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1. 发明申请

WO2011019864A2 METHODS FOR MOBILE ZINC MEASUREMENT 审中-公开
标题翻译：移动ZINC测量方法
公开(公告)号：WO2011019864A2
公开(公告)日：2011-02-17
申请号：PCT/US2010/045245
申请日：2010-08-12
申请人： THE GENERAL HOSPITAL CORPORATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LIPPARD, Stephen J. , ZHANG, Xiao-an , MEDAROVA, Zdravka , MOORE, Anna
发明人： LIPPARD, Stephen J. , ZHANG, Xiao-an , MEDAROVA, Zdravka , MOORE, Anna
IPC分类号： G01N33/52 , C07D311/86 , C07D405/12
CPC分类号： G01N33/5308 , G01N33/57434 , G01N33/582
摘要： This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc homeostasis, such as prostate cancer. The zinc sensor compound comprises an optical reporter having two or more recognition units where each of the recognition units is capable of associating with at least one zinc ion.
摘要翻译：本发明涉及一种使用锌传感器化合物检测与锌稳态破坏相关的疾病如前列腺癌的方法。锌传感器化合物包括具有两个或多个识别单元的光学报告物，其中每个识别单元能够与至少一种锌离子缔合。

2. 发明申请

WO2011163476A2 COLORIMETRIC METHOD AND DEVICE FOR DETECTING ANALYTE QUANTITIES IN FLUIDS AND MATERIALS 审中-公开
标题翻译：用于检测流体和材料中分析数量的彩色方法和装置
公开(公告)号：WO2011163476A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041630
申请日：2011-06-23
申请人： THE GENERAL HOSPITAL CORPORATION , MOORE, Anna , MEDAROVA, Zdravka , GHOSH, Subrata
发明人： MOORE, Anna , MEDAROVA, Zdravka , GHOSH, Subrata
IPC分类号： G01N33/52 , G01N21/31 , G01N21/78 , G01N33/20
CPC分类号： G01N21/78 , G01N21/03 , G01N21/0303 , G01N21/253 , G01N21/8483 , G01N33/493 , G01N33/52 , G01N2021/0325
摘要： A method and device for detecting an analyte in a solution or compound mixture use colorimetric detection to detect the quantity of an analyte in the solution or compound. The analyte sensor demonstrates a clear change in peak light absorption wavelength as a function of the stoichiometric relationship between the analyte sensor and the analyte. The method involves combining the analyte sensor and the analyte in solution and observing a color change of the mixture. Additionally, predefined amounts of the analyte sensor can be added until color change is detected and the quantity of analyte can be determined as a function of the total amount of analyte sensor in the mixture. Alternatively, a device having multiple wells or compartments, each with a different concentration of the analyte sensor. The analyte sample can be introduced to each well and the well that demonstrates the color change can, from its know analyte sensor concentration, be used to quickly and accurately determine the concentration of the analyte.
摘要翻译：用于检测溶液或化合物混合物中的分析物的方法和装置使用比色检测来检测溶液或化合物中分析物的量。分析物传感器表现出峰值光吸收波长的明显变化，作为分析物传感器和分析物之间的化学计量关系的函数。该方法包括将分析物传感器和分析物结合在溶液中并观察混合物的颜色变化。另外，可以添加预定量的分析物传感器，直到检测到颜色变化，并且可以将分析物的量确定为混合物中分析物传感器的总量的函数。或者，具有多个孔或隔室的装置，每个具有不同浓度的分析物传感器。可以将分析物样品引入每个孔，并且证明颜色变化的孔可以从其已知的分析物传感器浓度用于快速且准确地确定分析物的浓度。

3. 发明申请

WO2018005732A1 HALF-CURCUMINOIDS AS AMYLOID-BETA PET IMAGING AGENTS 审中-公开
标题翻译：半胱氨酸蛋白酶作为淀粉样蛋白PET成像剂
公开(公告)号：WO2018005732A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039885
申请日：2017-06-29
申请人： THE GENERAL HOSPITAL CORPORATION , RAN, Chongzhao , MOORE, Anna , YANG, Jian
发明人： RAN, Chongzhao , MOORE, Anna , YANG, Jian
IPC分类号： C07F5/02 , A61K51/04 , C07C49/248 , C07C49/252
摘要： Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.
摘要翻译：本文提供的是能够与淀粉样蛋白β（Aβ）相互作用并减弱铜诱导的Aβ交联的姜黄素类似物。本文还提供了使用这些化合物作为淀粉状蛋白β的显像剂并且用于治疗与淀粉状蛋白β相关的疾病的方法。还提供了制备可用于与淀粉状蛋白β和药物组合物相互作用的未标记和放射性标记的化合物的方法。

4. 发明申请

WO2010111066A2 INNATELY MULTIMODAL NANOPARTICLES 审中-公开
标题翻译：国际多模式纳米粒子
公开(公告)号：WO2010111066A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/027406
申请日：2010-03-16
申请人： THE GENERAL HOSPITAL CORPORATION , MEDAROVA, Zdravka , MOORE, Anna , YIGIT, Mehmet
发明人： MEDAROVA, Zdravka , MOORE, Anna , YIGIT, Mehmet
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： A61K49/1833 , A61K41/0052 , A61K49/0002 , A61K49/001 , A61K49/0423 , A61K49/183 , A61K49/1863 , B82Y5/00
摘要： A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses.
摘要翻译：公开了一种镀金氧化铁纳米颗粒，其制备方法及其使用方法。纳米颗粒基本上不含毒素（使其临床适用），易于功能化，并且可用作多种成像技术的造影剂，包括以至少两种不同成像模式成像受试者。此外，纳米颗粒非常适合于治疗用途。

5. 发明申请

WO2015034996A1 IMAGING BROWN ADIPOSE TISSUE WITH CURCUMIN DERIVATIVES 审中-公开
标题翻译：使用CURCUMIN衍生物成像棕色ADIPOSE组织
公开(公告)号：WO2015034996A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054012
申请日：2014-09-04
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： RAN, Chongzhao , MOORE, Anna , BROWNELL, Anna-Liisa
IPC分类号： C07D401/02
CPC分类号： A61K49/0002 , A61K49/0017 , A61K49/06 , A61K49/22 , A61K51/04 , C07D401/06 , C07D403/06 , C07D471/04
摘要： Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.
摘要翻译：用于在活体哺乳动物（例如人）中成像棕色脂肪组织（BAT）的方法和组合物。

6. 发明申请

WO2014025808A1 CURCUMIN ANALOGS 审中-公开
公开(公告)号：WO2014025808A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/053833
申请日：2013-08-06
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： RAN, Chongzhao , ZHANG, Xueli , MOORE, Anna
IPC分类号： C07D403/12 , C07D401/12 , C07C211/50 , A61K31/4178 , A61K31/4427 , A61P25/28
CPC分类号： C07D401/06 , C07C49/248 , C07C49/252 , C07C225/16 , C07C225/22 , C07D213/74 , C07D213/89 , C07D231/12 , C07D233/60 , C07D277/64 , C07D405/14 , C07D471/06 , C07F5/022
摘要： Provided herein are curcumin analogues that are able to interact with amyloid β (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder.
摘要翻译：本文提供了能够与淀粉样β（Abeta）相互作用并减弱铜诱导的Abeta交联的姜黄素类似物。本文还提供了使用该化合物治疗阿尔茨海默病或相关病症的方法。

7. 发明申请

WO2011014648A3 METHODS AND SYSTEM FOR DETECTING SOLUBLE AMYLOID-β 审中-公开
公开(公告)号：WO2011014648A3
公开(公告)日：2011-02-03
申请号：PCT/US2010/043700
申请日：2010-07-29
申请人： THE GENERAL HOSPITAL CORPORATION , RAN, Chongzhao , MOORE, Anna
发明人： RAN, Chongzhao , MOORE, Anna
IPC分类号： G01N33/50 , G01N33/52 , C07D213/02 , C07F5/05
摘要： The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a range of changes, qualifying them as "smart" probes. In addition, the invention provides methods of detecting soluble amyloid β by positron emission tomography (PET), magnetic resonance imaging (MRI) and multimodal imaging based on the curcumin-derived NIR imaging probes and derivatives thereof.

8. 发明申请

WO2013126501A1 METHODS AND ASSAYS RELATING TO PROSTATE CANCER 审中-公开
标题翻译：与前列腺癌相关的方法和测定
公开(公告)号：WO2013126501A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027022
申请日：2013-02-21
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： MOORE, Anna , MEDAROVA, Zdravka
IPC分类号： G01N33/493 , G01N33/70 , G01N33/84
CPC分类号： G01N33/20 , G01N33/493 , G01N33/57434 , G01N33/70 , G01N33/84 , G01N2800/52
摘要： The technology described herein relates to determining the zinc score in a sample obtained from a subject, e.g. for treating a subject for prostate cancer.
摘要翻译：本文所述的技术涉及确定从受试者获得的样品中的锌得分，例如，用于治疗前列腺癌的受试者。

9. 发明申请

WO2013016126A1 THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF 审中-公开
标题翻译：治疗性纳米颗粒及其使用方法
公开(公告)号：WO2013016126A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047366
申请日：2012-07-19
申请人： THE GENERAL HOSPITAL CORPORATION , MEDAROVA, Zdravka , YIGIT, Mehmet V. , MOORE, Anna
发明人： MEDAROVA, Zdravka , YIGIT, Mehmet V. , MOORE, Anna
IPC分类号： A61K31/7115 , A61K9/62 , A61K9/51 , A61P35/04 , B82Y5/00
CPC分类号： A61K9/51 , A61K9/0009 , A61K9/5036 , A61K9/5063 , A61K9/5115 , A61K31/7115 , A61K31/713 , A61K39/39558 , A61K45/06 , A61K47/62 , A61K47/6923 , A61K49/1824 , A61K2039/505 , A61N5/10 , B82Y5/00 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/3231 , C12N2310/351 , C12N2320/31 , C12N2320/32
摘要： Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject.
摘要翻译：本文提供了直径在10nm至30nm之间且含有聚合物涂层的治疗性纳米颗粒，以及含有与被鉴定为在癌细胞转移或抗癌作用中的作用的微小RNA内的序列互补的序列的核酸，癌细胞（例如miR-10b）中的凋亡活性或编码与纳米颗粒共价连接的促凋亡蛋白的mRNA内的序列。还提供含有这些治疗性纳米颗粒的药物组合物。本文还提供了减少患有癌症的受试者中的癌细胞侵袭或转移的方法以及治疗需要向受试者施用这些治疗纳米颗粒的受试者的淋巴结中的转移性癌症的方法。

10. 发明申请

WO2010017094A3 CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING 审中-公开
公开(公告)号：WO2010017094A3
公开(公告)日：2010-02-11
申请号：PCT/US2009/052335
申请日：2009-07-31
申请人： THE GENERAL HOSPITAL CORPORATION , CHONGZHAO, Ran , MOORE, Anna
发明人： CHONGZHAO, Ran , MOORE, Anna
IPC分类号： C07D213/24 , C07D213/16 , C07D319/06 , A61K31/4418 , A61K31/357 , A61P25/28
摘要： The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as "smart" probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques.

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