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1. 发明申请

WO2013176955A1 CARDIOPROTECTIVE COMPOUNDS, THEIR USE WITH CHEMOTHERAPY, AND METHODS FOR IDENTIFYING THEM 审中-公开
标题翻译：保护性化合物，其与化疗有关的使用方法及其鉴定方法
公开(公告)号：WO2013176955A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/041334
申请日：2013-05-16
申请人： THE GENERAL HOSPITAL CORPORATION , PETERSON, Randall, T. , LIU, Yan
发明人： PETERSON, Randall, T. , LIU, Yan
IPC分类号： A61K31/122 , A61K31/136 , A61K31/704 , A61K31/353 , A61K31/37
CPC分类号： A61K31/352 , A61K31/17 , A61K31/37 , A61K31/496 , A61K31/704 , A61K49/0008 , A61K2300/00
摘要： The invention provides a method of reducing anthracycline-induced cardiotoxicity by administering a toxicity-reducing compound, such as a compound of Formulas (I), (II) or (III) or a combination thereof, and/or diphenyl urea (DPU), dexrazoxane (DEX), to a patient receiving an anthracycline. The invention also provides a method of identifying toxicity-reducing compounds.
摘要翻译：本发明提供了通过施用毒性降低化合物，例如式（I），（II）或（III）的化合物或其组合和/或二苯基脲（DPU），降低蒽环类诱导的心脏毒性的方法，右美沙芬（DEX）给予接受蒽环类抗生素的患者。本发明还提供鉴定毒性降低化合物的方法。

2. 发明申请

WO2018232251A1 TRICYCLIC COMPOUNDS AS CYP1 INHIBITORS 审中-公开
公开(公告)号：WO2018232251A1
公开(公告)日：2018-12-20
申请号：PCT/US2018/037770
申请日：2018-06-15
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PETERSON, Randall T. , ASNANI, Aarti , LIU, Yan , ZHENG, Baohui , WANG, You
IPC分类号： A61K31/365 , A61K31/366 , A61K31/37 , C07D493/00 , C07D493/02 , C07D493/04
摘要： The present application provides tricyclic compounds useful, e.g., in treating or preventing cardiotoxicity and cardiomyopathy in patients undergoing cardiotoxic chemotherapy. Methods of making and using the tricyclic compounds to treat cancer are also described.

3. 发明申请

WO2009144623A1 CONTROL OF MEASUREMENT AND/OR TREATMENT MEANS OF A PROBE 审中-公开
标题翻译：探测器和/或处理手段的控制
公开(公告)号：WO2009144623A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052094
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , THUMMA, Kiran, K.
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , THUMMA, Kiran, K.
IPC分类号： A61B5/00 , A61B5/103
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/443 , A61B5/6843 , A61B2562/0247 , A61B2562/046
摘要： The present invention provides a system (110) for controlling measurement and/or treatment means of a probe (10). The system (110) comprises a probe (10) with an outwardly curved probe head (11) having a contact surface (12) adapted for contacting skin (13) of a human or animal body. A plurality of pressure sensors (23) is distributed over the contact surface (12), the plurality of pressure sensors (23) being for obtaining a feedback signal indicative of locations where contact exists between the probe (10) and skin (13) of the human or animal body, also referred to as target locations. The system (110) furthermore comprises a controller (17) for selectively driving measurement and/or treatment means located at the target location based on the feedback signal from the pressure sensors (23). The present invention also provides a method for making a system (110) for controlling measurement and/or treatment means of a probe (10) and a method for controlling measurement and/or treatment means of a probe (10).
摘要翻译：本发明提供一种用于控制探针（10）的测量和/或处理装置的系统（110）。系统（110）包括具有向外弯曲的探针头（11）的探针（10），所述探头具有适于接触人体或动物体的皮肤（13）的接触表面（12）。多个压力传感器（23）分布在接触表面（12）上，多个压力传感器（23）用于获得指示探针（10）和皮肤（13）之间存在触点的位置的反馈信号人体或动物体，也称为目标位置。系统（110）还包括控制器（17），用于基于来自压力传感器（23）的反馈信号选择性地驱动位于目标位置处的测量和/或处理装置。本发明还提供了一种用于制造用于控制探针（10）的测量和/或处理装置的系统（110）的方法和用于控制探针（10）的测量和/或处理装置的方法。

4. 发明申请

WO2009144622A1 LOCATION INDICATING DEVICE 审中-公开
标题翻译：位置指示装置
公开(公告)号：WO2009144622A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052093
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , KOLEN, Alexander, F. , WAGEMAKERS, Femke , VON BASUM, Golo
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , KOLEN, Alexander, F. , WAGEMAKERS, Femke , VON BASUM, Golo
IPC分类号： A61B5/053 , A61B5/103 , A61B5/15
CPC分类号： A61B5/0531 , A61B5/0053 , A61B5/150022 , A61B5/150106 , A61B5/150748 , A61B5/150824 , A61B5/151 , A61B5/4824 , A61B5/4827 , A61B5/489 , A61B5/6842 , A61B2562/0209 , A61B2562/046
摘要： The present invention provides a location indicating device (10) for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body. The location indicating device (10) comprises a matrix (7) of electrodes for determining skin resistance at different locations on skin of a human or animal body and a calculating unit (8) for calculating a location with highest skin resistance. The location indicating device (10) furthermore comprises visualisation means (9) for indicating the location of highest skin resistance to a user. The present invention also provides a method for making such a location indicating device (10) and a method for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body by using such a location indicating device (10).
摘要翻译：本发明提供一种位置指示装置（10），用于在人体或动物体的皮肤上确定用于在人体或动物体内进行和/或治疗的生理参数的测量的位置。位置指示装置（10）包括用于确定人体或动物体皮肤上不同位置处的皮肤电阻的电极矩阵（7）和用于计算具有最高皮肤电阻的位置的计算单元（8）。位置指示装置（10）还包括用于指示对使用者的最高皮肤电阻位置的可视化装置（9）。本发明还提供了一种用于制造这样的位置指示装置（10）的方法和用于在人或动物身体的皮肤上确定用于在人或动物体内进行和/或治疗的生理参数的测量的位置的方法通过使用这样的位置指示装置（10）。

5. 发明申请

WO2009117726A3 HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS 审中-公开
公开(公告)号：WO2009117726A3
公开(公告)日：2009-09-24
申请号：PCT/US2009/037907
申请日：2009-03-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, Jiayu , SONG, Yang , ZHAO, Yongfeng , LIU, Yan
发明人： LIAO, Jiayu , SONG, Yang , ZHAO, Yongfeng , LIU, Yan
IPC分类号： C07K11/00 , G01N33/68 , G01N33/52
摘要： The disclosure provides method and composition utilizing fluorescent amino acids and fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors.

6. 发明申请

WO2009092198A1 HYBRID VEHICLE HAVING TORSIONAL COUPLING BETWEEN ENGINE ASSEMBLY AND MOTOR-GENERATOR 审中-公开
标题翻译：发动机总成与发电机之间具有扭转耦合的混合动力车
公开(公告)号：WO2009092198A1
公开(公告)日：2009-07-30
申请号：PCT/CN2008/002072
申请日：2008-12-25
申请人： BYD COMPANY LIMITED , LUO, Hongbin , REN, Yi , YANG, Shenglin , WANG, Tao , LIU, Yan
发明人： LUO, Hongbin , REN, Yi , YANG, Shenglin , WANG, Tao , LIU, Yan
IPC分类号： B60K6/38 , B60W10/02 , B60W20/00 , B60K6/44 , B60W10/08 , B60L11/02 , F16F15/134 , F16D21/06 , F16D48/06
CPC分类号： B60W20/40 , B60K1/02 , B60K6/387 , B60K6/405 , B60K6/442 , B60L2240/421 , B60L2240/441 , B60W10/02 , B60W10/06 , B60W10/08 , B60W10/26 , B60W20/00 , B60W2510/0638 , B60W2510/081 , F16D3/66 , F16D48/02 , F16D2500/1024 , F16D2500/1066 , F16D2500/3024 , F16D2500/30401 , F16D2500/7027 , F16D2500/70406 , F16D2500/7041 , Y02T10/6234 , Y02T10/6269 , Y02T10/6286 , Y02T10/642 , Y10S903/912 , Y10S903/946
摘要： A hybrid vehicle has a power system (102) with a torsional coupling (206). The power system (102) includes a battery system (110) for receiving, storing and providing electrical power, an internal combustion engine (104) configured to provide rotational power through a flywheel (1804), a first motor-generator (106), a second motor-generator (108), a control system (202), and a torsional coupling (206). The torsional coupling (206) may absorb rotational shock caused by angular or rotational speed differences between the engine (104) and the first motor-generator (106). The torsional coupling (206) includes a driven plate assembly (1806), a cover assembly (1808) and an interconnecting plate assembly (1810). The interconnecting plate assembly (1810) may include a plurality of shock absorbing elements (1910) that absorb shock and vibration between the engine (104) and the motor-generator (106; 108).
摘要翻译：混合动力车辆具有带扭转联轴器（206）的动力系统（102）。电力系统（102）包括用于接收，存储和提供电力的电池系统（110），配置成通过飞轮（1804）提供旋转动力的内燃机（104），第一电动发电机（106）第二电动发电机（108），控制系统（202）和扭转联轴器（206）。扭转联轴器（206）可以吸收由发动机（104）和第一电动发电机（106）之间的角速度或转速差引起的旋转冲击。扭转联轴器（206）包括从动板组件（1806），盖组件（1808）和互连板组件（1810）。互连板组件（1810）可以包括吸收发动机（104）和电动发电机（106; 108）之间的冲击和振动的多个减震元件（1910）。

7. 发明申请

WO2008036486A1 MEMBRANE SUPPRESSOR WITH AN OUTLET SUBSTANTIALLY NON-RETENTIVE FOR IONIC SPECIES 审中-公开
标题翻译：具有出口的膜抑制剂对于离子物质具有非常重要的作用
公开(公告)号：WO2008036486A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/076211
申请日：2007-08-17
申请人： DIONEX CORPORATION , LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
发明人： LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
IPC分类号： G01N30/02
CPC分类号： G01N30/96 , G01N2030/965
摘要： An apparatus for ion chromatography comprising a suppressor comprising a housing and a liquid conduit segment disposed in the housing, the liquid conduit segment including a membrane, the membrane having an inlet section adjacent the inlet of the conduit segment and an outlet section adjacent the outlet of the conduit segment, the inlet section having ion exchange sites capable of transmitting ions of one charge, positive or negative, and the outlet section being substantially non-retentive electrostatically for charged ionic species. Also, the method of using the apparatus.
摘要翻译：一种用于离子色谱的装置，包括抑制器，其包括壳体和设置在壳体中的液体导管段，液体导管段包括膜，所述膜具有邻近导管段入口的入口部分和邻近出口的出口部分导管部分，入口部分具有能够传输一个电荷的离子的正离子或负离子的离子交换位置，并且对于带电离子物质，出口部分静电地基本上是非保持性的。另外，使用该装置的方法。

8. 发明申请

WO2007035346A1 RECYCLING OF SUPPRESSOR REGENERANTS 审中-公开
标题翻译：抑制剂再生剂的回收
公开(公告)号：WO2007035346A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035628
申请日：2006-09-13
申请人： DIONEX CORPORATION , LIU, Yan , BARRETO, Victor, Manuel, Berber , POHL, Christopher, A. , RIVIELLO, John, M.
发明人： LIU, Yan , BARRETO, Victor, Manuel, Berber , POHL, Christopher, A. , RIVIELLO, John, M.
IPC分类号： G01N30/96
CPC分类号： G01N30/96 , G01N2030/965
摘要： A suppressed ion chromatographic apparatus using a regenerant recycle loop, comprising (a) an ion separation device (34) , (b) a membrane suppressor (36) , (c) a detector (38) , (d) a container for regenerant solution (40) , (e) a first conduit between the ion separation device and the suppressor, (f) a second conduit between the regenerant solution container and the suppressor, (g) a third conduit between the suppressor and the regenerant solution container, and (h) a regenerant solution recycle loop out of fluid communication with the detector outlet.
摘要翻译：一种使用再生剂循环回路的抑制离子色谱装置，包括（a）离子分离装置（34），（b）膜抑制剂（36），（c）检测器（38），（d）再生剂溶液容器（40），（e）离子分离装置和抑制器之间的第一导管，（f）再生剂溶液容器和抑制器之间的第二导管，（g）抑制器和再生剂溶液容器之间的第三导管，以及（h）与检测器出口流体连通的再生剂溶液循环回路。

9. 发明申请

WO2006004797A2 METHODS AND SYSTEMS FOR FEATURE SELECTION 审中-公开
标题翻译：特征选择的方法和系统
公开(公告)号：WO2006004797A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023018
申请日：2005-06-27
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK , LIU, Yan , KENDER, John, R.
发明人： LIU, Yan , KENDER, John, R.
IPC分类号： G06K9/62
CPC分类号： G06K9/6228 , G06K9/6229 , Y10S707/99937
摘要： Methods and systems for feature selection are described. In particular, methods and systems for feature selection for data classification, retrieval, and segmentation are described. Certain embodiments of the invention are directed to methods and systems for complement sort-merge tree (CSMT), fast-converging sort-merge tree (FSMT), and multi-level (ML) feature selection. Accurate and fast results may be obtained by the feature selection methods and systems described herein.
摘要翻译：描述用于特征选择的方法和系统。特别地，描述了用于数据分类，检索和分割的特征选择的方法和系统。本发明的某些实施例涉及用于补码分类合并树（CSMT），快速聚合分类合并树（FSMT）和多级（ML）特征选择的方法和系统。通过本文描述的特征选择方法和系统可以获得准确和快速的结果。

10. 发明申请

WO2021034888A1 MESOPOROUS SUPPORT-IMMOBILIZED METAL OXIDE-BASED NANOPARTICLES 审中-公开
公开(公告)号：WO2021034888A1
公开(公告)日：2021-02-25
申请号：PCT/US2020/046918
申请日：2020-08-19
申请人： OHIO STATE INNOVATION FOUNDATION , FAN, Liang-Shih , LIU, Yan , QIN, Lang , CHENG, Zhuo
发明人： FAN, Liang-Shih , LIU, Yan , QIN, Lang , CHENG, Zhuo
IPC分类号： B01J23/745 , B01J23/90 , B01J23/94 , C01B3/38 , C01B3/40 , C01B32/40
摘要： Exemplary oxygen carrier particles may comprise a mesoporous support and a plurality of metal oxide-based nanoparticles immobilized on the mesoporous support. The plurality of metal oxide-based nanoparticles may comprise 10 volume percent to 80 volume percent of mesopores in the mesoporous support. A reactor may comprise a feedstock inlet in fluid communication with a carbonaceous feedstock source, a product stream outlet, and oxygen carrier particles. Exemplary reactors may be operated by providing a carbonaceous feedstock to an inlet of the reactor, providing oxygen carrier particles within the reactor, and collecting a product stream from an outlet of the reactor.

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