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1. 发明申请

WO2009120769A1 HUMAN ANTI-MESOTHELIN MONOCLONAL ANTIBODIES 审中-公开
标题翻译：人类抗美援素单克隆抗体
公开(公告)号：WO2009120769A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038228
申请日：2009-03-25
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , DIMITROV, Dimiter, S. , FENG, Yang , PASTAN, Ira, H.
发明人： DIMITROV, Dimiter, S. , FENG, Yang , PASTAN, Ira, H.
IPC分类号： C07K16/30 , G01N33/48 , A61P35/00
CPC分类号： C07K16/30 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2319/55 , G01N33/57484
摘要： Disclosed herein are isolated human monoclonal antibodies that specifically bind human mesothelin with a binding affinity of about 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human mesothelin in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.
摘要翻译：本文公开了以约25nM或更低的结合亲和力特异性结合人间皮素的分离的人单克隆抗体。还公开了编码这些抗体的核酸，包括这些核酸分子的表达载体和表达核酸分子的分离的宿主细胞。抗体可用于检测样品中的人间皮素。本文公开了利用这些抗体的诊断癌症或确认癌症诊断的方法。还公开了治疗患有癌症的受试者的方法。

2. 发明申请

WO2005080436A2 ANTIBODIES THAT BIND POTE AND USES THEREOF 审中-公开
标题翻译：抗体，其包装和其使用
公开(公告)号：WO2005080436A2
公开(公告)日：2005-09-01
申请号：PCT/US2005/005419
申请日：2005-02-18
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan , LEE, Byungkook , NAGATA, Satoshi , ISE, Tomoko
发明人： PASTAN, Ira, H. , BERA, Tapan , LEE, Byungkook , NAGATA, Satoshi , ISE, Tomoko
IPC分类号： C07K16/18
CPC分类号： G01N33/574 , C07K14/47 , C07K16/30
摘要： POTE-21 and its paralogs are expressed in cancer, such as breast, prostate, lung, colon, pancreatic and ovarian cancer. Antibodies are disclosed herein that bind the N-terminal (extracellular) portion of POTE, or a paralog of POTE. These antibodies are of use in the detection and treatment of cancer. Methods for the treatment of cancer using a POTE polypeptide or fragment thereof are also described.
摘要翻译： POTE-21及其旁系同源物在癌症中表达，如乳腺癌，前列腺癌，肺癌，结肠癌，胰腺癌和卵巢癌。本文公开了结合POTE的N末端（细胞外）部分或POTE的旁系同源物的抗体。这些抗体可用于癌症的检测和治疗。还描述了使用POTE多肽或其片段治疗癌症的方法。

3. 发明申请

WO2005014644A1 GENE EXPRESSED IN BREAST CANCER AND METHODS OF USE 审中-公开
标题翻译：乳腺癌中表达的基因及其使用方法
公开(公告)号：WO2005014644A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/025448
申请日：2004-08-06
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , EGLAND, Kristi , LEE, Byungkook , VINCENT, James
发明人： PASTAN, Ira, H. , EGLAND, Kristi , LEE, Byungkook , VINCENT, James
IPC分类号： C07K14/705
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/705
摘要： A polypeptide is disclosed that is detected in the breast cancer cells termed 68h05. Polynucleotides encoding 68h05 are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind 68h05. Methods are disclosed for using a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05, such as in the treatment of breast cancer or prostate cancer. Assays are disclosed for the detection breast or prostate cancer. Pharmaceutical compositions including a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05 are also disclosed. These pharmaceutical compositions are of use in the treatment of breast or prostate cancer.
摘要翻译：公开了在称为68h05的乳腺癌细胞中检测到的多肽。还公开了编码68h05的多核苷酸，以及包括这些多核苷酸的载体也是公开的。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合68h05的抗体和免疫偶联物。公开了使用68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的方法，例如用于治疗乳腺癌或前列腺癌。公开了检测乳腺癌或前列腺癌的检测。还公开了包含68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的药物组合物。这些药物组合物可用于治疗乳腺癌或前列腺癌。

4. 发明申请

WO2002102985A3 PATE, A GENE EXPRESSED IN PROSTATE CANCER, PROSTATE AND TESTIS, AND USES THEREOF 审中-公开
公开(公告)号：WO2002102985A3
公开(公告)日：2002-12-27
申请号：PCT/US2002/019086
申请日：2002-06-14
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
IPC分类号： C07K16/00
摘要： An antibody is disclosed that specifically binds a PATE polypeptide. A nucleic acid sequence is disclosed that includes a PATE promoter or a conservative variant thereof. Methods are also disclosed for detecting prostate cancer in a subject. In one embodiment, a method is disclosed for producing an immune response against a cell expressing a PATE polypeptide in a subject. In another embodiment, a method is disclosed for inhibiting the growth of a malignant cell expressing a PATE polypeptide. A method is also disclosed for reducing the number of prostate cancer cells in a subject that includes administering to the subject a therapeutically effective amount of the PATE polypeptide or a polynucleotide encoding the PATE polypeptide. Kits for detecting PATE polypeptides and PATE polynucleotides are disclosed. In one embodiment, these kits are ofuse to detect prostate cancer. A method is also disclosed for increasing the proliferation of a prostate cell. The method includes contacting the prostate cell with a PATE polypeptide or transfecting the prostate cell with a nucleic acid encoding the P ATE polypeptide, thereby increasing the proliferation of the prostate cell.

5. 发明申请

WO2009032954A1 DELETIONS IN DOMAIN II OF PSEUDOMONAS EXOTOXIN A THAT REDUCE NON-SPECIFIC TOXICITY 审中-公开
标题翻译： PSEUDOMONAS EXOTOXIN的第二类中的残基减少非特异性毒性
公开(公告)号：WO2009032954A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075296
申请日：2008-09-04
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , WELDON, John , FITZGERALD, David
发明人： PASTAN, Ira, H. , WELDON, John , FITZGERALD, David
IPC分类号： C07K14/21 , C07K19/00 , C12N15/62 , C12N15/11 , A61K38/16
CPC分类号： C07K14/21 , A61K38/00 , C07K2319/30
摘要： The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
摘要翻译：本发明提供了突变的细胞毒性形式的假单胞菌外毒素A（PE），其包含与PE的残基395-613或该序列的变体直接缀合或融合的弗林蛋白酶切割序列。 PE的这些最小形式小于PE的先前细胞毒性形式，降低非特异性毒性，并降低由于PE的结构域II或结构域Ib引起的免疫原性。本发明还提供编码所述PE的核酸，含有它们的嵌合分子及其使用方法。

6. 发明申请

WO2003042370A3 NEW GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE 审中-公开
公开(公告)号：WO2003042370A3
公开(公告)日：2003-05-22
申请号：PCT/US2002/036648
申请日：2002-11-13
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , WOLFGANG, Curt , LEE, Byungkook , VINCENT, James
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , WOLFGANG, Curt , LEE, Byungkook , VINCENT, James
IPC分类号： C07K14/00
摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

7. 发明申请

WO2003042370A2 NEW GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE 审中-公开
标题翻译：在前列腺癌中表达的新基因和使用方法
公开(公告)号：WO2003042370A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036648
申请日：2002-11-13
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , WOLFGANG, Curt , LEE, Byungkook , VINCENT, James
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , WOLFGANG, Curt , LEE, Byungkook , VINCENT, James
IPC分类号： C12N
CPC分类号： C07K14/47 , A01K2217/05 , A61K39/00
摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译：公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合NGEP的抗体。公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。公开了检测前列腺癌的检测。还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。这些药物组合物可用于治疗前列腺癌。

8. 发明申请

WO2002102985A2 PATE, A GENE EXPRESSED IN PROSTATE CANCER, PROSTATE AND TESTIS, AND USES THEREOF 审中-公开
标题翻译： PATE，在前列腺癌，前列腺癌和TESTIS中表达的基因及其用途
公开(公告)号：WO2002102985A2
公开(公告)日：2002-12-27
申请号：PCT/US2002/019086
申请日：2002-06-14
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
IPC分类号： C12N
CPC分类号： C07K16/3069 , A61K2039/505
摘要： An antibody is disclosed that specifically binds a PATE polypeptide. A nucleic acid sequence is disclosed that includes a PATE promoter or a conservative variant thereof. Methods are also disclosed for detecting prostate cancer in a subject. In one embodiment, a method is disclosed for producing an immune response against a cell expressing a PATE polypeptide in a subject. In another embodiment, a method is disclosed for inhibiting the growth of a malignant cell expressing a PATE polypeptide. A method is also disclosed for reducing the number of prostate cancer cells in a subject that includes administering to the subject a therapeutically effective amount of the PATE polypeptide or a polynucleotide encoding the PATE polypeptide. Kits for detecting PATE polypeptides and PATE polynucleotides are disclosed. In one embodiment, these kits are ofuse to detect prostate cancer. A method is also disclosed for increasing the proliferation of a prostate cell. The method includes contacting the prostate cell with a PATE polypeptide or transfecting the prostate cell with a nucleic acid encoding the P ATE polypeptide, thereby increasing the proliferation of the prostate cell.
摘要翻译：公开了特异性结合PATE多肽的抗体。公开了包含PATE启动子或其保守变体的核酸序列。还公开了用于检测受试者中前列腺癌的方法。在一个实施方案中，公开了用于产生针对受试者中表达PATE多肽的细胞的免疫应答的方法。在另一个实施方案中，公开了抑制表达PATE多肽的恶性细胞生长的方法。还公开了一种减少受试者中前列腺癌细胞数量的方法，其包括向受试者施用治疗有效量的PATE多肽或编码PATE多肽的多核苷酸。公开了用于检测PATE多肽和PATE多核苷酸的试剂盒。在一个实施方案中，这些试剂盒可用于检测前列腺癌。还公开了用于增加前列腺细胞增殖的方法。该方法包括使前列腺细胞与PATE多肽接触或用编码P ATE多肽的核酸转染前列腺细胞，从而增加前列腺细胞的增殖。

9. 发明公开

EP1085908A2 RECOMBINANT IMMUNOTOXIN DIRECTED AGAINST THE HIV-1 GP120 ENVELOPE GLYCOPROTEIN 有权
标题翻译：抗HIV-1 GP120包膜糖蛋白定点重组免疫毒素
公开(公告)号：EP1085908A2
公开(公告)日：2001-03-28
申请号：EP99930180.7
申请日：1999-06-08
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , KENNEDY, Paul, E. , BERGER, Edward, A. , BARBAS, Carlos, F., III
IPC分类号： A61K47/48
CPC分类号： C07K16/1063 , A61K47/6829 , A61K47/6841 , A61K47/6849 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： This invention provides an immunotoxin that specifically binds to and kills cells displaying an HIV gp120 coat protein. The immunotoxin comprises an anti-gp120 antibody directed to the conserved CD4 binding site of gp120 attached to a cytotoxin e.g. a Pseudomonas exotoxin. In one preferred embodiment the immunotoxin is a recombinantly expressed fusion protein comprising a single chain Fv region attached to a modified Pseudomonas exotoxin (3B3(Fv)-PE38).

10. 发明授权

EP2197903B9 DELETIONS IN DOMAIN II OF PSEUDOMONAS EXOTOXIN A THAT REDUCE NON-SPECIFIC TOXICITY 有权
标题翻译：缺失的II绿脓杆菌外毒素域，非特异性毒性REDUCE
公开(公告)号：EP2197903B9
公开(公告)日：2015-04-22
申请号：EP08799197.2
申请日：2008-09-04
申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
发明人： PASTAN, Ira, H. , WELDON, John , FITZGERALD, David
IPC分类号： C07K14/21 , C07K19/00 , C12N15/62 , C12N15/11 , A61K38/16
CPC分类号： C07K14/21 , A61K38/00 , C07K2319/30

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