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1. 发明申请

WO2009075903A1 SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE 审中-公开
标题翻译：使用微波能量对指定组织产生影响的系统和方法
公开(公告)号：WO2009075903A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/060922
申请日：2008-04-18
申请人： THE FOUNDRY, INC. , MIRAMAR LABS, INC. , DEEM, Mark, E. , FRANCIS, Dan , JOHNSON, Jessi, Ernest , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HALLOCK, Dan
发明人： DEEM, Mark, E. , FRANCIS, Dan , JOHNSON, Jessi, Ernest , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HALLOCK, Dan
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/18 , A61B90/37 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00041 , A61B2018/00291 , A61B2018/0047 , A61B2018/00779 , A61B2018/0091 , A61B2018/1823 , A61F2007/0075 , A61N5/02 , A61N5/04 , A61N2005/007
摘要： Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.
摘要翻译：本文公开了用于产生使用微波能量到特定组织的效果的系统，方法和装置。在一些实施例中，用于将微波能量应用于组织的系统可以包括适于产生具有预定特征的微波信号的信号发生器，连接到发生器并适用于向组织施加微波能量的施加器，所述施加器包括一个或更多的微波天线和组织界面，连接到组织界面的真空源，连接到所述组织界面的冷却源，以及适于控制信号发生器，真空源和冷却剂源的控制器。组织可以包括第一层和第二层，第二层在第一层下面，并且控制器被配置为使得系统递送能量，使得在第二层中产生峰值功率损耗密度分布。

2. 发明申请

WO2008131306A1 SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE 审中-公开
标题翻译：使用微波能量对特定组织产生影响的系统和方法
公开(公告)号：WO2008131306A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060940
申请日：2008-04-18
申请人： THE FOUNDRY, INC. , MIRAMAR LABS, INC. , DEEM, Mark, E. , FRANCIS, Dan , JOHNSON, Jessi, Ernest , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HOLLOCK, Dan
发明人： DEEM, Mark, E. , FRANCIS, Dan , JOHNSON, Jessi, Ernest , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HOLLOCK, Dan
IPC分类号： A61B18/00
CPC分类号： A61B18/18 , A61B18/02 , A61B18/14 , A61B18/1815 , A61B18/20 , A61B2017/00106 , A61B2018/00023 , A61B2018/00214 , A61B2018/00291 , A61B2018/0212 , A61F2007/0075 , A61N1/406 , A61N5/062 , A61N7/02 , A61N2005/0651 , A61N2007/0008
摘要： Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.
摘要翻译：本文公开了用于使用微波能量产生对特定组织的效果的系统，方法和装置。在一些实施例中，用于将微波能量应用于组织的系统可以包括适于产生具有预定特征的微波信号的信号发生器，连接到发生器并适用于向组织施加微波能量的施加器，所述施加器包括一个或更多的微波天线和组织界面，连接到组织界面的真空源，连接到所述组织界面的冷却源，以及适于控制信号发生器，真空源和冷却剂源的控制器。组织可以包括第一层和第二层，第二层在第一层下面，并且控制器被配置为使得系统递送能量，使得在第二层中产生峰值功率损耗密度分布。

3. 发明申请

WO2009075879A1 SYSTEMS, APPARATUS, METHODS AND PROCEDURES FOR THE NONINVASIVE TREATMENT OF TISSUE USING MICROWAVE ENERGY 审中-公开
标题翻译：使用微波能量的组织非侵袭性治疗的系统，装置，方法和程序
公开(公告)号：WO2009075879A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/013650
申请日：2008-12-12
申请人： MIRAMAR LABS, INC. , THE FOUNDRY, INC. , JOHNSON, Jessi, Ernest , DEEM, Mark, E. , FRANCIS, Daniel , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HALLOCK, Daniel , BEN-HAIM, Yoav , SARAF, Shailendhar
发明人： JOHNSON, Jessi, Ernest , DEEM, Mark, E. , FRANCIS, Daniel , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HALLOCK, Daniel , BEN-HAIM, Yoav , SARAF, Shailendhar
IPC分类号： A61N5/02
CPC分类号： A61B18/1815 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00023 , A61B2018/00291 , A61F2007/0075 , A61N7/02 , A61N2007/0008
摘要： The present invention is directed to systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy. In one embodiment of the invention a medical device and associated apparatus and procedures are used to treat dermatological conditions using microwave energy.
摘要翻译：本发明涉及使用微波能量对组织进行非侵入性处理的系统，装置，方法和程序。在本发明的一个实施例中，使用医疗装置和相关联的装置和程序来使用微波能量来治疗皮肤病学条件。

4. 发明申请

WO2010047818A1 SYSTEMS, APPARATUS, METHODS, AND PROCEDURES FOR THE NON-INVASIVE TREATMENT OF TISSUE USING MICROWAVE ENERGY 审中-公开
标题翻译：使用微波能量对非组织治疗组织的系统，装置，方法和程序
公开(公告)号：WO2010047818A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/005772
申请日：2009-10-22
申请人： MIRAMAR LABS, INC. , KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUNG, Dong, Hoon , BEN-HAIM, Yoav , LOEW, Christopher , KOPELOW, Leo , CHEW, Sunmi
发明人： KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUNG, Dong, Hoon , BEN-HAIM, Yoav , LOEW, Christopher , KOPELOW, Leo , CHEW, Sunmi
IPC分类号： A61H1/00
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00115 , A61B2017/00199 , A61B2017/00477 , A61B2017/306 , A61B2018/00023 , A61B2018/00702 , A61B2018/183 , A61B2034/252 , A61B2034/254 , A61B2090/372 , A61H9/0057 , A61N5/02
摘要： A system applies, in a non- invasive manner, energy to a targeted tissue region employing a controlled source of energy, a multiple use applicator, and a single use, applicator- tissue interface carried by the applicator. The system can generate and apply energy in a controlled fashion to form a predefined pattern of lesions that provide therapeutic benefit, e.g., to moderate or interrupt function of the sweat glands in the underarm (axilla).
摘要翻译：系统以非侵入性的方式将能量应用于使用受控的能量源，多用途施用器和由施用器承载的单次使用的施用器 - 组织界面的目标组织区域。该系统可以以受控的方式产生和施加能量，以形成提供治疗益处的预定模式的病变，例如在腋下（腋窝）中的汗腺的中度或中断功能。

5. 发明申请

WO2009128940A1 SYSTEMS, APPARATUS, METHODS AND PROCEDURES FOR THE NONINVASIVE TREATMENT OF TISSUE USING MICROWAVE ENERGY 审中-公开
标题翻译：使用微波能量的组织非侵袭性治疗的系统，装置，方法和程序
公开(公告)号：WO2009128940A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/002403
申请日：2009-04-17
申请人： MIRAMAR LABS, INC. , KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUN, Dong, Hoon , BEN-HAIM, Yoav
发明人： KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUN, Dong, Hoon , BEN-HAIM, Yoav
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B2017/00106 , A61B2018/00023 , A61B2018/00291 , A61B2018/00452 , A61N5/04
摘要： The present invention is directed to systems, apparatus, methods and procedures for the noninvasive treatment of tissue, including treatment using microwave energy. In one embodiment of the invention a medical device and associated apparatus and procedures are used to treat dermatological conditions using, for example, microwave energy.
摘要翻译：本发明涉及用于非侵入性处理组织的系统，装置，方法和程序，包括使用微波能量的处理。在本发明的一个实施例中，使用医疗装置和相关联的装置和程序来使用例如微波能量来治疗皮肤病学病症。

6. 发明申请

WO2010096840A2 TISSUE INTERFACE SYSTEM AND METHOD 审中-公开
标题翻译：组织界面系统和方法
公开(公告)号：WO2010096840A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/025124
申请日：2010-02-23
申请人： MIRAMAR LABS, INC. , KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUNG, Dong, Hoon , BEN-HAIM, Yoav , LOEW, Christopher
发明人： KIM, Steven , FRANCIS, Daniel , JOHNSON, Jessi, E. , SALAMINI, Alexey , SU, Ted , CHUNG, Dong, Hoon , BEN-HAIM, Yoav , LOEW, Christopher
IPC分类号： A61H7/00 , A61M1/00 , A61B5/00 , A61B5/04 , A61B5/05
CPC分类号： A61B18/18 , A61B18/1815 , A61B90/98 , A61B2017/306 , A61B2018/00005 , A61B2090/3937 , A61H9/0057 , A61H2201/10 , A61H2201/1685 , A61N5/02 , A61N5/04
摘要： An applicator-tissue interface is disclosed for use in connection with medical device treatment applicators. The interface provides a cover to protect applicator components against contamination and may be disposable or reusable. Also included are tissue acquisition features including a tissue receiving chamber defined by a bio-barrier with vacuum ports or channels for tissue acquisition. Vacuum balancing is provided to prevent contamination on the applicator side of the bio-barrier. Locking mechanisms are disclosed for ensuring secure attachment between the interface and applicator. Methods of using the applicator-tissue interface in connection with an applicator are also disclosed.
摘要翻译：公开了一种与医疗器械治疗敷料器结合使用的涂抹器 - 组织界面。界面提供了一个保护涂料组件免受污染的盖子，可以是一次性的或可重复使用的。还包括组织采集特征，包括由具有用于组织采集的真空端口或通道的生物屏障限定的组织接收室。提供真空平衡以防止生物屏障的施用器侧的污染。公开了锁定机构以确保接口和施加器之间的牢固连接。还公开了与施用器相关地使用施用器 - 组织界面的方法。

7. 发明申请

WO2013019796A1 APPLICATOR AND TISSUE INTERFACE MODULE FOR DERMATOLGICAL DEVICE 审中-公开
标题翻译：用于人体器官的应用者和组织界面模块
公开(公告)号：WO2013019796A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/048999
申请日：2012-07-31
申请人： MIRAMAR LABS, INC. , BEN-HAIM, Yoav , BENTLEY, Peter, J. , CHUN, Dong Hoon , FRANCIS, Daniel , JOHNSON, Jessi, E. , SHAN, Kevin , SU, Ted , KIM, Steven
发明人： BEN-HAIM, Yoav , BENTLEY, Peter, J. , CHUN, Dong Hoon , FRANCIS, Daniel , JOHNSON, Jessi, E. , SHAN, Kevin , SU, Ted , KIM, Steven
IPC分类号： A61B18/18
CPC分类号： A61N5/04 , A61B18/1815 , A61B2018/00452 , A61N5/022
摘要： A dermatological energy applicator and tissue interface module are provided which may include any number of features. The dermatological energy applicator can be configured to apply microwave energy to tissue to treat conditions of the skin, including hyperhidrosis or excessive sweating. The energy applicator can further include a cooling element and vacuum ports. The tissue interface module can include an applicator chamber adapted to receive the energy applicator, and can further include a tissue acquisition chamber adapted to engage tissue, a bio-barrier configured to prevent passage of gas and liquid, and a filter disposed between the applicator chamber and the tissue acquisition chamber configured to prevent passage of gas but prevent passage of liquid.
摘要翻译：提供了皮肤能量施加器和组织接口模块，其可以包括任何数量的特征。皮肤能量施加器可以被配置为将微波能量施加到组织以治疗皮肤的状况，包括多汗症或过度出汗。能量施加器还可包括冷却元件和真空端口。组织接口模块可以包括适于接收能量施加器的施用器室，并且还可以包括适于接合组织的组织采集室，被配置为防止气体和液体通过的生物屏障以及设置在施用器室并且所述组织采集室被配置为防止气体通过，但是防止液体通过。

8. 发明申请

WO2013019785A1 APPLICATOR AND TISSUE INTERFACE MODULE FOR DERMATOLOGICAL DEVICE 审中-公开
标题翻译：用于皮肤装置的适用者和组织界面模块
公开(公告)号：WO2013019785A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/048957
申请日：2012-07-31
申请人： MIRAMAR LABS, INC. , BEN-HAIM, Yoav , BENTLEY, Peter, J. , CHUN, Dong, Hoon , FRANCIS, Daniel , JOHNSON, Jessi, E. , SHAN, Kevin , SU, Ted , KIM, Steven
发明人： BEN-HAIM, Yoav , BENTLEY, Peter, J. , CHUN, Dong, Hoon , FRANCIS, Daniel , JOHNSON, Jessi, E. , SHAN, Kevin , SU, Ted , KIM, Steven
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B2018/00023 , A61B2018/00172 , A61B2018/00291 , A61B2018/00452 , A61B2018/00464 , A61B2018/0047 , A61B2018/00476
摘要： An tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.
摘要翻译：组织接口模块在组织接口模块的近侧具有施用室，在组织接口模块的远端侧具有组织采集室。施用器室可以包括：适于接收施用器的开口; 定位在所述施用器腔室中并适于将所述组织界面模块附接到所述施用器的附接机构; 位于所述施用器腔室的近侧的密封构件; 以及位于所述施用器腔室的近侧的真空接口，并且适于接纳位于所述施用器的远端上的真空入口。本发明还包括相应的方法。

9. 发明公开

EP2142128A1 SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE 有权
标题翻译：系统创建具有微波能量关于指定结构的影响
公开(公告)号：EP2142128A1
公开(公告)日：2010-01-13
申请号：EP08746358.4
申请日：2008-04-18
申请人： The Foundry, Inc. , Miramar Labs, INC.
发明人： DEEM, Mark, E. , FRANCIS, Dan , JOHNSON, Jessi, Ernest , KIM, Steven , SALAMINI, Alexey , SU, Ted , SMITH, Peter , HALLOCK, Dan
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/18 , A61B90/37 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00041 , A61B2018/00291 , A61B2018/0047 , A61B2018/00779 , A61B2018/0091 , A61B2018/1823 , A61F2007/0075 , A61N5/02 , A61N5/04 , A61N2005/007
摘要： Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.

10. 发明申请

WO2003088806A2 LOCALIZATION ELEMENT WITH ENERGIZED TIP 审中-公开
标题翻译：具有能量提示的本地化元件
公开(公告)号：WO2003088806A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/010987
申请日：2003-04-11
申请人： VIVANT MEDICAL, INC. , SU, Ted , TUROVSKIY, Roman , KIM, Steven , PRAKASH, Mani
发明人： SU, Ted , TUROVSKIY, Roman , KIM, Steven , PRAKASH, Mani
IPC分类号： A61B
CPC分类号： A61B18/1815 , A61B18/1477 , A61B18/18 , A61B90/39 , A61B2018/1425 , A61B2018/1435 , A61B2018/1475 , A61B2018/183 , A61B2090/3908
摘要： This invention is an improved tissue-localizing device with an electrically energized locator element for fixedly yet removably marking a volume of tissue containing a suspect region for excision. The electrical energizing of the locator element facilitates the penetration of the locator element in to subject's tissue and minimizes resistance due to dense or calcified tissues. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Delivery of electric current may be achieved through monopolar or bipolar electronic configuration depending on design needs. Various energy sources, e.g. radio frequency, microwave or ultrasound, may be implemented in this energized tissue-localizing device.
摘要翻译：本发明是一种改进的组织定位装置，其具有用于固定地可移除地标记包含可疑区域的组织的体积的用于切除的电激励定位元件。定位器元件的电能激励定位元件穿透到受试者的组织中并使由于致密或钙化组织引起的阻力最小化。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。根据设计需要，可以通过单极或双极电子配置实现电流传递。各种能量源射频，微波或超声可以在这种激活的组织定位装置中实现。

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