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1. 发明申请

WO2013028848A1 BOUNDARY LAYER SUCTION FOR CELL CAPTURE 审中-公开
标题翻译：细胞捕获的边界层吸收
公开(公告)号：WO2013028848A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/052041
申请日：2012-08-23
申请人： THE GENERAL HOSPITAL CORPORATION , MITTAL, Sukant , TONER, Mehmet
发明人： MITTAL, Sukant , TONER, Mehmet
IPC分类号： C12Q1/00 , A61B6/02 , C12M3/00
CPC分类号： G01N1/34 , B01L3/502753 , G01N33/54366
摘要： Capturing particles includes introducing a fluid sample, which includes particles of a first type, into a first channel of a microfluidic device and flowing the fluid sample past a porous or partially porous membrane. The pores fluidly connect the first channel to a second channel, and the device further includes multiple binding moieties on a first side of the porous membrane adjacent to the first channel. The binding moieties are capable of binding to the first type of particles. Capturing particles also includes creating a pressure difference between the first and second channels to enable the fluid sample to flow from the first channel through the porous membrane into the second channel and to direct the particles toward the binding moieties, thereby capturing the first type of particles. In addition, by creating a modified capture surface that is impermeable near the walls of the channels, capture efficiencies and throughput can be increased.
摘要翻译：捕获颗粒包括将包括第一类型的颗粒的流体样品引入微流体装置的第一通道并使流体样品流过多孔或部分多孔的膜。孔隙将第一通道流体地连接到第二通道，并且该装置还包括在与第一通道相邻的多孔膜的第一侧上的多个结合部分。结合部分能够结合第一类型的颗粒。捕获颗粒还包括在第一和第二通道之间产生压差，使得流体样品能够从第一通道流过多孔膜进入第二通道并将颗粒引向结合部分，从而捕获第一类型的颗粒。此外，通过创建在通道壁附近不可透过的改进的捕获表面，可以提高捕获效率和产量。

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