide. A device according to the present invention includes a vial into which a CTC bearing solution is combined with antibody-bound-PMP beads. An electromagnet is used to apply a magnetic field to engage the beads along the magnetic lines across the vial. The magnetic field and in turn the beads are moved on a fine pitch helical trajectory. The entire volume of the vial is scanned in this manner, allowing beads to come into close proximity to any CTCs present, and to collect all of the CTCs in the vial.

9. 发明申请

WO2017205368A1 NEEDLE-GUIDE ROBOT WITH PRESET DEPTH OF INSERTION 审中-公开
标题翻译：具有预置插入深度的针引导机器人
公开(公告)号：WO2017205368A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/033991
申请日：2017-05-23
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , PETRISOR, Doru
IPC分类号： A61B10/02 , A61B90/11 , A61B34/30
CPC分类号： A61B10/0233 , A61B34/30 , A61B90/11 , A61B2017/3409 , A61B2090/034 , A61B2090/374
摘要： An embodiment in accordance with the present invention provides a robot structure that includes an MRI-Safe pneumatic stepper motor and optical encoding technologies. The present invention includes a needle guide and a needle depth limiter. The needle for biopsy is inserted through the needle guide and the depth of inserting is limited by the needle depth limiter. The robot is configured to control this procedure. The robot structure is adapted for biopsy, a novel way of setting the depth of needle insertion, image-to-robot registration. The system includes control for the robot.
摘要翻译：根据本发明的实施例提供了一种机器人结构，其包括MRI安全气动步进电机和光学编码技术。本发明包括针引导件和针深度限制器。活检针穿过导针器插入，深度限制器限制插入深度。机器人配置为控制此过程。机器人结构适用于活检，这是一种设置针插入深度，图像与机器人配准的新方法。该系统包含对机器人的控制。

10. 发明申请

WO2017184928A1 DEVICES AND METHODS FOR MAGNETIC ISOLATION AND ANALYSIS OF RARE CELLS 审中-公开
标题翻译：用于磁性分离和稀有细胞分析的装置和方法
公开(公告)号：WO2017184928A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028746
申请日：2017-04-21
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： STOIANOVICI, Dan , PIENTA, Kenneth J. , GORIN, Michael A.
IPC分类号： C12M3/06 , C12Q1/24 , G01N33/487 , B01D43/00
CPC分类号： C12M33/14 , B01L3/502 , B01L3/508 , B01L3/5635 , B01L2200/025 , B01L2200/026 , B01L2200/0631 , B01L2200/0668 , B01L2300/0609 , B01L2300/087 , B01L2400/043 , C12M3/06 , C12M25/02 , C12M47/04 , G01N1/2813 , G01N1/312 , G01N1/4077 , G01N33/54326 , G01N35/0098 , G01N2001/4088 , G01N2015/1006
摘要： An embodiment in accordance with the present invention provides two devices for the isolation of rare cell populations such as circulating tumor cells (CTCs). Both devices use magnetic fields to manipulate cells that are bounded to paramagnetic particles (PMP). One device uses surface tension and a sieve for cell filtration, whereas the other allows for the direct transfer of cells onto a standard microscope slide. Subsequent processing steps may be directly performed on the devices thereby minimizing cell losses. The first device is referred to as the ST (surface tension) device and the second device is referred to as the DT (direct transfer) device. The ST device can also be considered as a chip for the isolation of the rare cell populations.
摘要翻译：根据本发明的一个实施方案提供了用于分离稀有细胞群例如循环肿瘤细胞（CTC）的两种装置。这两种装置都使用磁场来操纵与顺磁性颗粒（PMP）结合的细胞。一个装置使用表面张力和筛子进行细胞过滤，而另一个装置允许将细胞直接转移到标准显微镜载玻片上。随后的处理步骤可以直接在设备上执行，从而最小化单元损耗。第一个装置称为ST（表面张力）装置，第二个装置称为DT（直接转移）装置。 ST器件也可以被视为分离稀有细胞群的芯片。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式