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1. 发明申请

WO1996011944A1 SYNTHETIC PEPTIDES AND VACCINES COMPRISING SAME 审中-公开
标题翻译：合成肽和包含相同的疫苗
公开(公告)号：WO1996011944A1
公开(公告)日：1996-04-25
申请号：PCT/AU1995000681
申请日：1995-10-16
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , COOPER, Juan, Anton , RELF, Wendy, Anne , GOOD, Michael, Frances , SAUL, Allan, James
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： C07K07/08
CPC分类号： C07K14/315 , A61K39/00 , C07K14/43545 , C07K14/705 , C07K2319/00
摘要： The present invention relates generally to chimeric peptides comprising one or more protective epitopes in a conformation enabling immunological interactivity and to vaccine compositions comprising same. The present invention is particularly directed to a chimeric peptide capable of inducing protecting antibodies against Group A streptococci.
摘要翻译：本发明一般涉及包含能够实现免疫交互作用的构象中的一种或多种保护性表位的嵌合肽和包含其的疫苗组合物。本发明特别涉及能够诱导针对A组链球菌的抗体的嵌合肽。

2. 发明申请

WO1997045444A1 EBV CTL EPITOPES 审中-公开
标题翻译： EBV CTL抗体
公开(公告)号：WO1997045444A1
公开(公告)日：1997-12-04
申请号：PCT/AU1997000328
申请日：1997-05-23
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , KHANNA, Rajiv , KERR, Beverley, Mavis , MISKO, Ihor, Spephan , MOSS, Denis, James , BURROWS, Scott, Renton
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C12N2710/16222 , Y02A50/466
摘要： The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.
摘要翻译：本发明提供细胞毒性的爱泼斯坦 - 巴尔病毒T细胞表位。这些表位是QVKWRMTTL，VFSDGRVAC，VPAPAGPIV，TYSAGIVQI，LLDFVRFMGV，QNGALAINTF，VSSDGRVAC，VSSEGRVAC，VSSDGRVPC，VSSDGLVAC，VSSDGQVAC，VSSDGRVVC，VPAPPVGPIV，VEITPYEPTG，VEITPYEPTW，VELTPYKPTW，RRIYDLIKL，RKIYDLIEL和PYLFWLAGI。本发明进一步提供疫苗，其包括这些表位中的一个或多个，任选地具有另外的表位。

3. 发明申请

WO1995024926A1 FORMULATION FOR USE IN INDUCING CYTOTOXIC T-CELLS 审中-公开
标题翻译：用于诱导细胞毒T细胞的配方
公开(公告)号：WO1995024926A1
公开(公告)日：1995-09-21
申请号：PCT/AU1995000141
申请日：1995-03-16
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , COX, John, Cooper , SUHRBIER, Andreas , ELLIOTT, Suzanne, Louise
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16722 , Y02A50/466
摘要： The present invention provides a composition where a CTL peptide is presented in such a way as to maximise the attachment of peptide to class 1 MHC molecules on the external surface of cells and the subsequent processing of these cells in the optimal way to induce high-affinity CD8 CTL responses. Preferably, the composition comprises a water-in-oil formulation including at least one antigen to which the individual will mount an anamnestic response and at least one cytotoxic T-cell epitope.
摘要翻译：本发明提供了一种组合物，其中CTL肽以使得肽在细胞外表面上与1类MHC分子的连接最大化的方式存在，并且以最佳方式随后处理这些细胞以诱导高亲和力 CD8 + CTL反应。优选地，组合物包含油包水制剂，其包含至少一种抗原，所述抗原将个体将载持至少一种毒性反应和至少一种细胞毒性T细胞表位。

4. 发明申请

WO1995024925A1 CYTOTOXIC T-CELL EPITOPES 审中-公开
标题翻译：细胞毒T细胞抗原
公开(公告)号：WO1995024925A1
公开(公告)日：1995-09-21
申请号：PCT/AU1995000140
申请日：1995-03-16
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , MOSS, Denis, James , BURROWS, Scott, Renton , KHANNA, Rajiv , KERR, Beverley, Mavis , BURROWS, Jacqueline, Margaret , SUHRBIER, Andreas
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16722 , Y02A50/466
摘要： The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. The epitopes are selected from the group consisting of QAKWRLQTL, RYSIFFDY, HLAAQGMAY, YPLHEQHGM, SVRDRLARL, AVLLHEESM, VSFIEFVGW, FRKAQIQGL, PYLFWLAAI, TVFYNIPPMPL, PGDQLPGFSDGRACPV, VEITPYKPTW, and variants thereof. In addition, the present invention provides compositions including these epitopes for use in inducing CTL's in a subject.
摘要翻译：本发明提供细胞毒性的爱泼斯坦 - 巴尔病毒T细胞表位。表位选自QAKWRLQTL，RYSIFFDY，HLAAQGMAY，YPLHEQHGM，SVRDRLARL，AVLLHEESM，VSFIEFVGW，FRKAQIQGL，PYLFWLAAI，TVFYNIPPMPL，PGDQLPGFSDGRACPV，VEITPYKPTW及其变体。此外，本发明提供包含用于在受试者中诱导CTL的这些表位的组合物。

5. 发明申请

WO1996003144A1 POLYEPITOPE VACCINES 审中-公开
标题翻译：多肽疫苗
公开(公告)号：WO1996003144A1
公开(公告)日：1996-02-08
申请号：PCT/AU1995000461
申请日：1995-07-27
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMENWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , SUHRBIER, Andreas , THOMSON, Scott, Anthony , KHANNA, Rajiv , BURROWS, Scott, Renton , COUPAR, Barbara, Elizabeth, Howieson , MOSS, Denis, James
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMENWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , C12N15/86 , C12N2760/16122
摘要： The present invention relates to a recombinant polyepitope cytotoxic T lymphocyte vaccine. The vaccine comprises at least one recombinant protein including a plurality of cytotoxic T lymphocyte epitopes from one or more pathogens, wherein the at least one recombinant protein is substantially free of sequences naturally found to flank the cytotoxic T lymphocyte epitopes. In addition the present invention also provides a polynucleotide including at least one sequence encoding a plurality of cytotoxic T lymphocyte epitopes from one or more pathogens.
摘要翻译：本发明涉及重组多表位细胞毒性T淋巴细胞疫苗。所述疫苗包含至少一种重组蛋白，其包含来自一种或多种病原体的多种细胞毒性T淋巴细胞表位，其中所述至少一种重组蛋白基本上不含天然存在于所述细胞毒性T淋巴细胞表位侧翼的序列。此外，本发明还提供了包含至少一种编码来自一种或多种病原体的多种细胞毒性T淋巴细胞表位的序列的多核苷酸。

6. 发明申请

WO1998006853A1 TREATMENT AND PREVENTION OF HELICOBACTER INFECTION 审中-公开
标题翻译：治疗和预防呼吸道感染
公开(公告)号：WO1998006853A1
公开(公告)日：1998-02-19
申请号：PCT/AU1997000515
申请日：1997-08-14
申请人： CSL LIMITED , THE UNIVERSITY OF NEW SOUTH WALES
发明人： CSL LIMITED , THE UNIVERSITY OF NEW SOUTH WALES , DOIDGE, Christopher, Vincent , LEE, Adrian , RADCLIFF, Fiona, Jane , HAZELL, Stuart, Lloyd
IPC分类号： C12N15/53
CPC分类号： C12N9/0065 , A61K39/00
摘要： An antigenic preparation for use in the treatment or prevention of Helicobacter infection in a mammalian host, comprises recombinant catalase enzyme of Helicobacter bacteria, particularly recombinant catalase enzyme of H. pylori or H. felis, or an immunogenic fragment thereof.
摘要翻译：用于治疗或预防哺乳动物宿主中幽门螺杆菌感染的抗原制剂包括幽门螺杆菌细菌的重组过氧化氢酶，特别是幽门螺杆菌或幽门螺杆菌的重组过氧化氢酶或其免疫原性片段。

7. 发明申请

WO1994015636A1 VACCINE PREPARATIONS 审中-公开
标题翻译：疫苗制剂
公开(公告)号：WO1994015636A1
公开(公告)日：1994-07-21
申请号：PCT/AU1993000677
申请日：1993-12-24
申请人： CSL LIMITED , COX, John, Cooper , SPARKS, Robert, Edward , JACOBS, Irwin, Clay , MASON, Norbert, Simon
发明人： CSL LIMITED
IPC分类号： A61K39/39
CPC分类号： A61K9/1647 , A61K39/39 , A61K47/52 , A61K2039/55505 , A61K2039/55555
摘要： Vaccine preparations in stable particulate form are disclosed. An immediate-release preparation comprises an immunogen adsorbed to an aluminium salt adjuvant. A controlled- or delayed-release preparation comprises microspherical particles comprising a continuous matrix of biodegradable polymer containing discrete, immunogen-containing regions.
摘要翻译：公开了稳定颗粒形式的疫苗制剂。立即释放制剂包含吸附在铝盐佐剂上的免疫原。受控或延迟释放制剂包含微球颗粒，其包含含分散的含免疫原区域的可生物降解的聚合物的连续基质。

8. 发明申请

WO1998023635A1 NOVEL PROMISCUOUS T HELPER CELL EPITOPES 审中-公开
标题翻译：新颖的促销细胞环节
公开(公告)号：WO1998023635A1
公开(公告)日：1998-06-04
申请号：PCT/AU1997000820
申请日：1997-12-01
申请人： THE UNIVERSITY OF QUEENSLAND , CSL LIMITED , FRAZER, Ian, Hector , TINDLE, Robert , AZOURY-ZIADEH, Rania
发明人： THE UNIVERSITY OF QUEENSLAND , CSL LIMITED
IPC分类号： C07K04/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/6075 , A61K2039/70 , C12N2710/20022 , C12N2710/20034
摘要： The invention is directed to a peptide encoding a promiscuous T helper cell epitope for generating an immune response against papillomavirus, wherein the peptide is selected from the group consisting of (i) VYRDGNPYA inclusive of a single amino acid deletion, substitution or addition made therein (SEQ ID NO. 1); and (ii) QYNKPLCDLL inclusive of a single amino acid deletion, substitution or addition made therein (SEQ ID NO. 2). The invention is also concerned with chimeric constructs as well as immunogenic compositions comprising the peptides of the invention.
摘要翻译：本发明涉及一种编码混杂T辅助细胞表位的肽，用于产生针对乳头瘤病毒的免疫应答，其中该肽选自（i）包含其中制备的单一氨基酸缺失，取代或加成的VYRDGNPYA（ SEQ ID NO.1）; 和（ii）QYNKPLCDLL，其包括其中制备的单个氨基酸缺失，取代或加成（SEQ ID NO.2）。本发明还涉及嵌合构建体以及包含本发明的肽的免疫原性组合物。

9. 发明申请

WO1995022556A1 PROCESS FOR REMOVING ENDOTOXINS 审中-公开
标题翻译：去除内毒素的方法
公开(公告)号：WO1995022556A1
公开(公告)日：1995-08-24
申请号：PCT/AU1995000071
申请日：1995-02-15
申请人： CSL LIMITED , DAVIES, Jeffrey, Raymond
发明人： CSL LIMITED
IPC分类号： C07K01/16
CPC分类号： C07K14/245 , C07K14/765
摘要： A process for the removal of endotoxins from a biological product, particularly a blood plasma fraction such as albumin, comprises contacting the biological product with a cross-linked hydrophilic matrix comprising a copolymer of allyl dextran and N,N'-methylene bisacrylamide under conditions effective to bind endotoxins in the biological product to the matrix, and recovering purified biological product from which endotoxins have been removed. After recovery of the purified biological product, the matrix can be regenerated under conditions effective to elute bound endotoxins from the matrix.
摘要翻译：用于从生物产物，特别是血浆级分如白蛋白中去除内毒素的方法包括使生物产物与包含烯丙基葡聚糖和N，N'-亚甲基双丙烯酰胺的共聚物的交联的亲水基质在有效的条件下接触将生物制品中的内毒素与基质结合，并回收已除去内毒素的纯化生物制品。在纯化的生物产物回收之后，可以在有效地从基质中洗脱结合的内毒素的条件下再生基质。

10. 发明申请

WO1995003824A1 TREATMENT OF H. PYLORI ASSOCIATED GASTRODUODENAL DISEASE 审中-公开
标题翻译： H. PYLORI相关胃肠病的治疗
公开(公告)号：WO1995003824A1
公开(公告)日：1995-02-09
申请号：PCT/AU1994000416
申请日：1994-07-25
申请人： CSL LIMITED , THE UNIVERSITY OF NEW SOUTH WALES , DOIDGE, Christopher, Vincent , LEE, Adrian
发明人： CSL LIMITED , THE UNIVERSITY OF NEW SOUTH WALES
IPC分类号： A61K39/02
CPC分类号： A61K39/105 , A61K2039/521 , A61K2039/542 , A61K2039/55544
摘要： A method for the treatment of Helicobacter infection, preferably H. pylori infection in a mammalian host such as a human comprises administration to the infected host of an immunologically effective amount of one or more Helicobacter antigen(s), preferably in association with a mucosal adjuvant such as cholera toxin or E.coli heat labile toxin.
摘要翻译：用于治疗哺乳动物宿主例如人的幽门螺杆菌感染，优选幽门螺旋杆菌感染的方法包括向感染的宿主施用免疫有效量的一种或多种幽门螺杆菌抗原，优选与粘膜佐剂如霍乱毒素或大肠杆菌热不稳定毒素。

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