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1. 发明申请

WO1997010820A1 STABLE VITAMIN C PREPARATION 审中-公开
标题翻译：稳定的维生素C制剂
公开(公告)号：WO1997010820A1
公开(公告)日：1997-03-27
申请号：PCT/JP1996002693
申请日：1996-09-18
申请人： THE GREEN CROSS CORPORATION , KIDO, Takae , KODAIRA, Hideto , MUNECHIKA, Koji , ABE, Shunichi , UEDA, Yasuo
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K31/375
CPC分类号： A61K9/0019 , A61K31/375 , A61K47/02
摘要： A stable vitamin C preparation and a method for stabilizing a vitamin C preparation. Because of the incorporation of magnesium ions having the effect of stabilizing vitamin C, the preparation can remain stable for a prolonged period of time.
摘要翻译：稳定的维生素C制剂和稳定维生素C制剂的方法。由于并入具有稳定维生素C作用的镁离子，所以制剂可以长时间保持稳定。

2. 发明申请

WO1995028906A1 TRANSFUSION CONTAINER, TRANSFUSION PREPARATION, AND COMPREHENSIVE VITAMIN-CONTAINING HIGH-CALORIE TRANSFUSION PREPARATION 审中-公开
标题翻译：转运容器，转运制剂和含有维生素的高分子量转运制剂
公开(公告)号：WO1995028906A1
公开(公告)日：1995-11-02
申请号：PCT/JP1995000778
申请日：1995-04-20
申请人： THE GREEN CROSS CORPORATION , KIDO, Takae , KODAIRA, Hideto , MUNECHIKA, Koji , II, Shigeo , ABE, Shunichi , YOKOYAMA, Kazumasa
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61J01/05
CPC分类号： A61K9/0029 , A61J1/10 , A61J1/2034 , A61J1/2093 , A61K45/06
摘要： A transfusion container useful for preparing a transfusion containing saccharide, amino acid, electrolyte, fat emulsion and vitamin. The container is composed of two compartments with a partitioning means provided therebetween, and a first compartment contains a transfusion containing fat emulsion, saccharide and specified vitamin, while a second compartment contains a transfusion containing amino acid, electrolyte and other specified vitamin. A transfusion preparation containing saccharide, amino acid, electrolyte, fat emulsion and vitamin can be readily and aseptically prepared by removing the partitioning means prior to use and mixing the transfusions contained in the two compartments together.
摘要翻译：用于制备含有糖，氨基酸，电解质，脂肪乳剂和维生素的输液的输液容器。容器由两个分隔部分组成，分隔装置设置在它们之间，第一隔室包含含有脂肪乳剂，糖类和特定维生素的输液，而第二隔室含有含有氨基酸，电解质和其它特定维生素的输液。包含糖，氨基酸，电解质，脂肪乳剂和维生素的输液制剂可以在使用前除去分隔装置并将包含在两个隔室中的输液混合在一起而容易地和无菌地制备。

3. 发明申请

WO1998018492A1 METHOD OF INHIBITING DRUG PRECIPITATION 审中-公开
标题翻译：抑制药物降解的方法
公开(公告)号：WO1998018492A1
公开(公告)日：1998-05-07
申请号：PCT/JP1997003859
申请日：1997-10-23
申请人： THE GREEN CROSS CORPORATION , KODAIRA, Hideto , KIDO, Takae , NAWA, Yoshihito , MUNECHIKA, Koji , UEDA, Yasuo
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K47/14
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1075 , A61K47/14 , A61K47/24
摘要： A method of inhibiting the precipitation of an acidic or basic drug which is liable to cause precipitation in aqueous solutions, such as a transfusion, by blending the drug with at least one ingredient selected among phospholipids, glycerides and synthetic surfactants, whereby it is possible to inhibit the precipitation of the drug liable to cause precipitation as a result of solubility lowering due to a pH change. Accordingly, it is possible to administer such a drug to a patient under the physiological pH conditions by mixing the drug with a transfusion having such an electrolyte composition as to fit the condition of the patient.
摘要翻译：通过将药物与选自磷脂，甘油酯和合成表面活性剂中的至少一种成分混合，抑制易于在水溶液中析出的酸性或碱性药物的沉淀的方法，例如输血，由此可以抑制由于pH变化引起的溶解性降低的结果，容易引起沉淀的药物的沉淀。因此，通过将药物与具有适合患者状况的电解质组成的输液混合，可以在生理pH条件下向患者施用这种药物。

4. 发明申请

WO1994008548A1 TRANSFUSION LIQUID-CONTAINING HOLDER AND PREPARED TRANSFUSION LIQUID 审中-公开
标题翻译：输送液含量保持器和准备好的转移液
公开(公告)号：WO1994008548A1
公开(公告)日：1994-04-28
申请号：PCT/JP1993001521
申请日：1993-10-21
申请人： THE GREEN CROSS CORPORATION , KIDO, Takae , II, Shigeo , ABE, Shunichi , YOKOYAMA, Kazumasa
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61J01/00
CPC分类号： A61K9/0029 , A61J1/10 , A61J1/2034 , A61J1/2093 , A61K45/06
摘要： A transfusion liquid set (transfusion liquid-containing holder) useful for preparing a transfusion liquid containing sugar, amino acid, electrolyte, fatty emulsion and vitamin. The present invention uses a holder formed so that the interior thereof is divided into two independent chambers by a partition means. A first chamber holds a transfusion liquid containing fatty emulsion, sugar, oil-soluble vitamin and specific water-soluble vitamin, and a second chamber a transfusion liquid containing amino acid, electrolyte and specific water-soluble vitamin. When a transfusion liquid is needed, the partition means is removed, and the transfusion liquids held in the first and second chambers are mixed with each other, so that a transfusion liquid containing sugar, amino acid, electrolyte, fatty emulsion and vitamin can be prepared easily and aseptically. The transfusion liquid components in each chamber have excellent stability.
摘要翻译：一种用于制备含有糖，氨基酸，电解质，脂肪乳和维生素的输液的输液装置（含输液装置）。本发明使用形成为通过分隔装置将其内部分成两个独立的室的保持器。第一室容纳含有脂肪乳剂，糖，油溶性维生素和特定水溶性维生素的输液，第二腔容纳含有氨基酸，电解质和特定水溶性维生素的输液。当需要输液时，移除分隔装置，并将保持在第一和第二腔室中的输液彼此混合，从而可以制备含有糖，氨基酸，电解质，脂肪乳和维生素的输液容易和无菌。每个室中的输液液体组分具有极好的稳定性。

5. 发明申请

WO1994018948A1 PROCESS FOR PRODUCING LIPOSOME COMPOSITION 审中-公开
标题翻译：生产脂质体组合物的方法
公开(公告)号：WO1994018948A1
公开(公告)日：1994-09-01
申请号：PCT/JP1994000075
申请日：1994-01-20
申请人： THE GREEN CROSS CORPORATION , MUNECHIKA, Koji , SEKI, Tomoyo , KISHI, Norihide , MATSUDA, Hiroshi , UEDA, Yasuo
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K09/127
CPC分类号： A61K9/1277
摘要： A process for producing a liposome composition which can inhibit the decomposition of the drugs contained therein, in particular, a physiologically active protein with a molecular weight of 500 to 100 thousand, has a high incorporation rate, can be administered subcutaneously or intramuscularly, and contributes to sustained release. The process comprises dissolving a lipid in a first organic solvent, preparing an emulsion by adding an aqueous drug solution to the lipid solution and emulsifying the resultant solution, mixing at a low temperature the emulsion with a second organic solvent wherein the lipid is sparingly soluble, recovering the precipitated fraction, and suspending the recovered fraction in an aqueous solvent.
摘要翻译：能够抑制其中所含药物分解的脂质体组合物的制造方法，特别是分子量为500〜10万的生理活性蛋白质具有高掺入率的方法，可以皮下或肌肉内给药，持续释放该方法包括将脂质溶解在第一有机溶剂中，通过向脂质溶液中加入药物溶液并乳化所得溶液来制备乳液，在低温下将乳液与第二有机溶剂混合，其中脂质微溶，回收沉淀的级分，并将回收的级分悬浮在水性溶剂中。

6. 发明申请

WO1994025059A1 NUTRITIONAL TRANSFUSION FOR PERIPHERAL VEIN ADMINISTRATION 审中-公开
标题翻译：营养管理外周血管理
公开(公告)号：WO1994025059A1
公开(公告)日：1994-11-10
申请号：PCT/JP1994000713
申请日：1994-04-27
申请人： THE GREEN CROSS CORPORATION , KIKUCHI, Masahiro , OKUTANI, Yoshihiko , INOUE, Tadaaki , MURASHIMA, Ryoichiro , ABE, Shunichi , KOSHIBA, Hiroshi , SHIBATA, Hiroshi , ISHII, Shunichiro , KAWABATA, Yoshiyasu , YOKOYAMA, Kazumasa
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K37/22
CPC分类号： A61K9/0029
摘要： A nutritional transfusion that can be administered via peripheral veins and is improved in stability and conservability. It contains a saccharide, an amino acid, an electrolyte and a fat emulsion each in a specified proportion and has specified pH value and titratable acidity. It has a good conservability because it is free from precipitation and denaturation in spite of its composition comprising the above various components. Further it is free from the problem of angialgia or the like even when administered via peripheral veins, since it has a specified pH value and a low titratable acidity.
摘要翻译：营养输液可通过外周静脉施用，并且稳定性和保守性得到改善。它含有糖，氨基酸，电解质和脂肪乳剂，每一种都以规定的比例，具有规定的pH值和可滴定的酸度。它具有良好的保守性，因为尽管其组合物包含上述各种组分，但它没有沉淀和变性。此外，即使通过周围静脉施用时，也没有血管紧张素等的问题，因为其具有指定的pH值和低滴定酸度。

7. 发明申请

WO1996033974A1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME 审中-公开
标题翻译：杂环酰胺化合物及其药物用途
公开(公告)号：WO1996033974A1
公开(公告)日：1996-10-31
申请号：PCT/JP1996001171
申请日：1996-04-26
申请人： THE GREEN CROSS CORPORATION , AKAHOSHI, Fumihiko , YOSHIMURA, Takuya , EDA, Masahiro , ASHIMORI, Atsuyuki , FUKUYAMA, Hajime , NAKAJIMA, Masahide , IMADA, Teruaki , OKUNISHI, Hideki , MIYAZAKI, Mizuo
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C07D213/64
CPC分类号： C07D213/73 , C07D213/75 , C07D239/47
摘要： Heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts of the same and a medicinal composition comprising the same, wherein each symbol has the meaning as defined in the specification. The heterocyclic amide compounds and pharmacologically acceptable salt thereof have excellent effects of inhibiting chymases on mammals including human being and can be orally or parenterally administered. Thus they are useful as a chymase inhibitor and can be used in the prevention and treatment of various diseases caused by chymases such as those caused by angiotensin II.
摘要翻译：由通式（I）表示的杂环化合物或其药理学上可接受的盐及包含其的药用组合物，其中每个符号具有说明书中定义的含义。杂环酰胺化合物及其药理学上可接受的盐具有抑制糜烂酶对包括人在内的哺乳动物的口服或肠胃外给药的优异效果。因此，它们可用作胃促胰酶抑制剂，并且可用于预防和治疗由糜酶如由血管紧张素II引起的各种疾病引起的各种疾病。

8. 发明申请

WO1996003503A1 PROCESS FOR PRODUCING URINARY TRYPSIN INHIBITOR AND DOMAINS THEREOF, NOVEL POLYPEPTIDE RELATED TO THE BOTH, AND PROCESS FOR PRODUCING THE POLYPEPTIDE 审中-公开
标题翻译：用于生产尿素抑制剂及其领域的方法，与两相关的新型多肽，以及生产多肽的方法
公开(公告)号：WO1996003503A1
公开(公告)日：1996-02-08
申请号：PCT/JP1995001449
申请日：1995-07-21
申请人： THE GREEN CROSS CORPORATION , IDENO, Shoji , GOTO, Takashi , HORII, Hajime
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C12N15/12
CPC分类号： C07K14/8103 , A61K38/00
摘要： A process for producing a urinary human trypsin inhibitor (UTI) and domains thereof by using a yeast of the genus Pichia as the host cell; an expression system related thereto; a novel polypeptide at least having the amino acid sequence represented by formula (I) in the specification; a DNA coding for the same; an expression vector containing the DNA; a transformant containing the vector; and a process for producing the polypeptide. The above UTI, expression system of each domain thereof, and process for producing the UTI and domains thereof enable UTI and domains thereof to be mass-produced readily and efficiently. The use of the expression system facilitates the preparation of variants or derivatives of UTI and so forth and contributes to the development of novel medicines such as a protease inhibitor. The invention also provides a novel useful polypeptide which is more excellent in elastase inhibitory activity than natural UTI and can be mass-produced.
摘要翻译：通过使用毕赤酵母属的酵母作为宿主细胞来制备尿胰蛋白酶抑制剂（UTI）及其结构域的方法; 与此有关的表达制度; 至少具有说明书中由式（I）表示的氨基酸序列的新型多肽; 编码相同的DNA; 含有DNA的表达载体; 含有载体的转化体以及产生该多肽的方法。上述UTI，其每个结构域的表达系统，以及UTI及其结构域的制备方法使得UTI及其结构域容易且有效地批量生产。表达系统的使用促进了UTI等变体或衍生物的制备，并有助于新型药物如蛋白酶抑制剂的开发。本发明还提供了一种与天然UTI相比弹性蛋白酶抑制活性更优异的新型有用多肽，可以批量生产。

9. 发明申请

WO1995007898A1 SUCCINAMIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 审中-公开
标题翻译：磺胺酸化合物，其生产方法及其用途
公开(公告)号：WO1995007898A1
公开(公告)日：1995-03-23
申请号：PCT/JP1994001266
申请日：1994-08-01
申请人： SENJU PHARMACEUTICAL CO., LTD. , THE GREEN CROSS CORPORATION , HOSONO, Hiroshi , NISHIO, Toshiyuki , ISHIKAWA, Hiromichi , NAKAMURA, Yoshiyuki , MATSUI, Tetsuo
发明人： SENJU PHARMACEUTICAL CO., LTD. , THE GREEN CROSS CORPORATION
IPC分类号： C07D277/64
CPC分类号： C07D277/64
摘要： A novel succinamic acid compound represented by general formula (1) or a pharmaceutically acceptable salt thereof; a preventive and/or a remedy for complications of diabetes containing the compound or the salt as the active ingredient; an aldose reductase inhibitor containing the compound or the salt as the active ingredient; and a process for producing the compound or the salt. In said formula, R represents alkyl or lower alkenyl, and R represents carboxyl which may be esterified. The invention compound (1) and the salt have a potent aldose reductase inhibitor activity on mammals including humans and an excellent safety, and hence are useful as a remedy for therapeutic treatment of complications of diabetes, such as failure of corneal lesion union, cataract, neurosis, retinopathy and nephropathy, especially cataract and neurosis. The invention process can provide the invention compounds having such a usefulness efficiently.
摘要翻译：一种由通式（1）表示的新型琥珀酰胺酸化合物或其药学上可接受的盐; 包含化合物或盐作为活性成分的糖尿病并发症的预防和/或补救措施; 含有该化合物或该盐作为有效成分的醛糖还原酶抑制剂; 以及该化合物或其盐的制造方法。在所述式中，R 1表示烷基或低级烯基，R 2表示可被酯化的羧基。本发明化合物（1）和盐具有对包括人类在内的哺乳动物有效的醛糖还原酶抑制剂活性，并且具有优异的安全性，因此可用作治疗糖尿病并发症的治疗方法，例如角膜损伤联合失败，白内障，神经症，视网膜病变和肾病，特别是白内障和神经症。本发明方法可以有效地提供具有这种有效性的本发明化合物。

10. 发明申请

WO1994021688A1 METHOD OF DECOLORING HUMAN SERUM ALBUMIN 审中-公开
标题翻译：分解人血清白蛋白的方法
公开(公告)号：WO1994021688A1
公开(公告)日：1994-09-29
申请号：PCT/JP1994000459
申请日：1994-03-22
申请人： THE GREEN CROSS CORPORATION , SUMI, Akinori , NODA, Munehiro , OHTANI, Wataru , OHMURA, Takao
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C07K15/06
CPC分类号： C07K14/625 , A61K38/00
摘要： A human serum albumin (HSA) derived from the plasma is treated with a chelate resin, preferably one having a nitrogenous exchange group as the ligand, in the step of purifying HSA, particularly preferably in the final stage thereof. This method serves to remove some kind of colored components of the plasma, such as bilirubin, which have been difficult to remove satisfactorily by the conventional method of purifying plasma-derived HSA. It is particularly useful for removing colored components having an absorption wavelength around 450 nm, i.e., red-colored components, thus giving HSA sufficiently reduced in coloration.
摘要翻译：在纯化HSA的步骤中，特别优选在最后阶段，用螯合树脂（优选具有含氮交换基团的螯合树脂作为配体）处理来源于血浆的人血清白蛋白（HSA）。该方法用于除去血浆衍生的HSA的常规方法难以令人满意地除去血浆中某些有色组分，如胆红素。特别有用于除去具有约450nm的吸收波长的有色成分，即红色成分，从而使HSA的着色充分降低。

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